ライフサイエンスコーパス: peripheral nerve injury

1 t underlie successful regeneration following peripheral nerve injury.

2 R) are upregulated in spinal microglia after peripheral nerve injury.

3 hwann cells undergo phenotypic modulation in peripheral nerve injury.

4 h neuropeptide Y (NPY) and galanin following peripheral nerve injury.

5 pha9alpha10 nAChRs in the pathophysiology of peripheral nerve injury.

6 Sensation is essential for recovery after peripheral nerve injury.

7 n of damaged axons in the early stages after peripheral nerve injury.

8 ms that contribute to neuropathic pain after peripheral nerve injury.

9 f spinal GABA(A)-receptor function following peripheral nerve injury.

10 sensory and motor neuron survival following peripheral nerve injury.

11 -H protein and mRNA are downregulated after peripheral nerve injury.

12 al and behavioral alterations resulting from peripheral nerve injury.

13 uting of the fibers into these laminae after peripheral nerve injury.

14 ithin the dorsal root ganglion (DRG) after a peripheral nerve injury.

15 ore robust, centrally mediated response than peripheral nerve injury.

16 rons become recoupled by gap junctions after peripheral nerve injury.

17 ic discharges and mechanical allodynia after peripheral nerve injury.

18 e etiology of mechanical allodynia following peripheral nerve injury.

19 lectrical properties that are observed after peripheral nerve injury.

20 les with gelatinases activity at the site of peripheral nerve injury.

21 hat matched patterns normally observed after peripheral nerve injury.

22 le in regulating motoneuron survival after a peripheral nerve injury.

23 KCgamma) show reduced neuropathic pain after peripheral nerve injury.

24 ritories are activated and proliferate after peripheral nerve injury.

25 neuronal plasticity after specific types of peripheral nerve injury.

26 ters the thermal hyperalgesic sensitivity to peripheral nerve injury.

27 following either peripheral inflammation or peripheral nerve injury.

28 le in regulating motoneuron survival after a peripheral nerve injury.

29 ant roles in the reactions of DRG neurons to peripheral nerve injury.

30 ng observed within sensory ganglia following peripheral nerve injury.

31 in the DRG at multiple time points following peripheral nerve injury.

32 d can persist after apparent resolution of a peripheral nerve injury.

33 (CGRP) decrease in the dorsal horn following peripheral nerve injury.

34 uting of sympathetic fibers in the DRG after peripheral nerve injury.

35 gical changes in a neuropathic pain model of peripheral nerve injury.

36 o regeneration and functional recovery after peripheral nerve injury.

37 transition from acute to chronic pain after peripheral nerve injury.

38 tactile and cold allodynia remain following peripheral nerve injury.

39 -138 in adult sensory neurons in response to peripheral nerve injury.

40 amed rats differ from those in animals after peripheral nerve injury.

41 gy as well as similar inflammatory events of peripheral nerve injury.

42 neuropathic and inflammatory pain following peripheral nerve injury.

43 d late-phase neuropathic pain behavior after peripheral nerve injury.

44 the mechanical hypersensitivity produced by peripheral nerve injury.

45 DF could contribute to pain generation after peripheral nerve injury.

46 i silkworms can support axon regeneration in peripheral nerve injury.

47 shown that it can also do this in mice after peripheral nerve injury.

48 te with pain behavior and inflammation after peripheral nerve injury.

49 y distinct degenerative insults: hypoxia and peripheral nerve injury.

50 he ipsilateral spinal cord dorsal horn after peripheral nerve injury.

51 d molecular therapies to improve outcomes of peripheral nerve injuries.

52 like expression in the spinal cord following peripheral nerve injuries.

53 re capable of dramatic reorganizations after peripheral nerve injuries.

54 regeneration and muscle reinnervation after peripheral nerve injuries.

55 ctional rehabilitation following central and peripheral nerve injuries.

56 y processing in excitatory neurons following peripheral nerve injuries.

