ライフサイエンスコーパス: perisynaptic

1 alpha3 targeting domain are excluded and are perisynaptic.

2 lel fibers (PFs), indicating that NMDARs are perisynaptic.

3 em and prevented live-cell discrimination of perisynaptic actin filaments.

4 Perisynaptic actin forms a uniquely dynamic structure we

5 ly in the CNS, and mediate both synaptic and perisynaptic activities of endogenous cholinergic inputs

6 yrus granule cells, most likely by targeting perisynaptic alpha4betadelta receptors expressed at dist

7 ynaptic sites; synaptic glycine receptor and perisynaptic alpha7-nAChR clusters were not altered.

8 he neighboring synaptic glycine receptors or perisynaptic alpha7-nAChRs on chick ciliary ganglion (CG

9 mography revealed lower synaptic, but higher perisynaptic, AMPAR density in stg RTN.

10 ction leads to activity-dependent removal of perisynaptic AMPARs and suppresses the subsequent expres

11 Here, we report that perisynaptic AMPARs are GluR2-lacking and they transloca

12 As long as perisynaptic AMPARs are present, both LTP and spine expa

13 ylation can alter the subunit composition of perisynaptic AMPARs by providing stability to GluR1 homo

14 Perisynaptic AMPARs do not normally detect synaptically

15 suggest that the delivery and maintenance of perisynaptic AMPARs may serve as a checkpoint in the exp

16 The appearance of perisynaptic AMPARs requires postsynaptic exocytosis, PK

17 the baseline state together with removal of perisynaptic AMPARs, or they can enter a stabilized stat

18 ease together with synaptic incorporation of perisynaptic AMPARs.

19 nduces an increase in MMP-9 activity that is perisynaptic and enriched at thalamo-cortical synapses.

20 ld-type synapses, we found that nonsynaptic (perisynaptic and extrasynaptic) AChEs are mobile and gra

21 neurotrophin-3 (NT3), is expressed by mouse perisynaptic and myelinating Schwann cells from birth th

22 as well as regulate glutamate levels in the perisynaptic and presynaptic domains, the ultrastructura

23 we identified cisternae of the GA in distal perisynaptic and subependymal processes, in perivascular

24 nit, and subcellular localization (synaptic, perisynaptic, and dendritic) unique within this protein

25 synaptic transmission; their localization in perisynaptic areas would appear to limit their activatio

26 ve been identified, the molecules underlying perisynaptic astroctye-neuron contacts are unknown.

27 t known contact-dependent mechanism by which perisynaptic astrocyte processes promote synaptogenesis.

28 novo protein synthesis occurs within distal, perisynaptic astrocyte processes.

29 es; and 3) Pcdh-gammaC5 is also localized in perisynaptic astrocyte processes.

30 Perisynaptic astrocytes express important glutamate tran

31 y brain, NPC1 was expressed predominantly in perisynaptic astrocytic glial processes.

32 EphA7, being preferentially in PSDs, and in perisynaptic astrocytic leaflets, provides morphologic e

33 The functional implications of GA in perisynaptic astrocytic processes and other processes ar

34 ficacy that were coordinated with changes in perisynaptic astrocytic processes in the border region b

35 to determine the extrinsic factors (such as perisynaptic astroglia) and the intrinsic factors (such

36 are characterized by unmyelinated axons and perisynaptic astroglial envelopes.

37 o alpha-bungarotoxin, though concentrated in perisynaptic clusters on neurons, can generate a large a

38 of Fabp7 mRNA and protein in the astrocytic perisynaptic compartment, and observed a diurnal change

39 ion (LTD) was associated with a reduction in perisynaptic CP-AMPAR levels.

40 This restrictive action of perisynaptic CSPGs in mature neural tissue may account f

41 ) synaptic signaling significantly decreases perisynaptic enshealthing of astroglial processes on syn

42 ently, the released histamine is taken up by perisynaptic epithelial glia and converted into inactive

43 Specifically, the perisynaptic expression of GAT1 enables it to regulate G

44 lutamate transport was inhibited, indicating perisynaptic expression of NR2B NMDARs.

