ライフサイエンスコーパス: permeabilization

1 y because of two different modes of membrane permeabilization.

2 ipidated peptide dimers exhibited strong LPS permeabilization.

3 tissue paper blotting is likely due to cell permeabilization.

4 totic stimuli and the onset of mitochondrial permeabilization.

5 th Bax, induces mitochondrial outer membrane permeabilization.

6 try and assembly pathway leading to membrane permeabilization.

7 ts dithiothreitol and tempol did not reverse permeabilization.

8 a transient electroporation and a persistent permeabilization.

9 es GzmB-induced mitochondrial outer membrane permeabilization.

10 ing to Bak homo-oligomerization and membrane permeabilization.

11 ation is important for fungal and tumor cell permeabilization.

12 e BAX-dependent mitochondrial outer membrane permeabilization.

13 ells leading to membrane destabilization and permeabilization.

14 es C, 3min and 10min with low degree of cell permeabilization.

15 ausing curvature-induced strain and eventual permeabilization.

16 merization, and mitochondrial outer membrane permeabilization.

17 t cell rounding within 2 minutes of perforin permeabilization.

18 g mitochondrial targeting and outer-membrane permeabilization.

19 only used as a molecular device for membrane permeabilization.

20 drial swelling, depolarization, and membrane permeabilization.

21 hibitor abolished Sap 4 activity in lysosome permeabilization.

22 n its ability to translocate without bilayer permeabilization.

23 blunting the TRAIL-induced lysosome membrane permeabilization.

24 reby regulating outer mitochondrial membrane permeabilization.

25 s in more complex ways than just by membrane permeabilization.

26 east primarily via channel-mediated membrane permeabilization.

27 keletal reorganization and lysosome membrane permeabilization.

28 g their deleterious effects through membrane permeabilization.

29 oxide sensitized mitochondria to Bid-induced permeabilization.

30 pon apoptosis and irreversible mitochondrial permeabilization.

31 ained obscure but is not related to membrane permeabilization.

32 rol, ergosterol, often resulting in membrane permeabilization.

33 in ceramide accumulation and plasma membrane permeabilization.

34 ss synthetic lipid bilayer membranes without permeabilization.

35 omes than CL and permitted more extensive OM permeabilization.

36 ntly, was necessary for late plasma membrane permeabilization.

37 ax and inhibiting Bax-induced outer membrane permeabilization.

38 is, hydrolysis of peptidoglycan and membrane permeabilization.

39 or antibody conjugation or cellular fixation/permeabilization.

40 lytic activation are necessary steps for PLB permeabilization.

41 o apoptosis via outer mitochondrial membrane permeabilization.

42 rbazone (Dp44mT), induces lysosomal membrane permeabilization.

43 ress diminished cell death but not lysosomal permeabilization.

44 crophages (BMDMs) as an indicator of this PM permeabilization.

45 neage kinase domain-like and plasma membrane permeabilization.

46 s, notably in relationship to outer membrane permeabilization.

47 et the lysosome to induce lysosomal membrane permeabilization.

48 ti-apoptotic components and by promoting MOM permeabilization.

49 microscopy, and methods assessing bacterial permeabilization.

50 Permeabilization activity is completely dependent on the

51 It also promotes phagosomal membrane permeabilization, allowing dsDNA and IgG to leak into th

52 The permeabilization also permitted immunostaining of CD38,

53 osol where it mediates mitochondria membrane permeabilization and activation of executioner caspases.

54 ins attached to membranes after fixation and permeabilization and can therefore be used in combinatio

55 neration, and are required for mitochondrial permeabilization and caspase activation in the axon.

56 F, delaying the mitochondrial outer membrane permeabilization and caspase-9 activation.

57 carbazone (Dp44mT) causes lysosomal membrane permeabilization and cell death.

58 osemicarbazones increased lysosomal membrane permeabilization and cell death.

59 Bid-induced mitochondrial membrane permeabilization and cytochrome c release are central to

60 We report that Bid-induced permeabilization and cytochrome c release regularly demo

61 Bak is critical for Bid-induced OMM permeabilization and cytochrome c release, and Mfn1/2(-/

62 that Silica NP exposure could increased cell permeabilization and decreased mitochondrial membrane po

63 oligomerization of defensins during membrane permeabilization and demonstrate the existence of a "pho

64 presentative analogue revealed cell membrane permeabilization and depolarization in M bovis BCG.

