ライフサイエンスコーパス: peroxiredoxin

1 sbF interaction partner, Rv1676, a predicted peroxiredoxin.

2 removal was observed following oxidation of peroxiredoxin.

3 des and regulates the expression of the OhrA peroxiredoxin.

4 tic mechanism of Asp f3, a two-cysteine type peroxiredoxin.

5 roxyperoxide reductase E (AhpE), among other peroxiredoxins.

6 entative of the major class of bacterial BCP peroxiredoxins.

7 ses, catalases, glutathione-peroxidases, and peroxiredoxins.

8 x homeostasis through reducing hyperoxidized peroxiredoxins.

9 xy-eicosatetraenoic acids also over-oxidized peroxiredoxins.

10 mple assay to quantify the hyperoxidation of peroxiredoxins.

11 was associated with increased expression of peroxiredoxin 1 (P<0.05), peroxiredoxin 3 (P<0.01), and

12 igomers and shifts in isoelectric points for peroxiredoxin 1 (Prdx-1), Prdx-3, and Prdx-4 isoforms wi

13 We previously demonstrated that peroxiredoxin 1 (Prdx1), a scavenger of reactive oxygen

14 Recent studies suggest that Peroxiredoxin 1 (Prdx1), in addition to its known H(2)O(

15 In particular, the antioxidant protein peroxiredoxin 1 (Prx1) exhibited both decreased expressi

16 Peroxiredoxin 1 (Prx1) has been found to be elevated in

17 Peroxiredoxin 1 (Prx1) is an antioxidant and molecular c

18 In the present study, we showed that peroxiredoxin 1 (Prx1), a member of the peroxiredoxin pr

19 re used to assess the effect of UVB on TOPK, peroxiredoxin 1 (Prx1), and apoptosis in RPMI7951 cells.

20 lar proteins such as heat shock proteins and peroxiredoxin 1 (Prx1).

21 f PUMA induced up-regulation (>1.34-fold) of peroxiredoxin 1 and down-regulation (by 25%) of stathmin

22 enerated from oxidation of Trx1 catalyzed by peroxiredoxin 1 in the presence of H2O2.

23 te-cysteine ligase catalytic subunit, ABCC1, peroxiredoxin 1).

24 ntified GAPDH, vimentin, beta-galactosidase, peroxiredoxin 1, beta-actin, and ubiquitin-conjugating e

25 1s) and the antioxidant enzymes catalase and peroxiredoxin 1, which may influence antioxidant potenti

26 Human peroxiredoxins 1 and 2, also known as Prx1 and Prx2, are

27 eroxide dismutase 1), anti-oxidant proteins (peroxiredoxins 1 and 6), and metabolic proteins (e.g., p

28 se-1, and cyclooxygenase-2 oxidize the 2-Cys-peroxiredoxins 1, 2, and 3 to their sulfinic and sulfoni

29 gi apparatus tether, and antioxidant enzymes peroxiredoxins 1-2.

30 been shown to reactivate oxidized 1-cysteine peroxiredoxin (1-Cys Prx, Prx VI, Prdx6, and AOP2).

31 xidases, or by overexpression of catalase or peroxiredoxin-1 (Prx-1).

32 /SNO may affect the redox cycle of mammalian peroxiredoxin-1 (Prx1), a representative of the 2-Cys Pr

33 ically interacts with the antioxidant enzyme peroxiredoxin-1 (PRX1), protects it from proteasome-medi

34 ation of primary antioxidant systems such as peroxiredoxins-1, heme oxygenase-1, and anti-apoptotic f

35 pectively), but comparable with TR-dependent peroxiredoxins (16.5 and 2.7x10(4) s(-1) M(-1), respecti

36 ed genes encoding Fe hydrogenase (9.m00419), peroxiredoxin (176.m00112), type A flavoprotein (6.m0046

