ライフサイエンスコーパス: peripheral tissue

1 an suppress protein misfolding in C. elegans peripheral tissue.

2 h blocks the export of lymph node cells into peripheral tissue.

3 cells residing in distinct locations within peripheral tissue.

4 development of inflammatory hyperalgesia of peripheral tissue.

5 l containment of HSV-2 reactivation in human peripheral tissue.

6 tein in neural tissue, but only minimally in peripheral tissue.

7 as to be balanced against excess exposure of peripheral tissue.

8 mechanism for controlling T cell function in peripheral tissue.

9 involved in a growing number of functions in peripheral tissues.

10 lymphoid organs and subsequent migration to peripheral tissues.

11 nscripts encoding proteins characteristic of peripheral tissues.

12 es metabolism and mitochondrial integrity in peripheral tissues.

13 he only known hunger signal derived from the peripheral tissues.

14 ed us to enumerate metastatic cells in mouse peripheral tissues.

15 n the SCN is also expressed and functions in peripheral tissues.

16 r, in regulating effector T cell egress from peripheral tissues.

17 on in the hypothalamus and that occurring in peripheral tissues.

18 re neuronal receptors for Sides expressed on peripheral tissues.

19 chiasmatic nucleus and subordinate clocks in peripheral tissues.

20 pture signatures of environmental insults in peripheral tissues.

21 ct capillary beds in the retina and in other peripheral tissues.

22 metabolic basis of vitamin A homeostasis in peripheral tissues.

23 hat elicit effects across insulin-responsive peripheral tissues.

24 ed ability to migrate into the parenchyma of peripheral tissues.

25 eptors CB1 and CB2 in the nervous system and peripheral tissues.

26 gestation, with abundant MECP2 mutations in peripheral tissues.

27 e central nervous system, but not in several peripheral tissues.

28 led neurons and synchronizes other clocks in peripheral tissues.

29 t is mediated by M2 activated macrophages in peripheral tissues.

30 rcadian oscillators in other brain sites and peripheral tissues.

31 n RagA loss, a myeloid population expands in peripheral tissues.

32 notype is accompanied by phase adjustment of peripheral tissues.

33 hrough its actions on the pancreas and other peripheral tissues.

34 or excitability and attenuate nociception in peripheral tissues.

35 both light entrainment and clock function in peripheral tissues.

36 e SCN stays close to the periods of cells in peripheral tissues.

37 s, which measure removal of cholesterol from peripheral tissues.

38 kines), helps regulate glucose metabolism in peripheral tissues.

39 of terminal arborization in certain NGF-rich peripheral tissues.

40 s are present in patient-derived central and peripheral tissues.

41 broblast growth factor receptor 4 (FGFR4) in peripheral tissues.

42 hway that mediates the effects of ghrelin on peripheral tissues.

43 the details of the mineralization process in peripheral tissues.

44 s energy storage vs expenditure in liver and peripheral tissues.

45 man beings and reverse insulin resistance in peripheral tissues.

46 pensable for maintaining B cell tolerance in peripheral tissues.

47 r selectivity and preferential expression in peripheral tissues.

48 ses that correlated with RVFV clearance from peripheral tissues.

49 king and ability to take up residence within peripheral tissues.

50 e 2 innate lymphoid cells (ILC2) resident in peripheral tissues.

51 he recruitment of leukocytes from blood into peripheral tissues.

52 e marrow homing, egress, or recruitment into peripheral tissues.

53 ical pathways, including circadian rhythm in peripheral tissues.

54 es improving the effectiveness of insulin in peripheral tissues.

55 ations, the latter of which migrate from the peripheral tissues.

56 important regulator of energy metabolism in peripheral tissues.

57 n enzyme responsible for H(2)S production in peripheral tissues.

58 prions from the draining lymphoid tissue to peripheral tissues.

59 perlipidemia and increased fat deposition in peripheral tissues.

60 Consequently, IL-7 is not available in peripheral tissues.

61 an important role in cholesterol efflux from peripheral tissues.

62 RAT to increase cellular vitamin A uptake in peripheral tissues.

63 matic nucleus (SCN) and local oscillators in peripheral tissues.

