ライフサイエンスコーパス: perineurial

1 Perineurial and subperineurial glia reside in two separa

2 n of hypertonic saline as a tool to open the perineurial barrier transiently in rats and elucidated t

3 isolated nerves only after disruption of the perineurial barrier, which, in return, allowed endoneura

4 The endoneurial and perineurial BLs of peripheral nerve also contain distinc

5 rexins are involved in axon-Schwann cell and perineurial cell interactions.

6 Perineurial cell tumors (PNTs) are rare neoplasms derive

7 Interestingly, loss of Notch signaling in perineurial cells also causes a failure of Schwann cell

8 Consequently, the origin of perineurial cells and their roles in motor nerve formati

9 ime-lapse imaging in zebrafish, we show that perineurial cells are born in the CNS, arising as ventra

10 Perineurial cells contained intermediate filaments and w

11 f Schwann cells, mast cells, fibroblasts and perineurial cells embedded in collagen that provide a la

12 zoster virus antigen was frequently found in perineurial cells expressing claudin-1 around nerve bund

13 In addition, we find that perineurial cells of the electromotor nerve also express

14 Perineurial cells produced surface basal lamina; however

15 However, NADPHd in locust glial and perineurial cells was histochemically different from tha

16 xonal processes, Schwann cells, fibroblasts, perineurial cells, and mast cells.

17 unctions between perineurial cells, glia and perineurial cells, and possibly between glia.

18 d-sheet) septate and tight junctions between perineurial cells, glia and perineurial cells, and possi

19 nn cells, were neural crest derived, whereas perineurial cells, pericytes and endothelial cells were

20 alized lining cells of the nerve sheath, the perineurial cells.

21 ut less than the value reported for isolated perineurial cylinders.

22 mechanism that mediates multiple aspects of perineurial development and reveal the critical importan

23 om different precursors, and that most adult perineurial, ensheathing, and astrocyte-like glia are pr

24 ciated cell cultures of adult sciatic nerve, perineurial fibroblasts but not Schwann cells express NG

25 Additionally, ectopic perineurial fibroblasts form aberrant fascicles througho

26 These results suggest a model in which perineurial fibroblasts secrete or shed NG2, which subse

27 to the mammalian Schwann cell) and an outer perineurial glia (analogous to the mammalian perineurium

28 h to investigate the role and requirement of perineurial glia after nerve injury.

29 Perineurial glia also bridge injury gaps before Schwann

30 Additionally, we show that perineurial glia and macrophages spatially coordinate ea

31 Additionally, reciprocal signaling between perineurial glia and Schwann cells was necessary for mot

32 ell interactions after injury and introduces perineurial glia as integral players in the regenerative

33 n the peripheral glia promotes growth of the perineurial glia by inhibiting FOXO.

34 aberrant axonal projections, indicating that perineurial glia carry out barrier and guidance function

35 Surprisingly, in the presence of OPCs, perineurial glia exited the CNS normally.

36 on, demonstrating that Schwann cells require perineurial glia for aspects of their own development.

37 opment and reveal the critical importance of perineurial glia for Schwann cell maturation and nerve f

38 ffort to better understand the plasticity of perineurial glia in response to myelin perturbations, we

39 lts demonstrate the incredible plasticity of perineurial glia in the presence of myelin perturbations

40 We show that growth of the perineurial glia is controlled by interactions among fiv

41 y coordinate early debris clearance and that perineurial glia require Schwann cells for their attract

42 We show that perineurial glia respond rapidly and dynamically to nerv

43 luding motor axons and the Schwann cells and perineurial glia that ensheath them.

44 The effects were observed in the perineurial glia that envelope the peripheral and centra

45 other essential nerve components, including perineurial glia, are poorly understood.

46 In embryos lacking perineurial glia, motor neurons inappropriately migrated

47 maining peripheral ensheathing glia, such as perineurial glia, properly encase the motor nerve despit

48 How perineurial glia, the ensheathing cells that form the pr

49 mediate the migration and differentiation of perineurial glia.

50 Notably, perineurial glial cells are made locally on the brain su

51 derived myelin, demonstrating that, although perineurial glial cells display plasticity despite myeli

52 s, which in turn are ensheathed by the outer perineurial glial cells.

53 Here, we report that certain aspects of perineurial glial development and injury responses are m

54 myelinate peripheral motor axons, we assayed perineurial glial development, maturation, and response

55 growth factor-beta1 as a partial mediator of perineurial glial development.

56 However, perineurial glial function is disrupted along nerves con

57 ptide, acting through Push and NF1, inhibits perineurial glial growth, whereas the substrate neurotra

58 e substrate neurotransmitter of Ine promotes perineurial glial growth.

59 axons and inner glia, surrounded by an outer perineurial glial layer.

60 m +/- 0.08) were abundant between peripheral perineurial glial processes; these were unaffected in th

61 the constitutively active Ras(V12) increases perineurial glial thickness.

62 We used perineurial injection of hypertonic saline as a tool to

63 shRNA or a small-molecule inhibitor, reduced perineurial invasion in KPC mice with PDAC.

64 r spread along nerves, a phenomenon known as perineurial invasion, is common in various cancers inclu

65 origenesis and its activation induces cancer perineurial invasion.

66 0 or BMT from CCR2-deficient donors, reduced perineurial invasion.

67 00 mM [K(+)] Ringer, indicating no effect on perineurial K(+) permeability.

68 pically includes Schwann cells, fibroblasts, perineurial-like cells, and mast cells.

69 participate in the barrier functions of the perineurial linings of the nerve.

70 Inhibition of perineurial macrophage recruitment, using the CSF-1R ant

71 Deletion of GDNF expression by perineurial macrophages, or inhibition of RET with shRNA

72 Trafficking of BM-derived macrophages to the perineurial microenvironment and secretion of GDNF are e

73 vasion by cancer cells, we characterized the perineurial microenvironment using a series of bone marr

74 te that Notch signaling is required for both perineurial migration and differentiation during nerve f

75 m LEMS patients reduces the amplitude of the perineurial P/Q-type current, and unmasks a dihydropyrid

76 n 100 mM [K(+)], n=20), indicating increased perineurial permeability caused by DOC, but the response

77 f 2.5 M sucrose or 5 M NaCl caused increased perineurial permeability to K+.

78 or neurons throughout development and in the perineurial sheath that covers the brain early in develo

79 and that they control the maturation of the perineurial sheath that protects nerves from inflammatio

80 reasing Dhh levels promotes formation of the perineurial sheath.