ライフサイエンスコーパス: peripherally

1 patic or perihilar, and a mixed form located peripherally.

2 elay significantly shorter than when applied peripherally.

3 ol of the animal body by this microbe occurs peripherally.

4 educed transcription from alleles positioned peripherally.

5 redominates centrally and rod loss increases peripherally.

6 sthetic duration when delivered centrally or peripherally.

7 tional TLR4 when administrated centrally and peripherally.

8 (Pe327; 7.2 pmol/kg/min; n = 5) was infused peripherally.

9 n though the stimulus was unseen and located peripherally.

10 to blood pressure homeostasis centrally and peripherally.

11 rant-conditioning paradigm when administered peripherally.

12 e at the macula with healthy tissues located peripherally.

13 degrees -diameter circle but decreased more peripherally.

14 in four rat models of pain when administered peripherally.

15 emodeling as granulocyte stores are released peripherally.

16 to induce antigen-specific T-cell tolerance peripherally.

17 potent at suppressing food intake when given peripherally.

18 measured at the same location centrally and peripherally.

19 1.41 layers centrally versus 10.33 +/- 1.37 peripherally.

20 mediated via the TRIF pathway when delivered peripherally.

21 uodenal cellular responses was not reflected peripherally.

22 nt of the image; this difference was greater peripherally (6.02 mum) than centrally (2.54 mum).

23 There were 48 nodules located peripherally (85.71%).

24 Many prion diseases are peripherally acquired (e.g., orally or via lesions to sk

25 r data suggest that the pathogenesis of many peripherally acquired transmissible spongiform encephalo

26 clinical findings highlight the potential of peripherally acting 5-HT(1) and 5-HT(2A) receptor agonis

27 In contrast, repeated injections of the peripherally acting analog of nicotine, nicotine pyrroli

28 Risk estimates were close to null for the peripherally acting drug amlodipine and for other antihy

29 cerns that underscore the need for effective peripherally acting drugs.

30 ed the efficacy and safety of naldemedine, a peripherally acting mu-opioid receptor antagonist, for t

31 In clinical trials, alvimopan--a peripherally acting mu-opioid receptor antagonist--accel

32 re neural mechanisms, and iv injections of a peripherally acting NIC analog, NIC pyrrolidine methiodi

33 effects of opioid induced constipation with peripherally acting opioid antagonists.

34 pe 1 (CB(1)) blockade with the centrally and peripherally acting rimonabant induces weight loss and i

35 e efficacy and safety of naloxegol, an oral, peripherally acting, mu-opioid receptor antagonist, for

36 eptor blockade in the brain, suggesting that peripherally-acting only CB1 receptor blockers may be us

37 that disease is mediated by antigen-specific peripherally activated CD4(+) T cells that infiltrate th

38 everal advantages over previously identified peripherally active cannabinoid compounds, and could hav

39 inct from these holds promise for developing peripherally active CB1 inverse agonists with fewer side

40 ophilicity compared to rimonabant to achieve peripherally active molecules with minimal central effec

41 RS194B compared with RS41A and the standard peripherally active oxime, 2-pyridinealdoxime methiodide

42 ed as "active" (DVR highest in the lesion), "peripherally active" (perilesional DVR highest), "inacti

43 r enhancing clearance of plasma Abeta with a peripherally administered Abeta-degrading protease would

44 he induction of adaptive immune responses to peripherally administered Ags as if they were responding

45 tenuates the intake-suppressive effects of a peripherally administered amylin analog, suggesting that

46 We demonstrate that peripherally administered anti-Abeta antibody crossed th

47 Peripherally administered antibodies against NPCT decrea

48 explain the rapid antinociceptive effects of peripherally administered CCR2 antagonists under these c

49 and show that a 3 week treatment regimen of peripherally administered FGF2 is highly effective at bl

50 Peripherally administered ghrelin in liver, heart, and a

51 e, but found that they responded normally to peripherally administered GLP-1 and exendin-4.

52 systemically in humans, we evaluated whether peripherally administered GLP-1R agonists access the LDT

53 linical trials by others show that repeated, peripherally administered high doses of recombinant NT3

54 Here we report that peripherally administered leptin-P85 conjugates exhibit

55 does not unequivocably demonstrate that the peripherally administered OT is entering the CSF.

