ライフサイエンスコーパス: permeation

1 and to their ionic conductance/selectivity (permeation).

2 a key role in defining both selectivity and permeation.

3 lecular mechanisms of channel gating and ion permeation.

4 ascular compartment, which reduces edema and permeation.

5 ecular sieving properties combined with fast permeation.

6 ive phenolics were not identified after cell permeation.

7 anslates into fast water and organic solvent permeation.

8 ic G loop) may serve as gates to control ion permeation.

9 l structures and concomitantly inhibits F(-) permeation.

10 of channel gating, desensitization, and ion permeation.

11 n as well as that of size-exclusion of anion permeation.

12 e that membrane interactions also affect ion permeation.

13 vation of structure-kinetic relationships of permeation.

14 ze-exclusion and ion dehydration of HCO3 (-) permeation.

15 ne ion-channel block by facilitating blocker permeation.

16 conductance and a closed state that prevents permeation.

17 tation of the bilayers and increase in water permeation.

18 toward accurate and efficient targeted cell permeation.

19 ubstantially contribute to the energetics of permeation.

20 tenuate polyamine block by enhancing blocker permeation.

21 e channels and is closely linked to chloride permeation.

22 orter subunit absolutely required for Ca(2+) permeation.

23 r mechanism of channel activation and proton permeation.

24 s that shed light on Orai channel gating and permeation.

25 decline in comparison with reverse magnesium permeation.

26 owel disease by allowing increased antigenic permeation.

27 tolerated toxicity, and blood-brain barrier permeation.

28 leaving the linkage intact, thus preventing permeation.

29 prolonging drug exposure and increasing drug permeation.

30 nt partitioning and diffusion to contaminant permeation.

31 e (TM) domains forming the pathway for anion permeation.

32 ter, as expected from rate-limiting membrane permeation.

33 ectivity filter that may serve as a gate for permeation.

34 ed tissue and to prevent blood-brain barrier permeation.

35 rophobic gating mechanism for control of ion permeation.

36 ns, reduced K(+) affinity, and increased ion permeation.

37 he main barrier of diffusion on percutaneous permeation.

38 tes that W583 is part of the gate for Ca(2+) permeation.

39 ctive layer thickness) that determine solute permeation.

40 es, consistent with its explicit role in ion permeation.

41 ailability of environmental contaminants via permeation across lipid nanoparticles (liposomes) as a m

42 ison with DCH, MCD enhanced the in vitro DFO permeation across lipophilic membranes, similarly as sho

43 Moreover, MCD were able to promote the DFO permeation across monolayers of PC 12 cells (neuron-like

44 The molecular paths of ammonia permeation across plasma membranes remain ill-defined, b

45 alues, the porins significantly enhance drug permeation across the proteoliposome membranes.

46 odified CGKRK peptide could enhance cellular permeation and delivery of siRNA targeted to tumor cells

47 to bacterial morphology, and cause membrane permeation and depolarization.

48 ligand recognition, heteromer assembly, ion permeation and desensitization in this prototypical rece

49 and M11, as important determinants of cation permeation and drug sensitivity.

50 higher mucoadhesion, greater transepithelial permeation and elevated cellular uptake.

51 y permitted modulation of properties such as permeation and especially P-glycoprotein efflux.

52 ndamental implications for understanding ion permeation and gating in P2X receptor channels, as well

53 To understand the chemical basis for F(-) permeation and how the antiparallel subunits convene to

54 Single-gas permeation and ion rejection tests were carried out to c

55 are shown to recapitulate the single-channel permeation and pharmacological specificity characteristi

56 mulation in tumor tissue due to the enhanced permeation and retention (EPR) effect.

57 sing tumor accumulation through the enhanced permeation and retention effect.

58 limited accessibility owing to the enhanced permeation and retention effect.

59 We attribute organic solvent permeation and sieving properties to randomly distribute

60 lating channel conformation to alter calcium permeation and single-channel conductance.SIGNIFICANCE S

61 this peptide by investigating model-membrane permeation and structural effects of fragments of the hu

62 o acid transporters (EAATs) mediate chloride permeation and substrate transport.

