ライフサイエンスコーパス: permeability to

1 I alone whereas rutin decreased water vapour permeability to 1.2 g mm/m(2)h kPa.

2 body to JAM-A demonstrated a 33% increase in permeability to 10,000 MWt dextran compared with monolay

3 nfocal Leak Score (CLS; range: 0=no impaired permeability to 100=complete loss of barrier function).

4 nstrated by high TEER values and a selective permeability to [14C] phenytoin and the well-known parac

5 Permeability to 150-kDa FITC-dextran decreased by a litt

6 C]urea (6.97 +/- 1.95) while having a higher permeability to 22Na (25.5 +/- 1.8) and [not readable: s

7 resulted in an increase in the paracellular permeability to [(3)H]inulin as a function of loss of TE

8 ance (TCER) greater than 100 ohm cm2 and low permeability to 4 kDa and 20 kDa dextrans.

9 barrier integrity was examined by measuring permeability to 4-kDa fluorescein isothiocyanate-dextran

10 n depletion increased diffusive paracellular permeability to 467 Da TAMRA by 15%, and permeability un

11 n protein with siRNA did not alter diffusive permeability to 70 kDa and 10 kDa RITC-dextran, and perm

12 ility to 70 kDa and 10 kDa RITC-dextran, and permeability to 70 kDa dextran was twofold lower in occl

13 d blocked part of the VEGF-induced monolayer permeability to 70-kDa dextran.

14 No significant differences in permeability to 70-kDa FITC-dextran were observed at pre

15 BBB permeability to 70kDa FITC-Dextran was measured 24h foll

16 nd study showed increased alveolar-capillary permeability to a 70-kD fluorescent-labeled dextran only

17 ies such as the need for restricting osmotic permeability to a constant area near the tip, which was

18 Measurements of permeability to a high molecular mass contrast agent (35

19 Dynamic MR imaging revealed microvascular permeability to a high-molecular-weight contrast agent w

20 in-1 in Can 10 clones increased paracellular permeability to a level similar to that of parental cell

21 By contrast, VEGF did not alter BBB permeability to AAV2/5-lacZ, as defined by beta-galactos

22 ndrial dysfunction, inhibiting mitochondrial permeability to ADP and inducing mitochondrial hyperpola

23 (L) can sustain outer mitochondrial membrane permeability to ADP.

24 y reduced in NRTN(-/-) mice, whereas corneal permeability to AFD was significantly increased.

25 The partition coefficient of permeability to albumin also showed a decline with incre

26 ied by a significant increase in endothelial permeability to albumin and a decrease in hyaluronic aci

27 h ATL313 also blocked the increased podocyte permeability to albumin and disruption of the actin cyto

28 onectin and AMPK activation reduced podocyte permeability to albumin and podocyte dysfunction, as evi

29 Whereas GH increased podocyte permeability to albumin in a paracellular albumin influx

30 ycocalyx depth and increased apparent solute permeability to albumin in the same vessels in a time-de

31 Increased permeability to albumin is a well-known feature of diabe

32 Increased permeability to albumin occurred throughout both phases

33 The early effect of CA-4-P on tumor vascular permeability to albumin was determined to assess whether

34 Tumor vascular permeability to albumin was increased to approximately 1

35 -1a+4_a animals have an increased glomerular permeability to albumin without significant changes in B

36 layed significantly lower levels of vascular permeability to albumin, compared to day 1.

37 adherins in podocytes and increased podocyte permeability to albumin.

38 ury equally as measured by plasma vWf:Ag and permeability to albumin.

39 as hypothesized that differences in membrane permeability to aldopentoses provide a mechanism for pre

40 Corneal permeability to AlexaFluor dextran (AFD; Molecular Probe

41 ate tight junction disruption, promoting BBB permeability to allow bacterial passage.

42 Restoration of outer membrane permeability to anionic metabolites does not occur direc

43 ilayer membrane accounts for its much larger permeability to anions than cations and affects the conf

44 the current study were to quantify placental permeability to antipsychotic medications and to documen

45 drial outer membrane (MOM), and modulate its permeability to apoptotic factors, controlling their rel

46 ociated with large increases in membrane Na+ permeability to approximately 80 pA/pF or more.

47 8 to glycine, was sufficient to restore K(+) permeability to AtHKT1.