56 Peripherally administered prolactin rapidly activates br

57 Rather, peripherally administered TAM-163 localized to areas in

58 osa induced the opening of the BBB, allowing peripherally administered VRP to invade the brain.

59 These data suggest a clear effect of a peripherally administered, Food and Drug Administration-

60 interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage.

61 alizing mRNA until its release from the mRNA peripherally, allowing ribosome binding.

62 The mass attributable to IgFLNa10 lies peripherally along the actin helix over the N-terminus o

63 is predominantly localized to the cell body peripherally along the Golgi zone.

64 At 0 min, somatostatin was given peripherally along with 4x basal insulin and basal gluca

65 Finally, it is shown that such peripherally and binding pocket-modified vancomycin anal

66 eripheral effects, by administering oxytocin peripherally and by blocking peripheral actions with ant

67 nhibits dietary fat intake when administered peripherally and centrally in animals.

68 inflammatory and nociceptive mediators both peripherally and centrally in sickle mice correlative to

69 enon did not differ between attacks starting peripherally and centrally.

70 ansmitter system that controls gut functions peripherally and centrally.

71 liver and high free exposures of drug, both peripherally and in the CNS.

72 ns in the dorso-central optic cup and sweeps peripherally and ventrally.

73 es to polyclonal TCR stimulation are present peripherally and within the lungs of sarcoid patients.

74 t appears to be selective for Adelta-fibers (peripherally) and HT neurons (centrally).

75 , Th-cell cytokine production was maintained peripherally, and IL-21R KO T cells mediated equivalent

76 to be even more drastic in the case of their peripherally annulated counterparts.

77 A variety of targets for peripherally applied analgesics exists, some of which ca

78 CD8alphaalpha T cells are found to circulate peripherally, as well as reside within the lymphoid tiss

79 and ClpP3/ClpP4/ClpP5/ClpP6 (the P-ring) and peripherally associated ClpT1/ClpT2 subunits.

80 Annexin A2 (AnxA2) is a peripherally associated membrane protein that can suppor

81 Here we analyzed the ability of one peripherally associated membrane protein, annexin A2 (An

82 ns; thus, its shape and size are governed by peripherally associated membrane proteins and possibly b

83 ne association is readily apparent, but many peripherally associated membrane proteins are outwardly

84 dynamic equilibrium: one in which zetacyt is peripherally associated with lipid headgroups and one in

85 The eisosome portion includes proteins peripherally associated with the cytoplasmic side of the

86 ary protein components such as M1 and NP are peripherally associated with the membrane.

87 demonstrate that, in the cytoplasm, Sox10 is peripherally associated with the mitochondrial outer mem

88 d microbial translocation (MT), and was only peripherally associated with viral loads.

89 s simplex virus (HSV-1) infects when applied peripherally at an epithelial surface that had been trea

90 er cells as a remnant that initially locates peripherally at the apical surface of one of the daughte

91 Oligomers of membrane-embedded caveolins and peripherally attached cavins form the caveolar coat whos

92 udies show that Nmnat2 is a neuronal protein peripherally attached to membranes via palmitoylation an

93 be used to modulate touch and may represent peripherally available drugs to treat tactile-driven pai

94 is increase of brain activity was not caused peripherally, because DCPQ insignificantly changed the p

95 Endophilin is a peripherally binding membrane protein that functions as

96 ue oxysterol binding protein of yeast (Osh4) peripherally binds to organelle and plasma membranes and

97 Such an equilibrium between the peripherally bound and embedded forms of zetacyt apparen

98 The peripherally bound, rapidly exchanging tetraphenylborate

99 Other large cells arise more peripherally by initiating endocycles and becoming polyp

100 Variable, Diversity, and Joining genes, and peripherally by somatic hypermutation and class-switchin

101 lucose metabolism, whereas insulin delivered peripherally cannot act on the liver without also affect

102 e that a TrkB agonist antibody, administered peripherally, causes species-dependent effects on body w

103 ease), indication for insertion (infusion of peripherally compatible infusates vs. vesicants), and du

104 For peripherally compatible infusions, PICC use was rated as

105 iol-ending-polyamido-based dendron (d-BAPAD) peripherally decorated with amoxicilloyl (AXO) groups (d

106 cally, the image statistics acquired under a peripherally deployed spotlight of attention are systema

107 Exploiting the natural homing properties of peripherally derived blood cells to deliver therapeutic

108 ated a temporally restricted accumulation of peripherally derived CCR2(+) macrophages, which were con

109 ussed are recent findings demonstrating that peripherally derived endocrine signals act on receptors

110 motif) ligand 2 (CCL2), a greater number of peripherally derived immune cells accumulating in the ol

111 Central nervous system resident and peripherally derived inflammatory cells respond to TBI a

112 mpaired the development and function of both peripherally derived iTregs and in vitro-induced Tregs.

