ライフサイエンスコーパス: periocular

1 is study demonstrates the efficacy of focal, periocular 2-DG as an adjunct to carboplatin chemotherap

2 was treated with topical (18/21, 86%) and/or periocular (4/21, 19%) corticosteroids.

3 Lid and periocular abnormalities, ocular surface pathologies, ne

4 eyelid swelling or a mass (10/14 cases), and periocular ache (5/14 cases).

5 kinetics of small lipophilic molecules after periocular administration can be described by compartmen

6 the corneal and retinal data obtained after periocular administration of 3 mg of celecoxib (a select

7 n corneal and retinal pharmacokinetics after periocular administration.

8 ed a dose-response relationship; P < 0.001), periocular (aHR, up to 7.96; P < 0.001), and intraocular

9 delivery and the unexpected omission of the periocular airpuff that served as the instructive signal

10 uli were novel or if they predicted that the periocular airpuff was about to be presented.

11 e observed that climbing fibers activated by periocular airpuffs also responded to stimuli from other

12 mice and measured their calcium responses to periocular airpuffs that serve as instructive stimuli du

13 HSV-1 periocular and eyelid disease was also more severe in ma

14 be well-tolerated and effective for treating periocular and orbital BCC in about half of all cases.

15 toma, including intravenous, intra-arterial, periocular, and intravitreal techniques.

16 in disorder (PEPD), characterized by rectal, periocular, and perimandibular pain.

17 Treatment includes intravitreal, periocular, and systemic antibiotics.

18 Previously we showed that periocular angioblasts and forming ocular blood vessels

19 nd 1 patient (1 malignancy) also developed a periocular basal cell carcinoma.

20 Margin-controlled excision for periocular BCC and close follow-up after excision for me

21 th locally advanced or metastatic orbital or periocular BCC or basal cell nevus syndrome and can obvi

22 th locally advanced or metastatic orbital or periocular BCC or basal cell nevus syndrome treated with

23 eristics were noted in primary and recurrent periocular BCC, implying that incomplete surgical excisi

24 ons; (2) elimination via the conjunctival or periocular blood and lymphatic systems contributes signi

25 rcent of patients had required treatment for periocular cancers and 2% for ocular surface cancers.

26 ngle-modality, and combination therapy using periocular carboplatin and 2-deoxy-d-glucose (2-DG).

27 cal vitreous seeds and additional concurrent periocular carboplatin in patients with diffuse vitreous

28 rimary high-dose chemotherapy and concurrent periocular carboplatin, and EBRT selectively in chemothe

29 Current globe-sparing therapies, including periocular carboplatin, selective ophthalmic artery chem

30 us vincristine for one course, with optional periocular carboplatin.

31 Periocular celecoxib microparticles are useful sustained

32 The periocular celecoxib-PLGA microparticles are safe and do

33 advances in the diagnosis and management of periocular cellulitis and to alert physicians to emergin

34 Periocular cellulitis remains an important and common en

35 Periocular chemotherapy is employed to boost local chemo

36 d 21 treated with OAC plus intravitreous and periocular chemotherapy).

37 s seed clouds with OAC and intravitreous and periocular chemotherapy, compared with OAC alone, result

38 C57BL/6J mice received weekly periocular conjunctival fornix injections of a dexametha

39 One group (n = 16), was injected with periocular corticosteroid (400 mug in 10 microL).

40 Intravitreal and periocular corticosteroids are also recommended.

41 t use of prednisone >7.5 mg/day (aHR, 1.86); periocular corticosteroids in the last 3 months (aHR, 2.

42 Iris JXG responds to topical or periocular corticosteroids, often with stabilization or

43 Periocular crow's feet lines and horizontal forehead lin

44 Both intravitreous and periocular delivery of CGC-11144 also caused significant

45 Periocular delivery of the polyamine analogues may be a

46 om the choroid and the anterior segment; the periocular depot location determines the predominant dif

47 id/retina by transscleral diffusion from the periocular depot.

48 e of recovery at 1 month, whereas the use of periocular dexamethasone injections (cRR, 0.05 [0.02-0.6

49 fected STING(-/-) mice also showed increased periocular disease and increased corneal and trigeminal

50 porter activity was followed by the onset of periocular disease on day 4.

