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1 opting bipartite topologies, whereas TprF is periplasmic.
2 e, although BoMan26A and BoGal36A are likely periplasmic.
4 AcrB located in the inner membrane, and the periplasmic AcrA, which bridges these two integral membr
6 mplex machinery comprised of outer membrane, periplasmic adaptor, and inner membrane protein componen
7 -ATPase proton pump efflux that dissociates periplasmic AGP-Ca(2+) resulting in a Ca(2+) influx that
9 s metabolic arrangement, the distribution of periplasmic and cytoplasmic carbon fluxes was studied in
12 ta indicated that, in the periplasm, various periplasmic and peripheral membrane enzymes transform ch
13 y which OprM is activated via opening of its periplasmic aperture through a concerted interaction wit
14 novel Hechtian oscillator that integrates a periplasmic arabinogalactan glycoprotein-calcium (AGP-Ca
16 rface endo-1,6-beta-glucanase, BT3312, and a periplasmic beta-glucosidase that targets primarily 1,6-
17 o results show that MtrE can be regulated by periplasmic binding events and that the interaction betw
18 As an alternative, we demonstrate use of a periplasmic binding protein (PBP) to provide high affini
19 h-throughput method relies upon the thiamine periplasmic binding protein (TBP) from Escherichia coli
22 Here we present how a gene duplication of a periplasmic binding protein in a mannose ATP-binding cas
24 e pathogenicity and are mediated through the periplasmic binding protein NspS and the transmembrane b
25 ed using three biological examples, namely a periplasmic binding protein, aspartate carbamoyltransfer
26 structures and ligand binding affinities of periplasmic binding proteins from bacterial phosphite an
29 nts and imported into the bacterial cell via periplasmic-binding proteins (PBPs) and ABC-transporters
30 d adaptive advantage for the presence of two periplasmic-binding proteins in ATP-binding cassette tra
32 Our results identify CccA, the most abundant periplasmic c-type cytochrome in C. jejuni, as a novel a
33 bouring TatC molecules from positions in the periplasmic cap but abolished a substrate-induced disulp
35 ght-transmembrane helix fold that supports a periplasmic carbon-nitrogen hydrolase domain containing
37 esent crystal structures revealing the MCR-1 periplasmic, catalytic domain to be a zinc metalloprotei
42 RND) system) and of a putative Cu(+)-binding periplasmic chaperone and the unusual presence of two cy
43 eta-galactosidase activity, we show that the periplasmic chaperone FkpA contributes to LacZ folding i
45 s thought to explain the essentiality of the periplasmic chaperone LolA and its OM receptor LolB that
46 g of proteins from the Sec translocon to the periplasmic chaperone network that contains SurA, Skp, D
48 irected cross-linking, we show here that the periplasmic chaperone PpiD is located in front of the la
49 mitochondria-targeted form of the bacterial periplasmic chaperone Skp, but not with SurA or SecB, re
53 se that TraR increases the concentrations of periplasmic chaperones and proteases by directly activat
57 of membrane thickness, the Escherichia coli periplasmic chaperones Skp and SurA, and BamA, the centr
59 gram-negative bacteria involves delivery by periplasmic chaperones to the beta-barrel assembly machi
60 brane efflux protein TolC and with PstS, the periplasmic component of the ABC transporter complex (Ps
61 ass ZipA, indicating that linkage of FtsA to periplasmic components of the divisome through FtsN was
62 ux kinetics through the determination of its periplasmic concentrations by quantitation of the first
63 cal BAM pathway, while formation of a stable periplasmic conformer involves an export-related, foldin
66 al envelope-restricts the expression of this periplasmic copper resistance protein solely to cells en
67 site is well preserved and the hydrolysis of periplasmic CSS anti-sigma factors is widely observed, w
68 ane transporters, whereas CopR/S responds to periplasmic Cu(+) Analysis of DeltacopR and DeltacueR mu
70 a CopR regulon composed of genes involved in periplasmic Cu(+) homeostasis and its putative DNA recog
