ライフサイエンスコーパス: perichondrium

1 nse preceded by ectopic BMP signaling within perichondrium.

2 ciated with ectopic bone collars in adjacent perichondrium.

3 elated protein (PTHrP), in the periarticular perichondrium.

4 sed in both the stacked chondrocytes and the perichondrium.

5 rentiation in the bone-forming region in the perichondrium.

6 pic cartilaginous tissues protruded into the perichondrium.

7 tal analysis showed to be dependent upon the perichondrium.

8 Cre activity in chondrocytes but not in the perichondrium.

9 en chondrocytes and cells in the surrounding perichondrium.

10 nchymal stem cells (MSCs) in bone marrow and perichondrium.

11 ite of bone collar formation in the adjacent perichondrium.

12 unding the early cartilage template form the perichondrium.

13 n level of several BMP genes in the adjacent perichondrium.

14 s synthesized by chondrogenic mesenchyme and perichondrium.

15 amma, while RARbeta expression was strong in perichondrium.

16 on in both growth plate cartilage and in the perichondrium.

17 in both growth plate chondrocytes and in the perichondrium.

18 The perichondrium, a structure made of undifferentiated mese

19 ssive intramembranous ossification along the perichondrium, accompanied by excessive Patched-1 expres

20 ssive intramembranous ossification along the perichondrium, accompanied by local expression of the he

21 ing so intimately associated with cartilage, perichondrium acquires and maintains its distinct phenot

22 ytes incorporating BrdU, indicating that the perichondrium also negatively regulates the proliferatio

23 ubsets of chondrocytes without affecting the perichondrium and found that Smo removal led to localize

24 to follow the fate of cells derived from the perichondrium and from the vasculature.

25 icroscopy is used to image through an intact perichondrium and into the cartilage of anesthetized mic

26 ression in hypertrophic chondrocytes and the perichondrium and is sufficient to induce Vegf expressio

27 Indeed, conditional Ext1 ablation in perichondrium and lateral chondrocytes flanking the epip

28 a third paralogue is expressed later in the perichondrium and mandibular arch.

29 at the histologically distinct layers of the perichondrium and periosteum are associated with distinc

30 letal tissues, we generated microarrays from perichondrium and periosteum cDNA libraries and used the

31 Previously, we observed that removal of the perichondrium and periosteum from tibiotarsi in organ cu

32 The perichondrium and periosteum have recently been suggeste

33 To determine if the perichondrium and periosteum regulate growth through the

34 irement for regulatory factors from both the perichondrium and periosteum suggests a novel mechanism

35 the inhibition of chondrocyte maturation by perichondrium and reveals that Runx2 fulfills antagonist

36 nding that VEGF is expressed robustly in the perichondrium and surrounding tissue of cartilage templa

37 spatially adjacent tissues such as cartilage/perichondrium and tendon/muscle connective tissue.

38 Here we show that Fgf18 is expressed in the perichondrium and that mice homozygous for a targeted di

39 is required for blood vessel recruitment in perichondrium and the differentiation of osteoblast prec

40 ll cultures of the region bordering both the perichondrium and the periosteum, (2) co-cultures of per

41 d, elongated cells called, respectively, the perichondrium and the periosteum.

42 into the hypertrophic cartilage and both the perichondrium and the vasculature are essential for endo

43 anization and morphogenesis of chondrocytes, perichondrium, and bone in uxs1 mutants.

44 esenchymal condensations of limbs, vertebral perichondrium, and mesenchymal cells of the intervertebr

45 h is expressed in chondrocytes, cells of the perichondrium, and the primary spongiosa in fetal growth

46 implicate three tissues, the cartilage, the perichondrium, and the vascular endothelium.

47 further the contributions of the cartilage, perichondrium, and vascular endothelium to long bone dev

48 cytes and in the outermost cell layer of the perichondrium, and Wnt-4 is expressed in cells of the jo

49 uggests that both types of regulation by the perichondrium are local effects.

50 Endothelial cells residing within the perichondrium are the first cells to participate in the

51 P38 was detected in articular cartilage and perichondrium; articular and sternal chondrocytes expres

52 Because perichondrium becomes deranged and interrupted by cartil

53 elayed recruitment of blood vessels into the perichondrium but also show delayed invasion of vessels

54 We found that the perichondrium, but not the host vasculature, is the sour

55 normal initiation of cartilage canals at the perichondrium, but the excavation of these canals into t

56 , changes in BMP5 and BMP7 expression in the perichondrium correspond to altered differentiation stat

57 premature osteoblast differentiation in the perichondrium, coupled with impaired proliferation, surv

58 The perichondrium decreased (r(2) = 0.684) from 20 weeks onw

59 s caused by dysregulation of chondrocyte and perichondrium development partially due to loss of Trps1

60 lization of fibrillin and fibulin-2 in skin, perichondrium, elastic intima of blood vessels, and kidn

61 ose expression in cartilage is restricted to perichondrium, favors chondrocyte maturation in a Runx2-

62 the important roles of TGF-beta signaling in perichondrium formation and differentiation, as well as

63 ition of bovine parathyroid hormone (PTH) to perichondrium-free cultures reversed the expansion of th

64 Partial removal of perichondrium from one side of the tibiotarsus led to ex

65 in chondrocyte layer located adjacent to the perichondrium in the peripheral cartilage.

