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3 namics by enhancing fusion and induced their perinuclear accumulation in HEK293 cells and rat primary
5 ximately 0.5%) led to impaired mitophagy and perinuclear accumulation of damaged mitochondria associa
6 n of tubular membrane carriers from the TGN, perinuclear accumulation of early endosomes and impaired
8 nt of HeLa cells with BIG2 siRNA resulted in perinuclear accumulation of integrin beta1 and its delay
9 utants, we define the mechanisms involved in perinuclear accumulation of PKCalpha and identify the no
12 tion both in vitro and in vivo and maintains perinuclear accumulations of capsids, facilitating produ
15 N) lines, which couple the nucleus to dorsal perinuclear actin cables undergoing retrograde flow.
16 ispensable for the retrograde flow of dorsal perinuclear actin cables, supporting the recently propos
17 of a subset of actin filament bundles - the perinuclear actin cap - connected to the nucleus through
19 al model explains why LINC complexes and the perinuclear actin cap are essential in 3D migration by p
20 ll subset of actin fibers, those forming the perinuclear actin cap that wraps around the nucleus, for
21 pond rapidly to external force by remodeling perinuclear actin in a unique Ca(2+)- and INF2-dependent
25 ate a critical role for FMN2 in generating a perinuclear actin/FA system that protects the nucleus an
26 cleator FMN2 associates with and generates a perinuclear actin/focal adhesion (FA) system that is dis
27 ptin 7 knockdown lead to a disruption of the perinuclear actomyosin and persistent directional migrat
29 ear export, promoting the formation of large perinuclear aggregates of RNPs along with cellular Rab11
38 RC3 prevented proper trafficking of STING to perinuclear and punctated region, known to be important
40 and autoantibodies consisting of high-titre perinuclear antineutrophil cytoplasmic antibodies (p-ANC
41 nuclear lamin A/C-mediated formation of the perinuclear apical actin cables protects the nuclear str
43 arned that Vasa interacted with mRNAs in the perinuclear area and at the spindle in an Importin-depen
44 of Atg16L1-positive recycling endosomes to a perinuclear area and for delivery of Atg16L1- and LC3-po
45 mostly cytoplasmic protein localizing in the perinuclear area and forms highly stable dimers/oligomer
48 remains under the control of IKKalpha in the perinuclear area following translocation of the ASC/IKKa
49 ant accumulation of these TG6 mutants in the perinuclear area led to activation of the unfolded prote
51 ear depletion, increased accumulation in the perinuclear area, insolubility and loss of enzymatic fun
52 protein mainly localized to the nucleus and perinuclear area, whereas five TG6 mutations showed nucl
53 ork in Miro1(-/-) MEFs was restricted to the perinuclear area, with few mitochondria present at the c
54 conjugate was distributed in cytoplasmic and perinuclear areas during the first 1 h of incubation and
55 ally, the ratio of ATP to ADP was highest at perinuclear areas of dense mitochondria and gradually de
57 constraints imposed by chromosome length and perinuclear attachment determine the amount of SCI that
59 er sustained oscillations of the nuclear and perinuclear Ca(2+) concentration (Ca(2+) spiking), which
60 in the rough ER/perinuclear region promotes perinuclear Ca(2+) signaling and predisposes to ryanodin
61 cardiac calsequestrin (CSQ2) trafficking on perinuclear Ca(2+) signaling, we manipulated the subcell
62 not induced and that both Nod factor-induced perinuclear calcium spiking and calcium influx at the ro
63 tent with this, microtubules extend from the perinuclear centrosome to the plasma membrane and allow
66 gradation upon internalization, did not form perinuclear clusters with PICK1, and PICK1 did not affec
67 unofluorescence images indicated a potential perinuclear co-localization between IGFBP-1 and CSNK-2be
69 in the case of overexpressed Cav1-GFP, this perinuclear compartment consists of cytoplasmic inclusio
70 trafficking, including its accumulation in a perinuclear compartment previously identified as the Gol
71 ains, and correlated with movement between a perinuclear compartment, adhesions, and the plasma membr
74 o aberrant localization of HIF-1alpha to the perinuclear compartments and surprisingly stimulates nuc
75 nificant delay in transferrin trafficking to perinuclear compartments, demonstrating an integral role
77 vitro but was necessary for the genesis of a perinuclear-concentrated network of keratin filaments, n
78 mal cadherin-catenin complex assembly in the perinuclear cytoplasm and subsequent localization to the
79 cells, we observed their colocalization in a perinuclear cytoplasmic compartment that was associated
82 3 regulates vascular endothelial cell shape, perinuclear cytoskeletal architecture, and important asp
83 discriminant of mechanical properties in the perinuclear cytoskeleton (pnCSK) of various stem cell ty
86 ular localization of altered ELOVL5 showed a perinuclear distribution with a signal increase in the G
91 nits in HeLa cells recapitulates the loss of perinuclear dynein in ASUN-small interfering RNA cells.