64 tion of the HMGB1-mediated response in these peripheral tissues.

65 expressed in the hypothalamus compared with peripheral tissues.

66 e in regulating immunity and inflammation in peripheral tissues.

67 owever, Abeta is generated in both brain and peripheral tissues.

68 s, and not Tem cells, predominantly surveyed peripheral tissues.

69 ogeneity and in regulating their function in peripheral tissues.

70 te the immune system, peritoneal cavity, and peripheral tissues.

71 stem might also control energy metabolism in peripheral tissues.

72 ion of GluT4 in the hippocampus from that in peripheral tissues.

73 ring the initiation of allergic responses in peripheral tissues.

74 cretion and increasing insulin resistance in peripheral tissues.

75 mmunicating external and internal signals to peripheral tissues.

76 o basolateral membranes for copper efflux to peripheral tissues.

77 , insulin regulates a variety of pathways in peripheral tissues.

78 ates metabolic and circadian rhythm genes in peripheral tissues.

79 onses necessary to control this infection in peripheral tissues.

80 ol leukocyte egress from lymphoid organs and peripheral tissues.

81 te T-cell activation and end-organ damage in peripheral tissues.

82 aneous proliferation of immature NK cells in peripheral tissues, a phenotype that is replicated under

83 to an equal extent enhances GSIS and acts as peripheral tissue activator of insulin-independent gluco

84 n vaccine biology is that DCs migrating from peripheral tissue and classical lymphoid-resident DCs (c

85 macrophages result in poised macrophages in peripheral tissue and negatively impact wound repair.

86 ppress dendritic cell maturation and present peripheral tissue and tumor Ags for autoreactive T cell

87 Virus infections usually begin in peripheral tissues and can invade the mammalian nervous

88 ensive viral sampling from several different peripheral tissues and cell types and from three distinc

89 iated with enhanced virus replication in the peripheral tissues and central nervous system (CNS).

90 mes that are differentially expressed in the peripheral tissues and central nervous systems.

91 CTRP4 is also produced by peripheral tissues and circulates in blood.

92 ars mutations, leading to sensory defects in peripheral tissues and correlating with overall disease

93 n network of sensory and autonomic fibers in peripheral tissues and high speed of neural transduction

94 ign against microbes that invade through the peripheral tissues and highlight new vaccination strateg

95 ting memory CD4 T cells that traffic between peripheral tissues and lymphoid sites.

96 apture pathogens and foreign antigen (Ag) in peripheral tissues and migrate to secondary lymphoid tis

97 that regulate glucose and fat metabolism in peripheral tissues and modulate inflammation in adipose

98 Not only the myocardium, but also peripheral tissues and organs are affected by metabolic

99 mals failed to prevent systemic pathology in peripheral tissues and organs, indicating fundamental mo

100 neuroprotection is offset by side effects in peripheral tissues and organs.

101 on the endogenously expressed HTT protein in peripheral tissues and post-mortem HD brain tissue, as w

102 rst time define CRY expression in Drosophila peripheral tissues and reveal that CRY acts together wit

103 ing, insulin promotes the uptake of sugar in peripheral tissues and suppresses the production of suga

104 ere a hypothesis on how a cross-talk between peripheral tissues and the brain might influence the dev

105 which result from the inhibition of FAAH in peripheral tissues and the consequent enhancement of ana

106 associated with enhanced fluid drainage from peripheral tissues and thus with a hypotensive phenotype

107 Th1 responses, to efficiently accumulate in peripheral tissues, and almost exclusively differentiate

108 p normally, are present in normal numbers in peripheral tissues, and are fully competent suppressors

109 (CyPA), a known mediator of inflammation in peripheral tissues, and by cyclosporine A, a CyPA inhibi

110 ulation, transmigration to and activation in peripheral tissues, and clearance of senescent neutrophi

111 ledge of how Treg cells home to lymphoid and peripheral tissues, and control antibody production and

112 al role in synchronizing circadian rhythm in peripheral tissues, and multiple mechanisms regulate tis

113 rcadian regulation in the nervous system and peripheral tissues, and plays an important role in the m

114 , which can trigger enhanced inflammation in peripheral tissues, and suggest that these processes are

115 ctions by apoptosis or by dissemination into peripheral tissues, and those residing in nonlymphoid or

116 is partially controlled by the expression of peripheral tissue antigens (PTAs) in lymph node stromal

117 ic endothelial cells (LECs) directly express peripheral tissue antigens and induce CD8 T-cell deletio

118 Thus, Aire-mediated expression of peripheral tissue antigens drives the thymic development

119 which promote thymic display of thousands of peripheral tissue antigens in a process critical for est

120 not promote AIRE-dependent transcription of peripheral tissue antigens in vitro.