63 junction is important for paracellular water permeation and that Ig-like domain containing receptor 1

64 ty underlies the coupling between gating and permeation and the poor ionic selectivity of CNG channel

65 therefore the structural basis of polyamine permeation and unblock is through a different mechanism.

66 Consequently, polyamine permeation and unblock occur at more negative and physio

67 esion, up to 30-fold greater transepithelial permeation and, at most 285% higher cellular uptake, com

68 tically compete with the process of membrane permeation and, therefore, inhibit it.

69 Ca(2+) permeation and/or binding to the skeletal muscle L-type

70 veal distinct physical segregation, membrane permeation, and amyloid aggregation processes that are m

71 KCNE1 significantly modulates the gating, permeation, and pharmacology of KCNQ1.

72 The gastrointestinal digestion, intestinal permeation, and plasma protein interaction of polyphenol

73 gregation process and its impact on membrane permeation are still unresolved.

74 penem and meropenem, measured using liposome permeation assays and single channel electrophysiology d

75 s simulations capturing the kinetic steps of permeation at the atomistic level with a dynamic mechani

76 with a dynamic mechanistic model describing permeation at the in vitro level, finding a high level o

77 We identify the water permeation barrier as the endothelial basolateral membra

78 findings are drawn from this study: the main permeation barrier is located in the lipid layers; the f

79 The artery wall is equipped with a water permeation barrier that allows blood to flow at high pre

80 is a unique bilayer that forms an efficient permeation barrier to protect the cell from noxious comp

81 he lipids or corneocytes constitute the main permeation barrier.

82 citly or explicitly included, we studied the permeation behavior of 2-aminoethoxydiphenyl borate (2-A

83 Light-gated ion permeation by channelrhodopsin-2 (ChR2) relies on the ph

84 Channel block and permeation by cytoplasmic polyamines is a common feature

85 resolution as a basis for understanding ion permeation, channel activation, the location of voltage-

86 Because permeation characteristics depend strongly on pore geome

87 Their structures were characterized by gel permeation chromatography (GPC) and (1)H nuclear magneti

88 final cleanup procedure consisted of (i) gel permeation chromatography (GPC) and adsorption chromatog

89 Gel permeation chromatography analysis confirmed that degrad

90 of action was observed and studied using gel permeation chromatography and (1)H NMR.

91 on products isolated from barley malt by gel permeation chromatography and ultrafiltration on the ant

92 f the APPL by over 50%, as determined by gel-permeation chromatography coupled with multi-angle light

93 Gel-permeation chromatography revealed a uniform distributio

94 Gel-permeation chromatography showed that the molecular weig

95 Gel permeation chromatography sub-fractionation of the crude

96 nthesized and characterized by (1)H NMR, gel permeation chromatography, and differential scanning cal

97 orption/ionization mass spectrometry and gel permeation chromatography, confirming successful molecul

98 Gel-permeation chromatography, dynamic and static light scat

99 ptide hydrolysate was fractionated using gel permeation chromatography, OFFGEL isoelectric focusing a

100 r magnetic resonance characterization of gel permeation chromatography-fractionated acetylated maize

101 anched starch fractions were analyzed by gel-permeation chromatography.

102 Estimated steady-state flux (Jss) and permeation coefficients (Papp) across the skin increased

103 These observations are explained by permeation coefficients, energy barriers, water density

104 ents are drawn tightly together to block ion permeation completely.

105 nd desalination technologies is limited by a permeation cutoff of approximately 9 A, which is larger

106 Analysis of permeation data suggests that the ultrahigh selectivitie

107 oncentrations (convoluted from in vitro skin permeation data) were compared with the observed serum c

108 harge-dependent effects on the rate of Cl(-) permeation, demonstrating their functional role in maxim

109 in the E203K mutant, which maintains proton permeation despite the substitution of a basic residue f

110 Unlike magnesium, reverse calcium permeation dramatically altered the biofilm architecture

111 olymer conjugation process that co-localizes permeation enhancer with the protein.