48 Furthermore, PE cells exhibited a decreased permeability to Ba2+ but an increased permeability to Mn

49 ry route that exhibits significantly greater permeability to Ba2+ than does capacitative calcium entr

50 cause intestinal inflammation and increased permeability to bacteria and toxins.

51 Permeability to bacteria in intestinal segments of ileum

52 ined implant-abutment assembly, the very low permeability to bacteria of the conical implant-abutment

53 Serologic measures of increased intestinal permeability to bacterial components are associated with

54 rn leads to increases in epithelial cellular permeability to bacterial products, leading to endotoxem

55 Determination of compound's permeability to BBB is prerequisite in CNS drug discover

56 ty of any compound with significant membrane permeability to be applied intracellularly by whole-cell

57 d to be directly observed, allowing membrane permeability to be determined easily from the transient

58 riant AQP4 channels reduced normalized water permeability to between 26 and 48% of the reference (P <

59 DL prevented shock-induced increases in lung permeability to both Evans blue dye and protein in addit

60 ression of claudin-5 and blood-brain barrier permeability to both exogenous sodium fluorescein and en

61 ular tracers in the neonates showed that BBB permeability to both large (70 kDa dextran) and small (3

62 Endothelial cell permeability to both small dye molecules and large lipos

63 er in parallel with defects in microvascular permeability to both water and albumin, in both continuo

64 lyx are critical regulators of microvascular permeability to both water and albumin.

65 egulate glycocalyx structure and microvessel permeability to both water and albumin.

66 eristic of these homomeric ASIC-1as is their permeability to Ca(2+) Activation of ASIC-1a in MNTB neu

67 channel properties, Mg(2+) block, selective permeability to Ca(2+) and single-channel conductance, w

68 e demonstrate for the first time hemichannel permeability to Ca(2+) by measuring Ca(2+) transport thr

69 Furthermore, potentiation by Ca(2+) and a permeability to Ca(2+) comparable with that of AMPA/kain

70 In addition, a slight permeability to Ca(2+) is detected when palytoxin binds

71 d EPSCs by external and internal polyamines, permeability to Ca(2+), and GluR2 immunoreactivity.

72 Because alpha7-nAChRs have a high permeability to Ca(2+), we performed TUNEL staining to i

73 The increased membrane permeability to Ca2+ cannot be attributed to activation

74 flop and GluR4 flop subunits and their high permeability to Ca2+ from selective post-transcriptional

75 re the major carriers of current, but finite permeability to Ca2+ leads to a significant intracellula

76 pearance of nonselective ion channels with a permeability to calcium and chloride ions.

77 se they are widespread, have a high relative permeability to calcium, and regulate numerous cellular

78 However, because of their permeability to calcium, GluR2-lacking but not WT AMPARs

79 family of cationic channels with significant permeability to calcium, potassium and sodium.

80 alpha7 gene product and has a high relative permeability to calcium.

81 because of their abundance and high relative permeability to calcium.

82 ce (MprF) virulence factors control cellular permeability to cationic antibiotics by aminoacylating i

83 ng to the membrane, MPX increases the cell's permeability to cations leading to a disruption in the e

84 Furthermore, the outer membrane permeability to cephalothin and cephaloridine, measured

85 hen we change the width of the EUF, membrane permeability to CO(2), native extra- and intracellular c

86 that is partly a result of reduced vascular permeability to contrast agents rather than a true antit

87 els also appear to have sufficient HCO(3)(-) permeability to contribute directly to HCO(3)(-) secreti

88 Torsional motility and junctional permeability to dextran are greatly increased in cells e

89 d with a Rho-dependent increase in monolayer permeability to dextrans, suggesting that such functiona

90 potentials showed the relative BzATP-induced permeabilities to different substrates to be Na+, 1 > Cl

91 Permeability to diffusion of fluorescein in a static cha

92 Permeability to diffusion of fluorescein in a static cha

93 lasmodium falciparum have markedly increased permeabilities to diverse organic and inorganic solutes.

94 Malaria parasites increase erythrocyte permeability to diverse solutes including anions, some c

95 This protein increases host cell permeability to diverse solutes.

96 or vessel to the permeability of that vessel permeability to DOX-PLD, indicating that collagen conten

97 Cells also showed immediate increased permeability to doxorubicin with the addition of US + MB

98 lterations of extracellular Ca(2+) and their permeability to dyes and small atomic ions (conductance)

99 are consistent with the known difference in permeability to each molecule.

