ライフサイエンスコーパス: perinatal

1 fatty acids (PUFAs) is believed to regulate perinatal adipogenesis, but the cellular mechanisms and

2 lation, intraventricular bleeding, and other perinatal adverse events.

3 to 1.18; P=0.90) or in secondary maternal or perinatal adverse outcomes.

4 ll death in 16 forebrain regions across nine perinatal ages from embryonic day (E) 17 to postnatal da

5 While the effects of perinatal air pollution exposure have been investigated,

6 g taxation has been associated with improved perinatal and child health outcomes.

7 control policies (MPOWER) was of benefit to perinatal and child health.

8 important in Africa, where the incidence of perinatal and early risk factors is high.

9 ng a mouse model system, we report here that perinatal and juvenile neuronal ablation of AnkG has dif

10 We used probabilistic linking of perinatal and maternal vaccination records to establish

11 ered by community health workers in reducing perinatal and neonatal mortality is well established, ev

12 dge of the association between abruption and perinatal and neonatal outcomes.

13 uterine therapy provides benefits during the perinatal and neonatal period; however, it may not provi

14 nscious mice of any postnatal age, including perinatal and neonatal stages, with precise spatiotempor

15 trend, nature, and correlates of suicide in perinatal and non-perinatal women in contact with psychi

16 We compared suicides among perinatal and non-perinatal women with logistic regressi

17 c regression analysis was used to adjust for perinatal and postnatal confounders.

18 RATIONALE: Perinatal and postnatal influences are presumed importan

19 974-1994), including BCG vaccination status, perinatal and sociodemographic characteristics, and use

20 ing HIV/AIDS and tuberculosis) and maternal, perinatal, and nutritional causes, non-communicable dise

21 st regarding the influence of preconception, perinatal, and postnatal exposures on general lung healt

22 We used a mouse model of perinatal antibiotic exposure to examine the effect of G

23 al dentate gyrus (DG), drastically increased perinatal apoptosis, altered DG cell composition, and im

24 rth, low-birth-weight, congenital anomalies, perinatal asphyxia, postsurgical, and sepsis categories.

25 We recently demonstrated that perinatal BPA exposure is associated with higher body fa

26 H) regulates many cellular events underlying perinatal brain development in vertebrates.

27 may explain why males are more vulnerable to perinatal brain injuries than females.

28 Perinatal brain injuries, including hippocampal lesions,

29 brains is important for better understanding perinatal brain injuries, of which the most common etiol

30 Hippocampal volume was reduced in the perinatal brain injury group relative to controls (Cohen

31 pamine synthesis capacity was reduced in the perinatal brain injury group relative to those without b

32 pared adults who were born very preterm with perinatal brain injury to those born very preterm withou

33 in injury to those born very preterm without perinatal brain injury, and age-matched controls born at

34 erapy interventions in infants with pre- and perinatal brain injury.

35 All these 25 patients suffered from pre- or perinatal brain lesions.

36 thways with direct protective effects on the perinatal brain.

37 mely preterm infants who had received active perinatal care, 293 (66.4%) had no or mild disability at

38 The setting was a regional perinatal center in Hamilton, New Zealand.

39 After adjusting for perinatal characteristics and preligation morbidities, t

40 assava (risk ratio 5.68, 95% CI 3.22-10.03), perinatal complications (4.34, 3.21-5.81), seizure disor

41 iatric operation had a greater likelihood of perinatal complications compared with infants of NOMs.

42 To examine the risk for perinatal complications in women with a history of baria

43 did not increase the risks of pregnancy and perinatal complications, except for a higher rate of ind

44 Associations between perinatal data and subsequent atopic diseases were exami

45 gic examination in the age of 4-10 years and perinatal data assessment for risk factor analysis.

46 Perinatal data were collected from the Medical Birth Reg

47 Exposures: Perinatal data were collected from the Swedish Medical B

48 Perinatal data were collected prospectively, including d

49 We hypothesized that perinatal DDT exposure causes hypertension in adult mice

50 Perinatal DDT exposure induces hypertension and cardiac

51 ibition reverses the hypertension induced by perinatal DDT exposure.

