ライフサイエンスコーパス: periostin

1 anced fibrosis (collagen, laminin, vimentin, periostin).

2 as extracted tumor samples were stained for periostin.

3 and suppression of PPARalpha in response to periostin.

4 or (VEGF), type I collagen, fibronectin, and periostin.

5 mulated eosinophils on a surface coated with periostin.

6 tor-beta-induced expression of CCN2/CTGF and periostin.

7 oduction of type I collagen, HSP-47, FN, and periostin.

8 ed with PDGF receptor beta, procollagen, and periostin.

9 sue repair, such as type I collagen, FN, and periostin.

10 y density was increased in animals receiving periostin.

11 proteins, such as the matricellular protein periostin.

12 eased osteoblast apoptosis in the absence of periostin.

13 r matrix proteins: collagen I, tenascin, and periostin.

14 tor for advanced glycation end products, and periostin.

15 ed for alterations in expression of FHL1 and periostin.

16 ming annulus fibrosis, marked by the protein periostin.

17 evant genes, including TGFbeta(2), Has2, and periostin.

18 the actin cytoskeleton and is stimulated by periostin.

19 migration of IL-5-stimulated eosinophils on periostin.

20 versus 9% (95% CI, -24 to 34; P = 0.54); and periostin, 30% (95% CI, -2 to 51; P = 0.07) versus 3% (9

21 , presented in this report, demonstrate that periostin, a component of the extracellular matrix, is p

22 Here, we report that periostin, a highly expressed cell adhesion molecule, is

23 on of an extracellular matrix (ECM) protein, periostin, a known valvulogenic matrix maturation mediat

24 Periostin, a matricellular adapter protein highly expres

25 Previously, we showed that periostin, a matricellular protein involved in tissue re

26 Periostin, a matricellular protein, has an important rol

27 De novo expression in the kidney of periostin, a protein involved in odontogenesis and osteo

28 Increased renal expression of periostin, a protein normally involved in embryonic and

29 Periostin, a secreted extracellular matrix protein, has

30 sent understanding regarding the function of Periostin, a useful marker of the noncardiomyocyte linea

31 renal function and is a key intermediate for periostin activation of signaling pathways involved in c

32 Further, RGD peptide inhibition of periostin/alpha(v)beta(3) interaction resulted in a mark

33 Periostin also inhibited the expression of Gob5, a putat

34 Recombinant periostin also suppressed Sost expression, which was med

35 sults support a potential mechanism by which periostin alterations could act as a contributing factor

36 modulus of the collagen gel, indicating that periostin alters collagen fibrillogenesis or cross-linki

37 nhances eosinophil adhesion and migration on periostin, an extracellular matrix protein upregulated i

38 Periostin, an extracellular matrix protein, has recently

39 We investigated the role of periostin, an extracellular matrix protein, in the patho

40 Periostin, an extracellular matrix protein, plays key ro

41 hus, the combination of an autocrine loop of periostin and a paracrine loop composed of IL-1alpha and

42 -47 (HSP-47), fibronectin (FN), ED-A-FN, and periostin and activation of the Smad pathway were evalua

43 Conversely, both genetic ablation of periostin and administration of a periostin-neutralizing

44 There was no association between logarithm periostin and age or sex, although levels were low in cu

45 Periostin and betaIGH3 proteins were also detected and s

46 fluorescent-labeled antibody that recognizes periostin and binds specifically to ESCC xenograft tumor

47 n bronchial epithelial cells stimulated with periostin and epithelial cells overexpressing periostin,

48 rized a PET tracer that specifically targets periostin and evaluated the probe in preclinical models

49 PTH stimulated periostin and inhibited MEF2C and sclerostin (Sost) expr

50 Notably, periostin and integrin-beta3 were highly colocalized in

51 The distribution of periostin and logarithm-transformed periostin levels was

52 ocalization of beta-catenin and induction of periostin and matrix gla protein but does not induce gen

53 to mesenchymal transition, and more recently periostin and members of the lysyl oxidase family of enz

54 e results demonstrate that interplay between periostin and renal inflammation orchestrates inflammato

55 We demonstrate that STAT3/periostin and STAT6 signaling are critical mediators of

56 Periostin and TGF-beta inducible gene clone H3 (betaIGH3

57 reaction was used to quantify mRNA levels of periostin and TGF-beta.