100 so reduced postischemic blood--brain barrier permeability to endogenous immunoglobulin G.

101 This inhibits potassium permeability to enhance neuronal excitability.

102 rs still suffered from too low cell membrane permeability to enter into CNS drug development.

103 The lptE14 mutation increased OM permeability to erythromycin, even when the wild-type lp

104 ed LptD-LptE14 complexes in the OM decreases permeability to erythromycin.

105 f ATP that within minutes increases membrane permeability to ethidium (Etd(+)) and Ca(2+) by activati

106 Furthermore, AS101 treatment reduced colonic permeability to Evans blue and decreased colonic TUNEL(+

107 o, resulting in tissue collapse and membrane permeability to Evans blue.

108 sms beyond simply increasing plasma membrane permeability to exert their lethal effects.

109 hannels, Ca-A/K channels exhibit the highest permeability to exogenously applied Zn2+.

110 s termed viroporins, which modulate membrane permeability to facilitate critical steps in a viral lif

111 The chamber permeability to FcMeOH can be tuned by varying printing

112 wild-type mice increased both ileal mucosal permeability to FD4 and bacterial translocation to mesen

113 alyzed at specific times after infection for permeability to fibrin and albumin, quantitation of intr

114 It also led to a significant increase in permeability to FITC dextran.

115 r integrity was further assessed in terms of permeability to FITC dextran.

116 Human transscleral permeability to FITC-albumin (70 kDa) and 70-kDa and 150

117 Permeability to FITC-albumin was decreased by approximat

118 495, increasing NO production, and elevating permeability to FITC-dextran 70 in monolayers of cells e

119 PAF failed to increase permeability to FITC-dextran 70 in monolayers of cells t

120 In both tissues, permeability to FITC-dextran was significantly greater 2

121 nificantly increased paracellular intestinal permeability to FITC-dextran.

122 sepithelial electrical resistance (TEER) and permeability to fluorescein isothiocyanate (FITC)-conjug

123 Mucosal permeability to fluorescein isothiocyanate dextran (mole

124 in levels, serum HMGB1 levels, ileal mucosal permeability to fluorescein isothiocyanate dextran, bact

125 ons in TJ proteins correlated with increased permeability to fluorescein isothiocyanate-dextran molec

126 esistance, a marked decrease in paracellular permeability to fluorescence isothiocyanate-dextran, and

127 monolayers do exhibit increased paracellular permeability to fluorescent dextrans.

128 al resistance that correlated with increased permeability to fluorescently labeled albumin.

129 s, paracellular gap formation, and increased permeability to fluxes of dextran and albumin.

130 onductance G cannot be considered markers of permeability to gliadin peptides.

131 t strategies aimed at controlling epithelial permeability to gluten.

132 a dramatic perforin-independent increase in permeability to GrzB released by the CTLs.

133 A lower limit of lipid bilayer permeability to H(2)S, P(M,H(2)S) >or = 0.5 +/- 0.4 cm/s

134 e, we determined that the relative capillary permeability to hydrophilic macromolecule tracers is sig

135 in flock house nodavirus increases membrane permeability to hydrophilic solutes and can alter both m

136 ing transepithelial resistance, paracellular permeability to hydrophilic solutes, and the TJ proteins

137 HMPV SH expression resulted in increases in permeability to hygromycin B and alteration of subcellul

138 form a dityrosine network that decreases gut permeability to immune elicitors.

139 zer (with very large membrane pores and high permeability to immunoglobulin light chains) or a conven

140 ial target for biochemical modulation of BTB permeability to increase antineoplastic drug delivery se

141 ed neuronal and synaptic function, increased permeability to inflammatory molecules, disrupted glutam

142 ng and attachment, and minimized endothelial permeability to infused fluorescence dextrans, assessed

143 Permeability to inositol phosphates was assessed by flux

144 The absence of correlation between G and permeability to intact 33-mer or p31-49 did not favor pa

145 e celiac disease, increases in transcellular permeability to intact gliadin peptides might be conside

146 catenin, decrease in resistance, increase in permeability to inulin, and redistribution of occludin a

147 Their transient permeability to ion flow makes possible the rapid detect

148 nt, combined with the lack of sensitivity of permeability to ion type or even ion pairs, led us to qu

149 fected with malaria parasites have increased permeability to ions and nutrients, as mediated by the p

150 nd hydraulic permeability indeed showed that permeability to ions and water significantly decreases w

151 cess requires a membrane with relatively low permeability to ions to minimize energy dissipation.