45 g spillover from synapses due to their dense perisynaptic expression primarily on astroglia.

46 e postsynaptic NMDAR current is reliant on a perisynaptic extracellular alkaline shift generated by t

47 -labeled D1Rs were distinctly distributed on perisynaptic/extrasynaptic membranes and the axoplasm of

48 Instead, it reduces recruitment of perisynaptic/extrasynaptic NR2B-containing NMDARs, there

49 ge in the molecular composition of NMDARs at perisynaptic/extrasynaptic sites.

50 nsports neurotransmitter metabolites between perisynaptic glia and neuronal cell bodies to mediate lo

51 ork transports histamine metabolites between perisynaptic glia and photoreceptor cell bodies to media

52 Thus, perisynaptic GluR2-lacking AMPARs play a critical role i

53 er as well as alterations in the kinetics of perisynaptic glutamate buffering and uptake contributing

54 uggesting that astrocyte-mediated removal of perisynaptic glutamate is important in limiting NSV-indu

55 This retardation boosts activation of perisynaptic group I metabotropic glutamate receptors (m

56 aptic or postsynaptic cell, suggesting local perisynaptic influences on the development and/or state

57 ceptors, thought to mediate tonic (extra- or perisynaptic) inhibition, are unknown.

58 smaller synapses and with slower kinetics of perisynaptic ion transients.

59 s either were nonimmunoreactive or displayed perisynaptic labeling.

60 Our results demonstrate a perisynaptic localization of delta subunit-containing GA

61 Functional correlates of this perisynaptic localization were obtained by comparing inh

62 pes exhibiting substantial extrasynaptic and perisynaptic localization.

63 shift of the gamma2 subunit from synaptic to perisynaptic locations and potential partnership of the

64 rmed a decrease in delta subunit labeling at perisynaptic locations in the molecular layer of the den

65 R1-S845A mutants, CP-AMPARs were absent from perisynaptic locations mainly due to lysosomal degradati

66 mma2 subunit labeling was also found at many perisynaptic locations on granule cell dendrites, consis

67 ed mice, alpha4 subunit labeling remained at perisynaptic locations, but increased gamma2 subunit lab

68 Chmp2b was shown to concentrate beneath the perisynaptic membrane of dendritic spines.

69 ted from the postsynaptic density toward the perisynaptic membrane within the spine, leading to synap

70 57% particles were evenly distributed along perisynaptic membranes and the remaining 43% of particle

71 C1 indicate an extrasynaptic localization on perisynaptic membranes that are near release sites.

72 onal glutamate transporter, localized on the perisynaptic membranes that are near release sites.

73 must be overwhelmed by glutamate to activate perisynaptic metabotropic glutamate receptors.

74 st that Car14 regulates pH transients in the perisynaptic microenvironment and govern their impact on

75 , our study indicates that the activation of perisynaptic MMP-3 supports L-type channel-dependent LTP

76 in neuron-astrocyte interactions, including perisynaptic neuron-astrocyte interactions.

77 ent of glutamate spillover and activation of perisynaptic NMDA receptors at ON GCs.

78 This morphological evidence for exclusively perisynaptic NMDARs localizations suggests a distinct ro

79 on generated by the persistent activation of perisynaptic or extrasynaptic GABA(A)Rs, which can detec

80 Although most GIRK subunit labeling was perisynaptic or extrasynaptic, GIRK2 was found occasiona

81 ptophysin, synaptotagmin, or proteins of the perisynaptic plasma membrane such as GABA transporter 1

82 s in expression and trafficking Fabp7 to the perisynaptic process are not known.

83 he ephrin-A3 ligand, which is located in the perisynaptic processes of astrocytes, is essential for m

84 xpressed by astrocytes and localize to their perisynaptic processes.

85 n pre- and postsynaptic profiles and also in perisynaptic processes.

86 C amplitude, which is primarily dependent on perisynaptic receptor occupancy.

87 lel fibre synapses can lead to activation of perisynaptic receptors that mediate short- and long-term

88 Because group I mGluRs are localized to the perisynaptic region in juxtaposition to synaptic NMDARs

89 otransmitter receptors that are found in the perisynaptic region of the postsynaptic membrane.