113 -dominant response occurred in microglia and peripherally derived macrophages as remyelination starte

114 se from resident microglia and infiltrating, peripherally derived monocytes.

115 replaced the pool of resident microglia with peripherally derived myeloid cells in Abeta-carrying APP

116 cells with amyloid plaques neither directed peripherally derived myeloid cells to amyloid plaques no

117 owed by a rapid repopulation of the brain by peripherally derived myeloid cells.

118 Peripherally derived regulatory T (pT(reg)) cell generat

119 ed in a marked reduction in both thymus- and peripherally derived Tregs, accompanied by the developme

120 specific demethylation and also induction of peripherally derived Tregs.

121 e from the brain and a second population was peripherally derived.

122 sis, most recovering regulatory T cells were peripherally derived.

123 action, and, ultimately, regulates local and peripherally-derived immune cells to provide a supportiv

124 to thymus-derived natural Tregs (tTregs) and peripherally-derived induced Tregs (pTregs).

125 as been no demonstration of proliferation of peripherally-derived inflammatory macrophages under phys

126 We found that centrally and peripherally directed forces exerted on LBCs are of simi

127 ch less, the actin is centrally, rather than peripherally distributed and the edge dynamics is largel

128 from neuromyelitis optica patients injected peripherally does not cause lesions in naive rats, but o

129 e anorectic and glucose tolerance effects of peripherally dosed GLP-1RA exendin-4 and liraglutide wer

130 iggering transient neural activation, such a peripherally driven action might play a crucial role in

131 closely associated with neurites projecting peripherally during formation of the vestibular and coch

132 tumors were implanted both in the brain and peripherally, emulating systemic cancer metastasis, tumo

133 their olfactory organs with the potential to peripherally encode temporal information about odor enco

134 t that histamine itch and capsaicin pain are peripherally encoded in C-MIAs, and that primate polymod

135 ion and identify GINIP as a key modulator of peripherally evoked GABAB-receptors signaling.

136 em of rodents is an excellent model to study peripherally evoked neural activity in the brain.

137 em of rodents is an excellent model to study peripherally evoked neural activity in the central nervo

138 EAAT4 reporter transgenic mice, we show that peripherally evoked patch-like responses in Crus II are

139 Infiltration of the lamina propria by peripherally expanded CD8(+) T cells was observed after

140 rs from ontogeny, specifically identifying a peripherally expanded oligoclonal population of activate

141 results from a reduced period of priming to peripherally expressed antigen versus ubiquitously expre

142 but maintain efficacy through antagonism of peripherally expressed CB1 receptors.

143 , recent studies indicate that regulation of peripherally expressed CB1 with CNS-sparing compounds is

144 ure CD4(+)Vbeta5(+) T cells that recognize a peripherally expressed endogenous superantigen are toler

145 in C57BL/6 mice respond to encounter with a peripherally expressed endogenous superantigen by underg

146 Glucagon-like peptide-1 (GLP-1) is both a peripherally expressed incretin and a centrally active n

147 in a tissue-specific manner, as loss of the peripherally expressed maternal allele leads to signific

148 Injecting the same dose of IL-1RA peripherally failed to have a protective effect.

149 Peripherally, Flx has anti-resorptive properties, direct

150 verlaps significantly with many conventional peripherally-focused neuromodulatory therapies.

151 In summary, the study of peripherally functionalised multiple bonds with heavier

152 ers are replaced by metal-organic polyhedra, peripherally functionalized so as to have the same conne

153 convenient access to derivatives containing peripherally fused phenanthrene and benzo[g]chrysene uni

154 -generated natural T reg (nT reg) cells, and peripherally generated adaptive T reg (iT reg) cells.