92 tion sequence blocks its capacity to restore perinuclear dynein in both cultured human cells lacking
94 is required in Drosophila spermatocytes for perinuclear dynein localization and nucleus-centrosome c
95 his paper, we reveal the passage of LDs from perinuclear endoplasmic reticulum association to entry i
97 r mechanisms underlying Ca(2+) regulation by perinuclear endoplasmic/sarcoplasmic reticulum (ER/SR) c
98 endosomes (PEs), c-Met needs to traffic to a perinuclear endosome (PNE) to sustain Rac1 signalling, t
101 We present a model in which ASUN promotes perinuclear enrichment of dynein at G2/M that facilitate
103 ression in HEK293T cells localizes it to the perinuclear ER region and it trans-rescues the ankB muta
104 sociated with lipid droplet formation in the perinuclear ER, is responsible for the initial rapid exi
105 e-bound organelles and highlight research on perinuclear factories induced by the nucleocytoplasmic l
107 membranes and is internalized to hydrophobic perinuclear features, the nuclear membrane and inside th
111 cation of Gbetagamma to the Golgi stimulated perinuclear Golgi PI4P depletion and nuclear PKD activat
112 a indicate that Gbetagamma regulation of the perinuclear Golgi PI4P pathway and a separate pathway at
113 hosphate (PI4P) and binds GABARAPs, from the perinuclear Golgi region to autophagosomes to generate P
114 , these cisternae are stitched together as a perinuclear Golgi ribbon, which is required for the esta
116 wn facilitates the spatial relocalization of perinuclear H3K9me3-positive heterochromatin, thus promo
117 and transcriptional upregulation through the perinuclear hydrolysis of phosphatidylinositol 4,5-bipho
118 ype HMGCLL1 exhibits a punctate as well as a perinuclear immunostaining pattern, indicating myristoyl
120 frequently concentrated to the aggresome, a perinuclear inclusion body, and subsequently removed by
123 , medium spiny neurons (MSNs) that exhibited perinuclear inclusions expressed cell-cycle markers typi
128 ormation (PGL-1 and PGL-3) and promote their perinuclear localization (GLH-1 and GLH-4) [9] and inves
129 HCMV-induced, amino acid depletion-resistant perinuclear localization and activation of mTORC1 occurs
134 t the molecular motor dynein is required for perinuclear localization of mTORC1 in both uninfected an
135 To investigate the role of nesprin-3 in the perinuclear localization of plectin, we generated nespri
139 ZDHHCs 3, 7, and 15, which showed a defined perinuclear localization pattern, suggesting that the lo
140 ocalization of XIST, depletion of Cot-1 RNA, perinuclear localization, and ubiquitination of H2A occu
143 assive accumulation in the lumen of enlarged perinuclear, lysosomal-associated membrane protein 1 (LA
144 promotes rather than inhibits rab7-dependent perinuclear lysosome clustering, with these effects of m
147 riminate between stem cell types by coupling perinuclear mechanical properties to nuclear shape.
