ライフサイエンスコーパス: permeability barrier

1 fferentiation and formation of the epidermal permeability barrier.

2 ave epidermal hyperkeratosis and a defective permeability barrier.

3 ion and its coupled translocation across the permeability barrier.

4 well as in the development of the epidermal permeability barrier.

5 evaluated the function of this membrane as a permeability barrier.

6 e-containing outer membrane, which acts as a permeability barrier.

7 amellar membranes required for the epidermal permeability barrier.

8 PRn-mediated enhancement of the nuclear pore permeability barrier.

9 dividual FG domains in yeast relaxes the NPC permeability barrier.

10 rkeratosis and a disruption in the epidermal permeability barrier.

11 all, providing structure and forming a major permeability barrier.

12 e in mediating the negative effects of SP on permeability barrier.

13 rane without compromising its ion and proton permeability barrier.

14 re complex (NPC), which contains a selective permeability barrier.

15 e enzymes and the formation of the epidermal permeability barrier.

16 bladder epithelium functions as an effective permeability barrier.

17 aused only moderate damage to the intestinal permeability barrier.

18 ut inflammation and damage to the intestinal permeability barrier.

19 this occurs only after they have lost their permeability barrier.

20 the vascular wall and endothelial glomerular permeability barrier.

21 ane to form stable channels that disrupt the permeability barrier.

22 teria, is thought to act as a protective and permeability barrier.

23 ceramide, a major component of the epidermal permeability barrier.

24 in fenestrated endothelium with a functional permeability barrier.

25 intaining the selective nuclear pore complex permeability barrier.

26 e for a direct involvement in the junctional permeability barrier.

27 , meiosis, and the integrity of the eggshell permeability barrier.

28 t contains unusual lipids and functions as a permeability barrier.

29 rders characterized by an aberrant epidermal permeability barrier.

30 auses the loss of the membrane function as a permeability barrier.

31 on factor for the formation of the epidermal permeability barrier.

32 upporting a role for this nucleoporin in the permeability barrier.

33 as a bottom-up nanoscale model system of the permeability barrier.

34 The stratum corneum (SC) is an effective permeability barrier.

35 ponent of the glomerular endothelial protein permeability barrier.

36 e for a link between innate immunity and the permeability barrier.

37 to overcome the Gram-negative outer membrane permeability barrier.

38 profound defect in the cytoplasmic membrane permeability barrier.

39 d-bound cornified envelopes, and a defective permeability barrier.

40 in surface that was paralleled not only by a permeability barrier abnormality but also altered stratu

41 Thus, the baseline permeability barrier abnormality in epidermolytic hyperk

42 ory infiltrate, elevated serum IgE levels, a permeability barrier abnormality, and Staphylococcus aur

43 enomenon] and is associated with a prominent permeability barrier abnormality, excess VEGF production

44 his nature or can promote restoration of the permeability barrier after damage by such agents.

45 Both strains could repair the outer membrane permeability barrier after Mg2+-induced displacement of

46 by lipids and carbohydrates that provides a permeability barrier against hydrophilic drugs and is cr

47 late the lamellar body secretory response to permeability barrier alterations, whether modulations in

48 olecular species that subserve the epidermal permeability barrier, an essential function for survival

49 alian cell biology, both through providing a permeability barrier and acting as substrates for synthe

50 ium of mucosal and skin surfaces serves as a permeability barrier and affords mechanisms for local im

51 functions in creating both an intercellular permeability barrier and an intramembrane diffusion barr

52 membrane (OM) of Gram-negative bacteria is a permeability barrier and an intrinsic antibiotic resista

53 This breakdown of the membrane permeability barrier and destabilization of the bilayer

54 ocytosis; perturbation to the outer membrane permeability barrier and hypersensitivity to bile salts

55 the N-terminal domain of Epa1p through this permeability barrier and into the external environment.

