ライフサイエンスコーパス: permeability

1 gh-flux dialyzer (with small pores and lower permeability).

2 reflection coefficient and diffusive solute permeability).

3 in mucosal healing have increased intestinal permeability.

4 revent an LPS-induced increase in intestinal permeability.

5 cocalyx structure and associated microvessel permeability.

6 junction (TJ) formation and reduced barrier permeability.

7 ives were not toxic, neither changed TEER or permeability.

8 nt outcomes in contexts of enhanced vascular permeability.

9 hanced proteolytic stability as well as cell-permeability.

10 3 in the regulation of VEGF-induced vascular permeability.

11 rough comparison of fracture parameters with permeability.

12 ticity of adherens junctions and endothelial permeability.

13 s, die and slough off, resulting in enhanced permeability.

14 ier integrity in vitro, therefore increasing permeability.

15 former enhancing selectivity and the latter permeability.

16 te early atherogenesis by enhancing vascular permeability.

17 block TRPV4 to maintain BRB and endothelial permeability.

18 gents, single-channel conductance and Ca(2+) permeability.

19 overlaps and temperature effects on membrane permeability.

20 rting our hypothesis of increased intestinal permeability.

21 forces to transiently increase cell membrane permeability.

22 mother's milk into the blood via intestinal permeability.

23 trans , attributed to increased blood vessel permeability.

24 toxicity and limited central nervous system permeability.

25 ein decreased barrier function and increased permeability.

26 which investigate ablation-induced cellular permeability.

27 nique structure that explains Na(+) and K(+) permeability.

28 d BTB tight junctions and increased vascular permeability.

29 , kidney and liver showed increased vascular permeability.

30 tion of vessels with significantly increased permeability.

31 oxylic acid, improving DGAT1 potency and gut permeability.

32 s investigated to probe cytochrome c-induced permeability.

33 iseases associated with increased intestinal permeability.

34 angiogenesis, inflammation, and endothelial permeability.

35 ibited the LPS-induced increase in Caco-2 TJ permeability.

36 ow nanomolar potencies and improved cellular permeability.

37 et properties impact molecular diffusion and permeability.

38 protein, which correlated with increased SCB permeability.

39 ses in whole gut transit time and intestinal permeability.

40 nctions, including angiogenesis and vascular permeability.

41 functions, including motility and epithelial permeability.

42 epithelial integrity, increasing intestinal permeability.

43 testinal barrier damage/dysfunction, and gut permeability.

44 tight junctions, while increased intestinal permeability accompanies many intestinal disorders.

45 This is determined by their permeability across the endothelial barrier.

46 ources of variability in expression and anti-permeability activity, including the potential effect of

47 was measured in human Caco-2 cells to assess permeability after application of OEA and PEA and releva

48 al electric resistance (TEER) and decreasing permeability against macromolecules.

49 The LPS-induced increase in mouse intestinal permeability also required an increase in MLCK expressio

50 and was associated with augmented intestinal permeability, an altered microbiome and activation of in

51 nvestigate the effects of bevacizumab on BBB permeability and (18)F-FET uptake in a human xenograft m

52 l approach to study three well-characterized permeability and absorption marker drugs in the intestin

53 y findings demonstrate endothelial monolayer permeability and adhesion protein expression change in r

54 testinal epithelial integrity leading to gut permeability and bacterial translocation.

55 Moreover, observations in terms of BBB permeability and brain inflammation underline age suscep

56 eletion of ami1 leads to increased cell wall permeability and enhanced susceptiblity to cell wall tar

57 ontrol, miR-143 or miR-145 were used in cell permeability and flow cytometry assays for apoptosis and

58 The microbiome regulates intestinal permeability and helps to metabolise the human diet into

59 erived ECs demonstrate a greater increase in permeability and impaired recovery of barrier function i

60 of calcific plaques resulted in greater drug permeability and improved adjunct drug delivery to disea

61 ice grew faster and showed enhanced vascular permeability and increased angiogenesis as compared with

62 h, or neutralizing MMP-9 activity, decreased permeability and increased TJP expression in the Mtb-sti

63 2 activates airway apical membrane chloride permeability and increases ciliary beating.