51 In addition, no periocular disease symptoms were observed.

52 Retinal pharmacokinetics after periocular drug administration can be explained with a f

53 gly, conditional deletion of beta-catenin in periocular ectoderm results in the formation of Prox-1 a

54 athway reporter TOPGAL is expressed in nasal periocular ectoderm, these data suggest that, in this lo

55 His symptoms included right eye proptosis, periocular edema and redness.

56 All cases presented with pain and periocular erythema increasing over approximately 1 week

57 ons and Relevance: Half of the patients with periocular facial dystonias used alleviating maneuvers.

58 pace and cornea, with a dissolution step for periocular formulation) model, with parallel elimination

59 Nine infants with periocular IH were treated with propranolol (oral) for 2

60 then used as a bioassay to determine whether periocular immune modulation affects intraocular transge

61 the medical literature on new treatments for periocular infantile (capillary) hemangioma.

62 ropranolol (3 mg/kg/day) in the treatment of periocular infantile hemangioma (IH) based on clinical a

63 roups experienced a significant reduction in periocular inflammation, the radiotherapy-treated group

64 Sarcoidosis is a major cause of ocular or periocular inflammation.

65 914 patients (1192 eyes) who received >/= 1 periocular injection during follow-up, 286 (31.3%) were

66 Posterior periocular injection led to much lower levels.

67 tial in all three compartments 20 days after periocular injection of 25% microspheres.

68 reous peak of 0.99 +/- 0.26 mug . h/mL after periocular injection of 5 mg of fluorescein (P < 0.01 fo

69 ous were measured either 10 or 20 days after periocular injection of 50% PKC microspheres or at 20 da

70 Ten days after periocular injection of 50% PKC412 microspheres, PKC412

71 Twenty days after periocular injection of 50% PKC412, high levels of PKC41

72 in tumor burden was detected after a single periocular injection of anecortave acetate.

73 ere given intraperitoneal, intravitreous, or periocular injection of CGC-11144, CGC-11150, or vehicle

74 Within 2 days of periocular injection of CGC-11144, there was apoptosis i

75 membrane in young domestic pigs, and then a periocular injection of control microspheres or microsph

76 Within 20 minutes of a periocular injection of fluorescein, peak fluorescence w

77 ignificantly smaller in eyes that received a periocular injection of microspheres containing 25% (P=0

78 New Zealand White rabbits were given a periocular injection of sodium fluorescein (fluorescein,

79 levels are markedly increased compared with periocular injection of the same amount of fluorescein.

80 The patient underwent periocular injection of triamcinolone acetonide, with re

81 nterior subconjunctival injection, posterior periocular injection, intramuscular injection, or topica

82 reduced in the exoplant group compared with periocular injection.

83 ibutes significantly to drug clearance after periocular injection; (3) corneal pharmacokinetics of sm

84 Periocular injections and surgically implanted drug rese

85 area of CNV, with a similar reduction after periocular injections of 0.2 mg CGC-11144 three times a

86 (Pharmacia & Upjohn Co, Bridgewater, NJ) and periocular injections of botulinum toxin A.

87 or anterior uveitis is well-established, but periocular injections of corticosteroid can also be used

88 Periocular injections of d,l-alpha-difluoromethyl-ornith

89 vitreous cavity of newborn rats, followed by periocular injections of EDL-155 (20 mg/kg/day) or an eq

90 ng protein 1177-1191 peptide were treated by periocular injections of increasing doses of MSC-Exo sta

91 Same-aged mice (n = 30) received periocular injections of saline, carboplatin, and 2-DG.

92 ) transgenic mice (n = 25) were treated with periocular injections of varying doses of 2-DG (62.5, 12

93 sgenic retinoblastoma mice were treated with periocular injections to the right eye only of saline (n

94 Periocular injections were effective in treating active

95 vitreous (melphalan, topotecan) or topotecan periocular injections.