66 We examined the role of perichondrium in this process using an organ culture sys

67 monstrated accelerated mineralization of the perichondrium in Trps1 mutant mice and impaired dentin m

68 rentiation and accelerated mineralization of perichondrium in Trps1 mutant mice.

69 Removal of perichondrium, in addition, resulted in an extended zone

70 We show that although the perichondrium influences the rate of chondrocytes matura

71 sion are also observed in endothelial cells, perichondrium, intestine, and mesenchyme of the face and

72 dothelial cells and osteoclasts migrate from perichondrium into primary ossification centers of carti

73 The absence of perichondrium is correlated with an extended zone of car

74 The perichondrium is crucial for the proper invasion of bloo

75 n cultures and that TGFbeta signaling in the perichondrium is required for inhibition of differentiat

76 ten into a definitive, endothelial cell-rich perichondrium like their wild-type counterparts.

77 sing chondrocytes and fibronectin-expressing perichondrium-like cells surrounding chondrocyte nodules

78 These defects in the perichondrium likely caused the short bones and ectopic

79 P-2 colocalized with tropoelastin within the perichondrium, lung, dermis, large arterial vessels, epi

80 es expression of Tgfb2 and Tgfb3 mRNA in the perichondrium of embryonic mouse metatarsal bones grown

81 rsely, Bmp4 expression is upregulated in the perichondrium of Fgfr3-/- mice.

82 A transcripts were strongly expressed in the perichondrium of Meckel's cartilage and mesenchymal area

83 ensive expression of Preb is observed in the perichondrium of the craniofacial, axial, and appendicul

84 pression of human WNT11 is restricted to the perichondrium of the developing skeleton, lung mesenchym

85 and this together with its expression in the perichondrium of the developing skeleton, makes it a pla

86 yseal shape, secondary ossification, and the perichondrium on 1.5-T echo-planar MR images and correla

87 le of Smad3 independently of its role in the perichondrium or other tissues.

88 ipulations to address how the absence of the perichondrium or the vascular endothelium affected skele

89 ilage and bone are surrounded by the fibrous perichondrium (PC) and periosteum (PO), respectively, wh

90 essing osteoblast precursors, labeled in the perichondrium prior to vascular invasion of the cartilag

91 model in which overexpression of Wdr5 in the perichondrium promotes chondrocyte differentiation by mo

92 se results are consistent with a model where perichondrium regulates both the exit of chondrocytes fr

93 anism by which overexpression of Wdr5 in the perichondrium regulates chondrocyte differentiation, stu

94 ressing collagen type X, suggesting that the perichondrium regulates chondrocyte hypertrophy in a neg

95 one at the site of removal but not where the perichondrium remained intact.

96 and HS are needed to establish and maintain perichondrium's phenotype and border function, restrain

97 in mutants, reflecting improper chondrocyte/perichondrium signaling.

98 , the first osteoblasts differentiate in the perichondrium surrounding avascular cartilaginous rudime

99 A expression was localized to the periosteum/perichondrium, syno-vium, and articular cartilage.

100 l plate mesoderm-derived tissues (cartilage, perichondrium, tendon, muscle connective tissue, and der

101 e connective tissue fibroblasts of the outer perichondrium, tendons and muscle connective tissue of t

102 e, which is derived from the Dlx5-expressing perichondrium that surrounds the diaphyses of the cartil

103 nonendothelial Nes(+) cells in the embryonic perichondrium; the latter were early cells of the osteob

104 ck loop that signals through the periosteum/ perichondrium to inhibit cartilage differentiation.

105 Perichondrium was quite rich in atRA (about 4.9 nM).

106 The direct target of Ihh signaling is the perichondrium, where Gli and Ptc flank the expression do

107 that resemble chondrocytes derived from the perichondrium, which is not typical of Indian hedgehog m

108 and their growth plates become delimited by perichondrium with which they interact functionally.

109 the chicken limb: Wnt-5a is expressed in the perichondrium, Wnt-5b is expressed in a subpopulation of