ライフサイエンスコーパス: peritumoral

1 ass (intratumoral) or surrounding the tumor (peritumoral).

2 luation or SLN mapping (ex vivo, subserosal, peritumoral, 1% isosulfan blue dye) and ultrastaging wit

3 Peritumoral (50 micro g/tumor, twice a week) or i.p. (10

4 In vivo experiments confirm the presence of peritumoral acid gradients as well as cellular toxicity

5 hanger-1, both of which were associated with peritumoral acidosis.

6 y acinar cells, becoming highly prominent in peritumoral acini, and particularly high in acinar ducta

7 We show that peritumoral administration of these vectors results in t

8 mice, we found that SIX1 expression promoted peritumoral and intratumoral lymphangiogenesis, lymphati

9 reveal higher WNT5A and GdECs expression in peritumoral and recurrent GBMs relative to matched intra

10 ADV.RSV-tk vector and HSV1-tk expression in peritumoral and remote liver tissue at higher doses.

11 addition, we identified CARD11 mutations in peritumoral and sun-exposed skin, suggesting that CARD11

12 n an area </= 500 mum from the tumor border (peritumoral) and was correlated with recurrence, metasta

13 es by tofacitinib inhibited STAT3 signaling, peritumoral angiogenesis, and cellular scattering.

14 un therapy with interleukin-12 cDNA into the peritumoral area of immunocompetent 129/J mice with life

15 f monocytes/macrophages, particularly in the peritumoral area, since we found no evidence for monocyt

16 he tumor mass; (3) decreases astrogliosis in peritumoral area; and (4) reduces glioma cell infiltrati

17 al analysis of chronic pancreatitis (CP) and peritumoral areas in PDAC tissues showed that AGR2 was p

18 etastatic nodules were associated with focal peritumoral areas of infiltrating inflammatory cells and

19 ells are clustering around the mature DCs in peritumoral areas, thus resembling the DC-T cell cluster

20 reg) cells in the intratumoral compared with peritumoral areas.

21 ls, whereas mature DCs adhere selectively to peritumoral areas.

22 ), present in 20/32 samples, are confined to peritumoral areas.

23 he brain by infiltrative cell migration into peritumoral areas.

24 in endothelial cells of tumor-associated and peritumoral arteries.

25 tumor and increases NF-kappaB activation in peritumoral astrocytes.

26 When measured using histomorphometry, peritumoral BIO administration improved bone quality at

27 radioactive colloid injection also received peritumoral blue dye injection.

28 hasone in an experimental model of vasogenic peritumoral brain edema.

29 s all carried a Braf V545E mutation, whereas peritumoral brain tissue of either strain had the wild-t

30 A decrease in the water content of tumor and peritumoral brain tissue was observed with proton-densit

31 ociated necrosis and possibly to seizures in peritumoral brain tissue.

32 The microanatomic distribution of benign peritumoral Ca++ in relation to the mass is detailed.

33 liferation of phytohaemagglutinin-stimulated peritumoral CD4+ T cells was shown after the addition of

34 ly suppressed phytohaemagglutinin-stimulated peritumoral CD4+ T-cell proliferation (p=0.005, n=10), p

35 ssion in MCPyV-negative tumors and increased peritumoral CD8+ T lymphocytes surrounding MCPyV-positiv

36 l CD4+ T-cell proliferation (p=0.005, n=10), peritumoral CD8+ T-cell proliferation (p=0.015, n=9), an

37 nation, the lesion periphery showed moderate peritumoral changes.

38 ic signal was significantly increased in the peritumoral ciliary body compared with the nonperitumora

39 -40-positive lymphatics were detected in the peritumoral ciliary body.

40 Therapeutic interventions aimed at reducing peritumoral clot formation and enhancing NK cell functio

41 unity following cryoablation with or without peritumoral CpG injection were conducted using two HER2/

42 arative proteomic profiling was performed on peritumoral cyst fluid and serum.

43 CNS peritumoral cyst formation is initiated by increased tum

44 tunity to examine the pathophysiology of CNS peritumoral cyst formation.

45 Because they commonly produce peritumoral cysts and because serial magnetic resonance

46 occurrence and frequent clinical effects of peritumoral cysts in the central nervous system (CNS), t

47 lial growth factor levels were determined in peritumoral cysts.

48 ociated with the appearance and evolution of peritumoral cysts.

