ライフサイエンスコーパス: peroxin

1 ced pex4 defects, confirming that PEX22 is a peroxin.

2 p, and the intraperoxisomal presence of this peroxin.

3 d that the encoded protein, Pex22p, is a new peroxin.

4 suggesting distinct roles of individual RING peroxins.

5 PEX13 and possibly PEX14 and all three RING peroxins.

6 , showing distinct differences between these peroxins.

7 ng and subsequent budding of the RING-domain peroxins.

8 ikely to require interaction with additional peroxins.

9 on requires the peroxisomal membrane protein Peroxin 11 (Pex11p), which remodels the membrane, result

10 stimuli such as arsenic and is regulated by peroxin 11a (PEX11a), as Arabidopsis pex11a RNAi lines a

11 Homologs of peroxin 16 genes (PEX16) have been identified only in Ya

12 ort that the peroxisomal E3 ubiquitin ligase peroxin 2 (PEX2) is the causative agent for mammalian pe

13 The predicted Gim1 protein is related the peroxin 2 family of integral membrane proteins, which ar

14 Peroxin 5 (PEX5), the peroxisomal protein shuttling rece

15 signal recognition by the cytosolic receptor peroxin 5 (PEX5).

16 uman MCD onto the peroxisomal import protein peroxin 5, which revealed interactions that extend beyon

17 have revealed numerous Arabidopsis thaliana peroxins acting in peroxisomal matrix protein import; th

18 4p, Pex17p) and RING (Pex2p, Pex10p, Pex12p) peroxins and is also implicated in cargo release of PTS1

19 the peroxisome membrane via interaction with peroxins, and during pexophagy it colocalizes transientl

20 Peroxins are genetically defined as proteins necessary f

21 5 with peroxisomes, demonstrating that these peroxins are not required for receptor docking.

22 Peroxins are proteins involved in peroxisome, glycosome

23 Although at least 20 proteins (mostly peroxins) are required for peroxisome biogenesis, the ro

24 (Pp) Pex8p, the only known intraperoxisomal peroxin at steady state, is targeted to peroxisomes by e

25 Mutations in peroxisome biogenesis proteins (peroxins) can lead to developmental deficiencies in vari

26 etermine whether destabilization of the RING peroxin complex observed in pex12-1 stems from PEX4-depe

27 kes the functional characterization of human peroxins critical.

28 Altered activity of the peroxin defective in CG7 cells leads to accumulation of

29 PTS1 receptor was extremely unstable in the peroxin-deficient CG1, CG4, and CG8 cells.

30 as of progress are the identification of new peroxins, definition of protein-protein interactions amo

31 Peroxisomal defects were exacerbated in RING peroxin double mutants, suggesting distinct roles of ind

32 and that AMC functions in gametophytes as a peroxin essential for protein import into peroxisomes.

33 indicating that they constitute a two-member peroxin family specifically required for Pex7p and PTS2

34 he adrenoleukodystrophy-related gene and the peroxin gene, PEX11alpha, was found in PBD fibroblasts.

35 ome biogenesis to the parasite, render these peroxins highly promising drug targets.

36 ummary, AtPex16p is the only authentic plant peroxin homolog known to coexist at steady state within

37 eptor PEX5 and is the most commonly affected peroxin in human peroxisome biogenesis disorders.

38 es, aspects of import/biogenesis the role of peroxins in human disease, and involvement of the endopl

39 he elucidation of the role of many conserved peroxins in human disease.

40 Unlike the roles of specific RING peroxins in Pex5 ubiquitination, we found that all the R

41 7 levels, supporting the involvement of RING peroxins in receptor ubiquitination in Arabidopsis.

42 ort of peroxisomal enzymes is facilitated by peroxins including PEX5, a receptor that delivers cargo

43 Furthermore, this peroxin interacts with Pex5p and Pex13p(SH3) and is dire

44 PEX14 and PEX13 are peroxins involved in docking cargo-receptor complexes at

45 ling was used to identify PEX genes encoding peroxins involved in peroxisome assembly and genes invol

46 Among peroxins involved in peroxisome biogenesis, only Pex8p i

47 This includes mutants that lack peroxins involved in receptor docking at the membrane (D

48 resenting a defect in a peroxisomal protein (peroxin) involved in peroxisome biogenesis.

49 The identification of vesicle-associated peroxins is novel and implies a role for these vesicles

50 ng that PEX1, like several other Arabidopsis peroxins, is essential for embryogenesis.

51 nition of protein-protein interactions among peroxins leading to the recognition of complexes involve

52 rved that disruption of any Arabidopsis RING peroxin led to decreased PEX10 levels, as seen in yeast

53 ation and characterization of an Arabidopsis peroxin mutant, pex7-1, which displays peroxisome-defect

54 tination-related mutants and found that RING peroxin mutants displayed elevated PEX5 and PEX7 levels,

55 Two peroxins of the AAA family, PpPex1p and PpPex6p, are req

56 matrix protein import, suggesting that this peroxin pair may have novel plant targets in addition to

57 Several peroxisome biogenesis PEROXIN (PEX) genes encode proteins acting in the import

58 Peroxin (PEX) proteins generate and maintain peroxisomes

59 y enzymes enter peroxisomes with the help of peroxin (PEX) proteins is increasing, mechanisms by whic

60 eroxisome biogenesis require the function of peroxin (PEX) proteins, among which PEX12 is a RING fing

61 rganelle matrix depends on more than a dozen peroxin (PEX) proteins, with PEX5 and PEX7 serving as re

62 ed into the organelle with the assistance of peroxin (PEX) proteins.

63 import proteins to the peroxisome matrix by peroxins (PEX proteins), but how the function of the PEX

64 isome division is regulated by the conserved peroxin Pex11p.

65 We also show that another integral PMP, the peroxin PEX13, also contains two independent sets of per

66 nterference (RNAi)-mediated knockdown of the peroxin PEX14.

67 ng complex PEX13-PEX14 and the (RING)-finger peroxin PEX2.

68 5 ubiquitination, we found that all the RING peroxins (Pex2, Pex10, and Pex12) are required as E3 ubi

69 (ER) sorting and budding of the RING-domain peroxins (Pex2, Pex10, and Pex12).

70 ors Pex8p, Pex10p, and Pex12p, and two other peroxins, Pex2p and Pex17p.

71 We demonstrate that the peroxin Pex3 is not required for the formation of peroxi

72 ructure of the first three TPR-motifs of the peroxin PEX5 from Trypanosoma brucei, the causative agen

73 1 gene, codes for a predicted 42-kD membrane peroxin protein (AtPex16p).

74 which the functional roles of many of the 23 peroxins (proteins involved in peroxisomal protein impor

75 study, we report that two integral membrane peroxins (proteins required for peroxisome biogenesis) i

76 8p and Pex21p are structurally related yeast peroxins (proteins required for peroxisome biogenesis) t

77 The role of most PEX gene products, peroxins, remains to be determined, but a variety of stu

78 Ypl112p, renamed Pex25p, is a novel peroxin required for the regulation of peroxisome size a

79 g signal (PTS1) receptor, one of at least 15 peroxins required for peroxisome biogenesis.

80 Pex18p and ScPex21p, two novel S. cerevisiae peroxins required for protein targeting via the PTS2 bra

81 Loss of peroxins required for protein translocation into the per

82 Pex11 is a peroxin that regulates the number of peroxisomes in euka

83 EX genes and the altering of their proteins, peroxins, which are necessary for the importation of tar

84 e biogenesis is mediated by proteins called "peroxins," which are considered to be promising drug tar