64 ence to the EE hypothesis that increased gut permeability and inflammation adversely affects subseque

65 us be considered as potent regulators of BBB permeability and inflammation that influence leukocyte t

66 The role of CB1 in intestinal permeability and inflammation.

67 s of PGA2 on pulmonary endothelial cell (EC) permeability and inflammatory activation and identified

68 A) and 2-arachidonoyl glycerol (2-AG) on the permeability and inflammatory response of intestinal epi

69 This modification, which induces cell wall permeability and is complementary to the glycopeptide in

70 ructure, showed approximately 10-fold higher permeability and metabolic stability and 39 times higher

71 inal functions, including epithelial barrier permeability and motility.

72 olved in CF, which include impaired chloride permeability and persistent lung inflammation, a multidr

73 Membrane permeability and polarization were measured using the dy

74 Tie2 disruption increased basal endothelial permeability and prevented permeability recovery followi

75 liminate glia in mice, intestinal epithelial permeability and proliferation increase; this led to the

76 IFNAR signaling in astrocytes regulates BBB permeability and protects the cerebellum from infection

77 Evaluating the trade-off between increased permeability and reduced fitness identifies bus-5(br19)

78 enhanced paracellular magnesium and calcium permeability and reduced sodium permeability in the thic

79 tomas seems to be largely independent of BBB permeability and reflects the viability of tumor tissue

80 re to a bacteriophage cocktail on intestinal permeability and relative abundance of taxonomic units i

81 is sufficient to increase lysosomal membrane permeability and restore autophagic cell death in Bax/Ba

82 ad tissue, which is consistent with enhanced permeability and retention (EPR) effects.

83 , leading to an effect called super-enhanced permeability and retention (SUPR).

84 ing to cancerous tissues through an enhanced permeability and retention effect.

85 n peripheral glia; for example, their Ca(2+) permeability and single-channel conductance.

86 d pore surface characteristics, complicating permeability and storage security predictions.

87 l epithelial barrier, resulting in increased permeability and subsequently translocation of bacterial

88 lization of the ECs clearly reduced vascular permeability and suppressed alveolar hemorrhage in an or

89 nd show that in turn this affects intestinal permeability and systemic immunity.

90 article size and formulation influences skin permeability and that lipophilic particles smaller than

91 or an EPAC antagonist increases endothelial permeability and that VEGF has no additive effect, sugge

92 acterial peptidoglycan, resulting in altered permeability and the capacity of bacteria to form biofil

93 ng simultaneously high CO2 resistance and O2 permeability and the exploitation of phase reactions to

94 ression in Caco-2 cells modulated epithelial permeability and the expression levels of junctional pro

95 Increased intestinal permeability and translocation of gut bacteria trigger v

96 increased BBB junction proteins, reduced BBB permeability, and decreased neurodeficits 24 h post-SBI.

97 substrate (pore size distribution, porosity, permeability, and deposited particulate inside the porou

98 matory cells in the lung, increased vascular permeability, and induced histologic ALI in naive mice.

99 structural stability, binding affinity, cell permeability, and inhibition of RAB25:FIP complex format

100 olar IC50 values for both proteins, membrane permeability, and no interference with estrogen receptor

101 on, capillary engraftment, reduced capillary permeability, and re-established perivascular end-feet a

102 c waves had a negative correlation with coal permeability, and the freeze-thaw cycles significantly a

103 production, increases apical membrane Cl(-) permeability approximately 3-5-fold, and increases cilia

104 Pathological changes in vascular permeability are driven by growth factors such as VEGF a

105 ipid bilayer membranes with a relative water permeability as high as 17 mum s(-1).

106 in a significant decrease (P = 0.004) in BBB permeability, as assessed by EBD fluorescence.