155 om endogenous natural T(reg) but rather were peripherally generated from naive Foxp3(-) precursors.

156 sions demonstrate that PFs contribute to the peripherally generated responses in Crus I.

157 The peripherally grafted, green fluorescent protein-labelled

158 Sirt1 inhibitor (EX-527) was injected either peripherally (i.p., 10 mg/kg) or directly into the brain

159 s ascending centrally in the spinal cord and peripherally in large myelinated nerves.

160 ological alterations occurring centrally and peripherally in PD.

161 after the administration of different doses peripherally in rats.

162 itochondria that are motile are located more peripherally in the cell than non-motile mitochondria.

163 aptive variation unlike genes operating more peripherally in the network.

164 Together with the peripherally induced Ag-specific Foxp3(+) Treg cells, th

165 and dependent on IL-10 and thymic as well as peripherally induced Ag-specific Treg cells.

166 nted central nervous system infiltrating and peripherally induced antigen-specific TH17 cells.

167 Thymus-derived Tregs (tTregs) and their peripherally induced counterparts (pTregs) are imprinted

168 Peripherally induced Foxp3(+) cells sustain tolerance by

169 ved IL-10, and Ag-specific thymic as well as peripherally induced Foxp3(+) regulatory T (Treg) cells.

170 TGF-beta is essential for the development of peripherally induced Foxp3(+) regulatory T cells (iTreg

171 blation of NMBR neurons partially attenuated peripherally induced itch without compromising nocicepti

172 o sensory ganglia dramatically reduced acute peripherally induced nociception and alleviated neuropat

173 on neurons in vivo reduced acute and chronic peripherally induced nociception.

174 to sensory ganglia triggered or exacerbated peripherally induced nociception.

175 Both spinally and peripherally induced priming is prevented by intrathecal

176 nd a significant increase in the quantity of peripherally induced regulatory donor T (pTreg) cells in

177 regulatory T cells, which have a natural and peripherally induced subset, IL-17 production by iNKT ce

178 Indeed, the generation of peripherally induced Treg (iTreg) by TGF-beta was highly

179 iated with CD103(+) dendritic cells, such as peripherally induced Treg development or imprinting CCR9

180 ammation in extraintestinal tissues, whereas peripherally induced Tregs retained in the absence of B7

181 also be imprinted in natural iNKT17 cells or peripherally induced.

182 nction and stability of both thymically- and peripherally-induced Treg cells.

183 main TLR9-responsive cell and accumulated in peripherally inflamed tissues during TLR9-driven inflamm

184 utations might undergo positive selection in peripherally inflamed tissues with elevated levels of IL

185 S parenchyma and protect CNS function during peripherally initiated, acquired immune inflammatory res

186 , these findings support our hypothesis that peripherally injected alphaviruses enter the CNS by hema

187 xamined its role for the febrile response to peripherally injected lipopolysaccharide.

188 ntral 5-HT2A receptors are also required for peripherally injected liraglutide to reduce feeding and

189 s of studies was completed in mice that were peripherally injected with lipopolysaccharide and later

190 post-CPG group were less likely to receive a peripherally inserted central catheter (2.5%, n = 3 vs 3

191 e administered orally or intravenously via a peripherally inserted central catheter (PICC).

192 The rate of peripherally inserted central catheter line complication

193 common catheters inserted were single-lumen peripherally inserted central catheters (n = 1,653; 36.3

194 laboratory tests, parenteral nutrition (PN), peripherally inserted central catheters (PICC), and hosp

195 d whether red blood cell transfusion through peripherally inserted central catheters (PICCs) affects

196 Peripherally inserted central catheters (PICCs) are a co

197 Peripherally inserted central catheters (PICCs) are asso

198 Is parenteral nutrition via peripherally inserted central catheters (PICCs) associat

199 Insertion of peripherally inserted central catheters (PICCs) at the b

200 Use of peripherally inserted central catheters (PICCs) has grow

201 to growing demand, and possible overuse, of peripherally inserted central catheters (PICCs).

202 ity within Australia, most other centres use peripherally inserted central catheters (PICCs).