121 Because LECs express numerous peripheral tissue antigens, lack of costimulation couple

122 the metabolic effects of ghrelin on AMPK in peripheral tissues are abolished by the lack of function

123 not been shown whether lipid oscillations in peripheral tissues are driven by diurnal cycles of rest-

124 bolic effects of ghrelin on AMPK activity of peripheral tissues are mediated by cannabinoid receptor

125 t CD13(+) CD14(-) macrophages in mucosal and peripheral tissues are preferentially infected very earl

126 CNS function since they are found throughout peripheral tissues as well as being highly expressed in

127 s, a significant part of the cells expressed peripheral tissue-associated, functional homing markers.

128 dysia spp) and suffer substantial removal of peripheral tissue at larval feeding sites.

129 es, and the emerging literature on fluid and peripheral tissue biomarkers.

130 ory mechanisms of immune responses through a peripheral tissue-bone marrow axis.

131 and glial cells or between neurons and other peripheral tissues, both in physiological and pathologic

132 hat these cells preferentially accumulate in peripheral tissues but not in the primary tumor.

133 ed from the liver was acquired mainly by the peripheral tissues but not retained efficiently, causing

134 mouse model that expresses ApoE normally in peripheral tissues, but has severely reduced ApoE in the

135 one factor that sets the circadian clock in peripheral tissues, but relatively little is known about

136 for their control of cellular physiology in peripheral tissues, but their influence in brain under n

137 Telomeres have been studied extensively in peripheral tissues, but their relevance in the nervous s

138 ipts, large amounts of lamin A were found in peripheral tissues, but there was very little lamin A in

139 n the accumulation of lipid intermediates in peripheral tissues, but this was not associated with a w

140 accumulation was observed in their brains or peripheral tissues, but very low infectivity was detecte

141 e to inhibition of estrogens biosyntheses in peripheral tissue by the aromatase (CYP19) inhibitors ap

142 the immature state are positioned throughout peripheral tissues by acting as sentinels, sensing the p

143 Frataxin measurements from peripheral tissues can be used to identify FRDA patients

144 This result indicates that peripheral tissues can contain higher levels of infectiv

145 These mitochondrion-related disorders in peripheral tissues can impact on brain functions through

146 extent to which different brain regions, and peripheral tissues can sustain HSF1 activity and HS prot

147 Cholesterol from peripheral tissue, carried by HDL, is metabolized in the

148 ice to constant light disrupted the clock in peripheral tissues, causing loss of the nighttime repres

149 ders, but it remains unclear to which extent peripheral tissue clocks contribute to this effect.

150 LC2 progenitors (ILC2Ps) and mature ILC2s in peripheral tissues compared with females.

151 Increasing SMN exclusively in peripheral tissues completely rescued necrosis in mild S

152 phils are well characterized as mediators of peripheral tissue damage in lupus, but it remains unclea

153 To investigate the immune capabilities of peripheral tissue DCs generated in vivo from the BM of U

154 Following antigen acquisition in peripheral tissues, DCs migrate to draining lymph nodes

155 uggest that the inflammatory hyperalgesia in peripheral tissue depends on activation of COX-1 and COX

156 on of a dynamic role for oxygen sensing in a peripheral tissue directly modifying cardiovascular resp

157 akdown are harmful inflammatory responses in peripheral tissues driven by innate immunity and self an

158 permit monocytes to tailor miRNA profiles in peripheral tissues during differentiation to macrophages

159 ell migration is crucial to the formation of peripheral tissues during vertebrate development.