49 he generation of MDA-MB-231-stable clones or peritumoral delivery in MDA-MB-231 xenografted mice, str

50 CM showed a significantly higher intra- and peritumoral density of proliferating lymphatics than did

51 c hepatic parenchymal changes, which include peritumoral desmoplastic reaction, inflammatory cell inf

52 related with a thick tumor border containing peritumoral desmoplastic reaction, peritumoral inflammat

53 Peritumoral diffusion-tensor MR imaging metrics enable t

54 One single peritumoral dose of poly A:U was sufficient to induce IF

55 he most common locations of Ca++ were benign peritumoral ducts (62%) and ductal carcinoma in situ (54

56 L-R2 in sections of PDACs and non-neoplastic peritumoral ducts from patients.

57 MRI clearly showed peritumoral edema that developed and slowly and progress

58 to enhancing necrotic portions of tumor and peritumoral edema were drawn, and quantitative image fea

59 patients involve the management of seizures, peritumoral edema, medication side effects, and venous t

60 mably caused by tumor cells infiltrating the peritumoral edema.

61 neation of white matter tracts in regions of peritumoral edema.

62 or size, nonsmooth tumor margins, TTPVI, and peritumoral enhancement were significantly related to th

63 adiologic features (nonsmooth tumor margins, peritumoral enhancement, and TTPVI) was associated with

64 as tumor dimension, nonsmooth tumor margins, peritumoral enhancement, and TTPVI, have high accuracy i

65 number of lesions, tumor margins, TTPVI, and peritumoral enhancement.

66 rcumscribed mass, perinephric fat stranding, peritumoral fat planes obscured, retroperitoneal fluid (

67 rom the lungs associated with an increase in peritumoral fibrin and platelet clot formation was obser

68 The expression of SPARC by peritumoral fibroblasts portends a poorer prognosis for

69 The demonstration that peritumoral fibroblasts synthesize most of the MMPs in h

70 s of human intrahepatic CCA, including dense peritumoral fibrosis, increased inducible nitric oxide s

71 In contrast, TLR5 activation by peritumoral flagellin treatment substantially increased

72 Increased peritumoral fluorocholine uptake is a distinguishing cha

73 Tumoral gas, peritumoral gas, and PVG dissipated within 20 minutes af

74 ign cause of transient PVG, tumoral gas, and peritumoral gas.

75 Peritumoral gene gun introduction of interleukin-12 may

76 on was increased in HCC and benign-appearing peritumoral hepatocytes compared with remote benign hepa

77 icant, and the difference in FA decreases in peritumoral hyperintense regions between these tumors ap

78 Mean FA values in peritumoral hyperintense regions were 0.178 (43% of norm

79 Mean ADCs in peritumoral hyperintense regions were 1.309 x 10(-3) mm2

80 creased Dukes stage was associated with less peritumoral infiltrate (Jass criteria: P < 0.001, Klintr

81 The results of the present study suggest low peritumoral infiltrate (Klintrup criteria) and increased

82 d neutrophil count (P < 0.001) and low-grade peritumoral infiltrate (P < 0.05, Klintrup criteria).

83 Jass and Klintrup criteria for peritumoral infiltrate were directly associated (P < 0.0

84 according to Jass and Klintrup criteria for peritumoral infiltrate.

85 nic tumor because they lacked endotumoral or peritumoral infiltrates almost entirely.

86 ontaining peritumoral desmoplastic reaction, peritumoral inflammation, and vascular proliferation at

87 Both localized peritumoral inflammatory cell infiltrate and the host sy

88 y and diameter and with impaired drainage of peritumoral injected liposomes specific for lymph vessel

89 ET/CT lymphoscintigraphy was performed after peritumoral injection of (89)Zr-nanocolloidal albumin.

90 ar injection of technetium is as accurate as peritumoral injection of blue dye.

91 In 560, peritumoral injection of isosulfan blue dye was also per

92 Peritumoral injection of isosulfan blue dye was performe

93 the axilla (MOVA) started immediately after peritumoral injection of Millipore-filtered 99mTc-sulfur

94 Peritumoral injection of radioactive colloid has been us

95 dermal injection compared with subdermal or peritumoral injection of radioactive colloid.

96 is being revisited via the strategy of intra/peritumoral injection with the idea of stimulating the p

97 rial would drain to the same lymph node as a peritumoral injection, regardless of the location of the

98 ive- to sevenfold more radioactive than with peritumoral injection, which simplifies SLN localization

99 the dermal injection technique compared with peritumoral injection.