203 inserted lines and up to day 7 for dialysis, peripherally inserted central catheters, and unspecified

204 Peripherally inserted central venous catheters (PICCs) a

205 selective TLR4 antagonist, was administered peripherally (intravenous) and centrally (intracerebrove

206 hypothesis here that overexpression of BDNF peripherally leads to a disrupted terminal field organiz

207 A third subpopulation, constituting the most peripherally localized bacteria, directly contacted neut

208 ulmonary lesions) had pleural origin or were peripherally located in the lung with a small amount of

209 lgesic effect is attributed to activation of peripherally located kappa receptors, since 14b did not

210 ns that are innervated by efferents in their peripherally located parts, and efferents also innervate

211 ith exocytosis of cortical granules that are peripherally located subcellular organelles unique to ov

212 As development progresses, most oriCs become peripherally located.

213 M1 is peripherally membrane associated, whereas NP associates

214 f SpoIVFB, a portion of the Pro-sigma(K) was peripherally membrane associated.

215 These peripherally membrane-anchored virulence factors mediate

216 ransform infrared measurements show that the peripherally membrane-bound cyt-c experiences significan

217 pathogenic myelin-specific immune responses peripherally, MIF-deficient mice have reduced EAE severi

218 nd thioamide) are disclosed as well as their peripherally modified (4-chlorobiphenyl)methyl (CBP) der

219 t combined binding pocket and chlorobiphenyl peripherally modified analogues exhibit a remarkable spe

220 dicates that combined pocket amidine and CBP peripherally modified analogues exhibit a remarkable spe

221 ll molecule protease inhibitors administered peripherally or centrally decreased food intake in both

222 out (KO) and/or wild-type mice were injected peripherally or intracerebroventricularly with ghrelin a

223 d portally (PoHI; 1.8 pmol/kg/min; n = 7) or peripherally (PeHI; 1.8 pmol/kg/min; n = 8) and insulin-

224 demonstrate the ability of a small number of peripherally placed sources to generate acoustic vortex

225 dependent manner provides a new mechanism to peripherally produce a regulatory T cell.

226 Ghrelin, a peripherally produced peptide hormone, circulates at hig

227 l tolerance and shows a functional impact of peripherally produced TNFalpha and GM-CSF on the migrati

228 lation and errors in growth cone guidance of peripherally projecting nerves.

229 study, we analyzed whether CT-1 also acts to peripherally regulate metabolic rhythms and adipose tiss

230 lls, probably in concerted action with other peripherally released cytokines.

231 The rich repertoire of peripherally released peptides and hormones provides fee

232 Conversely, peripherally-responsive primary visual cortex demonstrat

233 Linaclotide, a peripherally restricted 14 aa peptide approved for the t

234 s in mice (1 mg kg(-1)), act as systemic and peripherally restricted ABHD6 inhibitors, respectively.

235 suggesting poor BBB penetration and possible peripherally restricted activity.

236 Pretreatment with a peripherally restricted alpha(2)-adrenoceptor agonist, S

237 n of fibers may allow for the development of peripherally restricted analgesics that control BTP and

238 -cyclohexyl]-3-pyr idinecarboxamide] and its peripherally restricted analog 14H: [5-(4-chlorophenyl)-

239 These results indicate that peripherally restricted CB(1) antagonists, which may lac

240 ects, these may be mitigated by using novel, peripherally restricted CB(1) antagonists.

241 o rimonabant, systemic administration of the peripherally restricted CB(1)-receptor antagonist, URB 4

242 synapse loss, and CNS inflammation, while a peripherally restricted CB(2) receptor antagonist blocks

243 Our efforts aimed at rationally designing peripherally restricted CB1 antagonists have resulted in

244 , which was blocked by pretreatment with the peripherally restricted CB1 cannabinoid receptor antagon

245 diet-induced obesity (DIO), using JD5037, a peripherally restricted CB1 R inverse agonist.

246 Similarly, a neutral, peripherally restricted CB1 receptor antagonist (AM6545)

247 entification of compound 4 (B/P = 1/64) as a peripherally restricted CB1R antagonist.

248 rt the rationale for the clinical testing of peripherally restricted CB1R antagonists or the developm

249 of the highly potent, kinase-selective, and peripherally restricted clinical candidate PF-06273340.

