ライフサイエンスコーパス: periportal

1 nt mice was predominantly hepatocellular and periportal.

2 Immunohistochemistry revealed the periportal accumulation of CCR6(+) mononuclear cells and

3 atosplenomegaly, retroperitoneal adenopathy, periportal adenopathy, mesenteric adenopathy, thickening

4 Although periportal and lobular necroinflammation vanished, porta

5 e model, we identify key differences between periportal and pericentral cells accounting for higher s

6 livers from BDL rats, ET-1 was localized in periportal and pericentral hepatocytes and hepatic sinus

7 in the livers of mice and the expression of periportal and perivenous hepatocyte markers was determi

8 erent cell populations, suggesting that both periportal and perivenous hepatocytes are induced.

9 to the perisinusoidal space surrounding the periportal and the pericentral regions.

10 developed progressively severe perivascular, periportal, and hepatic parenchymal lesions consisting o

11 ive hepatitis characterized by perivascular, periportal, and parenchymal infiltrates of mononuclear a

12 eage stage cells into bile, flow back to the periportal area and regulate the stem cells and other ea

13 marked extension of the gradient towards the periportal area was observed, indicating that the increa

14 cally transplanted cells were distributed in periportal areas (zone 1) in mice, whereas in larger ani

15 (+)/C/EBP-alpha(-) were shown to extend from periportal areas into the SPHC clusters, differentiating

16 genesis, and biliary hyperplasia occurred in periportal areas of Prox1-deficient livers.

17 mpaired Kupffer cell function, especially in periportal areas, where transplanted cells were localize

18 6-phosphatase and lesser glycogen content in periportal areas.

19 ellular apoptosis but triggered autophagy in periportal areas.

20 , while there was no transgene expression in periportal areas.

21 eactions within regions of rapidly expanding periportal biliary fibrosis.

22 P=0.016), with most of the difference due to periportal/bridging necrosis (P=0.009) and lobular activ

23 crophage numbers with massive infiltrates of periportal CCR2(+) macrophages that display a proinflamm

24 greater in perivenous hepatocytes; however, periportal cells rapidly acquired this facility in cultu

25 ia manifested by a increased number of small periportal cells.

26 infected with the G133E virus had increased periportal cellular proliferation and numerous lysed apo

27 ut in which K19 staining revealed widespread periportal CoH loss, a finding we termed "minimal change

28 l cell response and AFP gene expression than periportal damage.

29 adual reduction in activity in a pericentral-periportal direction.

30 2(mut) mice had elevated hepatic iron with a periportal distribution and increased plasma iron, trans

31 itoneal injection resulted in a preferential periportal distribution of human hepatocytes that produc

32 t mice was predominantly in hepatocytes in a periportal distribution.

33 rom cells derived from either intraportal or periportal ductules.

34 udwig-Batts stage 0); 10 had early portal or periportal fibrosis (stages 1 and 2); and 6, advanced fi

35 curs in the absence of ultrasound-detectable periportal fibrosis and may be due to immunological infl

36 r since birth, were examined for evidence of periportal fibrosis by ultrasound using the Niamey proto

37 The specific pathways leading to periportal fibrosis in HIV-infected men with newly acqui

38 n-producing PROM1pos cells within regions of periportal fibrosis is associated with activated FGF and

39 These results demonstrate that periportal fibrosis is associated with cytokine producti

40 on is highly endemic in parts of Uganda, and periportal fibrosis is common in communities along the s

41 tic cholestasis of pregnancy was followed by periportal fibrosis or cirrhosis in 4 sisters.

42 score (P < 0.0001), specifically, the portal/periportal fibrosis or greater fibrosis) (P < 0.01).

43 cific effects such as severe hepatosplenism, periportal fibrosis with portal hypertension, and urogen

44 ment of regenerative nodules and concomitant periportal fibrosis, inflammatory infiltration, and acti

45 cent to ductular reactions within regions of periportal fibrosis.

46 th progressive cyst formation and associated periportal fibrosis.

47 nduces liver injury in fa/fa rats leading to periportal fibrosis.

48 nantly CD8+ T lymphocyte infiltration in the periportal fields and sinusoids.

49 AIH, characterized by lymphoplasmacytic and periportal hepatic infiltrates, autoantibodies, elevated

50 splantation, specifically the development of periportal hepatic steatosis apparently induced by the l

51 s of chronic hepatitis, including portal and periportal hepatitis with lymphocytes and plasma cells,

52 cases of acute hepatitis E showed portal and periportal hepatitis, with polarization of neutrophils t

53 All 32 livers had varying degrees of diffuse periportal hepatocellular hyperplasia with multifocal at

54 glucose intermediates was less severe in the periportal hepatocyte compartments.

55 s fats being metabolised more rapidly in the periportal hepatocyte compartments.