112 ility of 1-phenylpiperazine as an intestinal permeation enhancer, we synthesized protein-polymer conj

113 Although chemical permeation enhancers can improve macromolecular transpor

114 o investigate alternative safe and effective permeation enhancers for buccal peptide delivery.

115 ve drug release, motion-based responses, and permeation enhancers have been incorporated into such pl

116 S-NAC), which exhibit marked bioadhesion and permeation enhancing effect, was synthesized.

117 showed a significant improvement in insulin permeation especially for 10 mug/mL of lysine (p < 0.05)

118 rate constants determining each step in the permeation event allows derivation of structure-kinetic

119 r performing free energy calculations of the permeation event.

120 r dynamics simulations revealed partial pore permeation events of NH3 but not of NH4 (+) and a reduce

121 Finally, permeation experiments revealed increases in both water

122 the syb2 residues that influence fusion pore permeation fell along two alpha-helical faces of its TMD

123 robe the structural determinants of membrane permeation, finding that the desolvation/loss of hydroge

124 ed by measurement of sheet resistance, water permeation flux and capacitance.

125 n high performance membranes with pure water permeation flux substantially higher than those with sim

126 formation on the NF membrane coupon (without permeation flux) was observed by the salinity-stressed b

127 Apart from the high water permeation flux, the prepared membranes also show excell

128 T had the lowest capacitance and the highest permeation flux.

129 ivity as demonstrated by the enhanced oxygen permeation flux.

130 rried out to obtain the percent of estradiol permeation from marketed products.

131 s unavailable and the molecular basis of its permeation function is unknown.

132 Our data enhance the understanding of the permeation functions of Bot1.

133 dependence, suggesting the absence of an ion permeation gate at the cytosolic side of BK channel.

134 conditions, although their mechanisms of ion permeation gating are not well understood.

135 conditions, although their mechanisms of ion permeation gating are not well understood.

136 ramework for understanding mechanisms of ion permeation, gating and channelopathy of cyclic-nucleotid

137 c activity was determined rapidly after cell permeation, generating five-point temperature-response c

138 een technique', gas stripping assisted vapor permeation (GSVP), was introduced in this work.

139 nism has been studied extensively, polyamine permeation has been considered less significant as it oc

140 he effect of vehicle mixtures on transdermal permeation has been studied using transient flux profile

141 channels open and close their pores for ion permeation has remained unclear.

142 date, applications of non-cancerous enhanced permeation have been relatively unexploited as target ti

143 The Mo layer likely hinders O2 gas permeation, impeding contact with active Pt.

144 e neck is as a "gate" that controls chloride permeation in a Ca(2+)-dependent manner.

145 Sodium permeation in alpha-SNAP-deficient cells cannot be corre

146 insight into the mechanism of selective ion permeation in bacterial Na(v) channels.

147 as a unit in a loose "knock-on" mechanism of permeation in both inward and outward directions, and th

148 dentify an unappreciated impact of polyamine permeation in shaping the signalling properties of neuro

149 udy and compare monovalent (Na(+), K(+)) ion permeation in the open-activated TRP vanniloid-1 (TRPV1)

150 y dependent on local tumor perfusion and Fab permeation in the SUDHL-4 and Granta-519 tumors.

151 nding and protein chemistry facilitate lipid permeation in the TMEM16 family, and we hypothesize that

152 t with Ogston's 1958 equation describing how permeation into gels is related to molecular size.

153 ur observations indicate that size-dependent permeation into the lamina densa of the GBM and the podo

154 ligoclusters of gold nanoparticles show that permeation into the lamina densa of the GBM is size-sens

155 )-dependent inactivation, open probability), permeation (ion selectivity, affinity for Ca(2+) block,

156 Modulation of ion permeation is crucial for the physiological functioning

157 In GluK2/GluK5 heteromers, enhanced permeation is due to a single proline residue in GluK5 t

158 A quantitative and thorough study of skin permeation is essential for chemical exposure assessment

159 In this regime, ion permeation is found to be thermally activated with energ

160 rly swollen, the lamina densa is absent, and permeation is increased.