152 ssion of claudin-5 selectively decreased the permeability to ions.

153 OsHKT2;4 displayed a high permeability to K(+) compared with that to Na(+) (permea

154 Furthermore, the high permeability to K(+) in OsHKT2;4 supports the hypothesis

155 438, 443, or 446 significantly increased the permeability to K(+) versus Na(+).

156 reviously described changes in microvascular permeability to K(+) with U, suggest that if the flow-de

157 and A443C mutants showed slightly increased permeability to K(+), Rb(+), and Cs(+), suggesting that

158 e, nonselective cation channel function with permeability to K+ > Na+ >> tetraethylammonium.

159 Human erythrocytes have a low basal permeability to L-glutamate and are not known to have a

160 ude to those of WT, but had altered relative permeability to large anions.

161 oncentration-dependent increases in relative permeability to large cations and changes in Ca2+ permea

162 mark of this dynamic process is an increased permeability to large cations such as N-methyl-D-glucami

163 electivity, low unitary conductance, and low permeability to large cations.

164 g delivery method that can increase vascular permeability to large molecular agents.

165 novel regulation of P2X7R outward and inward permeability to large molecules by Cl-(o) and Na+(o), re

166 olayers had markedly enhanced tight junction permeability to large molecules that could be modeled by

167 es a large inward current and an increase in permeability to large molecules, mediated by the opening

168 lial cells demonstrate enhanced paracellular permeability to large molecules, revealing a potential r

169 but not ADF, depletion increased epithelial permeability to large molecules.

170 train and the extent of cytoplasmic membrane permeability to large molecules.

171 primarily as a result of increased capillary permeability to larger molecules.

172 ndothelial cathepsins, increased endothelial permeability to LDL, and the development of lipid streak

173 of the IEB; the addition of 15-HETE restored permeability to levels of control tissues.

174 lective Na(+) conductance with a substantial permeability to Li(+) that is subject to acute regulatio

175 ncreased, to different extents, the relative permeability to Li(+), K(+), Rb(+), and Cs(+).

176 We observe that these channels have high permeability to liquid flow and facilitate the transport

177 Caco-2 monolayers and increases paracellular permeability to macromolecular FITC-dextran.

178 of penetration enhancers that increase skin permeability to macromolecules (approximately 1-10 kDa)

179 entary approaches in which (i) assessment of permeability to macromolecules of different Stokes radii

180 Platelet-activating factor (PAF) increases permeability to macromolecules via translocation of endo

181 Permeability to macromolecules was assessed by simultane

182 locations to increase endothelial monolayer permeability to macromolecules.

183 AGE-bound RAGE increases endothelial permeability to macromolecules.

184 ty that exhibits considerable plasticity and permeability to macromolecules.

185 om anti-CD3-treated mice exhibited increased permeability to mannitol at 1 hour and decreases in elec

186 arasite Plasmodium falciparum have increased permeabilities to many solutes.

187 illus species are impermeable or exhibit low permeability to many compounds that readily penetrate ge

188 e anion channel (PSAC) increases erythrocyte permeability to many solutes in malaria but has uncertai

189 reased permeability to Ba2+ but an increased permeability to Mn2+ and Gd3+, suggesting that PE is ass

190 ss-linking Fas was associated with increased permeability to molecules that were <400 Da but not thos

191 Panx1 is unique in its permeability to molecules up to 1 kDa in size and its re

192 , which has a characteristically low passive permeability to monovalent cations.

193 expression was found to reduce paracellular permeability to monovalent inorganic and organic cations

194 ntamination index values demonstrated higher permeability to most microbes in the cemented group.