58 rway smooth muscle (Asm) area with decreased periostin and transforming growth factor beta-positive c

59 Periostin and vascular cell adhesion protein 1 (VCAM-1),

60 hemical studies indicated that the source of periostin and VCAM-1 was the inflamed sheep liver tissue

61 d pancreatic stellate cells, lower levels of periostin, and alterations in collagen production and or

62 fractional exhaled nitric oxide, serum IgE, periostin, and blood and sputum eosinophils.

63 Expression of airway mucosal CCL26, periostin, and IL-13-IVS all facilitated segregation of

64 esophageal transcripts, including eotaxin-3, periostin, and markers of mast cells and barrier functio

65 thepsin-L1, vascular cell adhesion molecule, periostin, and neutrophil gelatinase-associated lipocali

66 RNAs encoding cell-cycle proteins, Tgf-beta, periostin, and other profibrotic proteins.

67 Furthermore, delayed administration of periostin antisense oligonucleotides in wild-type animal

68 For example, serum periostin appears to be a biomarker for responsiveness t

69 ntegrin and metalloprotease 33 (ADAM33), and periostin are hypothesized to be involved in subepitheli

70 to investigate the potential role of sputum periostin as a biomarker of severe asthma phenotypes.

71 These findings implicate periostin as a catabolic protein that promotes cartilage

72 The clinical utility of serum periostin as a type 2 biomarker in asthma is limited by

73 Collectively, our studies reveal periostin as an important mediator of ESCC tumor invasio

74 long with the potential utility of DPP-4 and periostin as biomarkers of interleukin-13 pathway activa

75 ion, peripheral blood eosinophils, and serum periostin as potential biomarkers of asthma in children.

76 tion to FE(NO), blood eosinophils, and serum periostin at baseline.

77 on (marked reduction in collagen 3), but not periostin, biglycan, or fibronectin accumulation, was im

78 tion, siRNA-mediated knockdown of endogenous periostin blocked constitutive MMP-13 expression.

79 h the integrin alphaVbeta3 receptor, whereas periostin-blocking antibody prevented inhibition of MEF2

80 ese are the blood eosinophil count and serum periostin, both of which have demonstrated utility in id

81 Gene expression levels of CLCA1 and periostin, but not SerpinB2, were significantly higher t

82 ium from the epithelial cells overexpressing periostin caused TGF-beta-dependent secretion of type 1

83 The 3-gene signature of periostin, chloride channel accessory 1 (CLCA1), and Ser

84 ithelial cell signature of IL-13 activation (periostin, CLCA1, and SERPINB2), TH2 genes (IL4, IL5, an

85 differentially express TGF-beta2, VEGF, and periostin compared with cells from atopic nonasthmatic a

86 entially express TGF-beta2, VEGF, ADAM33, or periostin compared with cells from atopic nonasthmatic a

87 ma medications, geographic region, screening periostin concentration, and blood eosinophil counts as

88 domisation was stratified by screening serum periostin concentration, history of asthma exacerbations

89 FEV1, ACQ-6, and AQLQ(S), and, in those with periostin concentrations higher than the median, we note

90 cularis were detected via increased fibrosal periostin content, which tracked the presence of the CD4

91 s of TGF-beta, suggesting that inhibition of periostin could represent a unique treatment approach.

92 The Periostin Cre (Postn-Cre) lineage includes endocardial a

93 In our system, we determined that periostin deficiency leads to increased cell death and d

94 In the lungs, periostin deficiency resulted in increased airway resist

95 , inflammation, and remodelling were made in periostin deficient mice and wild-type controls followin

96 chial hyperresponsiveness are exaggerated in periostin deficient mice challenged with inhaled aeroall

97 prisingly, compared with wild-type controls, periostin deficient mice developed increased AHR and ser

98 ssion of TGF-beta1 and Foxp3 in the lungs of periostin deficient mice.