56 e of the Gram-negative bacterium serves as a permeability barrier and is composed of lipopolysacchari

57 roles in the integrity of the outer-membrane permeability barrier and participate extensively in host

58 ten consist of tight junctions, which form a permeability barrier and prevent the diffusion of lipids

59 prevented the disruption of Sertoli cell TJ permeability barrier and redistribution of TJ proteins (

60 The eukaryotic nuclear permeability barrier and selective nucleocytoplasmic tra

61 hat mummy mutants have a disrupted epidermal permeability barrier and that the nonsense mutation in m

62 90s, it became clear that the outer membrane permeability barrier and the activity of periplasmic bet

63 ss is tuned to promote rapid assembly of the permeability barrier and to generate a stable and compac

64 1, contribute to maintenance of the vascular permeability barrier and to its re-establishment followi

65 trast, the protein compositions of the outer permeability barriers and cytoplasmic membranes were fou

66 of cell-cell adhesion, reduces the monolayer permeability barrier, and compromises cellular contracti

67 epidermis exhibited dry flaky skin, impaired permeability barrier, and enhanced sensitivity to cutane

68 id due to leakage of the brain's microvessel permeability barrier, and swelling of astrocytes as they

69 Membrane permeability barriers are among the factors contributing

70 rhl3), an ancient regulator of the epidermal permeability barrier, as acting downstream of Irf6.

71 ns mediated by drug efflux transporters, and permeability barriers associated with biofilms.

72 eed resealed the Sertoli cell tight junction-permeability barrier based on a functionalin vivoassay i

73 xins would move to sites of breakdown of the permeability barrier because of the calcium-dependent pr

74 Mammalian epidermis provides a permeability barrier between an organism and its environ

75 m-negative bacteria functions as a selective permeability barrier between cell and environment.

76 ions (TJs) create ion-selective paracellular permeability barriers between extracellular compartments

77 malian urothelium can function not only as a permeability barrier but also as a secretor of urinary p

78 on of the outer membrane (OM) as a selective permeability barrier, but how it is established and main

79 affects the major function of epidermis, the permeability barrier, by altering the structure of the s

80 Dysfunction of the epidermal permeability barrier can result in dehydration, electrol

81 rturbed the Sertoli cell tight junction (TJ)-permeability barrier, causing disruption of actin microf

82 against Gram-negative bacteria is due to the permeability barrier conferred by the outer membrane.

83 eficient (Scd2-/-) neonatal mice have a skin permeability barrier defect and a specific repartitionin

84 e postnatally and exhibit a severe epidermal permeability barrier defect, which may originate from ep

85 pla1-deficient neonates die due to epidermal permeability barrier defects with severe transepidermal

86 with a spreading disruption of the membrane permeability barrier determined by three-dimensional com

87 Interestingly, the epidermal permeability barrier developed normally during embryogen

88 he PPARdelta ligand, GW 610742X, accelerates permeability barrier development, evidenced by a decreas

89 also accelerates the formation of the SC and permeability barrier development.

90 hat PPARdelta has a role in SC formation and permeability barrier development.

91 respectively) increase 1-8 hours after acute permeability barrier disruption and normalize by 24 hour

92 wn to induce the Sertoli cell tight junction permeability barrier disruption via changes in localizat

93 as infection, injuries, UV irradiation, and permeability barrier disruption) in parallel with induct

94 the calcium gradient disappears after acute permeability barrier disruption, and returns after 6 h i

95 that mirror the lipid metabolic response to permeability barrier disruption.

96 osed mitosis, does not maintain a continuous permeability barrier during mitosis.

97 eases, such as epidermal thinning (atrophy), permeability barrier dysfunction, and chronic nonhealing

98 rovokes both a typical scaling phenotype and permeability barrier dysfunction.

99 The epidermal permeability barrier (EPB) prevents organisms from dehyd

100 lamellar layers and giving rise to epidermal permeability barrier (EPB).