90 -term potentiation (LTP) but are absent from perisynaptic regions after the full expression of LTP.

91 hat AMPA receptors (AMPARs) are delivered to perisynaptic regions after the induction of long-term po

92 TRPC1 is expressed in perisynaptic regions of the cerebellar parallel fibre-Pu

93 t undergo CEDE are in somata, dendrites, and perisynaptic regions, identified by using immunocytochem

94 amino acid carrier 1 (EAAC1) is enriched in perisynaptic regions, where it may regulate synaptic spi

95 c inhibition of PKC activity holds AMPARs at perisynaptic regions.

96 ontaining beta-isoform primarily to non-PSD, perisynaptic regions.

97 emonstrate the presence of dynamic D1R/NMDAR perisynaptic reservoirs favoring a rapid and bidirection

98 -deficient mdx mice, but was retained on the perisynaptic sarcolemma even in mice lacking both utroph

99 spine structure and function, probably as a perisynaptic scaffold and barrier within the spine neck.

100 occurs in this model, concomitant injury to perisynaptic Schwann cells (pSC) could indirectly contri

101 sing a novel technique to selectively ablate perisynaptic Schwann cells (PSCs) at the neuromuscular j

102 mmunofluorescence, COX-2 was detected in the perisynaptic Schwann cells (PSCs) surrounding the NMJ.

103 rvation occurs early in the process and that perisynaptic Schwann cells (PSCs), glial cells at the NM

104 developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at th

105 Emerging studies demonstrate that perisynaptic Schwann cells (PSCs), which are the glia ce

106 ese new insights, this article suggests that perisynaptic Schwann cells and synaptically associated a

107 ated that presynaptic neuronal membranes and perisynaptic Schwann cells are targets for anti-GQ1b ant

108 velopment resulted in an increased number of perisynaptic Schwann cells at neuromuscular synapses, wi

109 T3 is not required for normal development of perisynaptic Schwann cells or synapses.

110 ng the nuclei of the motor end plate, and in perisynaptic Schwann cells, and localized close to nicot

111 nduction is required to retain AMPARs at the perisynaptic site after their appearance.

112 AMPARs can be detected at this perisynaptic site before, but not after, the full expres

113 from the NMDARs and diffuse to a presumably perisynaptic site, where they become available to an end

114 ols causes the rapid delivery of AMPARs to a perisynaptic site.

115 being expressed largely at extrasynaptic and perisynaptic sites in neuronal cell bodies, dendrites, a

116 he PSD, but were reduced near the PSD and at perisynaptic sites of dendritic spines in extinction-res

117 strate that AMPARs are rapidly trafficked to perisynaptic sites shortly after LTP induction and sugge

118 ning CP-AMPARs on the surface, especially at perisynaptic sites, and suggest that the regulation of t

119 ering is likely to take place at synaptic or perisynaptic sites.

120 urocan), brevican is mainly expressed in the perisynaptic space closely associated with both the pre-

121 esicular structures in dendrites, and in the perisynaptic space encircling presynaptic terminals of t

122 ineuronal nets and is highly enriched in the perisynaptic space suggesting a role for synaptic transm

123 ic vGlut1 and ultrastructural changes in the perisynaptic space.

124 pre- and postsynaptic as well as extra- and perisynaptic structures of the primate prefrontal cortex

125 lation and molecular characterization of the perisynaptic subset of astrocytic Golgi may be feasible,

126 d glial processes were often perivascular or perisynaptic, surrounding asymmetric excitatory-type axo

127 nctions requires appropriate channel gating, perisynaptic targeting, and linkage to intracellular sig

128 d type A (GABAA) receptors (GABAR) increases perisynaptic to excitatory synapses in CA1 hippocampus.

129 pic glutamate receptors (mGluRs) are located perisynaptic to the postsynaptic specializations of asym

130 ic shafts and spines, ERbeta-ir was near the perisynaptic zone adjacent to synapses formed by unlabel