100 erative lymphatic mapping was performed with peritumoral injections of blue dye alone or in combinati

101 uid flow velocity, we used a simple model of peritumoral interstitial fluid flow to calculate the flu

102 f radioactivity distribution was observed in peritumoral liver tissue in animals given injections of

103 , we used samples of human blood, normal and peritumoral liver, and hepatocellular carcinoma (HCC) to

104 activity accumulation was more pronounced in peritumoral liver, which was confirmed by reverse transc

105 of primary human HCCs compared with matching peritumoral livers.

106 The peritumoral LNR exceeded 2.0 in seven high-grade gliomas

107 have documented a strong correlation between peritumoral lymphangiogenesis and tumor dissemination.

108 ed heparanase levels significantly increased peritumoral lymphangiogenesis in vivo and promoted the t

109 Peritumoral lymphangiogenesis was present in the ciliary

110 As a result of peritumoral lymphangiogenesis, metastases in lymph nodes

111 primary tumor but also in lymph nodes, with peritumoral lymphatic vessel density reduced in SK1-I-tr

112 Hot spots of proliferating intratumoral and peritumoral lymphatic vessels were detected in a large n

113 ine T241 fibrosarcomas induced the growth of peritumoral lymphatic vessels, which occasionally penetr

114 ular extension, and as such, the presence of peritumoral lymphatics is not recommended as a prognosti

115 IFNgamma) ELISPOT assays were used to assess peritumoral lymphocyte function in vitro.

116 expressed in TILs (81% vs 28%; P < .001) and peritumoral lymphocytes (90% vs 28%; P < .001) of POLE a

117 The numbers of peritumoral lymphocytes and macrophages increased during

118 tumors that are locally invasive and exhibit peritumoral lymphovascular invasion.

119 Peritumoral MD and FA values indicated no statistically

120 garding intraaxial tumors, the measured mean peritumoral MD of metastatic lesions, 0.733 x 10(-3) mm(

121 egative mammary fat pad (MFP) tumors; and by peritumoral MFP injection of the targeted imaging probe

122 as defined by (18)F-FDG imaging, but also in peritumoral microvasculature.

123 direct evidence that intratumoral as well as peritumoral monocytes/macrophages act to limit tumor siz

124 pressing OSM-induced cellular scattering and peritumoral neovascularization of orthotopic xenografts.

125 n, n=10 tumours) and 4-1BB (12.6%, n=9) than peritumoral non-regulatory T cells and Tregs from periph

126 coefficient (ADC) measurements compared with peritumoral nonenhancing biopsy regions (P < .01).

127 3 adult patients yielded 16 enhancing and 14 peritumoral nonenhancing specimens.

128 board-approved study, multiple enhancing and peritumoral nonenhancing stereotactic neurosurgical biop

129 sue, Moussai et al. show that macrophages in peritumoral nonlesional skin near squamous cell carcinom

130 to remain proliferative and migrate into the peritumoral normal tissue producing the invasive phenoty

131 ate protons will diffuse from the tumor into peritumoral normal tissue subjecting nontransformed cell

132 This chronic exposure of peritumoral normal tissue to an acidic microenvironment

133 The difference in FA decreases in peritumoral normal-appearing WM between gliomas and meni

134 Mean FA values for peritumoral normal-appearing WM were 0.375 (83% of norma

135 Mean ADCs in peritumoral normal-appearing WM were 0.723 x 10(-3) mm2/

136 hase II clinical testing of intratumoral and peritumoral ONYX-015 injection in 37 patients with recur

137 Two women each were given peritumoral or circumareolar injections of 100, 200, 300

138 ected directly into the tumor, as opposed to peritumoral or distant sites.

139 me results were obtained when recruitment of peritumoral or intratumoral monocytes/macrophages was bl

140 es the SLN identification rate compared with peritumoral or subdermal injection.

141 Dermal, subdermal, peritumoral, or subareolar radioactive colloid injection

142 odium bicarbonate was sufficient to increase peritumoral pH and inhibit tumor growth and local invasi

143 In every case, the peritumoral pH was acidic and heterogeneous and the regi

144 In the current work, tumor invasion and peritumoral pH were monitored over time using intravital

145 ging the intratumoral pHe in relation to the peritumoral pHe can provide a novel readout of therapeut

146 The peritumoral physical microenvironment consists of comple

147 Intratumoral and peritumoral proliferating lymphatic vessels were detecte

148 site-specific probe for detecting a secreted peritumoral protease expressed by cancer cells and the s

149 Proteases responsible for the increased peritumoral proteolysis associated with cancer represent

150 and extension of ablation zones into aerated peritumoral pulmonary parenchyma, possibly forming the e

151 The peritumoral region featured elevated lipid metabolism an

152 hat can be subsequently used to evaluate the peritumoral region in glioblastoma.