107 s linked to increased respiratory epithelial permeability, as revealed by intratracheal FITC-dextran

108 Artificial and cell-based membrane permeability assays provided evidence that the unusual c

109 Permeability assays revealed that OligoG CF-5/20 had vir

110 tides displayed a steep drop-off in membrane permeability at molecular weights above 1000 Da and it a

111 e postnatally and exhibit a severe epidermal permeability barrier defect, which may originate from ep

112 pla1-deficient neonates die due to epidermal permeability barrier defects with severe transepidermal

113 Blood-Brain-Barrier (BBB) is a rigorous permeability barrier for maintaining homeostasis of Cent

114 first that acute disruption of the epidermal permeability barrier in young mice leads not only to a r

115 Fourth, disruption of the permeability barrier induced similar elevations in epide

116 PS molecules, the OM behaves as an effective permeability barrier that makes Gram-negative bacteria i

117 , meiosis, and the integrity of the eggshell permeability barrier.

118 ess fiber formation and enhanced endothelial permeability, both of which were reduced by PAR1 antagon

119 herent CO2 resistance, typically have low O2 permeability but this can be improved via different appr

120 tunnel volume had [Formula: see text] higher permeability, but the bulk flow was still insignificant.

121 sh gelatin matrix decreased the water vapour permeability by more than 30%.

122 l that IL-22 increases intestinal epithelial permeability by upregulating Claudin-2 expression throug

123 contribute to the regulation of BRB and RPE permeability by vasoinhibins under diabetic or hyperglyc

124 toward the design of compounds with improved permeability can be difficult.

125 and JZL184 increased the enhanced (worsened) permeability caused by inflammation and hypoxia (P < 0.0

126 , with changes in all three true vessel wall permeability coefficients (hydraulic conductivity, refle

127 ately, a quantitative study of the diffusion permeability coefficients (Pd) of NPs is difficult with

128 The calculated permeability coefficients for the neutral compounds CH3S

129 ed chronic morphine induced increases in gut permeability, colonic mucosal destruction, and colonic I

130 ranes elements and resulted in elements with permeability comparable to commercial brackish water RO

131 meable compounds) and atenolol (low-moderate permeability compound) were orally co-administered to ra

132 metabolism in moss erect growth and cuticle permeability, consistent with importance in plant adapta

133 We investigated whether impaired intestinal permeability contributes to these symptoms.

134 ty with ongoing bowel symptoms; increases in permeability correlated with increased severity of diarr

135 /10), there was an increase in microvascular permeability, cyclical abolition of preload, and progres

136 Gas permeability data for PIM-TMN-Trip surpass the 2008 Robe

137 With addition of cholesterol, the permeability decreases somewhat, reaching 40 +/- 2 cm/s

138 al MTs behave like a porous medium, with its permeability decreasing with increasing the number of MT

139 imes based on an optimized compartment shell permeability determined by maximizing metabolic flux in

140 The epithelial permeability, determined by fluorescently labeled dextra

141 function in vivo, we used vesicle-based ion permeability, direct membrane association, and intrinsic

142 protected from the neuroinflammatory and BBB permeability effects of MWCNTs.

143 orming colicin and has been reported to have permeability effects on both intracellular and plasma me

144 n of tight junction proteins, VEGF-dependent permeability, efflux pump activity and receptor-mediated

145 significant positive effect on the fracture permeability enhancement of the coal reservoir.

146 We combine state of the art laboratory permeability experiments with high-resolution X-ray comp

147 The increased permeability fell to within the previously reported norm

148 ng IAV infection and show decreased vascular permeability, fewer pulmonary neutrophils, and a reducti

149 Mefv-/- mice had increased epithelial permeability following administration of DSS than contro

150 bserved significant increase in paracellular permeability following siRNA-mediated suppression of TJ

151 EER), indicating an increase of paracellular permeability for ions.

152 system (CNS) through regions of altered BBB permeability - for example, into circumventricular organ

153 nd introduce a novel approach to predict BBB permeability from drug clinical phenotypes (drug side ef

154 ing chemical reactions and fluid flow in low-permeability geologic formations and clay-based engineer

155 plex mixtures of nutrients affect intestinal permeability, gut microbial density, and development of

156 In this regard, l-lactate/lactic acid permeability has been shown for various isoforms of the

157 EGCG's poor stability and intestinal permeability, however, can strongly impair its biologica

158 knockout animals whereas paracellular ionic permeabilities in the Ildr1 knockout mouse renal tubules

159 ntegrity parameters suggesting increased BBB permeability in aging rats.