56 tal triads and periportal zone (zone 1) with periportal hepatocyte necrosis.

57 inantly expressed in the plasma membranes of periportal hepatocytes and in the basolateral membranes

58 toplasmic inclusions with a predilection for periportal hepatocytes but sometimes present throughout

59 ile salt uptake along the acinus and protect periportal hepatocytes from harmful bile salt concentrat

60 patients with PBC, PDC-E2 mRNA was found in periportal hepatocytes in 16 of 17 cases (94%).

61 1/1A2 levels in centrilobular, midzonal, and periportal hepatocytes were increased by 82%, 159%, and

62 In control liver, periportal hepatocytes were positive in 15 of 17 cases (

63 We found that a pre-existing population of periportal hepatocytes, located in the portal triads of

64 Periportal hepatocytes, proliferating bile ductules and

65 YP1A1/1A2 as do centrilobular, midzonal, and periportal hepatocytes, respectively.

66 ring the last few hours of the daily fast in periportal hepatocytes, the oxygen-rich zone of the live

67 chrome P450 activity, which was deficient in periportal hepatocytes.

68 le duct BEC, canals of Hering, and immediate periportal hepatocytes.

69 ion was observed to localize strictly to the periportal hepatocytes.

70 al hepatocytes) and glutamine catabolism in (periportal) hepatocytes represents the high-affinity amm

71 Higher portal/periportal Hh-ligand production was associated with male

72 Periportal immune complex deposition may play an importa

73 t in 16% in both biopsies, limited to portal/periportal in 73% in the first biopsy, and 64% in the fi

74 Because periportal infiltration is a common feature in both IMT

75 This is manifested by increased periportal infiltrations, bile duct damage, granulomas a

76 there is lymphocytic liver infiltration with periportal inflammation analogous to the histological pr

77 ate biliary hyperplasia and hypertrophy with periportal inflammation and fibrosis.

78 examination of the liver at 10 days revealed periportal inflammation and fibrosis.

79 ient with FLUX-induced liver injury revealed periportal inflammation and the infiltration of cytotoxi

80 hatase, atypical ductular proliferation, and periportal inflammation compared with wild-type animals,

81 Portal/periportal inflammation was the same in all groups; howe

82 individual features of portal inflammation, periportal inflammation/piecemeal necrosis, lobular infl

83 ccompanying histologic evidence of increased periportal inflammatory infiltration.

84 It identified periportal injury and fibrosis with an early peak and sl

85 hin 1 to 2 days after carcinogen exposure or periportal injury in the rat, but both type II and type

86 ntrilobular injury) with allyl alcohol (AA) (periportal injury), as well as in a bile duct ligation (

87 ve periductular stem cell, which responds to periportal injury, such as induced by allyl alcohol and

88 phate synthetase I (CPS I) is present in the periportal, intermediate, and the first few layers of th

89 tes reversal in mice due to the emergence of periportal islet-like cell clusters.

90 P-101 and CX-1 colon cancer cells adhered to periportal Kupffer cells, the CX-1 cells resulted in Kup

91 of non-cirrhotic portal hypertension due to periportal liver fibrosis or nodular regenerative hyperp

92 tocarcinogenesis in rats; and in response to periportal liver injury induced by allyl alcohol in rats

93 The cellular response to periportal liver injury, induced by phenobarbital feedin

94 M caused extended apoptosis predominantly in periportal liver regions, indicating that NF-kappaB acti

95 A predominantly periportal location is specifically found in oral contra

96 e placed in pancreas (n = 5), liver (n = 7), periportal lymph nodes (n = 1), and gallbladder bed (n =

97 nted with the 2-AA/AA model suggest that the periportal matrix may be as important as the cells that

98 By day 6, regression of periportal MIP-101 tumor growth correlated with ingrowth

99 s macrovesicular steatosis and predominantly periportal mononuclear cell infiltration.

100 rse of infection demonstrated hepatitis with periportal mononuclear infiltrates, hepatocellular micro

101 SNAT5 shows a more periportal mRNA distribution than SNAT3 in rat liver, in

102 orrelated independently with increasing age, periportal necroinflammation, and ALT elevations but not

103 se levels, and those with the most extensive periportal necrosis on initial liver biopsy.

104 s associated with elevated serum bile acids, periportal necrosis, and increased serum alanine aminotr

105 the histological activity index (P =.007 for periportal necrosis,.001 for lobular necrosis, and.013 f

106 I cells, but most of the cells that span the periportal necrotic zone are type III hepatocyte-like ce

107 +) vein phenotype, associated with a loss of periportal Nestin(+)NG2(+) cells and emigration of HSCs

108 cells (Kupffer cells, endothelial cells and periportal nondescript cells) became evident 12 hours af

109 wed diffuse microvesicular steatosis, marked periportal nuclear glycogen, and variable portal fibrosi

110 No immunoreactivity was identified in periportal or midzonal hepatocytes.

111 fferentiated HCCs display mutually exclusive periportal or perivenous zonation programs.