65 idly bactericidal compounds primarily act by permeabilization and depolarization of bacterial membran

66 This interaction induced membrane permeabilization and depolarization.

67 es undergo subsequent mitochondrial membrane permeabilization and die.

68 lipotoxicity through lysosomal-mitochondrial permeabilization and ER stress that ultimately result in

69 down of the erythrocyte cytoskeleton, before permeabilization and eventual rupture of the erythrocyte

70 evention of inflammatory endothelial barrier permeabilization and explain the underlying signaling me

71 , which is known to be required for membrane permeabilization and explains the strong inhibition by C

72 also knockout its ability to induce membrane permeabilization and fungal growth arrest.

73 al activity were membrane active and induced permeabilization and fusion of virus-like lipid vesicles

74 e FISH-Flow protocol involves cell fixation, permeabilization and hybridization with a set of fluores

75 that a complex landscape with optimal stroma permeabilization and immune cell activation is able to m

76 structures have been implicated in membrane permeabilization and ion homeostasis via pore formation.

77 Electrosensitization facilitated membrane permeabilization and reduced survival in cell suspension

78 ective lysosomes leads to lysosomal membrane permeabilization and release of cathepsin D, which contr

79 is, as indicated by enhanced plasma membrane permeabilization and release of danger-associated molecu

80 ptor stimulation are required for lyososomal permeabilization and release of GzmB into the cytosol.

81 and PIP-containing vesicles, histones caused permeabilization and release of vesicular aqueous conten

82 ondria through a novel mode of mitochondrial permeabilization and through Smac degradation can compet

83 to the lysosome, where it triggers membrane permeabilization and thus lysosomal cell death (LCD).

84 pH-range shift for the onset of the membrane permeabilization and translocation activity of the T dom

85 ckground, acting downstream of mitochondrial permeabilization and upstream of caspase-9 activation in

86 n Bak oligomerization, Bak-mediated membrane permeabilization and, in a cellular context, Bak-mediate

87 namely, lateral segregation that facilitates permeabilization, and at longer times, trans-bilayer fli

88 s cell enlargement, membrane alterations and permeabilization, and biofilm and vesicle formation is d

89 e Bak oligomerization, Bak-mediated membrane permeabilization, and cell death.

90 ts), cellular fixation coupled with membrane permeabilization, and complex spectral deconvolution.

91 cell membrane, resulting in depolarization, permeabilization, and concentration-dependent, rapid cel

92 III, attenuated mitochondrial outer membrane permeabilization, and decreased reactive oxygen species

93 ts including acidification, nuclear envelope permeabilization, and DNA fragmentation of the nurse cel

94 activity could be monitored just 40 s after permeabilization, and five point dose-inhibition curves

95 ochondrial membrane potential, mitochondrial permeabilization, and fragmentation of the mitochondrial

96 of wild-type mice by SP-A-mediated membrane permeabilization, and not by opsonization.

97 l activity, Gram-negative bacterial membrane permeabilization, and proteolytic stability.

98 Herein, we present cell fixation and permeabilization approaches as an alternative tool for v

99 ns, the rate and lag time of the Bid-induced permeabilization are dose-dependent, but even very low d

100 Both LMP and mitochondrial membrane permeabilization are inhibited by potassium, scavenging

101 ion was detected, and it correlated with BBB permeabilization as indicated by the magnitude of the MR

102 ally involved in protection against membrane permeabilization as it provides little protection agains

103 perties: (i) little synthetic lipid membrane permeabilization at physiological pH 7 at high peptide c

104 e a hypothesis for the mechanism of membrane permeabilization based on the results featuring a loosel

105 ucible protein BNIP3 result in mitochondrial permeabilization, but impairment in autophagic removal o

106 DAMP activity involved bacterial binding and permeabilization, but the activity was unaffected by pep

107 n cellular cryoprotection and lipid membrane permeabilization, but the governing mechanisms at membra

108 ogeneous assay for the detection of membrane permeabilization by antimicrobial peptides and synthetic

109 ctive caspases, mitochondrial outer membrane permeabilization by Bax and Bak results in the expressio

110 that cardiolipin directly inhibits membrane permeabilization by daptomycin.