160 AMPs induce membrane permeability in E. coli spheroplasts or giant unilamella

161 liac disease might have increased intestinal permeability in early life.

162 Herein we map the water permeability in intact arteries, using coherent anti-Sto

163 antioxidant enzymes reversed the increase in permeability in KRIT1 heterozygous mice as shown by intr

164 The increased epithelial permeability in Lpa1(-/-) mice correlated with increased

165 4, IFN-gamma, and TNF-alpha enhanced mucosal permeability in mice.

166 We examined lactulose:mannitol (Lac:Man) permeability in obese individuals with and without liver

167 In a prospective study of intestinal permeability in patients with IBD and mucosal healing, w

168 The primary endpoint was intestinal permeability in patients with symptomatic IBD in mucosal

169 well as in tumors, and exacerbated vascular permeability in response to VEGF, administered via intra

170 whereas the selected prodrug 1r showed good permeability in the PAMPA-BBB model and high in vitro an

171 l and chemical stimuli and regulate vascular permeability in the retina is unknown.

172 and calcium permeability and reduced sodium permeability in the thick ascending limb (TAL), leading

173 hat IFNAR signaling critically regulates BBB permeability in this brain region.

174 tion in gut microbial density and intestinal permeability in unchallenged mice, as well as the severi

175 ar-tissue interface with tunable endothelial permeability in vitro based on microfluidics.

176 nd palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPARalpha.

177 in proteinuria, as well as glomerular water permeability, in the context of progressive depletion of

178 where bacterial membrane reorganization with permeability increase and release of the TFD from the na

179 Furthermore, this permeability increase was selective, as the permeability

180 nt in ECs prevented the increase in vascular permeability induced by the thrombin receptor, protease

181 Once formed, membrane permeability (integrity) was unaffected by minerals.

182 of rIL18 to Mefv-/- mice reduced epithelial permeability, intestinal inflammation, the severity of c

183 for effects of CXCR4, we studied endothelial permeability, intravital leukocyte adhesion, involvement

184 Intestinal permeability is increased in obese patients with steatos

185 heme, the influence of cholesterol on oxygen permeability is large enough to warrant further attentio

186 terial cells provided that thylakoid network permeability is maintained to facilitate diffusion, and

187 f sedimentary laminations, where the highest permeability is measured parallel to laminations and the

188 T1-weighted MRI, we determined that vascular permeability is not homogeneous but rather confined to s

189 sured parallel to laminations and the lowest permeability is perpendicular to laminations.

190 asma leakage that leads to enhanced vascular permeability, likely due to a cytokine storm.

191 In this study, we propose a permeability-limited PBPK model to estimate the toxicoki

192 Both chloride and potassium permeability linearly correlated with the mass of ApoL1

193 wever, the resulting compounds had decreased permeability, low human nNOS activity, and low selectivi

194 rcome existing challenges in remediating low permeability materials, particularly associated with del

195 wild type, indicating that increased cation permeability may lead to dehydration of PIEZO1-mutant HX

196 KLF2 manipulation, permeability measurements, small GTPase activity, lucife

197 n insulin secretion assays, and gap junction permeability measurements.

198 tions including sealing leakage pathways and permeability modification.

199 all animals survived) were studied to assess permeability (n = 4 per group), echocardiography (n = 4

200 ith confined phase behavior is analyzed with permeabilities of 0.01 md and 0.1 md.

201 cavities of the ZIF-8, but very low methanol permeability of 1.25 x 10(-8) cm(2) s(-1) due to the sma

202 Selective permeability of a biofilm matrix to some drugs has resul

203 tive effects and together increase the water permeability of AQP0 40-fold to a level comparable to th

204 To study this dysfunction, we assessed the permeability of cervical mucus from non-pregnant ovulati

205 herin, whereas Nlrp3 knockdown increased the permeability of cholangiocyte monolayers.