57 Neuropathic pain accompanies peripheral nerve injury after a wide variety of insults

58 plete (i.e. sciatic nerve transection (SNT)) peripheral nerve injury altered the mean threshold inten

59 We conclude that, following peripheral nerve injury, an immediate acute immune respo

60 Peripheral nerve injuries and neuropathies lead to profo

61 is also implicated in neuropathic pain after peripheral nerve injury and apoptosis after spinal cord

62 are upregulated by sensory neurons following peripheral nerve injury and appear to participate in neu

63 ore, to the reduced levels of cAMP following peripheral nerve injury and are likely critical to the p

64 wann cells readily dedifferentiate following peripheral nerve injury and become repair cells.

65 le spindle-motoneurone connection both after peripheral nerve injury and during development.

66 ative of persistent pain in rodent models of peripheral nerve injury and inflammation and prevented n

67 changes in cortical circuits also accompany peripheral nerve injury and may represent additional the

68 nation during both development and following peripheral nerve injury and repair.

69 ctivity is microglial cells activated by the peripheral nerve injury and secreting the enzyme, as a r

70 o a peripheral nerve can mimic the effect of peripheral nerve injury and significantly increase the n

71 in higher-order spinal sensory neurons after peripheral nerve injury and suggest a link between misex

72 ate the efficacy of hMDSPC-based therapy for peripheral nerve injury and suggest that hMDSPC transpla

73 mouse Celf2 expression is upregulated after peripheral nerve injury and that Celf2 mutant mice are d

74 inal cord dorsal horn could change following peripheral nerve injury and that the Hippo signaling pat

75 ibute to efficient axonal regeneration after peripheral nerve injury and, when grafted to the central

76 the spinal first sensory synapse induced by peripheral nerve injury, and presynaptic NMDARs might be

77 ease in analgesic potency and efficacy after peripheral nerve injury, and their effects are blocked b

78 ical hypersensitivity in the mouse models of peripheral nerve injury- and paclitaxel-induced neuropat

79 in CSF samples increased significantly after peripheral nerve injury, associated with spinal microgli

80 ays a role in the early neuronal response to peripheral nerve injury at sites distal to the cell body

81 which is dramatically upregulated following peripheral nerve injury at the site of injury, in the do

82 After peripheral nerve injury at the spinal nerve level, some

83 ve axonal regeneration in superimposed acute peripheral nerve injury attributable to tissue-damaging

84 After peripheral nerve injury, axons are able to regenerate, a

85 hared with an important repair program after peripheral nerve injury, but lead to neural perturbation

86 d neuronal function in development and after peripheral nerve injury, but little is known regarding i

87 suggests that A-fibre sprouting arise after peripheral nerve injury, but mainly from small calibre A

88 ry sensory neurons readily regenerates after peripheral nerve injury, but the central branch, which c

89 alter spinal glial activation resulting from peripheral nerve injury by specific manipulation of IL-6

90 Peripheral nerve injury can lead to a persistent neuropa

91 Peripheral nerve injury can trigger neuropathic pain in

92 Our findings demonstrate that a peripheral nerve injury causes activated microglia withi

93 Peripheral nerve injury causes sensory dysfunctions that

94 Peripheral nerve injury causes spontaneous and long-last

95 Peripheral nerve injury causes spontaneous electrical ac

96 eurial hypoxia in a mouse model of traumatic peripheral nerve injury, causing painful mononeuropathy.

97 Pain resulting from peripheral nerve injury, characterised by ongoing pain,

98 ement cascade in spinal cord microglia after peripheral nerve injury contributes to neuropathic pain

99 Here we show that peripheral nerve injury decreased agrin expression in th

100 brain injury, ischemia, spinal cord injury, peripheral nerve injury, demyelinating disease, neuromus

101 Here we present novel evidence that peripheral nerve injury diminishes glycine-mediated inhi

102 Moreover, unilateral peripheral nerve injury evokes parallel, but smaller eff

103 Neuropathic pain accompanies peripheral nerve injury following a variety of insults i

104 After peripheral nerve injury, following frequencies were incr

105 Progress in experimental studies of root and peripheral nerve injuries has identified potential candi

106 Poor functional recovery found after peripheral nerve injury has been attributed to the misdi

107 hich time resolution of the hyperalgesia and peripheral nerve injury has occurred according to previo