161 ance signals, investigation of real-time dye permeation kinetics, and the surface profiling and 3D im

162 orters are known to be relevant, but passive permeation may also be involved.

163 a high level of agreement with experimental permeation measurements.

164 This permeation mechanism has considerable physiological sign

165 channel pore allowed us to rationalize their permeation mechanism in terms of a pathway involving thr

166 The ion permeation mechanism in the transient receptor potential

167 Thus, we propose a membrane permeation mechanism that is dependent on the continuous

168 A selective diffusion-permeation mechanism was consistent with the results obt

169 extracellular vestibule, we propose a Ca(2+) permeation mechanism.

170 Studies evaluating BBB permeation mechanisms of these compounds together with t

171 devices such as oxidation catalysts, oxygen permeation membranes, and solid oxide fuel cells.

172 k, we employed a simulation strategy for ion permeation (molecular-dynamics simulations with bias-exc

173 Cell-based assays of BBB permeation, neurotoxicity, and neuroprotection supported

174 rtant implications for understanding how ion permeation occurs, and further how it may be controlled

175 ed for their ability to enable the selective permeation of a range of racemates, including mandelic a

176 EOF through a nanopore by investigating the permeation of alpha-cyclodextrin through CymA, a cyclode

177 l research, is to better understand membrane permeation of antibiotics in clinically relevant bacteri

178 that a single Abeta monomer does not promote permeation of calcium ions through the zwitterionic bila

179 rostatic barrier that substantially inhibits permeation of cations such as K(+) into the pore.

180 ed as effective adjuvants, allowing improved permeation of commercial antibiotics in bacteria and enh

181 ergy landscape depicts a low barrier for the permeation of cytochrome C into the Bax C-terminal mouth

182 This process, occurring by direct permeation of D-serine through hemichannels or indirectl

183 centration of CS and the concomitant protein permeation of extracts which were obtained from previous

184 inted 3D-muPAD that enables more homogeneous permeation of fluids along the cellulose matrix than oth

185 olecular dynamics simulations of the passive permeation of Hg(II) and [CH3Hg(II)](+) complexes with t

186 of NaVAb/1-226 as an open state that allows permeation of hydrated Na(+), and these results also sup

187 er, we also observed a slight dose-dependent permeation of ins-asp into the circulation.

188 role of possible pore-lining residues in the permeation of ions and ethidium through Cx30 hemichannel

189 PANX1 channel opening is directly linked to permeation of ions and large molecules (ATP and fluoresc

190 m channels are responsible for the selective permeation of K(+) ions across cell membranes.

191 of P2X receptors is wide enough to allow the permeation of large organic cations, including natural o

192 he necessary design parameters for effective permeation of lipoplexes through the skin layers and dep

193 divalent ions, including Ca(2+), inhibit the permeation of monovalent ions by directly blocking the T

194 s and enzymes couple their mechanisms to the permeation of Na(+) or H(+), thereby harnessing the ener

195 Liposome swelling assays indicated the bulk permeation of neutral monosaccharides and showed the siz

196 te that the molecular motions leading to the permeation of NMDG(+) are very similar to those that dri

197 enhanced cellular uptake and transepithelial permeation of QC, which was related to the much-enhanced

198 Treating the ear with microneedles showed permeation of siRNA in the skin and could reduce Gapdh g

199 ing of Slo2.1 or Slo2.2, suggesting that ion permeation of Slo2 channels is not predominantly gated b

200 Passive membrane permeation of small molecules is essential to achieve th

201 lubility-diffusion model of passive membrane permeation of small molecules, translocation of the perm

202 tance in reaching the epithelia and the high permeation of the conjugates through epithelia.