73 both cytochrome bd-type quinol oxidases and periplasmic cytochromes requires the ATP-binding cassett
75 um vinosum, the reaction is catalyzed by the periplasmic diheme c-type cytochrome thiosulfate dehydro
77 y, nickel import ATP-binding protein (NikE), periplasmic dipeptide transport protein (DppA), and oute
78 lasm upon activation is complementary to the periplasmic displacement of 3-4 A of the C-terminal part
79 Z misfolding and that, in the absence of the periplasmic disulfide bond catalyst DsbA, LacZ folds in
81 velocity depends on the concentration of the periplasmic DNA-binding protein ComE, indicating that Co
82 and produced a soluble version of AcrB [AcrB periplasmic domain (AcrBper)], which is highly congruent
83 bitopic inner membrane proteins with a large periplasmic domain (denoted FtsQp, FtsBp, and FtsLp) tha
84 d LptG are composed of a beta-jellyroll-like periplasmic domain and six alpha-helical segments in the
87 ified-PbgA oligomers are tetrameric, and the periplasmic domain contains a globular region that binds
88 ructure thus far reported for TolR is of the periplasmic domain from Haemophilus influenzae in which
89 onent analysis, we study the dynamics of the periplasmic domain of aspartate chemoreceptor Tar dimer
93 on of this protein, the apo-structure of the periplasmic domain of PslG (PslG(31-442)) and its comple
94 We prove this using a chimera in which the periplasmic domain of RodZ-a type II membrane protein in
97 PelB, a membrane-embedded porin with a large periplasmic domain predicted to contain 19 tetratricopep
98 rithms predict to possess a large N-terminal periplasmic domain that is absent from FliO of Escherich
99 sts of a membrane-embedded beta-barrel and a periplasmic domain with five polypeptide translocation-a
100 inner membrane-anchored protein with a large periplasmic domain Y3729 (HmsC) inhibits HmsD DGC activi
101 almonella Typhimurium, we identified PbgA, a periplasmic domain-containing transmembrane protein, whi
104 nscription factors with relatively undefined periplasmic domains and transcription activator cytoplas
107 occurred with high efficiency for all TM and periplasmic domains tested, thus eliminating the need fo
109 mains drives opening and closing of the MacB periplasmic domains via concerted movements of the secon
111 hydrophobic cavity toward the transporter's periplasmic domains.Lipopolysaccharides (LPS) are synthe
112 , the rod substructure of the flagellum is a periplasmic driveshaft that couples the torque generated
113 is cytoplasmic motif had to be linked to the periplasmic E domain of FtsN to bypass ZipA, indicating
114 correlated with the reduction levels of the periplasmic electron transfer proteins; the limiting fir
115 terestingly, a spontaneous suppressor, D35E (periplasmic end of helix I), was isolated from the R363Q
122 ansfer of l-Ara4N to the LPS molecule at the periplasmic face of the inner membrane, but its topology
123 americ adaptor that binds and closes off the periplasmic face of the secretion channel, creating a 24
124 adD21, and Pks3/4; that of PAT occurs on the periplasmic face via transesterification reactions betwe
127 gy with hook-shaped ends and the presence of periplasmic flagella (PF) with pronounced spontaneous su
128 investigated the role played by T. denticola periplasmic flagella (PF), unique motility organelles of
129 for spirochetal morphology and motility, the periplasmic flagella display no additional properties re
131 rted that a nonmotile flaB mutant that lacks periplasmic flagella is rod shaped and unable to infect
132 tor rotation or merely the possession of the periplasmic flagella was crucial for cellular morphology
133 pathogenicity; indeed, spirochaete flagella (periplasmic flagella) reside and rotate within the perip
134 hete, and motility, which is provided by its periplasmic flagella, is critical for every part of the
138 pathogen, Campylobacter jejuni, possesses a periplasmic formate dehydrogenase and two terminal oxida
139 equent electron transfer could proceed via a periplasmic formate dehydrogenase and/or hydrogenase, al
141 entral secretin PilQ shift by ~30 A, and two periplasmic gates open to make way for pilus extrusion.