52 associated with a lower risk of in-hospital perinatal death (0.08% versus 0.26%; adjusted risk ratio

53 e no significant differences in the rates of perinatal death (3.2% in the pessary group and 2.4% in t

54 ampsia is an important cause of maternal and perinatal death and complications.

55 evel rates of preterm birth, stillbirth, and perinatal death in Ontario between 2003 and 2012.

56 nd under-recording of induction of labour or perinatal death in the dataset.

57 The risks of stillbirth, neonatal death, and perinatal death increased with the amount smoked by the

58 Stillbirth and perinatal death rates were similarly not associated with

59 ffect with protection from preterm birth and perinatal death, and partial correction of reduced birth

60 cterize the relationship between smoking and perinatal death, defined as the combination of stillbirt

61 ldbirth Checklist, on a composite outcome of perinatal death, maternal death, or maternal severe comp

62 f routine induction of labour on the risk of perinatal death.

63 r at 40 weeks would be required to prevent 1 perinatal death.

64 on in rates of preterm birth, stillbirth, or perinatal death.

65 the risks of stillbirth, neonatal death, and perinatal death.

66 rm parturition, to prevent preterm birth and perinatal death.

67 The primary outcome was perinatal death.

68 aged >/=35 years may reduce overall rates of perinatal death.

69 gnancies, is a leading cause of maternal and perinatal death.

70 tio [OR] 3.3, 95% CI 1.2-9.0, I(2)=58%), and perinatal deaths (2.3, 1.2-4.1, I(2)=73%) compared with

71 studies (in which cases were stillbirths or perinatal deaths), and randomised controlled trials of m

72 r coagulation (both in the Foley group); ten perinatal deaths, including two stillbirths (both in the

73 ew studies that focus on the epidemiology of perinatal depression (ie, during antepartum and post-par

74 nical diagnoses of depression separated into perinatal depression and nonperinatal depression in a Sw

75 partially overlapping genetic etiologies for perinatal depression and nonperinatal depression.

76 depression, and the genetic overlap between perinatal depression and nonperinatal depression.

77 rd of the genetic contribution was unique to perinatal depression and not shared with nonperinatal de

78 Perinatal depression comprises a heterogeneous group of

79 The authors suggest that perinatal depression constitutes a subset of depression

80 In the sibling design, the heritability of perinatal depression was estimated at 44% (95% CI=35%-52

81 In the twin study, the heritability of perinatal depression was estimated at 54% (95% CI=35%-70

82 The heritability of perinatal depression was estimated at 54% and 44%, respe

83 variance (or 33% of the genetic variance) in perinatal depression was unique for perinatal depression

84 so summarise evidence for the association of perinatal depression with infant and childhood outcomes.

85 ere might be different types and severity of perinatal depression with varying time of onset througho

86 e clinically relevant phenotypic subtypes of perinatal depression, and further characterise subtypes

87 e of genetic and environmental influences on perinatal depression, and the genetic overlap between pe

88 atments that improve outcomes for women with perinatal depression.

89 ance) in perinatal depression was unique for perinatal depression.

90 nd childhood health outcomes associated with perinatal depression.

91 ons, we identified five distinct subtypes of perinatal depression: severe anxious depression, moderat

92 pment in children exposed to higher maternal perinatal depressive symptoms.

93 ction(s) for future research in prenatal and perinatal determinants of lung health and disease in ear

94 protein L-plastin (LPL) is required for the perinatal development of alveolar macrophages.

95 regnancy may be associated with maternal and perinatal disease and death.

96 midwives who had all experienced a traumatic perinatal event defined using the Diagnostic and Statist

97 e-response association between the number of perinatal events and increased OCD risk, with HRs rangin

98 e relationship between the number of adverse perinatal events and increased risk for TD/CTD was also

99 Adverse perinatal events may increase the risk of Tourette's and

100 ocal development was not linked to genetics, perinatal experience, or body growth; nor did the amount

101 to the mechanisms through which common early perinatal experiences may shape the somatosensory scaffo

102 These data demonstrate that perinatal exposure to DDT causes hypertension and cardia

103 actors (4%), intrauterine factors (2.0%) and perinatal factors (4.4%).