37 Intriguingly, we identified peroxiredoxin 2 (PRDX2) as a novel potential tumor suppr

38 Peroxiredoxin 2 (Prx2) is a thiol protein that functions

39 nduces CDK5/p25-dependent phosphorylation of peroxiredoxin 2 (Prx2), resulting in inhibition of its p

40 estigated interactions between PTP1B and the peroxiredoxin 2 (Prx2)/thioredoxin 1 (Trx1)/thioredoxin

41 y in vitro; during therapy, disulfide-linked peroxiredoxin 2 dimer did not accumulate in red blood ce

42 tropomyosin alpha4 p=0.0108), antioxidative (peroxiredoxin 2 p=0.0092), and anti-inflammatory effects

43 ansfer flavoprotein were increased, nm23/H1, peroxiredoxin 2, nucleophosmin 1/B23, and inorganic pyro

44 pical thioredoxin ACHT1 is oxidized by 2-Cys peroxiredoxin (2-Cys Prx) in Arabidopsis plants illumina

45 Here, we reveal that the 2-Cys peroxiredoxin (2-Cys Prx) Tpx1 is required for the perox

46 NTRC is an efficient reductant of 2-Cys peroxiredoxins (2-Cys Prxs) and thus is involved in the

47 on of Cys-sulfinic acid derivatives of 2-Cys peroxiredoxins (2-Cys Prxs), has been shown to catalyze

48 alysis revealed that the antioxidant enzymes peroxiredoxin-2 (Prdx2) and heme oxygenase-1 were upregu

49 lammatory stimuli induce release of oxidized peroxiredoxin-2 (PRDX2), a ubiquitous redox-active intra

50 For example, S-nitrosylation of peroxiredoxin-2 (Prx2), a peroxidase widely expressed in

51 ased expression of peroxiredoxin 1 (P<0.05), peroxiredoxin 3 (P<0.01), and heme oxygenase-1 (HO-1) (P

52 e (Sod), glutathione peroxidase 4 (Gpx4) and peroxiredoxin 3 (Prdx3) that render them susceptible to

53 Peroxiredoxin 3 (Prx3), a mitochondrial thioredoxin-depe

54 merase gamma, mitochondrial topoisomerase I, peroxiredoxin 3 and manganese superoxide dismutase--are

55 Peroxiredoxin-3 (PRDX3) is a mitochondrial antioxidant e

56 LRRK2 has been shown to bind peroxiredoxin-3 (PRDX3), the most important scavenger of

57 interacts with the mitochondrial peroxidase peroxiredoxin-3 (PRDX3).

58 uctions (P<0.001) in the antioxidant enzymes peroxiredoxin-3 and CuZn-superoxide-dismutase.

59 The mitochondrial peroxidase peroxiredoxin-3 reduces H(2)O(2) to water using reducing

60 ion of a mitochondria-localized antioxidant (peroxiredoxin-3) was protective against VIDD.

61 unolabeling for markers of oxidative stress (peroxiredoxin-3/5) and for a lipid peroxidation product

62 Here, we report that peroxiredoxin 4 (PRDX4) is a putative tumor driver.

63 The endoplasmic reticulum (ER)-localized peroxiredoxin 4 (PRDX4) supports disulfide bond formatio

64 Peroxiredoxin 4 (Prdx4), an ER-specific antioxidative pe

65 llothionein 3 (Mt3), tetraspanin 2 (Tspan2), peroxiredoxin 4 (Prdx4), stathmin-like 2 (Stmn2), myelin

66 Peroxiredoxin 4 (Prx4) has been implicated in a wide var

67 Blocking either Akt or peroxiredoxin 4 activity with Akt Inhibitor IV or a pero

68 study examined the role of Akt signaling and peroxiredoxin 4 expression in human umbilical cord blood

69 o increased Akt phosphorylation and elevated peroxiredoxin 4 expression in oligodendrocytes.