111 in, phagolysosomal trafficking, or phagosome permeabilization by Franciscella tularensis.

112 This led to the conclusion that membrane permeabilization by LL-37 is a nonpore carpet-like mecha

113 In addition, membrane permeabilization by lysosomotropic agent l-leucyl-l-leuc

114 effects, ascorbate did not prevent thrombin permeabilization by obstructing calcium influx.

115 Within the synaptic cleft, target cell permeabilization by perforin resulted in the rapid diffu

116 sm of membrane binding, oligomerization, and permeabilization by pro- and antiapoptotic Bcl-2 members

117 drogenase (GDH), are used to detect membrane permeabilization by the antimicrobial peptides MSI-594 a

118 mbiguously predict the mechanism of membrane permeabilization by the peptides.

119 rm cell barcoding that does not require cell permeabilization, can be completed in 10 minutes and can

120 p-by-step procedures for tissue preparation, permeabilization, cardiac-tissue pretreatment and hybrid

121 embrane (MOM), oligomerizes, and induces MOM permeabilization, causing the release of cytochrome c, w

122 ltaC21 follow similar mechanisms of membrane permeabilization characterized by the formation of prote

123 However, the harsh permeabilization conditions also led to the leakage of t

124 pport for the notion that lysosomal membrane permeabilization contributes to cerebellar degeneration

125 Persistent permeabilization could also be elicited by single depola

126 We used selective permeabilization coupled with immunofluorescence as well

127 r the pulse, and a long-term, or persistent, permeabilization covering the whole voltage range.

128 actin reorganization, and lysosomal membrane permeabilization, culminating in cell death.

129 We find that Bax can induce both transient permeabilization, detected by protein release, and more

130 in that regulates the mitochondrial membrane permeabilization, did not interact with p53 but continue

131 pport BAX-dependent membrane association and permeabilization due to an inability to stabilize BAXalp

132 ed yeast mitochondria undergo inner membrane permeabilization due to PTP opening.

133 in controlling mitochondrial outer membrane permeabilization during apoptosis.

134 osis, autophagy, mitochondrial dynamics, and permeabilization during apoptosis.

135 espite the requirement for lysosome membrane permeabilization during TRAIL-induced apoptosis, little

136 how through quantitative studies of membrane permeabilization, electron microscopy, and soft X-ray to

137 mbrane that are unmasked upon outer membrane permeabilization facilitate the autophagic destruction o

138 three cell lines, we found that the minimum permeabilization field for any given cell does not depen

139 cedure balances conflicting requirements for permeabilization, fixation and preservation of antigenic

140 y and automated cell staining including cell permeabilization, fluorescent staining, and molecular de

141 two sequential phases: a first precursor for permeabilization, followed by a second one for molecular

142 oporation can serve as a method for membrane permeabilization for use with D-DNP in cell cultures.

143 ease of ROS and oxidation products, envelope permeabilization (for larger molecules), and metabolic i

144 pplication of short electric pulses for cell permeabilization) generates reproducible results for del

145 ter tolerance to the Ca(2+)-induced membrane permeabilization, greater ADP-phosphorylating activity a

146 l Ca(2+) overload --> mitochondrial membrane permeabilization --> secondary energy failure.

147 fixation of leukocytes from blood, membrane permeabilization, hybridization of cellular DNA with pep

148 e led to perforin exocytosis and target cell permeabilization in as little as 30 seconds.

149 adiation, modelling the alteration of oxygen permeabilization in blood vessels against repeated doses

150 status controls outer mitochondrial membrane permeabilization in hepatosteatosis.