150 sted of expanded endoplasmic reticulum (ER), perinuclear mitochondria, and a higher abundance of stre
153 ed by pathological erythroid precursors with perinuclear mitochondrial iron deposition in bone marrow
154 lcium entry through L-type channels elevates perinuclear mitochondrial oxidant stress in SNc dopamine
156 g, EGFR accumulates in a subset of LBPA-rich perinuclear multivesicular bodies (MVBs) distinct from t
158 oplasmic P granules at the nuclear pores and perinuclear Mutator foci contribute to target mRNA surve
159 4 is necessary for the formation of a stable perinuclear network of keratin filaments (with type II p
160 MSP300 (nesprin) and rigidity provided by a perinuclear network of microtubules stabilized by Shot (
164 gulated, resulting in an increased number of perinuclear nuage-like granules where Piwi proteins loca
166 ne (Aub) and Argonaute-3 (Ago3), localize to perinuclear "nuage" granules and use guide piRNAs to tar
169 olution of our approach are 1) conversion of perinuclear organelle clustering into a two-dimensional
170 ining proteins, namely endophilin B2, in the perinuclear organization of intermediate filaments.
173 ts with the NF-kappaB ortholog Relish inside perinuclear particles and delivers active Relish to PARP
174 n pattern: Although beta-catenin exhibited a perinuclear pattern in undifferentiated wild-type cells,
178 b (Ras homology enriched in brain)-GTP, to a perinuclear position that corresponds to the viral cytop
180 hsp-16.2 promoter was sufficient to mediate perinuclear positioning under basal level conditions of
181 hery; (2) PM invagination and formation of a perinuclear pre-DMS; (3) expansion through membrane deli
184 n, complex I specifically was sequestered in perinuclear PTEN-induced putative kinase 1 (PINK1) and P
185 calization of NS1, Scribble, and Dlg1 within perinuclear puncta and mislocalization of plasma membran
187 ly intersects the TfR and pIgR pathways at a perinuclear Rab11-negative compartment termed common rec
188 K-2beta interactions were also predominantly perinuclear rather than nuclear as indicated by mTOR and
190 Moreover, E5-expressing cells exhibit a perinuclear redistribution of annexin A2 and p11 and sho
191 ral genome replication and recapitulated the perinuclear redistribution of NS5A seen in the S225A mut
192 tion to the nuclear envelope, there exists a perinuclear region (PNR or perinucleus) with unknown com
194 y, pDox nanoparticles are transported to the perinuclear region and cleaved into Dox, thereby avoidin
195 MCECs), Borg5 associates with septins in the perinuclear region and colocalizes with actomyosin fiber
196 Osm extended CLN3 distribution away from the perinuclear region and enhanced the lysosomal localizati
198 BP-1 and CSNK-2beta interactions were in the perinuclear region and mTOR and CSNK-2beta interactions
199 xpressed in skeletal muscle, enriched in the perinuclear region and the triad, and found in intracell
200 1 is localized in the nucleus, cytoplasm, or perinuclear region but is transiently redistributed to c
201 t KCNQ1 and KCNE1 are both translated in the perinuclear region but traffic by different routes, inde
202 ile population of endosomes moved toward the perinuclear region in directed bursts of microtubule-bas
206 ancreas, S100PBP is expressed in the nuclear/perinuclear region of both exocrine and endocrine compar
207 ions were found to rapidly accumulate in the perinuclear region of cells within 2h, 37+/-19% and 47+/
209 that the majority of rAAV accumulates in the perinuclear region of cells, presumably unable to traffi
211 based GSTs) are also over-represented in the perinuclear region of mammalian cells, possibly for nucl
213 from ER+ breast tumors, HDAC6 localizes to a perinuclear region of the cell, undergoing transport to
216 transcription is completed in the nucleus or perinuclear region of the infected cell, where it is dep
219 rst time that CSQ2 retention in the rough ER/perinuclear region promotes perinuclear Ca(2+) signaling
221 tructures and are found to accumulate in the perinuclear region with increasing incubation time.