99 g growth factor-beta responsiveness indicate periostin-deficient fibroblasts are unable to support no

100 Sensitization and challenge of periostin-deficient mice with OVA resulted in increased

101 opment of allergic pulmonary inflammation in periostin-deficient mice.

102 Periostin-dependent activation of JNK resulted in activa

103 Together, these results identify a periostin-dependent pathway that mediates obesity-induce

104 Periostin detection levels were reduced over time in res

105 Periostin did not identify blood or sputum eosinophilia,

106 Mice lacking expression of periostin displayed preserved renal function and structu

107 encodes for the extracellular matrix protein periostin dramatically reduced with age.

108 with extracellular regeneration factors like periostin enhances cardiac repair in rodents.

109 odosomes along with clearance of the Stiny-1 periostin epitope.

110 Migrating IL-5-activated eosinophils on periostin exhibit loss of nucleopodal features and appea

111 peripheral blood eosinophils, serum IgE, or periostin exhibited a greater reduction in LAR compared

112 Our results define the myofibroblast as a periostin-expressing cell type necessary for adaptive he

113 d in a genetically engineered mouse model of periostin-expressing distal esophageal/forestomach ESCC.

114 tional Cre-expressing mouse lines shows that periostin-expressing myofibroblasts in the heart derive

115 activity in cardiomyocytes and reduction of periostin expression allowing for a more homeostatic ext

116 Lack of periostin expression also blunted the de novo renal expr

117 We examined periostin expression by immunohistochemical analysis of

118 We conclude that the decline in periostin expression in adult rabbit BM does not solely

119 rulence factors (P. gingivalis LPS) decrease periostin expression in human PDL fibroblasts.

120 HDM exposure increased periostin expression in the airway epithelium, subepithe

121 proinflammatory transcription factors induce periostin expression in vitro and that binding of these

122 Whether and how periostin expression influences bone anabolism, however,

123 ery of antisense oligonucleotides to inhibit periostin expression protected animals from L-NAME-induc

124 Periostin expression was 3.7-fold higher in bronchial ce

125 ADAM33 and periostin expression was assessed by using real-time PCR

126 or, at both mRNA and protein levels, whereas periostin expression was repressed by adding noggin or d

127 s to dysregulation of fibrillar collagen and periostin expression, as well as enlarged hypercellular

128 Reductions in FHL1 and periostin expression, direct consequences of reduced AC6

129 l lines, TE-11 with high and TT with minimal periostin expression, were implanted in nu/nu mice to ge

130 potential autocrine effects and to increase periostin expression.

131 genic mice had higher levels of fibrosis and periostin expression.

132 We generated a (64)Cu-DOTA-anti-periostin-F(ab')2 with a dissociation constant of 29.2 +

133 mor necrosis factor-alpha (TNF-alpha), RAGE, periostin, fibronectin, and type I collagen.

134 dence of two common genetic alterations with periostin function.

135 These data suggest that periostin functions as a disease determinant in MD by pr

136 In contrast, mice lacking the periostin gene showed less injury-induced interstitial f

137 Analyses of periostin gene targeted mice demonstrate that it is with

138 Here we generate Postn (periostin) gene-targeted mice containing a tamoxifen-ind

139 ns over 52 weeks in biomarker-high patients (periostin >/=50 ng/mL or blood eosinophils >/=300 cells

140 ients with high pretreatment levels of serum periostin had greater improvement in lung function with

141 Because periostin has been reported to induce cell differentiati

142 nhaled corticosteroid therapy, especially in periostin-high patients.

143 BrdU labeling, Ki67 antigen expression, and periostin immunohistochemistry in the fibrotic regions o

144 Recent studies have implicated a role for periostin in allergic eosinophilic esophagitis.

145 Epithelial cell-derived periostin in asthma has roles in TGF-beta activation and

146 tial, indicating an in vitro requirement for periostin in B lymphopoiesis.

147 hat specific imaging of extracellular matrix periostin in ESCC is feasible using a targeted PET trace

148 Genetic ablation of periostin in HCM mice reduced but did not extinguish non

149 flammatory cytokines alter the expression of periostin in PDL cells.