108 Current approaches for treating peripheral nerve injury have resulted in promising, yet

109 Using both in vivo and in vitro models for peripheral nerve injury, here we show that inhibition of

110 In animals with peripheral nerve injury, however, the antinociceptive po

111 in the mechanisms of neuropathic pain after peripheral nerve injury; however, how central GRs and NM

112 Peripheral nerve injury in a rat model (spinal nerve lig

113 e cortical "recovery" that typically follows peripheral nerve injury in adult monkeys is apparently d

114 then discuss the pathways that contribute to peripheral nerve injury in DN.

115 eriences associated with limb amputation and peripheral nerve injury in humans.

116 Peripheral nerve injury in neonatal rats results in the

117 Peripheral nerve injury in rodents results in hypersensi

118 scular junctions and hastened recovery after peripheral nerve injury in wild type mice.

119 ehavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WKY) rats, a ge

120 Pathophysiological responses to peripheral nerve injury include alterations in the activ

121 Peripheral nerve injury increased Kcna2 antisense RNA ex

122 Here, we report that peripheral nerve injury increases expression of the DNA

123 Peripheral nerve injury increases nNOS expression in fib

124 response of CX(3)CR1-deficient microglia to peripheral nerve injury indicates unimpaired neuronal-gl

125 n causes delayed axon degeneration following peripheral nerve injury, indicating that it participates

126 We found that peripheral nerve injury induced de novo expression of co

127 The fact that peripheral nerve injury induced de novo GRP expression i

128 Unexpectedly, however, peripheral nerve injury induced significant GRP expressi

129 These findings indicate that peripheral nerve injury induced time-dependent and regio

130 h-clamp recording technique, we investigated peripheral nerve injury-induced changes in excitatory sy

131 Mechanistically, peripheral nerve injury induces DNA demethylation and up

132 Peripheral nerve injury induces increased expression of

133 Peripheral nerve injury induces permanent alterations in

134 Peripheral nerve injury induces upregulation of the calc

135 nerve injury, few studies have examined how peripheral nerve injury influences spinal somatosensory

136 However, if the neurons are conditioned by a peripheral nerve injury into an actively growing state,

137 Peripheral nerve injury is a debilitating condition.

138 Neuropathic pain caused by peripheral nerve injury is a debilitating neurological c

139 Peripheral nerve injury is a major neurological disorder

140 demonstrate using immunohistochemistry that peripheral nerve injury is also sufficient to alter the

141 Herein, we show that peripheral nerve injury is associated with activation of

142 Neuropathic pain following peripheral nerve injury is associated with hyperexcitabi

143 iately regulated inflammatory response after peripheral nerve injury is essential for axon regenerati

144 Peripheral nerve injury is known to induce changes in th

145 Peripheral nerve injury is known to upregulate the rapid

146 o find that cold hypersensitivity induced by peripheral nerve injury is reduced in eIF4E(S209A) and M

147 A rapid proinflammatory response after peripheral nerve injury is required for clearance of tis

148 Recovery of motor and sensory function after peripheral nerve injury is suboptimal, even after approp

149 Peripheral nerve injury leads to deficient recovery of s

150 Peripheral nerve injury leads to various injury-induced

151 Following peripheral nerve injury, low threshold mechanoreceptive

152 After peripheral nerve injury, macrophages infiltrate the dege

153 ific subcellular redistribution of PN3 after peripheral nerve injury may be an important factor in es

154 herapeutic enhancement of regeneration after peripheral nerve injury may require a combination of fac

155 These RNA-Seq data analyses indicate that peripheral nerve injury may result in highly selective m

156 horn of the spinal cord in response to three peripheral nerve injury models of neuropathic pain.

157 eus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain.

158 s mechanical and thermal hypersensitivity in peripheral nerve injury models of neuropathic pain.