70 cord blood cells converge on Akt to elevate peroxiredoxin 4 levels, and these effects contribute to

71 occlusion increased Akt phosphorylation and peroxiredoxin 4 protein expression while reducing proteo

72 edoxin 4 activity with Akt Inhibitor IV or a peroxiredoxin 4-neutralizing antibody, respectively, neg

73 t enzymes, superoxide dismutase 1 (SOD1) and peroxiredoxin-4 (PRDX4) during hyperosmotic stress.

74 s), NAD(P)H quinone oxidoreductase-1 (Nqo1), peroxiredoxin-4 (Prdx4), and serine peptidase inhibitor

75 anganese-containing superoxide dismutase and peroxiredoxin 5 were only upregulated by PgLPS1690.

76 e E1, PYGB, Pgm2), and antioxidant proteins (peroxiredoxin 5, ferritin heavy chain 1) following rapam

77 f four proteins (macrophage capping protein, peroxiredoxin 5, heterogeneous nuclear ribonucleoprotein

78 ther by crystallography or NMR for the human peroxiredoxin 5, their affinities were for the first tim

79 Herein we show that the transduction of Peroxiredoxin 6 (PRDX6) attenuates TNF-alpha- and glutam

80 Peroxiredoxin 6 (Prdx6) is a "moonlighting" protein with

81 Peroxiredoxin 6 (PRDX6) is a key regulator of cellular r

82 The antioxidant enzyme peroxiredoxin 6 (Prdx6) is a key regulator of the cellul

83 Peroxiredoxin 6 (Prdx6) is essential for activation of N

84 o show that following opioid administration, peroxiredoxin 6 (PRDX6) is recruited to the opioid recep

85 holipase A2 (PLA2)activity of phosphorylated peroxiredoxin 6 (Prdx6) is required for activation of NA

86 how that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Galphai complex

87 Peroxiredoxin 6 (Prdx6), a bifunctional enzyme with glut

88 Peroxiredoxin 6 (Prdx6), a bifunctional protein with pho

89 We identified peroxiredoxin 6 (Prdx6), a host factor that contributes

90 tathione peroxidase 2 and 3 (GPx2 and GPx3), peroxiredoxin 6 (Prdx6), and sulfyhydryl oxidase Q6 (Qsc

91 The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via

92 or of PRDX6 and suggest that co-targeting of peroxiredoxin 6 or modulating miR-371-3p expression toge

93 We identify PRDX6 (peroxiredoxin 6) as a key target of miR-371-3p in establ

94 d and confirmed that Saitohin interacts with peroxiredoxin 6, a unique member of that family that is

95 27, cathepsin D, triose-phosphate isomerase, peroxiredoxin 6, and electron transfer flavoprotein were

96 cs analysis, we found that uterine levels of peroxiredoxin-6 (PRDX6), a unique antioxidant, are signi

97 transporter (EAAT-2), apo-J (Clusterin), and peroxiredoxin-6) are selectively expressed in astrocytes

98 One Zap1 target gene encodes the Tsa1 peroxiredoxin, a protein with both peroxidase and protei

99 The peroxiredoxins, a family of peroxidases initially descri

100 roxidase and glutathione peroxidase, and the peroxiredoxin abundance were increased for ROS scavengin

101 soluble antioxidative systems, in particular peroxiredoxins, accumulate at higher levels in M chlorop

102 one and thioredoxin oxidation and suppressed peroxiredoxin activity in vitro.

103 this residue was not absolutely required for peroxiredoxin activity.

104 We have confirmed that the peroxiredoxin Ahp1 is such a substrate in S. cerevisiae

105 tributions of the sole catalase KatE and the peroxiredoxin AhpC produced by these strains in defense

106 The bacterial peroxiredoxin AhpC, a cysteine-dependent peroxidase, can

107 rains is restored by a mutant (ahpC*) of the peroxiredoxin AhpC, converting it to a disulfide reducta

108 tress includes the flavoprotein AhpF and the peroxiredoxin AhpC.