101 of PECAM-1 to support re-establishment of a permeability barrier following disruption with thrombin

102 Blood-Brain-Barrier (BBB) is a rigorous permeability barrier for maintaining homeostasis of Cent

103 ded that the OM of M. smegmatis represents a permeability barrier for phosphates and that Msp porins

104 negative bacteria is to provide a protective permeability barrier for the cell, and proper maintenanc

105 of the stratum corneum is important for both permeability barrier formation and cutaneous antimicrobi

106 (Epid)CaR(-/-) mice exhibited a delay in permeability barrier formation during embryonic developm

107 ta activation stimulates differentiation and permeability barrier formation in adults, we hypothesize

108 tes and accelerate epidermal development and permeability barrier formation in fetal rat skin explant

109 Defective skin permeability barrier formation in global CGI-58-deficien

110 eratinocytes, a process that is critical for permeability barrier formation.

111 VDR and coactivators in lipid production and permeability barrier formation.

112 o neonatal lethality due to perturbations in permeability barrier formation.

113 ellular junctions (TCJs) are uniquely placed permeability barriers formed at the corners of polarized

114 matic proteins converge to produce defective permeability barrier function and antimicrobial defense

115 re required for maintaining normal epidermal permeability barrier function and biosynthesis of lipids

116 Permeability barrier function and expression of differen

117 Basal permeability barrier function and stratum corneum (SC) i

118 discrete pH changes alone regulate cutaneous permeability barrier function and stratum corneum integr

119 s (urothelial plaques), which play a role in permeability barrier function and uropathogenic bacteria

120 Primary abnormalities in permeability barrier function appear to underlie atopic

121 way in mice is partly responsible for normal permeability barrier function but the mechanism awaits f

122 e are no known gender-related differences in permeability barrier function in adults, estrogens accel

123 erleukin-1 alpha signaling in the decline of permeability barrier function in aged skin, and point to

124 ebum influences stratum corneum hydration or permeability barrier function in asebia J1 and 2 J mice,

125 iated pathological disruption of endothelial permeability barrier function in cells exposed to vascul

126 with darkly pigmented skin display superior permeability barrier function in comparison with humans

127 role of ACh in AMP regulation of immune and permeability barrier function in keratinocytes is review

128 ates for energy metabolism and from impaired permeability barrier function in the skin.

129 Although basal permeability barrier function is established at birth, t

130 ion-fortifying arrangement that enhances the permeability barrier function of the endothelium.

131 The permeability barrier function of the epidermis is one of

132 ations was tested using TEWL to evaluate the permeability barrier function of the epidermis.

133 anes (AUM) that contribute to the remarkable permeability barrier function of the urinary bladder.

134 the urothelial plaque and contributes to the permeability barrier function of the urothelium, and UPI

135 Although basal permeability barrier function was normal, PPARbeta/delta

136 ed skin, have severely compromised epidermal permeability barrier function, and die within a few hour

137 aled abnormal corneocyte fragility and basal permeability barrier function, but accelerated repair ki

138 lied statins only modestly affects epidermal permeability barrier function, suggesting a possible com

139 ra long-chain ceramides could further impair permeability barrier function, thereby exacerbating the

140 mpeding drug transport across the BTB and TJ permeability barrier function, was not able to induce th

141 r disrupting the Sertoli cell tight junction-permeability barrier function.

142 rneum (SC), which is required for post-natal permeability barrier function.

143 er evidence that AMP expression is linked to permeability barrier function.

144 SC lamellar membranes that are essential for permeability barrier function.

145 (LB) in keratinocytes, which is critical for permeability barrier function.

146 ture of the lamellar membranes that regulate permeability barrier function.

147 nly barrier recovery kinetics but also basal permeability barrier function.

148 patients typically display an abnormality in permeability barrier function.

149 acellular lamellae, which regulate cutaneous permeability barrier function.

150 idermal VEGF in the maintenance of epidermal permeability barrier homeostasis and a link between epid

151 functional abnormalities, including aberrant permeability barrier homeostasis and decreased stratum c

152 Asebia J1 mice showed normal permeability barrier homeostasis and extracellular lamel

153 intrinsically aged skin displays compromised permeability barrier homeostasis and reduced stratum cor

154 n of neonatal SC results in abnormalities in permeability barrier homeostasis and SC integrity and ar

155 birth, neonatal epidermis displays decreased permeability barrier homeostasis and SC integrity, impro

156 y impacts key epidermal functions, including permeability barrier homeostasis and SC integrity.