151 te as a mediator of thrombin-induced barrier permeabilization in human umbilical vein endothelial cel

152 Here, we investigated whether BBB/BTB permeabilization in the tumor and surrounding brain tiss

153 activation and mitochondrial outer membrane permeabilization in vitro and promotes GBM tumor growth

154 transient overexpression system and membrane permeabilization in vitro, suggesting that the mutants a

155 urements have shown that the rate of vesicle permeabilization increases with sphingosine concentratio

156 stress might directly activate mitochondrial permeabilization, independently of the CypD-regulated mP

157 changes observed in the Raman spectra during permeabilization indicated acyl chain disordering along

158 es were reversed on saponin-induced membrane permeabilization, indicating that differences in [Na(+)]

159 Using selective permeabilization indirect immunofluorescence microscopy

160 Overall, this work suggests that BBB/BTB permeabilization induced by FUS and microbubbles can imp

161 P-evoked and ivermectin-potentiated membrane permeabilization induced by P2X4 pore dilation.

162 Membrane permeabilization is dominated by hexa-, hepta- and octam

163 Light-induced membrane permeabilization is enabled with liposomal inclusion of

164 Membrane permeabilization is enhanced by a positive charge at the

165 f membranes to small molecules and that this permeabilization is enhanced by homotypic fusion and vac

166 sults suggest that the threshold for vesicle permeabilization is evident even at low levels of alpha-

167 The mechanism of permeabilization is opening of Cx43 hemichannels, which

168 Membrane permeabilization is required for the antifungal activity

169 Permeabilization kinetics were affected in a reciprocal

170 of CCHFV NSs triggers mitochondrial membrane permeabilization, leading to activation of caspases, whi

171 ed reactive oxygen species and mitochondrial permeabilization, leading to cell death, which was atten

172 otic pathway is mitochondrial outer membrane permeabilization, leading to formation of the apoptosome

173 er complexes that induced lysosomal membrane permeabilization (LMP) and cytotoxicity.

174 estingly, cells with endo-lysosomal membrane permeabilization (LMP) are more vulnerable to the seedin

175 Lysosomal membrane permeabilization (LMP) is a poorly understood regulator

176 resulted in Pgp-dependent lysosomal membrane permeabilization (LMP) that relied on copper (Cu) chelat

177 on of ER stress, leads to lysosomal membrane permeabilization (LMP), a sustained accumulation of cyto

178 released during aging via lysosomal membrane permeabilization (LMP), leading to procaspase-3 cleavage

179 ancer effect of combining lysosomal membrane permeabilization (LMP)-inducing agent N-dodecylimidazole

180 (ROS) leads to subsequent lysosomal membrane permeabilization (LMP).

181 n release, and more substantial long-lasting permeabilization, measured by the rate of oxidation of a

182 Based on these results, a curvature-driven permeabilization mechanism dependent on the interaction

183 will be useful for further analysis of AMPs' permeabilization mechanisms.

184 Here we show that phagosomal permeabilization mediated by the bacterial ESX-1 secreti

185 oove to induce Bak oligomerization, liposome permeabilization, mitochondrial cytochrome c release, an

186 nanochannels induces mitochondrial membrane permeabilization (MMP), leading to depolarization, obser

187 BID) to induce mitochondrial outer membrane permeabilization (MOMP) and apoptosis and whether these

188 OMM) to promote mitochondrial outer membrane permeabilization (MOMP) and apoptosis.

189 ractions impact mitochondrial outer-membrane permeabilization (MOMP) and apoptosis.

190 tic Bax induces mitochondrial outer membrane permeabilization (MOMP) by forming oligomers through a l

191 on required for mitochondrial outer membrane permeabilization (MOMP) during apoptosis.

192 Mitochondrial outer membrane permeabilization (MOMP) has historically been thought to

193 stimuli require mitochondrial outer membrane permeabilization (MOMP) in order to execute cell death.

194 n subsequent to mitochondrial outer membrane permeabilization (MOMP) in several cancer cell lines.

195 Mitochondrial outer membrane permeabilization (MOMP) is a complex multistep process.

196 ax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP) is essential for "intrinsic" apo

197 ered by limited mitochondrial outer membrane permeabilization (MOMP) promote genomic instability that

198 and execution, mitochondrial outer membrane permeabilization (MOMP) represents one of the most funda

199 d the resultant mitochondrial outer membrane permeabilization (MOMP) via BAK and BAX oligomerization,

200 x/Bak-dependent mitochondrial outer membrane permeabilization (MOMP), a central apoptotic event prima

201 Bax induces mitochondrial outer membrane permeabilization (MOMP), a critical step in apoptosis in

202 Mitochondrial outer membrane permeabilization (MOMP), a key step in the intrinsic apo

203 in apoptosis is mitochondrial outer membrane permeabilization (MOMP), allowing apoptogen release.