104 d later child and adolescent mortality, with perinatal factors and congenital malformations explainin

105 port previous findings that intrauterine and perinatal factors can have long-lasting effects on the r

106 Prenatal and perinatal factors have been implicated as risks, but def

107 s for the influence of pregnancy-related and perinatal factors on subsequent respiratory and atopic d

108 None of the other perinatal factors showed statistically significant assoc

109 In infancy, perinatal factors, particularly respiratory issues and i

110 en born at term to reduce confounding due to perinatal factors.

111 al prepregnancy BMI and sociodemographic and perinatal factors.

112 elated with WNT4, plays an important role in perinatal germline cyst breakdown and primordial follicl

113 plicated in various human disorders, such as perinatal growth retardation.

114 gnancy) is associated with increased risk of perinatal health complications.

115 el social and economic factors contribute to perinatal health.

116 ector in leading efforts to improve maternal-perinatal health.

117 foetal-maternal circulation, which threatens perinatal health.

118 guarantee sustainable finances for maternal-perinatal health; and accelerate progress through eviden

119 nsformation of ischemic injury, and presumed perinatal hemorrhagic stroke.

120 terial ischemic stroke), and 5 were presumed perinatal hemorrhagic stroke.

121 idered to continue to decrease the burden of perinatal hepatitis B in the United States.

122 o suppress spontaneous network events in the perinatal hippocampus.

123 tence of antibody in immunized children with perinatal HIV (PHIV) and their association with number o

124 To estimate the number of perinatal HIV cases among infants born in the United Sta

125 ional data for live births, the incidence of perinatal HIV infection among infants born in the United

126 Despite reduced perinatal HIV infection in the United States, missed opp

127 As of 2013, the incidence of perinatal HIV infection remained 1.75 times the proposed

128 ternal characteristics, including receipt of perinatal HIV testing, treatment, and prophylaxis.

129 Data on the national incidence of perinatal HIV transmission and missed prevention opportu

130 cy virus (HIV) disease and the prevention of perinatal HIV transmission.

131 ella pertussis-associated hospitalization in perinatal HIV-exposed and -unexposed infants.

132 Among 234 US youths with perinatal human immunodeficiency virus, 75% had antiretr

133 une-activation paradigm to determine whether perinatal immune activation can also produce these comor

134 Our results show that perinatal immunisation strategies for children aged youn

135 These findings improve the understanding of perinatal immunity and might support the development of

136 Perinatal indoor aeroallergen exposure does not seem to

137 ers', 'Motherhood and fulfillment', 'Fear of perinatal infection and infection of partner(s)', 'Birth

138 term effect of virologic suppression (VS) in perinatal infection is unknown.

139 ion in CTL-targeted HIV-1 epitopes following perinatal infection.

140 event ocular injuries, vitamin A deficiency, perinatal infections and retinopathy of prematurity as w

141 normal lung development can be disrupted by perinatal inflammation in preterm infants, although the

142 Data collected included perinatal information and assessments during the neonata

143 CI-Nkx2.1 gene duplex results in a defective perinatal innate immune response, tissue damage, and pro

144 provements in intrauterine interventions and perinatal intensive care have resulted in increasing num

145 The Effective Perinatal Intensive Care in Europe (EPICE) study, a popu

146 al ischemic stroke (NAIS), arterial presumed perinatal ischemic stroke (APPIS), or fetal periventricu

147 erior neural tube and develop exencephaly, a perinatal lethal condition.

148 severe diseases, ranging from congenital or perinatal lethal disorders to somatically acquired cance

149 Because global knockout of Fst is perinatal lethal in mice, we generated a conditional kno

150 ed in skeletal muscle, and Stac3 knockout is perinatal lethal in mice.