206 Gas permeability of compacted samples was measured to be on

207 ure affect the bulk mechanical behaviour and permeability of crustal rocks.

208 encing also revealed that Snail enhanced the permeability of endothelial monolayers to macromolecules

209 freeze-thaw cycles significantly augment the permeability of frozen-thawed coal masses.

210 y intact with the inclusion of Ar atoms, the permeability of gasses (for example, CO) through them is

211 ssess enhanced proliferation, migration, and permeability of inflammatory cells by activating the mam

212 y provide a general equation to estimate the permeability of intact and fractured rocks, forming a ba

213 s of the immune barrier, including increased permeability of mucosal epithelium and reduced productio

214 ell death through direct effects on membrane permeability of multiple intracellular organelles.

215 ore diverse microclimates and the increasing permeability of natural and diversified landscape.

216 We report herein our studies to improve permeability of nNOS inhibitors as measured by both PAMP

217 In vivo, GSK101 increased the permeability of retinal blood vessels in wild type but n

218 mparting a macro-fracture both increases the permeability of rocks and their sensitivity to effective

219 The permeability of shales is important, because it controls

220 rotein, an ATP-driven efflux pump, regulates permeability of the blood-brain barrier (BBB).

221 ) combined with microbubbles can enhance the permeability of the BTB in brain tumors, as well as disr

222 etric responses correlate with the increased permeability of the films and electrochemically active s

223 o oxygen ingress, but instead the decreasing permeability of the grout, limiting oxidising species ac

224 The permeability of the mitochondrial inner membrane to HNO2

225 of drugs is often limited by the restricted permeability of the mycomembrane.

226 he LPS transporter, which in turn alters the permeability of the outer membrane.

227 riven water influx, we find the H2O membrane permeability of the rod OS to be (2.6 +/- 0.4) x 10(-5)

228 permeability increase was selective, as the permeability of the small molecule calcein co-incubated

229 ding decreasing their enhanced migration and permeability of tumor-stimulatory myeloid cells, and sup

230 acro-fractures and effective pressure on the permeability of volcanic rocks with a wide range of init

231 on loss and associated endothelial monolayer permeability on stiffer substrates.

232 Caco-2 assay also revealed improved membrane permeability over previous compounds.

233 e examined the relationship between membrane permeability, oxidative stress and chlorophyll allomers

234 The analysis of a permeability parameter (Papp), C60-serPF velocity, and t

235 increased nutrient uptake by generating new permeability pathways (NPP) including a Plasmodium surfa

236 ptry protein RhopH2, in the formation of new permeability pathways (NPPs) in Plasmodium-infected eryt

237 , inhibition of the mitochondrial transition permeability pore, and scavengers of reactive oxygen spe

238 ensive clinical usage, we aim to explore BBB permeability prediction from a new angle and introduce a

239 of connexins (Cxs) displays isoform-specific permeability profiles that are not directly determined b

240 IEC barrier formation and butyrate represses permeability-promoting claudin-2 tight-junction protein

241 1000-2000 Da but also have a high pure water permeability (PWP) of 82.5-117.6 L m(-2) h(-1) bar(-1).

242 Raising the HCO3(-) /Cl(-) permeability ratio of CFTR from 0.4 to 1.0 had little im

243 basal endothelial permeability and prevented permeability recovery following injury induced by the in

244 trifluoromethyl group led to improved Caco-2 permeability, reduced Caco-2 efflux, reduced hERG PC act

245 ate an LPS-induced increase in intestinal TJ permeability remain unclear.

246 ne critical vascular function, microvascular permeability, remains unclear.

247 chy of downstream kinases that transduce the permeability response to VEGF165.

248 V) and Fe(III) oxides in soil grains and low permeability sediments that are sequestered in pore spac

249 f the nuclear pore complex (NPC) controlling permeability, selectivity, and the speed of nucleocytopl

250 Two analogs with improved membrane permeability showed much increased DRG concentrations at

251 g areas with variable perfusion and vascular permeability, since individual tumor habitats vary in th

252 to achieve remediation of contaminated, low permeability soil.