204 -2 family cause mitochondrial outer membrane permeabilization (MOMP), allowing the release of cytochr

205 family controls mitochondrial outer membrane permeabilization (MOMP), but the dynamics of this regula

206 ax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP), which releases death-promoting

207 x and eliciting mitochondrial outer membrane permeabilization (MOMP).

208 at the level of mitochondrial outer membrane permeabilization (MOMP).

209 is initiated by mitochondrial outer membrane permeabilization (MOMP).

210 plasma membrane bilayer is unlikely and that permeabilization necessarily involves both anionic lipid

211 When nsEP caused a transient permeabilization of 83% of cells to propidium iodide, ce

212 ngineered in vitro model to characterize the permeabilization of adhered brain endothelial cells to l

213 Transient permeabilization of cancer cell membranes created by app

214 Membrane permeabilization of cardiac myocytes with saponin and/or

215 detailed molecular mechanisms underlying the permeabilization of cell membranes by pulsed electric fi

216 plied in combination or individually induced permeabilization of cell membranes in the tomato fractio

217 hort, high-voltage pulses causes a transient permeabilization of cell membranes that permits passage

218 Permeabilization of CLOOH-containing liposomes in the pr

219 regation, recombinantly produced TCPs induce permeabilization of Escherichia coli and phagocytic upta

220 f the Puma BH3 domain to induce Bak-mediated permeabilization of liposomes and mitochondria, and dete

221 ternalization of Saps 4-6 results in partial permeabilization of lysosomal membranes, measured by the

222 es requires death receptor-5 (DR5)-dependent permeabilization of lysosomal membranes.

223 was sufficient to trigger the BAX-dependent permeabilization of mitochondria or liposomes in vitro.

224 ally toxic, and acute damage can trigger the permeabilization of mitochondrial membranes to initiate

225 igomerization and coil formation, as well as permeabilization of PA-containing liposomes.

226 ility that proteins SP-B and SP-C induce the permeabilization of phospholipid membranes via pore form

227 circulating microbubbles inducing transient permeabilization of surrounding tissues which mediates n

228 minimum applied electric field required for permeabilization of suspended spherical cells as a funct

229 The permeabilization of the BBB will be controlled with, and

230 that insulin may also inhibit IAPP-mediated permeabilization of the beta-cell plasma membrane in viv

231 extravasation into the brain parenchyma via permeabilization of the blood-brain barrier.

232 Additional permeabilization of the cell membrane after fixation ena

233 reaction) and low DNA uptake due to partial permeabilization of the cell membrane.

234 Controlled permeabilization of the constituent brain endothelial ce

235 Within 30 s of permeabilization of the cytoplasmic membrane by the cati

236 tions of cells during the flow, we also show permeabilization of the entire cell membrane and markedl

237 lipopolysaccharide (LPS) and facilitate the permeabilization of the LPS barrier, thereby improving p

238 of the bilayer by detergents and consequent permeabilization of the membrane; and 4), transition of

239 promotion of the peptide's cytotoxicity and permeabilization of the mitochondrial membrane.

240 on the mitochondrial pathway to apoptosis is permeabilization of the mitochondrial outer membrane (MO

241 roapoptotic proteins Bax and Bak mediate the permeabilization of the mitochondrial outer membrane dur

242 In many systems, apoptosis relies on permeabilization of the mitochondrial outer membrane to

243 oapoptotic Bcl-2-associated X (Bax) protein, permeabilization of the mitochondrial outer membrane, an

244 into mitochondria, leading to Bax-dependent permeabilization of the mitochondrial outer membrane.

245 Dependence of ion-induced permeabilization of the NPC on the pathway and mode of m

246 n of green fluorescent protein-Bax triggered permeabilization of the outer membrane and apoptosis in

247 ult from its ability to inhibit Bax-mediated permeabilization of the outer mitochondrial membrane (OM

248 Permeabilization of the outer mitochondrial membrane is

249 oint of no return for this commitment is the permeabilization of the outer mitochondrial membrane.

250 Necroptosis is characterized by rapid permeabilization of the plasma membrane, which is associ

251 d (ii) interacted with antibodies only after permeabilization of the plasma membrane.

252 eleased into the cytosolic compartment after permeabilization of the secretory granules.