223 lysosomes appeared to be concentrated in the perinuclear region, and autophagy flux was impaired.
224 nal motion in the cortex with respect to the perinuclear region, and suggests that the tracking routi
225 cular and tubular membranes localized to the perinuclear region, collectively known as the endocytic
226 tion of vinculin from focal adhesions to the perinuclear region, formation of cortical actin-rich lar
227 creased organelle proximity primarily in the perinuclear region, rapamycin increased organelle contac
228 ed stimulation of ARP2/3 concentrated in the perinuclear region, resulting in defective cell adhesion
230 -dependent movement of effector kinases to a perinuclear region, thereby creating connections to uniq
231 mal compartments unidirectionally toward the perinuclear region, where most acidification events for
232 nt acted to prevent loss of virions from the perinuclear region, which correlated with increased cell
233 aberrant increase in ribosome-free ER in the perinuclear region, without inducing ER stress response.
244 ivity by immunohistochemistry accumulated in perinuclear regions and rimmed vacuoles in IBM muscle, l
248 , we show that oncogenic RAS and BRAF induce perinuclear relocalization of several RAS pathway protei
249 crease in promoter accessibility and exhibit perinuclear repositioning of the locus from a silent to
250 in a 10-fold reduction in replication and a perinuclear restricted distribution of NS5A, whereas the
253 conserved in two related proteins, spermatid perinuclear RNA-binding protein (SPNR) and zinc-finger R
259 GFP)-MyoVa colocalizes with mCherry-Rab8A in perinuclear small puncta, whereas GFP-MyoVa-CT collapses
260 of GABA-A receptors were distributed in the perinuclear space and along the processes of GFAP(+) cel
262 the C terminus of ORF67 that resides in the perinuclear space does not impair the functions of ORF67
265 and MKL2, respectively) are enriched in the perinuclear space of epicardial cells during development
266 ysis revealed vesicle-like structures in the perinuclear space of intestinal and germ cell nuclei, si
267 hat progeny nucleocapsids were retained in a perinuclear space surrounded by inner and outer nuclear
269 imod causes accumulation of TLR4 and TLR9 in perinuclear space, consistent with endoplasmic reticulum
270 ormation, nuclear export by budding into the perinuclear space, tegument formation, and envelopment t
276 The wild-type LHbeta subunit exhibited a perinuclear staining corresponding to the ER/nuclear env
277 mal tissues and particularly strong dot-like perinuclear staining in the lining epithelial cells, sug
278 ltaT and LHbetaL119A displayed no detectable perinuclear staining; only peripheral ER puncta were obs
279 y processed but retained in the aggresome, a perinuclear structure, where misfolded proteins aggregat
282 ositol 4-phosphate (PI4P) is identified as a perinuclear substrate in the Golgi apparatus for mAKAP-s
283 ng oocyte activation and being stored in the perinuclear theca, the sperm compartment whose content i
285 c recycling compartment (ERC) is a series of perinuclear tubular and vesicular membranes that regulat
286 overexpression causes localization of APP in perinuclear tubular structures, an increase of lipid raf
287 mentous forms in the cytoplasm to aggregated perinuclear tubules that form a cage-like structure arou
290 ive fusion and membrane biogenesis to form a perinuclear tubuloreticular structure enabling mixing of
292 lin-associated glycoprotein (MAG) in LAMP1(+)perinuclear vesicles that fail to migrate to the nascent
293 absence of the vitamin, TTP is localized to perinuclear vesicles that harbor CD71, transferrin, and
295 e in the densely packed nucleocapsids inside perinuclear viral inclusions and in the dispersed rod-li
296 port of ebolavirus (EBOV) nucleocapsids from perinuclear viral inclusions, where they are formed, to
297 ds bud at the inner nuclear membrane forming perinuclear viral particles that subsequently fuse with
298 ds bud at the inner nuclear membrane to form perinuclear virions that subsequently fuse with the oute
300 a homolog of the human pathogen KSHV, led to perinuclear wrapping by acetylated MT bundles and identi
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