195 Recent evidence has linked intestinal permeability to mucosal inflammation, but molecular stud

196 nd correlated with significant reductions in permeability to multiple solutes, consistent with uptake

197 n these families had an increase in membrane permeability to Na and K that is particularly marked at

198 It had equal permeability to Na(+) and K(+), but was less permeable t

199 Its permeability to Na(+), estimated from Goldman-Hodgkin-Ka

200 It may also have a limited permeability to Na+ and the zwitterion taurine.

201 c) lack of desensitization/inactivation, (d) permeability to Na+, and (e) inhibition by Brilliant Blu

202 It has similar permeability to Na+, K+ and Cs+, but the organic monoval

203 The properties of the current (permeability to Na+, K+, TEA+, and Cs+; voltage insensit

204 This indicates decreased paracellular permeability to NaCl but increased permeability to nonel

205 istent with this observation, differences in permeability to natural metabolites have been reported f

206 Basolateral membrane permeability to NH(3) was reduced in CDs from Rhcg(-/-)

207 The permeability to NMDG developed as quickly as the channel

208 Permeability to nonelectrolytes showed that linear-chain

209 acellular permeability to NaCl but increased permeability to nonelectrolytes.

210 EDE increased corneal permeability to OGD and fluorescein and corneal surface

211 lprednisolone or doxycycline reduced corneal permeability to OGD, improved corneal smoothness, and de

212 The switch in membrane permeability to OH(-)/HCO(3)(-) can also be recorded as

213 Corneal permeability to Oregon green dextran (OGD) and sodium fl

214 The weak permeabilities to organic cations were resolved by looki

215 alaria parasites exhibit marked increases in permeability to organic and inorganic solutes.

216 of small biomolecules that alter the bilayer permeability to other ions can upregulate and downregula

217 ion channel known, H(V)1 shows no detectable permeability to other ions.

218 of the tight-junction protein ZO-1 enhanced permeability to oxalate and mannitol in parallel.

219 e time-dependent increase in transepithelial permeability to paracellular marker inulin.

220 linear relationship was observed between the permeability to PFC-NP and accelerated thrombosis (P = 0

221 These observations suggest that excessive permeability to PFC-NP may indicate prothrombotic risk i

222 Permeability to PFC-NP remained minimal until 12 weeks o

223 -) mice, which lack caveolae, have increased permeability to plasma albumin.

224 The knockout mice exhibited reduced vascular permeability to plasma protein, resulting in chronically

225 fibrin deposition and increased endothelial permeability to plasma proteins.

226 re hypothesized to cause enhanced glomerular permeability to plasma proteins.

227 ession of outer membrane porins that lowered permeability to PNPP by approximately 70%.

228 ride selective, with a small but significant permeability to potassium (PNa+ : PK+ : PCl- = 0 : 0.03

229 ological treatment that alters cell membrane permeability to potassium affected the maintenance and e

230 found that ApoL1 confers chloride-selective permeability to preformed phospholipid vesicles and that

231 e exposure, caspase activation, and membrane permeability to propidium iodide in the absence and pres

232 hoid cell function and intestinal epithelial permeability to protect against allergen sensitization.

233 mesenchymal stem cells to restore epithelial permeability to protein across primary cultures of polar

234 f human MSC restored type II cell epithelial permeability to protein to control levels.

235 increased lung vascular and lung epithelial permeability to protein, and decreased alveolar fluid cl

236 increase in lung endothelial and epithelial permeability to protein, extravascular lung water, and a

237 eficial effect of MSC on alveolar epithelial permeability to protein.

238 ented by an apparent increase in the barrier permeability to protein.

239 latter including an increase in the passive permeability to proteins, smaller solutes, and water and

240 stat measurements, to estimate paracellular permeability to protons, ammonium and bicarbonate in MDC

241 An increased passive (leak) permeability to protons, together with reduced vacuolar

242 We find effective permeabilities to range from 10(-6) to 10(2) millidarcie

243 al fluid and solute homeostasis, we assessed permeability to rat serum albumin (P(RSA)(s)) in mesente

244 barrier function, as indicated by increased permeability to rose bengal diagnostic dye.

245 microvascular hemorrhage, enhanced vascular permeability to serum albumin, and vasogenic cerebellar

246 Deletion of the ompATb gene reduced permeability to several small water-soluble substances.

247 Such a pathway would limit flow-dependent permeability to small hydrophilic molecules and have min

248 is accompanied by strongly enhanced membrane permeability to small molecules and a measurable rate of

249 parasites have aberrant morphology, reduced permeability to small molecules, and structural instabil

250 The high membrane permeability to small monovalent ions is determined usin

251 ng the paracellular space included increased permeability to small solutes (<500 Da), enhanced phosph

252 FI itself is rejected as an index of permeability to small solutes (cf.

253 and demonstrated that enhanced paracellular permeability to small solutes occurred in the absence of

254 ed open probability and a proposed increased permeability to sodium compared with the longer form.