160 controls human female reproductive tract and peripheral tissue dynamics in single, dual and multiple

161 ddition to its well-characterized effects in peripheral tissues, emerging evidence suggests that neur

162 o the maintenance of glucose homeostasis and peripheral tissue energy balance.

163 Because in peripheral tissues, expression of PPARdelta increases li

164 The Lin28a/Let-7 axis has been studied in peripheral tissues for its role in metabolism regulation

165 glia and then to reactivate and move back to peripheral tissues for spread to other hosts.

166 otactic migration of effector T cells within peripheral tissue forms an important factor in the speed

167 or (Aire), is critical for the protection of peripheral tissues from autoimmune attack.

168 her the prion protein deposition reported in peripheral tissues from this MV individual correlates wi

169 the action of these hormones on behavior and peripheral tissue functions.

170 In mammals, most cells in the brain and peripheral tissues generate circadian ( approximately 24

171 Locally produced peripheral tissue GH, in contrast to circulating pituita

172 cose-stimulated insulin secretion (GSIS) and peripheral tissue glucose uptake.

173 ta cells from oxidative stress and improving peripheral tissue glucose utilization.

174 o difference in viral burden was detected in peripheral tissues, greater viral infection was detected

175 in plays in the inflammatory hyperalgesia of peripheral tissue has not been established.

176 believed to be a minor memory cell subset in peripheral tissues has been dramatically underestimated.

177 However, studying circadian action in peripheral tissues has been limited so far to mouse mode

178 unity, the role of memory T cells present in peripheral tissues has not been explored.

179 s the primary site of molecular pathology in peripheral tissues, has not been addressed.

180 Ectopic lipids in peripheral tissues have been implicated in attenuating i

181 s (LNs) and resident memory T (TRM) cells in peripheral tissues have distinct roles in protective imm

182 Peripheral tissue homing receptors enable T cells to acc

183 use of an overflow of lipids from the WAT to peripheral tissues; however, this did not occur when Ad-

184 e., neuromuscular junction) and infection of peripheral tissues (i.e., muscle cells).

185 The family of OT-like molecules affects both peripheral tissues implicated in reproduction, homeostas

186 ite evidence of TCF7L2 expression in various peripheral tissues important in glucose homeostasis.

187 d activated JNK, analogous to what occurs in peripheral tissue in patients with diabetes.

188 nsights into how vitamin A is distributed to peripheral tissues in a regulated manner and identify LR

189 icular benefits to a therapy that can target peripheral tissues in addition to brain.

190 n in the central nervous system (CNS) versus peripheral tissues in mouse models using a therapeutic s

191 or human CTRP6 impaired glucose disposal in peripheral tissues in response to glucose and insulin ch

192 nstrates potent efficacy in both the CNS and peripheral tissues in severe SMA mice following systemic

193 and demonstrate a role for BDNF produced by peripheral tissues in short-term controls of feeding, li

194 tely 150 brain pacemaker neurons and in many peripheral tissues in the head and body, but can also be

195 TRA project nonredundant representations of peripheral tissues in the thymus.

196 whether leptin has similar effects in human peripheral tissues in vivo, ex vivo, and in vitro and wh

197 or T cells exit the vasculature to enter the peripheral tissues in which an infection is ongoing.

198 litates insulin-stimulated glucose uptake in peripheral tissues including adipose, muscle, and heart.

199 growth, DR reduces parasite accumulation in peripheral tissues including the brain, and increases cl

200 e suprachiasmatic nucleus (SCN), but also in peripheral tissues including the liver.

201 ine can directly modulate immune function in peripheral tissues including the spleen and gastrointest

202 at steady-state levels of ATP7A are lower in peripheral tissues (including the heart, spleen, and liv

203 was transiently expressed at high levels in peripheral tissues, including adrenal cortex (E16-E21) a

204 o facilitates the efflux of cholesterol from peripheral tissues, including macrophages, back to liver

205 pathway by which cholesterol accumulated in peripheral tissues, including the artery wall, is transp

206 terized by impaired uptake of cholesterol in peripheral tissues, including the liver and the pancreas

207 ally delivers retinol from hepatic stores to peripheral tissues, including the placenta and fetal eye

208 embrane properties in a non-clock-containing peripheral tissue independent of light.