157 , as well as decreased CD, compromising both permeability barrier homeostasis and SC integrity.

158 tors correct the functional abnormalities in permeability barrier homeostasis and SC integrity/cohesi

159 e formation of an acidic SC and improve both permeability barrier homeostasis and SC integrity/cohesi

160 ) pH are accompanied by minor alterations in permeability barrier homeostasis and SC integrity/cohesi

161 est that an acidic pH is required for normal permeability barrier homeostasis and SC integrity/cohesi

162 f acidification mechanisms disturb cutaneous permeability barrier homeostasis and stratum corneum int

163 that PAR-2 plays a central role in epidermal permeability barrier homeostasis by mediating signaling

164 receptor (LXR) activation improved epidermal permeability barrier homeostasis by stimulating keratino

165 portion of the stratum corneum ceramides for permeability barrier homeostasis in mammalian skin.

166 opical H1/2r antagonists additively enhanced permeability barrier homeostasis in normal mouse skin by

167 Permeability barrier homeostasis is enhanced in SKH2/J v

168 mulate keratinocyte differentiation, improve permeability barrier homeostasis, and accelerate the in

169 idification in adults is required for normal permeability barrier homeostasis, and lipid processing o

170 unction, we studied stratum corneum (SC) pH, permeability barrier homeostasis, and SC integrity in th

171 the importance of SP/SPI balance for normal permeability barrier homeostasis, and second, they ident

172 LXR activation resulted in an improvement in permeability barrier homeostasis, associated with an inc

173 r, epidermal vegf(-/-) mice display abnormal permeability barrier homeostasis, attributable to decrea

174 <2% residual activity) demonstrate abnormal permeability barrier homeostasis, i.e., delayed recovery

175 and impairs keratinocyte differentiation and permeability barrier homeostasis, indicating a key role

176 udies demonstrated PS-induced alterations in permeability barrier homeostasis, mediated by increased

177 enous glucocorticoids (GCs) that compromises permeability barrier homeostasis, stratum corneum cohesi

178 Key functions of the skin including permeability barrier homeostasis, stratum corneum surfac

179 ocyte differentiation and improves epidermal permeability barrier homeostasis.

180 iggered or exacerbated by impaired epidermal permeability barrier homeostasis.

181 r requirements and (2) CRAMP is required for permeability barrier homeostasis.

182 sely, LB-derived AMPs are also important for permeability barrier homeostasis.

183 role for FAK: maintenance of adult epidermal permeability barrier homeostasis.

184 FA2H expression are essential for epidermal permeability barrier homeostasis.

185 ch PPAR and LXR activators promote epidermal permeability barrier homeostasis.

186 synthesis/secretion, which in turn influence permeability barrier homeostasis.

187 nd liver X receptor (LXR) activators improve permeability barrier homeostasis.

188 count for their ability to improve epidermal permeability barrier homeostasis.

189 n, though arguably its most important, i.e., permeability barrier homeostasis.

190 tone treatment, indicating an improvement in permeability barrier homeostasis.

191 lly, topical oxysterol pretreatment improved permeability barrier homeostasis.

192 repletion can have negative consequences for permeability barrier homeostasis.

193 he stratum corneum, where it is critical for permeability barrier homeostasis.

194 cyte lipid envelope are required elements in permeability barrier homeostasis.

195 /delta in the epidermis: (1) is required for permeability barrier homeostasis; (2) regulates keratino

196 lls and cell-free extracts and estimated the permeability barrier imposed by the cell wall to INH inf

197 impairment in epidermal differentiation and permeability barrier in (Epid)CaR(-/-) mice maintained o

198 n microscopy revealed a loss of the lamellar permeability barrier in Abca12-/- skin.

199 ter membrane that serves as a very effective permeability barrier in an environment that is poor in d

200 Herein, we describe a drug-permeability barrier in human and rodent CP mediated by

201 it diaphragm are essential components of the permeability barrier in the kidney.

202 al report that EspP L5 helps to maintain the permeability barrier in the outer membrane.