255 elopment of TEER, and increased paracellular permeability to sodium fluorescein in airway epithelial

256 n a two-chamber diffusion apparatus, and its permeability to sodium fluorescein, fluorescein isothioc

257 anied by an increase in the transendothelial permeability to substances such as sucrose that are norm

258 l electrical resistance (TEER) and selective permeability to sucrose and phenytoin.

259 Aged rats displayed increased BBB permeability to sucrose in the contralateral hemisphere

260 AT1002 increased in vivo permeability to sugar tracers, whereas scrambled control

261 eded, however, to optimally balance hydrogel permeability to support metabolic activities of encapsul

262 lation of inner mitochondrial membrane (IMM) permeability to sustain ATP production.

263 Diffusive and apparent permeabilities to TAMRA (467 Da), dextran (70 kDa), and

264 g6 abcg20 triple mutant plants had increased permeability to tetrazolium red and decreased suberin co

265 loads in the seed coat resulted in increased permeability to tetrazolium salts and a higher sensitivi

266 ats of gpat5 mutants had a steep increase in permeability to tetrazolium salts compared with wild-typ

267 ation temperatures cause differences in coat permeability to tetrazolium, and mutants with increased

268 deficient cells, which increased their water permeability to that of wild-type cells, corrected their

269 owed that glucagon increased the diffusional permeability to the ammonia analog [(14) C]methylamine (

270 s at the i and i+7 positions and confer cell permeability to the cross-linked peptides.

271 GBM permeability to the electron-dense tracer ferritin was d

272 eakage can be predicted by relating membrane permeability to the fraction of peptide translocated.

273 such as gastric glands, have no demonstrable permeability to the gases CO2 and NH3.

274 ytosis of SIgA-CD71 complexes and intestinal permeability to the gliadin 3H-p31-49 peptide were analy

275 enic expression of UT-A1 restores basal urea permeability to the level in wild-type mice but does not

276 Ghrelin treatment restored vascular permeability to the level of shams.

277 FL, it does not significantly affect the BBB permeability to the marker.

278 freely permeable membranes, yielding the NE permeability to the molecules that is at least 2 orders

279 triuretic peptide (ANP) to increase vascular permeability to the plasma protein albumin after an acut

280 d that the vitamin fully prevented increased permeability to the polysaccharide inulin by thrombin in

281 the essential role of ROS and mitochondrial permeability to the process.

282 Implant connection permeability to the studied microorganisms was estimated

283 which may be associated with different tumor permeability to therapeutic agents among patients.

284 Corneal epithelial permeability to three different-sized molecules increase

285 oral effects ranging from increased membrane permeability to toxicity, microinjection of DMSO as a ve

286 p between transepidermal water loss and skin permeability to tritiated water (3H2O) and the lipophili

287 ancement, and Val-3-HPG exhibited comparable permeability to valacyclovir.

288 These channels shared a similar relative permeability to various anions, but the expressed channe

289 Consistent with this, vascular permeability to vascular endothelial growth factor in mi

290 l closure requires an increase in guard cell permeability to water and possibly hydrogen peroxide, th

291 genesis while allowing the induction of high permeability to water and small solutes.

292 J) has a key role in regulating paracellular permeability to water and solutes in the kidney.

293 at could be related to the decreased cuticle permeability to water observed in the regions silencing

294 membrane ultrastructure and shows increased permeability to water vapor, demonstrating the importanc

295 extraordinary proton conductivity and super-permeability to water were overlooked.

296 ing angiogenesis while VEGF induces the high permeability to water, characteristic of the glomerular

297 s the air becomes dryer, which decreases its permeability to water, thus counterbalancing the increas

298 titutive surface expression levels and water permeability to wild-type AQP4.

299 d not lead to membrane blebbing or increased permeability to Yo-Pro-1.

300 contributors to selective injury: their high permeability to Zn2+ ions and the possibility that their