151 sulted in a partially penetrant embryonic or perinatal lethal phenotype, with the production of an ab

152 or dominant thrombosuppressor genes based on perinatal lethal thrombosis in mice homozygous for F5(L)

153 Plaa-null mice were perinatal lethal with reduced brain levels of prostaglan

154 G37S homozygotes are perinatal lethal, in contrast to the early embryonic let

155 rmline deletion of the gene encoding LAP1 is perinatal lethal, we explored its potential role in myog

156 notypes weeks after fertilization; including perinatal lethality and abnormal behavior in surviving a

157 Germline Cic inactivation causes perinatal lethality due to lung differentiation defects.

158 deamidase also rescues axonal outgrowth and perinatal lethality in a dose-dependent manner in mice l

159 rons that results in respiratory failure and perinatal lethality in mice.

160 defined role in development, also prevented perinatal lethality in Ripk1(RHIM/RHIM) mice.

161 functions during development and can trigger perinatal lethality when its RHIM-dependent interactions

162 Both mouse models display similar perinatal lethality with respiratory insufficiency, redu

163 To circumvent perinatal lethality, we have developed a novel method to

164 ersely, ubiquitous Bcl7a knockout results in perinatal lethality, while genetic deletion of Bcl7a in

165 e G37S mice results in partial rescue of the perinatal lethality, with viable mice exhibiting white s

166 specific deletion of Mpc1 presented as early perinatal lethality.

167 gans-especially lungs-at birth, and frequent perinatal lethality.

168 o association between dog or cat exposure in perinatal life and sensitization or rhinitis during chil

169 storting nucleotide lesions, resulted in the perinatal loss of hematopoietic stem cells, progressive

170 (Egr1/2/4) were consistently upregulated by perinatal LPD in both sexes.

171 ich co-occurred with sex-specific effects of perinatal LPD on both Npy1r DNA-methylation and gene tra

172 nscription factors affected by either sex or perinatal LPD.

173 Perinatal maternal depression is a serious health concer

174 Perinatal maternal stress and low mood have been linked

175 rediction of phenotypic outcomes and support perinatal medical care.

176 Here, we report that the meninges of perinatal mice contain a population of neurogenic progen

177 ed fetal growth is associated with increased perinatal morbidity and mortality and a greater risk of

178 der of pregnancy, remains a leading cause of perinatal morbidity and mortality worldwide.

179 dence that treatment can reduce maternal and perinatal morbidity and mortality, and the well-establis

180 pontaneous preterm birth is a major cause of perinatal morbidity and mortality.

181 ion of labour at >/=39 weeks and the risk of perinatal mortality among nulliparous women aged >/=35 y

182 than in those that did not, but maternal and perinatal mortality and maternal morbidity did not diffe

183 Perinatal mortality and morbidity continue to be major g

184 ongenital heart defects are a major cause of perinatal mortality and morbidity, affecting >1% of all

185 order that is a major cause for maternal and perinatal mortality and morbidity.

186 between April 2009 and March 2014 to compare perinatal mortality between induction of labour at 39, 4

187 piratory dysfunction is a notorious cause of perinatal mortality in infants and sleep apnoea in adult

188 Three of 11 neonates died, giving a perinatal mortality rate of 27.3%.

189 preterm birth, which is the leading cause of perinatal mortality worldwide.

190 f adverse perinatal outcomes, which included perinatal mortality, bronchopulmonary dysplasia, sepsis,

191 acenta) is associated with preterm birth and perinatal mortality, but associations with other neonata

192 sociation between smoke-free legislation and perinatal mortality, one showed significant reductions i

193 Our primary outcomes of interest were perinatal mortality, preterm birth, hospital attendance

194 tion in SGA births, but not preterm birth or perinatal mortality, was observed in the Netherlands aft

195 ity but did not report the overall effect on perinatal mortality, while the other showed no change in

196 rtality, while the other showed no change in perinatal mortality.