150 This study demonstrates the utility of periostin in phenotyping severe asthma.

151 he mechanism(s) of induction and the role of periostin in renal disease.

152 Elevation of periostin in response to mechanical stress was blocked b

153 pressing periostin, we reveal a function for periostin in stimulating the TGF-beta signaling pathway

154 To further define a role for periostin in Th2-mediated inflammatory diseases such as

155 Notably, overexpression of periostin in the livers of WT mice promoted hepatic stea

156 increase in the expression and synthesis of periostin in the obstructed kidney that associated with

157 to the non-loaded controls (higher levels of periostin in the supernatant in the non-loaded group).

158 Detection of periostin in the tumor microenvironment may help with ea

159 Periostin increased MMP-13 expression dose [1-10 microg/

160 Furthermore, treatment of these cells with periostin increased the expression of collagen I and sti

161 In vitro, recombinant periostin increased the expression of integrin-beta3 and

162 hibition or shRNA knockdown of ILK prevented periostin-induced Akt/mammalian target of rapamycin (mTO

163 Airway epithelial cell-derived periostin-induced conversion of CD4(+) CD25(-) cells int

164 Periostin induction of MMP-13 expression was inhibited b

165 Periostin is a 90-kDa member of the fasciclin-containing

166 Periostin is a matricellular protein essential for tissu

167 Periostin is a matricellular protein with roles in tissu

168 Periostin is a systemic biomarker of airway eosinophilia

169 Periostin is an integrin-binding protein that is importa

170 Periostin is considered to be a matricellular protein wi

171 Periostin is expressed in a variety of tissues and expre

172 Indeed, periostin is expressed throughout cardiovascular morphog

173 Here, we show that although periostin is induced in the heart following injury, it d

174 ated that the secreted cell adhesion protein periostin is markedly upregulated in livers of obese rod

175 we show that up-regulation and secretion of periostin is pathological and enhances disease in the de

176 We hypothesized that periostin is required for airway inflammatory responses

177 In mice, periostin is required for maximal airways hyperresponsiv

178 Periostin is required for maximal HDM-induced T-cell res

179 by using in situ hybridization, we show that periostin is specifically up-regulated in bronchial epit

180 This gene signature, which includes periostin, is present in approximately half of asthmatic

181 The periostin layer, detected with monoclonal antibody Stiny

182 sions of TNF-alpha and RAGE but elevated the periostin level in all three phases of periodontitis.

183 Age 2 year periostin level of 150 ng/mL or more predicted asthma at

184 hma showed that, of these indices, the serum periostin level was the single best predictor of airway

185 level and blood eosinophil count) and serum periostin level.

186 ion between postbronchodilator FEV1 /FVC and periostin levels (-0.276, P < 0.05).

187 ) and significantly elevated fibronectin and periostin levels (P <0.01).

188 Serum periostin levels are significantly higher in children th

189 Serum periostin levels are significantly increased in asthmati

190 ithelial fibrosis in asthmatic patients, and periostin levels have been linked to increases in IL-13.

191 Reference values for serum periostin levels in adults without asthma or COPD are pr

192 Serum periostin levels in adults without asthma or COPD are si

193 We found high periostin levels in human and rodent OA cartilage.

194 allergen-induced airway eotaxin-2/CCL24 and periostin levels in miR-155 KO mice.

195 Periostin levels in sputum are associated with persisten

196 ution of periostin and logarithm-transformed periostin levels was derived, and 90% confidence interva

197 Serum periostin levels were approximately 2- to 3-fold higher

198 Periostin levels were higher in patients with fixed as c

199 ic IgE levels, blood eosionophil counts, and periostin levels were measured in 244 children.

200 Serum periostin levels were measured in 480 individuals, compr

201 d eosinophil numbers, Feno levels, and serum periostin levels, in 59 patients with severe asthma show

202 f chondrocytes to knock down and up-regulate periostin levels, respectively, and analyzed its effect

203 on of exhaled nitric oxide levels, and serum periostin levels, to aid decision making in clinical tri

204 f patients, for example asthmatics with high periostin levels.