109 disulfide center of the antioxidant protein peroxiredoxin (AhpC) to detoxify ROS such as hydrogen pe

110 d catalase, H. pylori depends on a family of peroxiredoxins (alkylhydroperoxide reductase, bacteriofe

111 that mass spectrometry shows contained 2-Cys peroxiredoxin also formed and precedes the appearance of

112 ne, a residue that occurs in place of Pro in peroxiredoxins, also led to the formation of the cluster

113 arrying 2 functional elements, an N-terminal peroxiredoxin and a C-terminal chitinase domain.

114 ing the thioredoxin peroxidase activity of a peroxiredoxin and increasing the hydrogen peroxide resis

115 two proteins with antioxidative properties (peroxiredoxin and superoxide dismutase), and three prote

116 chanism is similar to that of atypical 2-Cys peroxiredoxin and that selenocysteine allows SelS to sus

117 and structural features of the mitochondrial peroxiredoxin and thioredoxin of P. falciparum.

118 in reveals a fold typical of the 2-Cys class peroxiredoxins and a dimeric form with an intermolecular

119 were identified, including ATPase, clathrin, peroxiredoxins and enolase, which may provide clues to t

120 h wild-type and mutant strains deficient for peroxiredoxins and glutathione peroxidases were equally

121 H2O2 is under sophisticated fine control of peroxiredoxins and glutathione peroxidases with their ba

122 d that Sesn2 physically interacts with 2-Cys peroxiredoxins and Nrf2 albeit under different reductive

123 ting from nonlinearity of H2O2 scavenging by peroxiredoxins and our study reveals that this regulator

124 s, including cysteine-dependent peroxidases (peroxiredoxins) and proteases, only relatively few pK(a)

125 y on select proteins, including thioredoxin, peroxiredoxins, and other validated redox active protein

126 Peroxiredoxins are a diverse and ubiquitous family of hi

127 d out in this list, as the related cytosolic peroxiredoxins are known to form disulfides in the prese

128 Typical 2-Cys peroxiredoxins are required to remove hydrogen peroxide

129 Peroxiredoxins are ubiquitous proteins that catalyze the

130 ain the phenotypic differences, and identify peroxiredoxin as an important component of virulence in

131 Here we show that the peroxiredoxin Asp f3 of Aspergillus fumigatus inactivate

132 ctrometry, we recently reclassified one such peroxiredoxin, bacterioferritin comigratory protein (BCP

133 2-Cys peroxiredoxins belonging to the Prx1 subfamily are Cys-b

134 ssion of an antioxidative enzyme, 2-Cysteine peroxiredoxin (BxPrx), was elevated in B. xylophilus fol

135 ces cerevisiae Altogether, the processing of peroxiredoxins by Imp2 or Oct1 likely represents systems

136 the selective benefits endowed to eukaryotic peroxiredoxins by their reversible hyperoxidation.

137 Hyperoxidation of peroxiredoxins can only occur efficiently in the presenc

138 The absence of Tsa1, a key peroxiredoxin, caused increased rates of mutations, chro

139 demonstrate a clear physiological role for a peroxiredoxin chaperone and reveal a novel and unexpecte

140 The peroxiredoxin clearly preferred PfTrx2 to PfTrx1 as a re

141 ongs to the atypical 2-cysteine subfamily of peroxiredoxins, commonly referred to as bacterioferritin

142 AhpC, the peroxide-reducing (peroxiredoxin) component of this alkyl hydroperoxidase s

143 We also explore how peroxiredoxins contribute to YROs.

144 In these 2-Cys peroxiredoxins, decamer formation is important for the c

145 Peroxiredoxin-dependent mechanisms may modulate the rece

146 The functional versatility of peroxiredoxins depends on progressive oxidation of key c

147 This is the first report of 2-cysteine peroxiredoxins efficiently utilizing reducing equivalent

148 Deletion of TSA1, which encodes a peroxiredoxin, exacerbated iron toxicity in Deltaccc1 ce

149 Prx1, a peroxiredoxin family member, was shown to be frequently

150 a thioredoxin fold similar to that of other peroxiredoxin family members.