96 To evaluate the pharmacokinetics of the periocular injections: posterior subtenon (PST), retrobu

97 male and 4 male patients were diagnosed with periocular lobular capillary hemangioma at a median age

98 The authors provide a summary of traditional periocular locations for the injection of neuromodulator

99 Nine patients developed 12 periocular malignancies and 3 patients required eyelid s

100 sexpression also leads to a reduction of the periocular mesenchymal cell population expressing Lmx1b,

101 meobox gene Six3 is expressed in a subset of periocular mesenchymal cells and in differentiating ante

102 and lmx1b.2 result in defective migration of periocular mesenchymal cells around the eye and lead to

103 ed levels of Six3 attenuate proliferation of periocular mesenchymal cells in vitro and differentiatin

104 opment, keratocan mRNA was first detected in periocular mesenchymal cells migrating toward developing

105 lmx1b.1 and lmx1b.2 promote the survival of periocular mesenchymal cells that influence multiple sig

106 s expressed in the dermis, skeletal muscles, periocular mesenchymal-like cells and corneal endotheliu

107 results in ectopic blood vessels within the periocular mesenchyme and PITX2 expression remains persi

108 cranial neural crest that gives rise to the periocular mesenchyme and the frontonasal process, retin

109 These defects in the periocular mesenchyme are correlated with a failure in f

110 Structures derived from periocular mesenchyme arise by complex interactions betw

111 strated the interaction of beta 1 and NG2 in periocular mesenchyme cells and corneal fibroblasts with

112 ynamically in the developing vasculature and periocular mesenchyme during development.

113 losure, is dramatically downregulated in the periocular mesenchyme in late VAD embryos, and dissoluti

114 Indeed, by blocking the death of the periocular mesenchyme in Lmx1b morphants, optic vesicle

115 euroectoderm, lens, and neural crest-derived periocular mesenchyme induced severe eye abnormalities w

116 m, but their function in the Fgf10-producing periocular mesenchyme is still poorly understood.

117 Conditional inactivation of Porcn in periocular mesenchyme led to defects in mid- and hindbra

118 pment or function of structures derived from periocular mesenchyme result in debilitating vision loss

119 results in agenesis or severe disruption of periocular mesenchyme structures and extrinsic defects i

120 In the lens, retina and periocular mesenchyme, G8-positive cells synthesized Myo

121 In mouse embryos Rieg mRNA localized in the periocular mesenchyme, maxillary and mandibular epitheli

122 ssues, including prechondrogenic mesenchyme, periocular mesenchyme, meninges, endothelial cells, and

123 The periocular mesenchyme, originating from the neural crest

124 hough Fgf10 RNA is expressed normally in the periocular mesenchyme, Ugdh mutation leads to excessive

125 t and the mesoderm-derived precursors of the periocular mesenchyme.

126 c cup, ventral coloboma, and a deficiency of periocular mesenchyme.

127 ions with specific environments and signals: periocular mesenchyme/BMP specifies pigmented epithelium

128 f Myf5, there is a clear distinction between periocular myogenic and non-myogenic cell lineages accor

129 Periocular necrotizing fasciitis is a rare but potential

130 As seen in these 5 cases, periocular necrotizing fasciitis may cause severe visual

131 We report 5 cases of periocular necrotizing fasciitis resulting in severe vis

132 nfections such as cytomegalovirus infection, periocular nerve involvement due to leprosy, and hyperse

133 tingly, neuropilin-1 (Npn-1) is expressed by periocular neural crest but down-regulated, in a manner

134 Furthermore, Sema3A inhibits periocular neural crest migration in vitro.

135 le of Sema3A/Npn-1 signaling in coordinating periocular neural crest migration that is vital for prop

136 The recurrence rate of periocular nodular basal cell carcinoma (PNBCC) followin

137 ional case series, consecutive patients with periocular or orbital BCC who met criteria for treatment

138 oculo[dermal]) melanocytosis is a congenital periocular pigmentary condition that can lead to the dev

139 , or three injections (intravitreal [IVT] or periocular [PO]) of AdNull.11D (empty cassette) at 2-wee

140 ular transgene expression is associated with periocular pretreatment with corticosteroid.

141 expressing neural crest cells remain in the periocular region and contribute to the anterior uvea an

142 Cranial neural crest cells migrate into the periocular region and later contribute to various ocular

143 ing alcohol-free antiseptic solutions in the periocular region and taking measures to protect the dep

144 ld be used with caution, particularly in the periocular region because the late effects of hypofracti

145 Patients with a periocular region nonmelanoma skin cancer (NMSC) or a no

146 capillary hemangiomas can also arise in the periocular region of adults.

147 Squamous cell carcinoma affecting the periocular region represents a risk of solid organ trans

148 Despite their ability to migrate to the periocular region, neither cardiac nor trunk neural cres

149 nced techniques utilizing injectables in the periocular region.