205 f chronic periodontal inflammation on tissue periostin levels.

206 with lebrikizumab than did patients with low periostin levels.

207 In addition, periostin localization by immunofluorescence was perform

208 unidentified molecule(s) probably compensate periostin loss because Postn(-/-) mice had normal number

209 Targeting periostin may be a novel therapeutic strategy for treati

210 se in response to TGF-beta and that blocking periostin may be a promising therapeutic strategy agains

211 Our studies suggest that periostin may be part of a negative-feedback loop regula

212 Serum periostin measurements do not need to be adjusted to tak

213 These data strongly suggest that periostin mediates renal disease in response to TGF-beta

214 Periostin might be a biomarker of the esophageal tumor m

215 well as reduced IL-4, IL-25, CD68, Gob5, and periostin mRNA expression.

216 Deletion of periostin(+) myofibroblasts reduces collagen production

217 57BL/6 mice treated with either IgM or OC-20 periostin neutralizing antibody.

218 blation of periostin and administration of a periostin-neutralizing antibody dramatically improved he

219 Periostin null mice exhibit atrial septal defects, struc

220 ctors responsible for bone and PDL damage in periostin-null mice (a periodontitis animal model) using

221 ere periodontal defects were observed in the periostin-null mice after tooth eruption.

222 Cementum, alveolar bone, and the PDL of periostin-null mice dramatically deteriorate following t

223 The periodontia from periostin-null mice were characterized followed by unloa

224 periostin was right skewed with a mean (SD) periostin of 51.2 (11.9) ng/mL, median (IQR) 50.1 (43.1

225 These data elucidate the complex role of periostin on bone anabolism, through the regulation of S

226 es of the effects of epithelial cell-derived periostin on murine T cells were also performed.

227 igh concentrations of type 2 biomarkers (eg, periostin or blood eosinophils).

228 the most differentially expressed gene), (2) periostin, or (3) a multigene IL-13 in vitro signature (

229 type 2 status based on airway mucosal CCL26, periostin, or IL-13-IVS gene expression.

230 ristic of osteogenic cell lineages including periostin, osteonectin, and Id2 are expressed specifical

231 associated with increased IL-5 (P < .05) and periostin (P < .05) tissue levels and colonization with

232 LV protein expression of FHL1 (p<0.02) and periostin (p=0.04) were reduced after TAC in AC6-KO mice

233 In conclusion, periostin PDL tissue levels significantly decrease under

234 Treatment with periostin peptide increased the EF from 31% to 41% and d

235 rolled release system to deliver recombinant periostin peptide into the pericardial space.

236 est the functional and structural effects of periostin peptide treatment in a large animal model of m

237 However, periostin peptide treatment increased myocardial fibrosi

238 Periostin peptide-treated animals had newly formed myoca

239 andomly assigned to receive either saline or periostin peptide.

240 Periostin (PN), a novel fasciclin-related matricellular

241 r) or in activated cardiac fibroblasts using periostin (Postn) (MerCreMer) .

242 d colleagues analyze messenger RNA levels of periostin (POSTN) in pulmonary fibroblasts, endothelial

243 Periostin (Postn) is a matricellular protein preferentia

244 The matrix-specific protein periostin (POSTN) is up-regulated in human cancers and a

245 Here, we demonstrate that Periostin (Postn) via interaction with Integrin-alphav (

246 Here, we identify periostin (POSTN), a secreted protein, as a key componen

247 expression of 70 genes, including IL13, IL5, periostin (POSTN), calcium-activated chloride channel re

248 The extracellular matrix molecule periostin (POSTN, encoded by POSTN), which is secreted b

249 les (desmoglein 1, DSG1), tissue remodeling (periostin, POSTN), and mast cells (carboxypeptidase A, C

250 PDCs were highly enriched for mRNAs encoding periostin, procollagen I, fibronectin I, vimentin, disco

251 tro and that binding of these factors on the periostin promoter is enriched in glomeruli during exper

252 ation in embryogenesis and activation of the periostin promoter, were induced by BMP-2 but repressed

253 Periostin promotes cell proliferation, cyst growth, inte

254 Genetic modulation of periostin promotes tumor cell migration and invasion as

255 Analysis of periostin protein expression in TAC-myocardium, as well

256 thmatic subjects, and in vitro, we show that periostin protein is basally secreted by airway epitheli

257 al virulence factors significantly decreased periostin protein levels in the loaded cultures.