203 first that acute disruption of the epidermal permeability barrier in young mice leads not only to a r

204 Fourth, disruption of the permeability barrier induced similar elevations in epide

205 Permeability barrier insults stimulate rapid secretion o

206 hat adherens junctions may regulate vascular permeability barrier integrity and cardiomyocyte functio

207 s at baseline, and in relation to changes in permeability barrier integrity.

208 adhesive strength, epithelial behavior, and permeability barrier integrity.

209 Defective permeability barrier is an important feature of many ski

210 The epidermal permeability barrier is comprised of corneocytes embedde

211 The cutaneous permeability barrier is essential for life and perturbat

212 The loop-gate permeability barrier is formed by a segment of the first

213 A prominent example of such a selective permeability barrier is given by mucus.

214 The blood-CSF drug-permeability barrier is localized to the epithelium of t

215 TR affinity, and the centrally located dense permeability barrier is overcome by multivalent interact

216 um, which play a key role in maintaining the permeability barrier, is reduced in atopic dermatitis an

217 iotactin results in SJ and TCJ breakdown and permeability barrier loss.

218 am-negative bacteria, is thought to act as a permeability barrier, making the outer membrane relative

219 emical basis for air-induced acceleration of permeability barrier maturation in premature infants.

220 tion of toxic agents may indicate incomplete permeability barrier maturation in the early neonatal pe

221 3 perturbed the Sertoli cell tight junction-permeability barrier, mediated by changes in the localiz

222 In Sertoli cell cultures with established permeability barrier mimicking the BTB in vivo, the knoc

223 In response to acute disruption of the permeability barrier of aged mammals there is a diminish

224 ntibacterial cargo across the outer membrane permeability barrier of Gram-negative pathogens utilizin

225 The permeability barrier of nuclear pore complexes (NPCs) co

226 structural and functional properties of the permeability barrier of nuclear pore complexes.

227 The epidermal permeability barrier of premature infants matures rapidl

228 mental importance to life of maintaining the permeability barrier of the cell membrane, it is propose

229 c and lumenal occur without compromising the permeability barrier of the ER membrane.

230 rypsin, a protease that cannot penetrate the permeability barrier of the inner envelope membrane, deg

231 m, is a necessary component of the selective permeability barrier of the kidney glomerulus.

232 h each translocon forms an aqueous pore, the permeability barrier of the membrane is maintained durin

233 ded protein substrates without breaching the permeability barrier of the membrane.

234 the mitotic poles appear 2-3 min before the permeability barrier of the nuclear envelope begins to c

235 The permeability barrier of the OM results partly from the l

236 ts as a ligand-expelled gate to preserve the permeability barrier of the OM.

237 lysaccharide (LPS) contributes to the robust permeability barrier of the outer membrane, preventing e

238 -affinity, cohesive interactions to form the permeability barrier of the pore, although the form and

239 ollowing acute and chronic challenges to the permeability barrier of the skin.

240 enzyme, 12R-LOX, to disruption of the normal permeability barrier of the skin.

241 the source of surface antigens and a primary permeability barrier of the spore, its molecular structu

242 findings suggest that the antimicrobial and permeability barriers of the skin are closely linked.

243 bers of the nuclear receptor family regulate permeability barrier ontogenesis by stimulating lipid me

244 ors of nuclear receptors accelerate not only permeability barrier ontogenesis, but also the expressio

245 cross cell monolayers without disrupting the permeability barrier or cell viability, and enabled tran

246 d promoted solely by an intrinsic intestinal permeability barrier perturbation, establishes St14 as a

247 ells with an established tight junction (TJ)-permeability barrier perturbed the TJ-barrier via change

248 ht packing could be a critical factor in the permeability barrier provided by LPS.

249 A permeability barrier, provided by bed-capping cements th

250 These are the establishment of the permeability barrier, provision of the environment for m

251 ated that cold exposure (4 degrees C) blocks permeability barrier recovery after acute disruption.

252 ions of PAR-2 agonist peptide, SLIGRL, delay permeability barrier recovery and inhibit LB secretion,

253 sociated epidermal functions and accelerates permeability barrier recovery and skin wound healing.