209 stored insulin sensitivity in both liver and peripheral tissues independent of body weight.

210 Analysis of peripheral tissues indicates that itk(-/-) innate PLZF(+

211 illumination, either of the thalamus or the peripheral tissues, induced JF-NP-26-mediated light-depe

212 could also be demonstrated in the absence of peripheral tissue injury by direct electrical stimulatio

213 nounced than the benefits of young, and that peripheral tissue injury compounds the negative effects.

214 ating nutritional status to both central and peripheral tissues involved in nutrient partitioning, an

215 chanism of prion transport in axons and into peripheral tissue is unresolved.

216 chanism of prion transport in axons and into peripheral tissue is unresolved.

217 Impaired insulin action in peripheral tissues is a major pathogenic factor.

218 Immune homeostasis in peripheral tissues is achieved by maintaining a balance

219 is of circadian signaling in single cells of peripheral tissues is as-yet uncharacterized.

220 Via RCT, excess cholesterol from peripheral tissues is carried back to the liver and henc

221 Metastatic invasion of tumors into peripheral tissues is known to rely upon protease-mediat

222 accumulation and leads to fat spillover into peripheral tissues, leading to the deleterious effects o

223 ould be detected in blood monocytes and some peripheral tissues (liver, spleen) up to 30 d after the

224 but recently the concept of immune memory in peripheral tissues mediated by resident memory T (T(RM))

225 vels of TSE infectivity and PrP-res within a peripheral tissue of this mouse model were investigated.

226 lock) mRNA expressions in various neural and peripheral tissues of buntings in different LHSs and dis

227 eases, including CAG repeat disorders, or in peripheral tissues of c9FTD/ALS.

228 ta TCR are disproportionately represented in peripheral tissues of mice and humans, suggesting they t

229 ily acquired but not retained efficiently in peripheral tissues of neonatal rats, suggesting that a m

230 and TSE infectivity was also present in the peripheral tissues of this disease model.

231 sue loss, and insulin activity is reduced in peripheral tissues of tumor-bearing hosts.

232 s significantly, and prions were detected in peripheral tissues only in NN animals.

233 a hunger signalling peptide derived from the peripheral tissues, overcomes the satiety signals evoked

234 diabetes and obesity (insulin sensitivity in peripheral tissue, pancreatic islet and beta cell functi

235 Changes in sublingual and peripheral tissue perfusion parameters were significantl

236 Circadian rhythms in peripheral tissues persisted but became desynchronized a

237 ong lived, poly-functional CD8(+) T cells to peripheral tissues, phenotypically displaying hallmarks

238 ibition of glucose uptake by liver and other peripheral tissues, principally adipose and muscle and w

239 receptor components in the hypothalamus and peripheral tissues, promoting FGF21 resistance.

240 Foxp3(+) regulatory T cells in peripheral tissues (pT(regs)) are instrumental in limiti

241 In peripheral tissues, PTP1B regulates insulin signaling, b

242 ly deposited excess nutrients to mammary and peripheral tissues rather than to the adjacent tumors.

243 pithelial genes critical for their long-term peripheral tissue residency.

244 sessed the expression of AIRE and of several peripheral tissue-restricted Ag genes by quantitative PC

245 by directly infecting nerves that innervate peripheral tissues, resulting in debilitating direct and

246 lar mechanisms that guide ILC migration into peripheral tissues, revealing common features among diff

247 esis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with inc

248 Additionally, we found that in peripheral tissues, SFB selectively expand dual T cell r

249 , vast numbers of T cells reside in multiple peripheral tissue sites including lungs, intestines, liv

250 Effector memory CD8+ T cells reside in peripheral tissue sites of initial pathogen encounter, i

251 moma samples for transcripts for AIRE and 16 peripheral tissue-specific autoantigens (TSAgs) by quant

252 ain at all ages and in all brain regions and peripheral tissues studied.