151 typhimurium AhpC is a founding member of the peroxiredoxin family, a ubiquitous group of cysteine-bas

152 osis Tpx is a member of the atypical two-Cys peroxiredoxin family.

153 obacter pylori contains three members of the peroxiredoxin family: AhpC (alkyl hydroperoxide reductas

154 Those studies, however, have not examined peroxiredoxin for a potential dual functionality as both

155 ved the crystal structure of a typical 2-Cys peroxiredoxin from Leishmania in the dimeric (pH 8.5) an

156 Thiol peroxidases (Tpxs) are dimeric 2-Cys peroxiredoxins from bacteria that preferentially reduce

157 to those obtained for two typical 2-cysteine peroxiredoxins from Saccharomyces cerevisiae (5.4 and 6.

158 atalase (encoded by hktE) and a bifunctional peroxiredoxin-glutaredoxin (encoded by pdgX) in resistan

159 on these data, we conclude that catalase and peroxiredoxin-glutaredoxin are determinants of bacterial

160 These include catalase (HktE), peroxiredoxin/glutaredoxin (PgdX), and a ferritin-like p

161 circadian oscillations in the redox state of peroxiredoxin have been described as an additional non-t

162 Cytosolic eukaryotic 2-Cys-peroxiredoxins have been widely reported to act as dual-

163 Using red blood cells, we found that peroxiredoxins, highly conserved antioxidant proteins, u

164 and contribute to osteoarthritis and suggest peroxiredoxin hyperoxidation as a potential mechanism.

165 Peroxiredoxin hyperoxidation was associated with inhibit

166 Peroxiredoxin hyperoxidation was observedin situin human

167 pecifically, our experiments have identified peroxiredoxin I (Prx I) as one of these up-regulated pro

168 stimulation, the expression and oxidation of peroxiredoxin II (PrdxII), a critical antioxidant enzyme

169 By proteomics analysis, we found that peroxiredoxin II (PrxII), a member of a family of peroxi

170 Overexpression of peroxiredoxin in Rahman rendered the transgenic trophozo

171 have been due to the absence of catalase and peroxiredoxin in the purified Hb.

172 perones, Hsp33 in bacteria and typical 2-Cys peroxiredoxins in eukaryotes.

173 ism to stabilize the decameric form of 2-Cys peroxiredoxins in Leishmania mitochondria.

174 the structure and function of typical 2-Cys peroxiredoxins in response to oxidative stress.

175 Thus, AhpC and potentially other peroxiredoxins in this widespread family can elaborate a

176 the expression of Prx III, the mitochondrial peroxiredoxin, in human cardiac fibroblasts.

177 l, Day et al. reveal a surprising benefit of peroxiredoxin inactivation at high H(2)O(2), showing tha

178 ans Srx1 was also found to be required for a peroxiredoxin-independent function in promoting fungicid

179 Mutagenesis of S. mansoni peroxiredoxins indicated that glutathione dependence and

180 igand, whereas catalase and a membrane-bound peroxiredoxin inhibited ligand-dependent signaling.

181 support the subdivision of the BCP family of peroxiredoxins into two classes based on their catalytic

182 tive cysteine, the resolving cysteine of BCP peroxiredoxins is not conserved across all members of th

183 Together with 2-cysteine peroxiredoxin, it forms a two-component peroxide-detoxif

184 ein folding, which led to the discovery that peroxiredoxin IV (PRDX4) catalyzes a parallel oxidation

185 Peroxiredoxin IV (PRDX4) stood out in this list, as the

186 produced can be metabolized by ER-localized peroxiredoxin IV (PrxIV).