142 In this study, we reveal that a putative periplasmic GH115 from the human gut symbiont Bacteroide
143 the first two crystal structures of soluble periplasmic globular domain of PbgA from S. typhimurium
144 e production of type I LTA and osmoregulated periplasmic glucans in gram-negative bacteria are highli
145 ween the ppgL gene (PA4204), which encodes a periplasmic gluconolactonase, and, in the opposite orien
146 first high resolution crystal structures of periplasmic glucose-binding protein fromPseudomonas puti
147 hat FoxR undergoes self-cleavage between the periplasmic Gly-191 and Thr-192 residues independent of
148 are consistent with the conclusion that the periplasmic half-channel is more easily protonated in a
149 phenomenon of production of both surface and periplasmic immunogenic lipoprotein isoforms has possibl
150 ToxR requires its operon partner ToxS, a periplasmic integral membrane protein, for full activity
151 dhesion proteins of the outer membrane via a periplasmic interaction platform, which presumably invol
153 of at least two VirB substrates that have a periplasmic intermediate and that it directly interacts
154 Furthermore, the mutant does not accumulate periplasmic L-amino acid oxidase during N deprivation.
155 flet of the inner membrane is flipped to the periplasmic leaflet by MsbA, an ATP-binding cassette tra
156 binds deep inside MsbA at the height of the periplasmic leaflet, establishing extensive hydrophilic
157 ement of 3-4 A of the C-terminal part of the periplasmic ligand-binding domain upon ligand occupancy
158 are long helical proteins that consist of a periplasmic ligand-binding domain; a transmembrane regio
160 from the nitrilase domain interacts with the periplasmic lipid leaflet, forming an interfacial entran
161 a gene, virJ, that codes for a protein with periplasmic localization that is involved in the intrace
162 s a broad impact on gene expression from its periplasmic location, a genetic screen was performed to
163 rane segments and reveals a newly identified periplasmic loop between the third and fourth transmembr
165 icularly a single residue located at the TM1/periplasmic loop interface, F47 of Staphylococcus aureus
166 ng binds and the other located in the second periplasmic loop of DsbB, which interacts with DsbA.
168 ransmembrane helices (TMHs), a large central periplasmic loop, and a C-terminal domain containing the
169 er contains 12 transmembrane helices and two periplasmic loops that suggest a plausible pathway for s
172 in modifications are well characterized, the periplasmic maturation steps are far from understood.
173 flux transporters function in complexes with periplasmic membrane fusion proteins (MFPs) that enable
175 ructural model of CnrX where a cradle-shaped periplasmic metal sensor domain is anchored into the inn
176 de two routes for methylamine oxidation: the periplasmic methylamine dehydrogenase (MaDH) and the cyt
177 M1, the best-studied aerobic methylotroph, a periplasmic methylamine dehydrogenase that catalyzes the
178 icotinate and related modulators on the BvgS periplasmic moiety by using site-directed mutagenesis an
181 MS also identified candidate partners for periplasmic MOSP, including TDE1658, a spirochete-specif
182 se, and unassembled lipopolysaccharides bind periplasmic MucB, releasing MucA and facilitating its pr
185 In contrast, a strain lacking a functional periplasmic nitrate reductase (napA mutant) exhibited a
186 results suggest that S. Typhimurium uses the periplasmic nitrate reductase to support its growth on t
187 he second section focuses on the features of periplasmic nitrate reductase where the catalytic subuni
188 iated growth inhibition, whereas all but the periplasmic nitrite reductase NrfA provide protection ag
189 e Escherichia coli K-12 nrf operon encodes a periplasmic nitrite reductase, the expression of which i
191 nst a LacY mutant immobilized in an outward (periplasmic)-open conformation bind to the flexible WT p
192 s (Nbs) against a LacY mutant in an outward (periplasmic)-open conformation to stabilize this state o
194 itrosoglutathione (GSNO) in vitro However, a periplasmic or extracellular denitrosylase has not been
196 actin, and their fluorophore is generated by periplasmic oxidation and cyclization reactions of d-tyr
200 ch is highly congruent in structure with the periplasmic part of the full-length protein, and is capa
201 ia coli, a proteolytic system comprising the periplasmic PDZ-protease Prc and the lipoprotein adaptor
203 upon cellular demand while still maintaining periplasmic plasticity; this could be broadly relevant t
204 nquenching of fluorescence in three pairs of periplasmic probes due to opening of the periplasmic cav
206 ies have established the essentiality of the periplasmic protease MarP for Mtb to survive in acidifie
209 e stalled autotransporter is not degraded by periplasmic proteases; and (v) inverse autotransporter p
211 a coli disulfide bond formation pathway, the periplasmic protein DsbA introduces disulfide bonds into
213 es and chaperones exhibit important roles in periplasmic protein quality control and stress responses
214 xin MqsR degrades YgiS mRNA, which encodes a periplasmic protein that promotes deoxycholate uptake an
216 -GMP production by YfiN was repressed by the periplasmic protein YfiR, and deletion of yfiR promoted
218 NAs encoding outer-membrane, cytoplasmic and periplasmic proteins are distributed throughout the cyto
219 olated were found to overexpress one or more periplasmic proteins including OsmY, Ivy, DppA, OppA, an
221 to be specifically involved in the repair of periplasmic proteins oxidized by hypochlorous acid.