253 abeled surface cells, causing DAPI labeling (permeabilization) of underlying cells.

254 the plasma membrane, which leads to membrane permeabilization or disruption.

255 ally mimicked by inducing lysosomal membrane permeabilization or inhibiting autophagy, and were rever

256 uadruplexes in untreated cells (no fixation, permeabilization or mounting steps), thus offering a uni

257 ring design of this instrument permits rapid permeabilization, or homogenization, of cells.

258 und regimes (that cause tissue liquefaction, permeabilization, or mild heating) to release tumor-deri

259 without any antibody labeling, cell membrane permeabilization, or thiol-oxygen scavenger systems requ

260 ophagy is consistent with lysosomal membrane permeabilization playing a role in the pathogenesis of A

261 ber of oligomeric species with high membrane permeabilization potential and rapid fibril formation.

262 ly bigger oligomers that lose their membrane permeabilization potential as fibrillation proceeds beyo

263 ytometry included energetics (ENR); membrane permeabilization (PRM); annexin V binding (ANX), and cel

264 hese results suggest that cytochrome-induced permeabilization proceeds through selective interaction

265 l by autophagy, or they can undergo a lethal permeabilization process that initiates apoptosis.

266 hat the MOM lipids play active roles in this permeabilization process.

267 could possibly be involved in other membrane permeabilization processes where lipids are thought to p

268 hanism of outer mitochondrial membrane (OMM) permeabilization remains unclear.

269 ce the discovery that mitochondrial membrane permeabilization represents a critical step in the regul

270 arated, since persistent (but not transient) permeabilization required repetitive pulse exposure.

271 bacterium remains within the phagosome, this permeabilization results in phagosomal and cytoplasmic m

272 onsistent with the reduced lysosome membrane permeabilization, shRNA knockdown of PACS-2 in Huh-7 cel

273 ver alternative methods involve fixation and permeabilization steps.

274 Digitonin-permeabilization studies of SINC-GFP-transfected HeLa ce

275 ondrial targeting signals, we used selective permeabilization studies to reveal that this KAT is orie

276 to ~71% for Chinese hamster ovary cells) and permeabilization suggests its potential for gene deliver

277 with AMZ, together with evidence of membrane permeabilization, suggests that Al reacts with membrane

278 uli, control of mitochondrial outer membrane permeabilization, switch-like activation of effector cas

279 into ECS preserved tissue with only minimal permeabilization, thereby enabling correlated light micr

280 ls which appear identical may have different permeabilization thresholds.

281 of Gram-positive pathogens, causing membrane permeabilization to ions and cell death.

282 We observed rapid membrane permeabilization to propidium iodide and ATP efflux in r

283 up received six weekly treatments of BTB/BBB permeabilization under MRI guidance combined with IV adm

284 Membrane permeabilization via channel formation represents a seco

285 efaction via boiling histotripsy, (b) tissue permeabilization via inertial cavitation, and (c) mild (

286 f focal adhesion protein and plasma membrane permeabilization, via the activation of caspase-7, and i

287 se activities but did block vacuole membrane permeabilization (VMP), which occurred at late stages of

288 and monocyte cells, we showed that membrane permeabilization was dependent on the presence of membra

289 bacterial activity of the pools and membrane permeabilization was investigated.

290 Cellular membrane permeabilization was monitored by a conductance increase

291 Membrane permeabilization was quantified in CHO and GH3 cells by

292 Interestingly, we found that digitonin permeabilization, which selectively releases soluble nuc

293 hesion kinase and subsequent plasma membrane permeabilization, which was blocked exclusively by fumon

294 We demonstrated that direct lysosome-permeabilization with a soluble peptide, Leu-Leu-OMe, mi

295 ombination of a non-invasive approach to BBB permeabilization with a therapeutically relevant polymer

296 report that the mechanism combines membrane permeabilization with rapid metabolic changes, including

297 f exosomes upon sonication and extrusion, or permeabilization with saponin resulted in high loading e

298 methods: the incubation at room temperature, permeabilization with saponin, freeze-thaw cycles, sonic

299 cell death is mediated by lysosomal membrane permeabilization with subsequent translocation of lysoso

300 ield intensity and number of pulses for safe permeabilization without significantly compromising cell