253 ed adipose tissue inflammation and decreased peripheral tissue substrate utilization after being rein

254 Neuropeptide Y (NPY) is induced in peripheral tissues such as adipose tissue with obesity.

255 o present in amyloid plaques, is aberrant in peripheral tissues such as blood and adrenal medulla tha

256 In mice, subpopulations of myeloid DCs in peripheral tissues such as lungs and in blood express CX

257 e cells to epithelial cells during injury of peripheral tissues such as the liver and colon, where IL

258 ASCT2 is highly expressed in peripheral tissues such as the lung and intestines where

259 It is expressed in low levels in healthy peripheral tissues, such as the lung epithelium, but is

260 cated in the blood from cells present within peripheral tissues, such as the lung.

261 Circadian oscillations in peripheral tissues, such as the retinal compartment of t

262 n previously reported in patients' brain and peripheral tissue, suggesting their relevance in sporadi

263 r, the wide distribution of MCH receptors in peripheral tissues suggests additional functions for MCH

264 binding of (123)I-CLINDE to blood cells and peripheral tissues, SUV is not a sufficient surrogate of

265 colon cancer, but rarely expressed in normal peripheral tissues, targeting GRM3 with such agents woul

266 from the thymus, secondary lymph organs, and peripheral tissues that are free of externally applied f

267 nal Ube3a but does not affect periodicity in peripheral tissues that are not imprinted for uniparenta

268 ched and fatty acid spillover occurs into to peripheral tissues that metabolic diseases develop.

269 This subset is found in peripheral tissues that require expression of specific c

270 T cells (TEM), which broadly migrate between peripheral tissues, the blood, and the spleen.

271 Sensory dendrites innervate peripheral tissues through cell-cell interactions that a

272 ILCs maintain their presence in lymphoid and peripheral tissues thus far has been unclear.

273 strointestinal tract before disseminating to peripheral tissues to cause disease, but intestinal fact

274 t lipogenesis in the liver communicates with peripheral tissues to control energy substrate homeostas

275 Migratory DCs traffic from peripheral tissues to draining lymph nodes charged with

276 igen-experienced memory T cells patrol these peripheral tissues to facilitate swift immune responses

277 er signals, and immune cells travelling from peripheral tissues to lymph nodes.

278 in glucose metabolism and communicates with peripheral tissues to maintain energy homeostasis.

279 edonic brain responses, altered responses of peripheral tissues to metabolic signals, and changes in

280 Little is known about how HDL-C leaves peripheral tissues to reach plasma.

281 Dendritic cells (DCs) migrate from peripheral tissues to secondary lymphoid organs (SLOs) t

282 complexes (ICs) stimulates DC migration from peripheral tissues to the paracortex of draining lymph n

283 often evade immune surveillance by adopting peripheral tissue- tolerance mechanisms, such as the exp

284 in brain, whereas infectivity was present in peripheral tissues too.

285 rested in studying the communication between peripheral tissues under metabolic homeostasis perturbat

286 induced Tregs (iTregs) that differentiate in peripheral tissues upon exposure to Ag in a tolerogenic

287 ins are also involved in leukocyte exit from peripheral tissues via afferent lymphatics to the draini

288 l signs, and their brains as well as several peripheral tissues were analyzed for the accumulation of

289 of prion protein that were found in multiple peripheral tissues were associated with diarrhea, autono

290 ssential carrier of energy from the liver to peripheral tissues when the supply of glucose is too low

291 s (MCp) leave the bone marrow and migrate to peripheral tissues where they mature.

292 ate directs virus access to nerve endings in peripheral tissue, whereas the second delivers virus par

293 f CCL2 and TNFalpha in FXYD5-expressing lung peripheral tissue, which suggests a possible role for FX

294 one protein, widely expressed in central and peripheral tissues, which can translocate to the plasma

295 iated with chronic low-grade inflammation in peripheral tissues, which contributes to the development

296 Here we report that unlike inflammation in peripheral tissues, which develops as a consequence of o

297 itute circadian oscillators in the brain and peripheral tissues, which drive rhythms in physiology an

298 by encounter with self-antigen expressed on peripheral tissues, which is likely to be relevant to th

299 KISS1R is expressed in other brain areas and peripheral tissues, which suggests that kisspeptin has a

300 hat increase energy expenditure by acting on peripheral tissues without severe side effects.