112 Acetaminophen injury was followed by periportal oval cell accumulation displaying a moderate

113 overexpressing TWEAK in hepatocytes exhibit periportal oval cell hyperplasia.

114 trictly compartmentalized in liver in a wide periportal pattern and the last downstream perivenous he

115 e in hepatocyte susceptibility occurs in the periportal (PP) and/or perivenous (PV) zones in response

116 The portal/periportal (progenitor) compartment of prepubescent male

117 nts with BA demonstrate similar expansion of periportal PROM1pos cells with activated Mothers Against

118 terogeneous population: those located in the periportal region do not coexpress desmin or alpha smoot

119 t emerge only under injury conditions in the periportal region of the liver.

120 4% of the glucose formed from lactate in the periportal region of the lobule was taken up by the most

121 -Cre-expressing cells are present within the periportal region shortly after injury.

122 NTPDase2 was expressed in the periportal region surrounding intrahepatic bile ducts, w

123 Oval cells are found in the periportal region under some circumstances and may repre

124 decreased distribution of fibronectin in the periportal region was found at 5 minutes after partial h

125 decreased distribution of fibrinogen in the periportal region was found by 15 minutes and continued

126 ound associated with small bile ducts in the periportal region, indicating that the duct-like structu

127 to the perisinusoidal space surrounding the periportal region.

128 lar regions (carbon tetrachloride [CCl4]) or periportal regions (allyl alcohol [AA]).

129 s, which is restricted to few liver cells in periportal regions in PPARalpha-/- AOX-/- mice, suggests

130 g of hepatocytes was diffuse and occurred in periportal regions of hepatic acinus, whereas perivenous

131 In some mice, hepatocytes in the periportal regions of liver lobules were also positive,

132 esized that peroxynitrite formed in normoxic periportal regions of the liver lobule has its reactivit

133 is and injury, oval cells proliferate in the periportal regions of the portal tracts and are suggeste

134 Under these conditions, periportal regions were well oxygenated but pericentral

135 he APAP challenge dose from centrilobular to periportal regions where CYP2E1 is not found, protective

136 resulted in accumulation of nitrotyrosine in periportal regions.

137 e portal region and then progresses into the periportal regions.

138 In female liver, a strong periportal signal also was observed that decreased in Zo

139 s-like lesion in two patients and an area of periportal soft-tissue infiltration in three; one patien

140 eveloped prominent perivenous steatosis with periportal sparing.

141 there is low-level expression of HGF mRNA by periportal stellate cells, and HGF protein localizes to

142 ), is associated with a 1.7 fold decrease in periportal sympathetic innervation, a 5 fold decrease in

143 ineage stages from the stem cells in zone 1 (periportal), through the midacinar region (zone 2), to t

144 me expression by splitting the sinusoid into periportal to pericentral compartments.

145 n 2 shows a lobular gradient increasing from periportal to pericentral hepatocytes, claudin 3 is unif

146 ition of transplanted cells was shifted from periportal to perivenous areas by targeted hepatic ablat

147 eversed when transplanted cells shifted from periportal to perivenous areas.

148 ing components, especially beta2SP, from the periportal to the pericentral zone as regeneration nears

149 ual hepatocytes use independently configured periportal-to-CV gradients to exhibit lobule-location de

150 protein is detectable on hepatocytes, with a periportal-to-perivenular gradient, but not on BEC.

151 ion in hepatocytes gradually spread from the periportal toward the central areas by 7 days after PHx,

152 ntiated, nonproliferation subclasses, namely periportal-type (wild-type beta-catenin) and perivenous-

153 Also, we identified an eight-gene periportal-type HCC signature, which was independently a

154 The new periportal-type subclass represented 29% of all HCCs; ex

155 Among all HCCs, periportal-type tumors have the lowest intrinsic potenti

156 a model in which HSCs are titrated against a periportal vascular niche with a fractal-like organizati

157 creased SOX9 expression, and thinning of the periportal vascular smooth muscle cell (VSMC) layer, whi

158 NG2-expressing cells are a population of periportal vascular stem/progenitors (MLpvNG2(+) cells)

159 nal patterns of Hh-ligand production, portal/periportal versus lobular, were observed.

160 Firstly, the periportal zonation of both glycogen synthase and the ox

161 Secondly, the periportal zonation of the enzymes mediating beta-oxidat

162 ocytic infiltration of the portal triads and periportal zone (zone 1) with periportal hepatocyte necr

163 During repair of the periportal zone, oval cells acquire differentiation mark

164 l (SEC) porosities were compared between the periportal (zone 1) and pericentral (zone 3) regions of