226 ant predators can replicate unusually in the periplasmic region between the peptidoglycan wall and th
227 uorimetry showed interaction of the isolated periplasmic region of McpX (McpX(PR) and McpX34-306 ) wi
228 olves association of the plug helices in the periplasmic region of the MotB dimer into a parallel coi
231 s with most of the transmembrane helices and periplasmic regions of SecY, with a clustering of intera
233 sought to determine whether PelB serves as a periplasmic scaffold that recruits other components of t
234 s direct interactions with transmembrane and periplasmic segments, as well as peripheral interactions
236 Salmonella PhoQ is a histidine kinase with a periplasmic sensor domain (PD) that promotes virulence b
239 The Escherichia coli Tsr protein contains a periplasmic serine-binding domain that transmits ligand
240 ight unique Nbs that bind exclusively to the periplasmic side and block transport, but increase the a
241 el with a large pore that is occluded on the periplasmic side by the N-terminal 15 residues of the pr
244 polysaccharides (LPS) are synthesized at the periplasmic side of the inner membrane of Gram-negative
248 almost occluded and is partially open to the periplasmic side; the cytoplasmic side is tightly sealed
251 main determinant of NccX dimerization is the periplasmic soluble domain and that the interaction betw
253 -electron tomograms show that tubes span the periplasmic space and are present while the genome is be
254 The rod subunits self-assemble, spanning the periplasmic space and stopping at the outer membrane whe
255 esis and translocation of DAT and PAT to the periplasmic space are coupled and topologically split ac
256 at rod length is limited by the width of the periplasmic space between the inner and outer membranes.
258 combinant chimeras that were produced in the periplasmic space of E. coli as soluble pentamers, as co
260 cetes, including a defined outer membrane, a periplasmic space that can be greatly enlarged and convo
262 rA and PEB3, depends on translocation to the periplasmic space via the general secretory pathway.
272 city may prepare the bacterium to endure the periplasmic stress of sex pilus biosynthesis during mati
274 ut the bulk of the protein exists as a large periplasmic structure enclosing an extensive lumen.
279 e transported into the cytoplasm, or via the periplasmic sugar binding protein, ChvE, play a critical
280 , which is able to bind both Hep and HS, and periplasmic sulfatases reveal the major specificity dete
281 toplasmic Cu(+) can be precisely directed to periplasmic targets via specific transporter-chaperone i
284 on of holocytochromes c by CcmFH and CcmG, a periplasmic thioredoxin, independent of CcmABCDE (we ter
287 ther proteobacteria that we termed PtaA for "periplasmic transaminase A" An in-frame-deleted ptaA mut
289 verdine-producing bacteria, its catalysis of periplasmic transaminations is most likely a general too
291 proteins, including overwhelmingly abundant periplasmic transporters for nutrient acquisition and pr
295 OSP in TDE exists as outer membrane (OM) and periplasmic trimeric conformers; PelB-MOSP, in contrast,
297 that this discrepancy can be resolved if the periplasmic volume decreases as the cell wall becomes so
299 The length of Braun's lipoprotein determines periplasmic width by tethering the outer membrane to the
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