153 sured relative cerebral blood volumes in the peritumoral region in high-grade gliomas and metastases

154 A lower FA in the peritumoral region indicated more white matter tract dis

155 -to-creatine ratio was 2.28 +/- 1.24) in the peritumoral region of gliomas but not in metastases (cho

156 The peritumoral region was defined as the area in the white

157 Spectra from the enhancing tumor, the peritumoral region, and normal brain were obtained from

158 to create a map of heterogeneity within the peritumoral region, and the variance of this map served

159 ge the pHe gradient between intratumoral and peritumoral regions (DeltapHe) in both untreated and tem

160 f fractional anisotropy (FA) in nonenhancing peritumoral regions (NEPTRs) at baseline is associated w

161 dized uptake value (SUV(max)) for lesion and peritumoral regions was measured on PET images, and a le

162 ted with increases in DC infiltration in the peritumoral regions.

163 resident microglia were localized mainly to peritumoral regions.

164 ous studies, dynamic in vivo observations of peritumoral rims demonstrated distended sinusoidal space

165 nation for previous histologic correlates of peritumoral rims.

166 ecruit existing endothelial cells to promote peritumoral satellite lesions, which serve as a niche su

167 FOXP3(+)CD4 T(reg) cells in intratumoral and peritumoral sections of metastatic melanoma tumors and f

168 To investigate peritumoral seizure etiology, we implanted human-derived

169 dered as an adjuvant treatment to ameliorate peritumoral seizures associated with glioma in humans.

170 sist in an immunosuppressive M2 state at the peritumoral site and promote the growth of gliomas.

171 investigated the ability of LCs from SCC and peritumoral skin to induce T-cell proliferation and pola

172 ation and IFN-gamma production than LCs from peritumoral skin.

173 ted the prognostic significance of tumor and peritumoral SPARC expression in patients with pancreatic

174 h the presence or absence of tumor SPARC and peritumoral SPARC status.

175 tion of fibronectin was also detected in the peritumoral stroma of HPV8-positive skin SCC.

176 er tumors contributing to HSC activation and peritumoral stromal transformation remain to be fully id

177 e 9.5%, 7.8%, and 6.5% (not significant) for peritumoral, subdermal, and dermal injection techniques,

178 Peritumoral, subdermal, or dermal injection of radioacti

179 Peritumoral, subdermal, or dermal injection of radioacti

180 n vivo by BCC tumor cells is associated with peritumoral T lymphocytes that are undergoing apoptosis.

181 ified using the ratio of intratumoral versus peritumoral T-cell densities (I/P ratio).

182 nflammation potentially accounted for a high peritumoral tCho signal in CSI, as supported by histolog

183 If Ca++ were peritumoral, their distance from the tumor was measured.

184 the tumor as well as morphologically normal peritumoral tissue samples lacked the caspase-3 transcri

185 Conversely, peritumoral tissue was still intact 24 h after the combi

186 ons of interest (ROI)--enhancing tumor (ET), peritumoral tissue, and normal tissue on the contralater

187 d miR-181a was also found in human cirrhotic peritumoral tissue, compared to normal liver.

188 patterns, with substantial leakage into the peritumoral tissue.

189 21 of hepatocellular carcinoma (both HCC and peritumoral tissues [PHCC]), and 10 controls (CONTR).

190 ents, whereas no toxicity to injected normal peritumoral tissues was demonstrated.

191 IP expression in HCC tumor and corresponding peritumoral tissues were determined by immunohistochemis

192 nd XBP1s were found expressed in CP and PDAC peritumoral tissues, but in contrast to AGR2, their expr

193 egulated in human HCC compared with adjacent peritumoral tissues.

194 res (88%), gas was also found in tumoral and peritumoral tissues.

195 Peritumoral toxicity developed 1-4 weeks after treatment

196 ctor Helios were expressed at high levels in peritumoral Tregs.

197 microvasculature but not in the established peritumoral vessels.

198 Of major clinical relevance, we show that peritumoral WIF1 gene transfer reduces not only cancer g

199 nt of established mice tumor xenografts with peritumoral WIF1 gene transfer results in a significant