258 found that FTY-720 treatment or knockdown of periostin protein was able to inhibit transforming growt

259 In a mechanically challenged environment, periostin protein was more efficiently incorporated into

260 The secreted periostin protein, which marks mesenchymal cells in endo

261 Here we investigated how periostin regulates proliferation and differentiation of

262 nts for FE(NO), blood eosinophils, and serum periostin, respectively.

263 bbit or murine BM cells, and reexpression of periostin restored this potential, indicating an in vitr

264 Overexpression of periostin resulted in reduced expression of peroxisome p

265 This suggests that loss of periostin results in inappropriate differentiation of me

266 was inversely correlated with the levels of periostin (rho = -0.545; p < 0.001).

267 ore, that eosinophils remodel and migrate on periostin-rich extracellular matrix in the asthmatic air

268 The mechanism of periostin's effect as a brake on allergen-induced respon

269 Periostin secreted from fibroblasts was required for IL-

270 epithelial cells increased the expression of periostin several-fold, leading to subsequent loss of th

271 ng with the fibrillar fibronectin/tenascin-C/periostin structures that characteristically surround me

272 Among patients in the low-periostin subgroup, the increase from baseline FEV(1) wa

273 Among patients in the high-periostin subgroup, the increase from baseline FEV(1) wa

274 (P < .001), and results were similar by the periostin subgroup, with no apparent differences between

275 the dose groups and the placebo group by the periostin subgroup.

276 pe p53 function were each found to attenuate periostin, suggesting the interdependence of two common

277 -inducible protein (Tgfbi or betaig-h3), and periostin] survived at least through weaning.

278 emilin-1), and other extracellular proteins (periostin, tenascin-X).

279 18, CCL26, thymic stromal lymphopoietin, and periostin), TH9/IL-9, IL-23 (p40 and p19), and IL-16 med

280 However, in the case of periostin the effects on cardiac fibrosis may limit its

281 Though one might expect periostin to play a deleterious role in asthma pathogene

282 porter mice, was inhibited in the absence of periostin (TOPGAL;Postn(-/-) mice).

283 Periostin-traced myofibroblasts also revert back to a le

284 netically engineered mouse models, ESCC high periostin tracer uptake anatomically correlated with the

285 the epithelial-mesenchymal interactions, and periostin tunes the magnitude of keratinocyte proliferat

286 roducts, vascular endothelial growth factor, periostin, Type I collagen, and fibronectin were also ev

287 microscopy, and migration of eosinophils on periostin was assayed.

288 Periostin was found in the extracellular matrix of carti

289 Periostin was measured in sputum supernatants.

290 a group of matricellular proteins, of which periostin was prominent.

291 The distribution of serum periostin was right skewed with a mean (SD) periostin of

292 eriostin and epithelial cells overexpressing periostin, we reveal a function for periostin in stimula

293 The 90% confidence limits for periostin were 35.0 and 71.1 ng/mL.

294 ges in eotaxin, epidermal growth factor, and periostin were also decreased in the lungs of house dust

295 Blood eosinophils adhering to adsorbed periostin were imaged at different time points by fluore

296 ription factors and also TGFbeta1, MMP16 and periostin, which are involved in oncogenic progression.

297 y be determined, in part, by a key molecule, periostin, which maintains the integrity of the PDL duri

298 However, the interaction of periostin with alpha(v)beta(3) on lymphoid progenitors p

299 In addition, mixing recombinant periostin with type 1 collagen in solution caused a dram

300 96.2% of adenocarcinoma stained positive for periostin, with most stained strongly (67.3% and 69.3%,

301 c oxide (Feno), peripheral blood eosinophil, periostin, YKL-40, and IgE levels and compared these bio