203 th different intrinsic properties that allow permeation of the heterogenous group of molecules acting

204 otein drug, which can result in non-specific permeation of the intestine as well as enhancer overdosi

205 tailed molecular dynamics simulations of the permeation of the lethal factor (LF) N-terminal segment

206 demonstrated undetectably low transplacental permeation of the liposomal Gd agent, while the clinical

207 It was observed that the permeation of the natural dyes were more uniform through

208 ing SjAQP in Xenopus oocytes facilitated the permeation of water, glycerol, and urea.

209 ave the smallest size and exhibited the best permeation parameters across the skin.

210 its wall that simultaneously lines the anion permeation path (global); and repacking of a cluster of

211 Opening of the anion permeation path in this iChS is controlled by the elevat

212 about their mechanistic consequences on ion permeation, pathological mutations, as well as functiona

213 We show how the permeation pathway changes upon channel opening and iden

214 periments revealed that SNAT7 is the primary permeation pathway for glutamine across the lysosomal me

215 m-conducting pore and the alternative cation permeation pathway in a membrane-delimited manner.

216 udies have painted a picture of the chloride permeation pathway in cystic fibrosis transmembrane cond

217 characterized the divalent cation-sensitive permeation pathway in primary cultured astrocytes.

218 nner helix, creating an hourglass-shaped ion permeation pathway in the channel tetramer.

219 The PKD2 ion permeation pathway is constricted at the selectivity fil

220 on of these mutations indicates that the ion permeation pathway lies between the core and gate ring o

221 ion further affects the thermodynamic of the permeation pathway of 2-APB, leading to different entrop

222 roscopy structure of chicken Slo2.2, the ion permeation pathway of the channel is closed by a constri

223 t ouabain is trapped within the external ion permeation pathway of the pump.

224 py structure of Slo2.2 suggests that the ion permeation pathway of these channels is closed by a sing

225 s detailed molecular insight into the Ca(2+) permeation pathway that can be extrapolated to other Ca(

226 assium channels, a main component of the ion permeation pathway, configures a stack of binding sites

227 Au(CN)2](-) and chloride ions share the same permeation pathway, these results imply a gate is situat

228 Along the ion permeation pathway, three relatively narrow regions (the

229 tween different protonation states along its permeation pathway.

230 a closure of the extracellular mouth of the permeation pathway.

231 is a site located at the exit of the proton permeation pathway.

232 mains (VSDs), each containing a gated proton permeation pathway.

233 s into features of channel gating and proton permeation pathway.

234 t TRPV1 channels have two gates within their permeation pathway: one formed by a 'bundle-crossing' at

235 teins, it is essential to first identify the permeation pathways of their natural substrates.

236 s connected to both sides of the membrane by permeation pathways, of which only one is accessible at

237 esidues in the extracellular and cytoplasmic permeation pathways, respectively.

238 ke), but like DCH, it did not modify the DFO permeation pattern across Caco-2 monolayers (epithelial-

239 ed changes in physicochemical properties and permeation performance of a RO membrane with fully aroma

240 These structures reveal the ion permeation pore and represent different functional state

241 ding site for dihydrostreptomycin within the permeation pore of the channel.

242 chanisms of receptor desensitization and ion permeation, principles of antagonism, and complete struc

243 terminal chain is unstructured and leads the permeation process for the LF protein.

244 , permitted semiquantitative analysis of the permeation profiles and strongly suggested that solvent

245 between mPiezo1 and dPiezo to show that ion-permeation properties are conferred by C-terminal region

246 izes tunable to angstrom precision, and with permeation properties further controlled through a wide

247 the design of new antibiotics with improved permeation properties in Gram-negative bacteria.

248 al advantages, we have demonstrated that the permeation properties of the hollow fiber membrane can b

249 nto TRPV2, demonstrating that the gating and permeation properties of this channel are similar to TRP

250 e oxide membranes show exceptional molecular permeation properties, with promise for many application

251 analysis, hair-bundle mechanics, and channel-permeation properties.