197 Perinatal mother-to-infant transmission of HBV remains t

198 strate that ex-myomiR levels are elevated in perinatal muscle development, during the regenerative ph

199 As adults, offspring that received low perinatal n-6/n-3 ratios were diet-induced obesity (DIO)

200 Relative to wild-type pups receiving high perinatal n-6/n-3 ratios, subcutaneous adipose tissue in

201 Microglia play important roles in perinatal neuro- and synapto-genesis.

202 tudy was to examine the long-term effects of perinatal neuroinflammation and the effectiveness of pre

203 ubset of mother-infant pairs enrolled in the perinatal NICHD HPTN 040 study (distinguished by no anti

204 Recently, perinatal nicotine injections in rats were reported to i

205 nsive rodent studies have shown that reduced perinatal nutrition programmes chronic cardiovascular di

206 nsive rodent studies have shown that reduced perinatal nutrition programmes chronic cardiovascular di

207 Perinatal or mother-to-child transmission (MTCT) of hepa

208 Few perinatal or social risk factors predicted longitudinal

209 proximity to conception or during in utero, perinatal, or childhood time periods.

210 We examined maternal and perinatal outcomes and GBS serotypes.

211 e evaluated the relationship between adverse perinatal outcomes and prenatal TDF use.

212 Studies with only perinatal outcomes and studies of individuals with a spe

213 epsy in pregnancy and risks of pregnancy and perinatal outcomes as well as whether use of AEDs influe

214 Adverse perinatal outcomes for the fetus and newborn include int

215 Many relevant perinatal outcomes have not been studied in this postope

216 l-fetal interface that contribute to adverse perinatal outcomes in a host with an intact immune syste

217 t studies and case-control studies reporting perinatal outcomes in HIV-positive women naive to antire

218 were included if they assessed maternal and perinatal outcomes in pregnant women exposed to anaesthe

219 We investigated whether changes in perinatal outcomes occurred following introduction of ke

220 tive: To describe the prenatal evolution and perinatal outcomes of 11 neonates who had developmental

221 y potential underlying mechanisms of adverse perinatal outcomes, we explored the association of place

222 e primary outcome was a composite of adverse perinatal outcomes, which included perinatal mortality,

223 ing the association of the OTB interval with perinatal outcomes.

224 ith increased risks of adverse pregnancy and perinatal outcomes.

225 Pregnancy, delivery, and perinatal outcomes.

226 ects model for the meta-analyses of specific perinatal outcomes.

227 large placebo-controlled trials, powered for perinatal outcomes.

228 ran Africa, a region that also has very poor perinatal outcomes.

229 th nifedipine or atosiban results in similar perinatal outcomes.

230 re-pregnancy BMI and excessive GWG influence perinatal outcomes.

231 al HIV infection is associated with specific perinatal outcomes.

232 Maternal TDF use did not adversely affect perinatal outcomes.

233 nancy has been linked to several unfavorable perinatal outcomes.

234 ileptic drug (AED) therapy and pregnancy and perinatal outcomes.

235 etermine the association of prenatal TDF and perinatal outcomes.

236 women naive to antiretroviral therapy and 11 perinatal outcomes: preterm birth, very preterm birth, l

237 sed intra-oocyte cyclic AMP (cAMP) levels in perinatal ovaries.

238 rotein 1 were highly expressed in oocytes in perinatal ovaries.

239 Group B Streptococcus (GBS) is an important perinatal pathogen, although previously focus has been p

240 link between maternal hypothyroidism in the perinatal period and childhood asthma risk.

241 on about onset of depressive symptoms in the perinatal period and complete prospective data for the t

242 more resources than a livebirth, both in the perinatal period and in additional surveillance during s

243 ing of A(H1N1)-vaccinated mothers beyond the perinatal period and into early childhood.

244 The perinatal period is a time of high risk for onset of dep

245 ion efforts in response to challenges in the perinatal period may persist into adulthood.

246 ho died by suicide within versus outside the perinatal period were also more likely to be younger (cr

247 ith UK psychiatric services, suicides in the perinatal period were more likely to occur in those with

248 he remaining women have episodes outside the perinatal period, usually within the bipolar spectrum.