150 and efficacious nonsurgical alternatives in periocular rejuvenation.

151 nced techniques using facial injectables for periocular rejuvenation.

152 PST is the best periocular route for vitreous NaF delivery with minimal

153 c staining) was present in 29 of 35 cases of periocular SC (82.9%).

154 p16 overexpression is common in periocular SC but unrelated to HR-HPV status.

155 as an etiologic agent in the development of periocular SC using multiple modalities to maximize sens

156 Unstained paraffin sections of 35 cases of periocular SC were analyzed with immunohistochemistry fo

157 ation of p16 positivity is not applicable to periocular SC.

158 All 10 sporadic periocular sebaceous carcinomas maintained strong staini

159 riocular NMSCs, ophthalmologic findings, and periocular sequelae after the repair.

160 Periocular sequelae included lower eyelid ectropion (6 m

161 d stimulus (CS) that was paired with a brief periocular shock unconditioned stimulus (US).

162 The most common abnormalities were in the periocular skin and ocular surface, including interpalpe

163 response, CD154(-/-) mice developed HSK and periocular skin disease with similar kinetics and severi

164 om ganglia to the cornea and failed to cause periocular skin disease, which requires zosteriform spre

165 (-/-) mice developed more severe corneal and periocular skin disease.

166 inished but was heaviest in mice with active periocular skin disease.

167 rowth in the cornea, trigeminal ganglia, and periocular skin following corneal infection compared to

168 Virus was present in the periocular skin from 24 h despite the lack of significan

169 d herpes stromal keratitis (HSK), as well as periocular skin lesions that are characterized by vesicl

170 l-depleted mice displayed moderate to severe periocular skin lesions, progressively became cachetic,

171 blepharitis and viral replication within the periocular skin of KOSV2-infected mice compared to mice

172 her than by direct spread from cornea to the periocular skin.

173 ornea can be described by a two-compartment (periocular space and cornea, with a dissolution step for

174 f the initial leak-back of the dose from the periocular space into the precorneal area.

175 on can be explained with a four-compartment (periocular space, choroid-containing transfer compartmen

176 compartment) model with elimination from the periocular space, retina, and choroid compartment.

177 parallel elimination from the cornea and the periocular space.

178 injected into the posterior subconjunctival (periocular) space in rats under anesthesia.

179 xture of 2 trial types: a tone paired with a periocular stimulation (A+) or a tone and light presente

180 and light presented simultaneously without a periocular stimulation (XA-).

181 citor, B) and retardation (X paired with the periocular stimulation) tests, the presence of inhibitio

182 Likewise, during reflexive blinks to periocular stimulation, IpN cells show excitation-suppre

183 slow to develop excitation when paired with periocular stimulation.

184 c to the orbit and ocular adnexa (eyelid and periocular structures) has changed in recent decades.

185 ht-shielding effects on the superior half by periocular structures.

186 neurotrophic keratitis without damaging the periocular structures.

187 erienced by two-thirds of patients receiving periocular subcutaneous anesthesia.

188 logic level decreases pain perception during periocular, subcutaneous anesthesia.

189 ctival tissue harvested from patients during periocular surgery.

190 before surgery to patients having bilateral, periocular surgery.

191 Periocular TA injection markedly decreased the acute inf

192 findings demonstrate that viral infection of periocular tissue and subsequent disease development occ

193 Histological studies of periocular tissue preparations demonstrated the presence

194 by zosteriform spread from the cornea to the periocular tissue via the trigeminal ganglion rather tha

195 d to evaluate the effect of exoplants on the periocular tissue.

196 replication in eyes, trigeminal ganglia, and periocular tissue.

197 tivity was observed in trigeminal ganglia or periocular tissue.

198 uence show that these genes are expressed in periocular tissues and in a pattern conserved with other

199 trong betaGal activity was first detected in periocular tissues of E13.5 embryos, and restricted to c

200 on capture assay in developing maxillary and periocular tissues suggest that the DNA region near the

201 no histopathological damage to the retina or periocular tissues.

202 Periocular treatment with corticosteroids may enhance ad

203 In contrast, periocular vaccination with gB2/gD2 in MF59 provided sig

204 s significantly reduced by therapeutic local periocular vaccination.

205 surgery for facial malignancies outside the periocular zone.