254 The superbases also delayed permeability barrier recovery, attributable to decreased

255 rease in mBD3 protein, CRAMP-/- mice delayed permeability barrier recovery, attributable to defective

256 eceptor 3 has an important role in signaling permeability barrier repair following injury induced by

257 ease the expression of genes associated with permeability barrier repair.

258 RNA may be another pathway for activation of permeability barrier repair.

259 e keratinocyte proliferation; (3) accelerate permeability barrier repair; (4) increase epidermal lipi

260 obial barriers are coordinately regulated by permeability barrier requirements and (2) CRAMP is requi

261 normal hairless mice, a specific response to permeability barrier requirements because up-regulation

262 Thus, permeability barrier requirements coordinately drive bot

263 d production could be coregulated by altered permeability barrier requirements.

264 Artificial permeability barrier restoration, which inhibits the lip

265 Disruption of the permeability barrier stimulates a repair response that l

266 d sphingolipid production and enhancement of permeability barrier structural markers.

267 pithelium, and a "tightened" Sertoli cell TJ permeability barrier, supporting the role of Arp2/3 comp

268 A selective permeability barrier that arises from a supramolecular a

269 This OM presumably acts as a permeability barrier that imparts high levels of intrins

270 PS molecules, the OM behaves as an effective permeability barrier that makes Gram-negative bacteria i

271 lls cultured in vitro with an established TJ permeability barrier that mimicked the BTB in vivo, Cdc4

272 ls isolated from rat testes that formed a TJ-permeability barrier that mimicked the BTB in vivo.

273 Sertoli cell cultures with an established TJ permeability barrier that mimicked the BTB in vivo.

274 itro with an established tight junction (TJ) permeability barrier that mimics the BTB in vivo, the kn

275 ral epithelia, generates an outer protective permeability barrier that prevents water loss, entry of

276 mmetric outer membrane (OM), which acts as a permeability barrier that protects the cell from externa

277 ontribution of the formidable outer-membrane permeability barrier that reduces the compounds efficacy

278 Occluding-junctions form a permeability barrier that regulates the accessibility of

279 uring and crack sealing may have created low-permeability barriers that seal fluids into the network

280 tify PAR-2 as a novel signaling mechanism of permeability barrier, that is, of response linked to LB

281 lthough these bilayers are important for the permeability barrier, the ECM contains not only lipids b

282 use they cannot penetrate the outer membrane permeability barrier, the vanX homologue (ddpX) is cotra

283 Following disruption of the permeability barrier, there is a rapid restoration of ba

284 (Cers) are key constituents of the epidermal permeability barrier, they also function as apoptogenic

285 Skin and bladder epithelia form effective permeability barriers through the activation of distinct

286 moved by phagocytosis before they lose their permeability barrier, thus preventing induction of an in

287 lthough transport receptors enable the NPC's permeability barrier to be overcome, directionality is e

288 We hypothesized that the responsible permeability barrier to CO(2) resides in the umbrella ce

289 To test whether the observed permeability barrier to CO(2) was due to an unstirred la

290 of the lipid bilayer in such a way that the permeability barrier to hydrophilic molecules and ions i

291 ctive layer around the cell that serves as a permeability barrier to prevent unrestricted access of n

292 or 4 complex, and acts as a component of the permeability barrier to prevent uptake of bactericidal c

293 molecules in the PDZ serves to function as a permeability barrier to regulate access of immunological

294 A key function of the skin is to provide a permeability barrier to restrict the movement of water,

295 ts provide evidence for the existence of low-permeability barriers to melt migration within the lower

296 fferentiation, and by function examining the permeability barrier using transepidermal water loss (TE

297 nd electron microscopy demonstrated that the permeability barrier was a distinct envelope that formed

298 As a bottom-up nanoscale model for the permeability barrier, we have used planar films produced

299 of the yeast cell wall is known to act as a permeability barrier; we found that the C-terminal Ser/T

300 In the liver, the absence of permeability barriers yields specific [18F]Tf binding to