252 pedes detailed study of their gating and ion permeation properties.

253 transmembrane cavity impacts both gating and permeation properties.

254 ndensed, highly crosslinked ECM impeded drug permeation, protecting tumor cells from exposure to smal

255 the droplets was imaged as a function of the permeation rate, J, droplet radius, R, membrane permeanc

256 ort on skin, combined with a low transdermal permeation rate, may thus be seen to be a key factor in

257 creasing membrane thickness, organic solvent permeation rates decay exponentially but water continues

258 Importantly, permeation rates decrease exponentially with decreasing

259 analytes, and both materials exhibited high permeation rates.

260 ructural bases for their assembly and Ca(2+) permeation remain obscure.

261 channel (and the varphi clamp), the initial permeation represents a critical step, which can be irre

262 , the sod-ZMOF-1 membrane exhibits favorable permeation selectivity toward carbon dioxide over releva

263 In vitro drug permeation studies across human skin were carried out to

264 lic membranes, similarly as shown by ex vivo permeation studies across porcine nasal mucosa.

265 The intestinal permeation studies showed a lag-time and apparent permea

266 Permeation studies showed enhanced (p<0.01) skin retenti

267 Barrier function and bacterial permeation studies that have been performed in primary h

268 Permeation studies using benzene derivatives whose kinet

269 In vitro permeation studies with Caco-2 cells confirmed the trans

270 The in vitro permeation test (IVPT) has been widely used to character

271 The Caco-2 cell monolayer permeation tests showed that PG-QC formulations resulted

272 es, during constant volume/variable pressure permeation tests.

273 of the drug cargos, rendering a deeper tumor permeation that could further enhance the therapeutic ef

274 ghts factors involved in selective molecular permeation that differ from those that define selectivit

275 e (HCO3 (-) ) are two major anions and their permeation through anion channels plays essential roles

276 NH4 (+) and a reduced energy barrier for NH3 permeation through AQP4 compared with that of a choleste

277 contributions of presynaptic release and its permeation through Ca(2+)- (and Zn(2+))-permeable AMPA c

278 es the postsynaptic afferent by altering ion permeation through hyperpolarization-activated cyclic nu

279 ized the postsynaptic neuron by altering ion permeation through hyperpolarization-activated cyclic nu

280 , dynamically altering the driving force and permeation through ion channels facing the synaptic clef

281 , dynamically altering the driving force and permeation through ion channels facing the synaptic clef

282 This unfavors probe permeation through membranes.

283 All charged photoswitch compounds require permeation through P2X receptors, whose gene expression

284 Water permeation through SGLT1 and other transporters bears di

285 ity and dissolution kinetics, enhancement of permeation through the intestinal mucosa, and triggering

286 t assumes no friction for the dye molecule's permeation through the pore.

287 ions decreased the rate of bulk chitohexaose permeation through the VhChiP channel.

288 ed and molecular dynamics simulations of ion permeation through these channels are consistent with ma

289 bdiffusive on timescales approaching typical permeation times.

290 cell shape, and can work together with water permeation to facilitate cytokinesis.

291 derstand how CaCCs mediate and control anion permeation to fulfil these physiological functions, know

292 We developed an automated, permeation tube-based calibrator for elemental and oxidi

293 enotypic consequences of non-specific sodium permeation via calcium channels remain unknown.

294 However, pronounced BBB permeation was noted, with frank albumin leakage around

295 pore-lining helix in channel gating and ion permeation was probed by replacing them with amino acid

296 l recognition of RNA molecule and subsequent permeation, we expressed the extracellular domain (ECD)

297 teractions that underlie selective molecular permeation, we investigated the energetics of two unchar

298 me seemed to undergo an enhanced basolateral permeation when both phenolic sources where exposed.

299 ments are not feasible, as well as long-time permeation, where ex vivo samples deteriorate, and thus

300 e IVIVC between the in vitro percent of drug permeation (X) and in vivo percent of drug absorption (Y