250 Our SAR studies generated a new series of peripherally restricted FAAH inhibitors and identified c

251 The peripherally restricted fatty acid amide hydrolase (FAAH

252 To address this question, we developed a peripherally restricted inhibitor (URB937) of fatty acid

253 dies of ABHD6, including brain-penetrant and peripherally restricted inhibitors that should prove of

254 In addition, the peripherally restricted molecule 22 also demonstrated si

255 dministration of methylnaltrexone bromide, a peripherally restricted MOR antagonist, was sufficient t

256 laxatives, new intestinal secretogogues, and peripherally restricted mu-opiate receptor antagonists,

257 agonists naloxone and naloxone methiodide (a peripherally restricted naloxone analog) and by local ad

258 inflammatory models, acute administration of peripherally restricted NaV1.7 inhibitors can only produ

259 Thus, PG-M may serve as prototype of a peripherally restricted opioid formulation designed to f

260 These were peripherally restricted via drug pumps that limit the CN

261 d classified as either "brain penetrant" or "peripherally restricted" on the basis of the experimenta

262 In this work, we describe the discovery of a peripherally restricted, potent, competitive NMDA recept

263 t they can function both polyclonally and as peripherally selected clones, and that they can be effec

264 algesics with mixed-opioid agonist activity, peripherally selective activity is expected to decrease

265 r latest results toward the development of a peripherally selective analog of the diphenyl purine CB1

266 Past efforts to develop peripherally selective antagonists of CB1 have largely t

267 ted here are our efforts toward developing a peripherally selective CB1 antagonist based on the otena

268 nt's withdrawal, several groups are pursuing peripherally selective CB1 antagonists.

269 properties that are normally associated with peripherally selective compounds.

270 t hindpaw skin in vitro; 2) the effects of a peripherally selective dose of ACEA on MO-induced nocife

271 When produced peripherally, serotonin acts as a hormone to inhibit bon

272 When it was administered peripherally, serum levels and neurotensin receptor bind

273 fficacy and that a selective, CNS-penetrant, peripherally short-acting, S1P(1) agonist would show ful

274 ate planar heterojunction devices comprising peripherally substituted subphthalocyanines as acceptors

275 position of two subphthalocyanines (SubPcs) peripherally substituted with hydrogen (H12SubPc) or flu

276 oligothiophene electron donor cores that are peripherally substituted with naphthalene diimide electr

277 d to penetrate the membrane headgroup region peripherally such that only the side chains of specific

278 Peripherally the IS/OS layer decreased in intensity, and

279 n be treated using CGRP antagonists that act peripherally, the relevant sites of CGRP action remain u

280 saccharide (LPS) or vehicle was administered peripherally to adult zebra finches and sickness behavio

281 the membrane but rather attaches the protein peripherally to endoplasmic reticulum membranes.

282 ecent results suggest that the protein binds peripherally to membranes containing negatively charged

283 ere loaded with glucocorticoids and injected peripherally to modify the infiltrated CD163 cells towar

284 r aorta and pulmonary artery are anastomosed peripherally to the femoral artery and vein of the recip

285 ers formed by nonideal lipid mixing, binding peripherally to the lipid headgroups with minimal pertur

286 The process is enhanced peripherally to the main flux of the injected mixture.

287 continuum-from those whose pain is generated peripherally to those whose pain is centralized (i.e., g

288 2 leaves this signaling complex and migrates peripherally together with vinculin to the membrane lead

289 ecretion demonstrate that this repertoire is peripherally tolerized.

290 Peripherally triarylborane decorated porphyrin (2) and i

291 uman insulin (HI) delivered intraportally or peripherally were compared with an acylated insulin mode

292 ntinuously presented native Chinese speakers peripherally with Chinese homophone characters in an odd

293 or wild-type (WT) littermates were injected peripherally with lipopolysaccharide (LPS), a bacterial

294 id binding protein, interacts reversibly and peripherally with liposomal NPs without experiencing sig

295 BORC associates peripherally with the lysosomal membrane, where it funct

296 ndicating that the BAR domain interacts only peripherally with the surface of a curved bilayer.

297 ronatin has also been shown to be translated peripherally within the dendrites of neurons, a finding

298 Thus, MDP scaffolds delivered centrally and peripherally within whole dental pulp tissue are shown t

299 lst the thick/thin filament lattice can form peripherally without a Z-disc.

300 tory neuroepithelium to the TG and reemerged peripherally without causing significant neurological di