249 management of hematologic cancers during the perinatal period, which were developed by a multidiscipl

250 on depression symptoms among men during the perinatal period.

251 ion for neonates that is applicable from the perinatal period.

252 ential adverse effects manifesting after the perinatal period.

253 died by suicide, of whom 98 (2%) died in the perinatal period.

254 aged 20-35 years, 74 (4%) women died in the perinatal period.

255 ticular torsion may concern boys even in the perinatal period.

256 rocess of germline cyst breakdown during the perinatal period.

257 l switch to license thermogenesis during the perinatal period.

258 ge into adulthood, long after the end of the perinatal period.

259 Furthermore, Ncoa4(-/-) mice are anemic in perinatal periods and fail to respond to TH by enhanced

260 e-like B cell repertoire during neonatal and perinatal periods, and the prospect of targeting B cell

261 During fetal and perinatal periods, many nutrients, such as long-chain po

262 because it is abundant during embryonic and perinatal phases before drastically decreasing during ad

263 a null allele (Copb2R254C/Zfn) show a severe perinatal phenotype including low neonatal weight, signi

264 Dystroglycan also regulates perinatal radial glial cell proliferation and transition

265 tein in mouse nephron progenitors results in perinatal renal hypoplasia; however, postnatal Six2creFr

266 During perinatal retinal angiogenesis, inhibition of PKA result

267 tively investigate a wide range of potential perinatal risk factors for OCD, controlling for unmeasur

268 aimed to prospectively investigate potential perinatal risk factors for TD/CTD, taking unmeasured fac

269 Conclusions and Relevance: A range of perinatal risk factors is associated with a higher risk

270 shared familial confounders, suggesting that perinatal risk factors may be in the causal pathway to O

271 etion of Arl13b in the distal nephron at the perinatal stage led to a cilia biogenesis defect and rap

272 ture of the core respiratory oscillator at a perinatal stage of development.

273 by apoptosis from early embryonic stages to perinatal stages.

274 Temporal- and sex-specific effects of perinatal stress have not been examined for childhood as

275 selectively vulnerable to adverse effects of perinatal stressors, and impaired cBF integrity results

276 gests possible associations between arterial perinatal stroke and prothrombotic disorders, but popula

277 c study suggests minimal association between perinatal stroke and thrombophilia.

278 Perinatal stroke causes cerebral palsy and lifelong disa

279 udy to determine the association of specific perinatal stroke diseases with known thrombophilias.

280 Understanding thrombophilia in perinatal stroke informs pathogenesis models and clinica

281 Perinatal stroke leads to significant morbidity and long

282 The Alberta Perinatal Stroke Project, a provincial registry, ascerta

283 women (mean age = 32 years) of the Jerusalem Perinatal Study Family Follow-up (2007-2009), we investi

284 During perinatal supporting cell transdifferentiation, which is

285 'biologic hard drives' that can characterize perinatal temporal dynamics in neuroplasticity.

286 We analyzed the mechanisms of perinatal tolerance induction to allergens, with particu

287 demonstrating the crucial role of B cells in perinatal tolerance induction.

288 Consistent with that hypothesis, perinatal transfection of hair cells in KO-TgAC1 mice wi

289 Cardiac maturation during perinatal transition of heart is critical for functional

290 iruria had significantly higher rates of HIV perinatal transmission (29.2% vs. 8.1%, P = .002).

291 The role of perinatal transmission in EOD is supported by its associ

292 Perinatal transmission of human immunodeficiency virus (

293 of ART for maternal health and prevention of perinatal transmission outweigh risks, but data for the

294 virologic suppression was maintained and no perinatal transmission was observed.

295 eatment-naive, and 84% were infected through perinatal transmission.

296 may provide a route for sexual and possibly perinatal transmission.

297 study was to assess the association between perinatal variables and the prevalence of asthma, bronch

298 EBGNs were first analyzed during the perinatal week.

299 d correlates of suicide in perinatal and non-perinatal women in contact with psychiatric services.

300 We compared suicides among perinatal and non-perinatal women with logistic regression of multiply imp