253 is influenced by agents that affect vascular permeability, such as antiangiogenic therapies.

254 This increases permeability, surface expression of endothelial adhesion

255 volume of the interstitial space, and lower permeability-surface area product were observed for meta

256 ages of small molecules with respect to cell permeability, temporal control, and the potential genera

257 67, MUC2, ZO-1, IgA, mucin and lower barrier permeability than those in untreated rats.

258 tor prevented the pericyte loss and vascular permeability that are characteristic of non-proliferativ

259 es have a well-known anisotropic directional permeability that is inherited from the depositional lay

260 Dengue can cause increased vascular permeability that may lead to hypovolemic shock.

261 in intestinal epithelial tight junction (TJ) permeability, the mechanisms that mediate an LPS-induced

262 Finally, increasing lysosomal permeability through a lysomotropic detergent in cells d

263 Cannabinoids modulate intestinal permeability through cannabinoid receptor 1 (CB1).

264 Smart regulation of substance permeability through porous membranes is highly desirabl

265 nfocal Leak Score (CLS; range: 0=no impaired permeability to 100=complete loss of barrier function).

266 ycocalyx depth and increased apparent solute permeability to albumin in the same vessels in a time-de

267 Endothelial cell permeability to both small dye molecules and large lipos

268 egulate glycocalyx structure and microvessel permeability to both water and albumin.

269 zer (with very large membrane pores and high permeability to immunoglobulin light chains) or a conven

270 ed neuronal and synaptic function, increased permeability to inflammatory molecules, disrupted glutam

271 Panx1 is unique in its permeability to molecules up to 1 kDa in size and its re

272 ological treatment that alters cell membrane permeability to potassium affected the maintenance and e

273 found that ApoL1 confers chloride-selective permeability to preformed phospholipid vesicles and that

274 J) has a key role in regulating paracellular permeability to water and solutes in the kidney.

275 , owing to low bioavailability and poor skin permeability, transdermal delivery of protein therapeuti

276 an essential component of the mitochondrial permeability transition pore (MPTP).

277 high-conductance channel: the mitochondrial permeability transition pore (mPTP).

278 scued by genetic inhibition of mitochondrial permeability transition pore activation.

279 the real-time monitoring of the endothelial permeability using integrated electrodes and the end-poi

280 e of the vascular opening (pore) with solute permeability values.

281 dy describes a new way of increasing protein permeability via a polymer conjugation process that co-l

282 Targeting granuloma-induced vascular permeability via vascular endothelial-protein tyrosine p

283 the main driver of angiogenesis and vascular permeability via VEGF receptor 2 (VEGFR2), whereas lymph

284 s at emergency department admission, and BBB permeability was assessed at 24 hour follow up via perfu

285 Epithelial cell permeability was increased in miR-143 and miR-145 transf

286 The LPS-induced increase in intestinal permeability was inhibited in MLCK(-/-) and TLR-4(-/-) m

287 Intestinal permeability was investigated by fluorescein isothiocyan

288 Water permeability was measured for eight GOALs characterized

289 Intestinal permeability was quantified by the Confocal Leak Score (

290 The magnitude of this increase in permeability was significantly higher in the presence of

291 ries with a high tunnel volume fraction, the permeability was too low to allow for any substantial bu

292 0, to the corresponding residues in the high-permeability water channel AQP1 have additive effects an

293 PEA (basolateral) also reversed increased permeability when added 48 or 72 h after cytokines (P <

294 ence of inductance arises from the change of permeability, which correlates with the stress dependenc

295 IBD) is associated with increased intestinal permeability, which involves paracellular passage regula

296 id phenylalanine produces increased membrane permeability, which is likely responsible for some of th

297 Pulmonary edema was due to increased permeability, which was augmented by a modest (approxima

298 eramic materials combining high porosity and permeability with good mechanical stability is challengi

299 l healing, we associated impaired intestinal permeability with ongoing bowel symptoms; increases in p

300 d-brain barrier (BBB) via increased vascular permeability, with the magnitude of changes dependent on