159 subject to divergent plasticity in different peripheral nerve injury models, reflecting the complexit

160 There is consensus that, distal to peripheral nerve injury, myelin and Remak cells reorgani

161 f central GRs in nociceptive behaviors after peripheral nerve injury (neuropathic pain behaviors) rem

162 After peripheral nerve injury, neurotrophins play a key role i

163 her central nervous system manifestations of peripheral nerve injury nor functional bowel disorders a

164 Traumatic peripheral nerve injuries often produce permanent functi

165 ated cognitive decline, Parkinson's disease, peripheral nerve injury, optic nerve degeneration, and d

166 d NMDAR-dependent persistent pain induced by peripheral nerve injury or injection of Complete Freund'

167 (DRG) neurones of rat alters as a result of peripheral nerve injury or localized inflammation.

168 ptible to myelination diseases such as adult peripheral nerve injury or multiple sclerosis.

169 may render the spinal neurons vulnerable to peripheral nerve injury or neuropathic pain stimuli.

170 Functional recovery after a peripheral nerve injury (PNI) is often poor.

171 e anterior cingulate cortex contralateral to peripheral nerve injury prevented exacerbation of mechan

172 he anterior cingular cortex contralateral to peripheral nerve injury prevented the exacerbation of me

173 mill training in the first 2 weeks following peripheral nerve injury produces a marked enhancement of

174 In normal animals, peripheral nerve injury produces a persistent, neuropath

175 elta1-dependent pathway activated by TSP4 or peripheral nerve injury promotes exaggerated presynaptic

176 Peripheral nerve injury reduces NECAB2, but not NECAB1,

177 drenoceptor agonist clonidine at the site of peripheral nerve injury reduces pain behavior and local

178 Currently, diagnosis and monitoring of peripheral nerve injury relies on clinical and electrodi

179 Peripheral nerve injury results in axonal degeneration a

180 Peripheral nerve injury results in axonal degeneration a

181 In a recent study, it was shown that peripheral nerve injury results in increased NKCC1 activ

182 Partial peripheral nerve injury results in pain-like behavioral

183 f GCS in wild-type mice, following transient peripheral nerve injury, reversed the overexpression of

184 In peripheral nerve injury, Schwann cells (SCs) must surviv

185 After peripheral nerve injury, Schwann cells transition from a

186 n this study, we hypothesized that (1) after peripheral nerve injury, second-order dorsal horn neuron

187 In humans with peripheral nerve injuries, shorter wait times to decompr

188 during development of SC lineage and during peripheral nerve injury, so we sought to study their fun

189 rats with a hypersensitivity state following peripheral nerve injury, spinal administration of an NO

190 It has been shown recently that in models of peripheral nerve injury, spinal cord microglia can becom

191 Peripheral nerve injury stimulates neuronal expression o

192 rved behavior in the rotarod, water maze and peripheral nerve injury tests was possibly affected by i

193 tive in alleviating mechanical allodynia for peripheral nerve injury than nerve root injury, suggesti

194 re observed in the rat spinal cord following peripheral nerve injuries that result in neuropathic pai

195 the aim of this study is to examine whether peripheral nerve injury that causes neuropathic pain mod

196 play an unique role in neuroplasticity after peripheral nerve injury that may contribute to allodynia

197 r RNA elevation in rat spinal cord following peripheral nerve injury that results in pain behaviors s

198 In the weeks following unilateral peripheral nerve injury, the deprived primary somatosens

199 Robust axon regeneration occurs after peripheral nerve injury through coordinated activation o

200 d nerve conduction examinations, evidence of peripheral nerve injury was seen.

201 ning can affect the functional outcome after peripheral nerve injury, we assessed the effect of up-co

202 sal horn of the spinal cord is reduced after peripheral nerve injury, we have studied synaptic transm

203 pression and function of spinal NMDARs after peripheral nerve injury were modulated by central GRs.

204 untered in lumbar DRGs in standard models of peripheral nerve injury were not observed in diabetic mi

205 ase in synthesis of NGF within the DRG after peripheral nerve injury, which contributes to the recove

206 st a role for NP-1 in the axonal response to peripheral nerve injury, which may be specific to a part