187 r mitochondria, leading to the protection of peroxiredoxin IV from hyperoxidation.

188 Our results demonstrate that peroxiredoxin IV recycling in the endoplasmic reticulum

189 quence similarity 213, member A (FAM213A), a peroxiredoxin-like antioxidative protein, was repressed

190 spectrometry reveal that DJ-1 is an atypical peroxiredoxin-like peroxidase that scavenges H(2)O(2) th

191 hysiological function of DJ-1 as an atypical peroxiredoxin-like peroxidase.

192 peroxidase, the parasites rely primarily on peroxiredoxin-linked systems for protection.

193 The sulfinic or sulfonic forms of peroxiredoxin lose their peroxidase activity, which allo

194 These results show that the mitochondrial peroxiredoxin of P. falciparum occurs in both dimeric an

195 or that represses expression of an inducible peroxiredoxin, OhrA.

196 riod determination by CK1 and GSK3, and have peroxiredoxin over-oxidation cycles.

197 2 is mediated by an evolutionarily conserved peroxiredoxin-p38/MAPK signaling cascade.

198 atalysis occurs via an atypical two-cysteine peroxiredoxin pathway.

199 oresistant cancer cells suggested that human peroxiredoxin plays an important role in eliminating the

200 ire GUR-3 and a conserved antioxidant enzyme peroxiredoxin PRDX-2.

201 he mitohormetic pathway is propagated by the peroxiredoxin PRDX-2.

202 The peroxiredoxin (Prdx) family of antioxidant enzymes uses

203 roxidase activity of the antioxidant protein peroxiredoxin (Prdx-1) in breast cancer cells.

204 regulation of ROS/RNS is largely attended by peroxiredoxins (Prdxs) and their main reductants, thiore

205 Peroxiredoxins (Prdxs) are small H(2)O(2) scavenging pro

206 rtile, and the deficiency or inactivation of Peroxiredoxins (PRDXs) is associated with human male inf

207 , peroxynitrite, and organic hydroperoxides, peroxiredoxins (Prdxs) represent a major potential prote

208 that peroxiredoxin 1 (Prx1), a member of the peroxiredoxin protein family, acts as a key mediator in

209 ediated by the membrane protein GDE2 and the peroxiredoxin protein Prdx1 that promotes neurogenesis.

210 n the oxidation state of a broadly conserved peroxiredoxin protein.

211 We identify oxidation of peroxiredoxin proteins as a transcription-independent rh

212 e we show that oxidation-reduction cycles of peroxiredoxin proteins constitute a universal marker for

213 TXNRD1) and sulfiredoxin (SRXN1), suggesting peroxiredoxin proteins had been oxidized during monoHAA

214 Genes encoding two novel 2-cysteine peroxiredoxin proteins were identified in the expressed

215 t discovery of oxidation-reduction cycles of peroxiredoxin proteins, which persist even in the absenc

216 ing, e.g., over-oxidation cycles of abundant peroxiredoxin proteins.

217 PREX is a database of currently 3516 peroxiredoxin (Prx or PRDX) protein sequences unambiguou

218 Although this Tp peroxiredoxin (Prx) closely resembles AhpC-like Prxs, Tp

219 PC-mutation-positive colorectal cancer.2-Cys peroxiredoxin (Prx) enzymes are highly expressed in most

220 Mammalian 2-Cys peroxiredoxin (Prx) enzymes are overexpressed in most ca

221 parasite Leishmania infantum, mitochondrial peroxiredoxin (Prx) exerts intrinsic ATP-independent cha

222 The peroxiredoxin (PRX) family of antioxidant enzymes helps

223 iscovery that the redox regulatory proteins, peroxiredoxin (Prx) I and Prx II are specific targets of

224 fects on apoptotic signaling of depletion of peroxiredoxin (Prx) III, a mitochondrion-specific H(2)O(

225 Srx preferentially interacts with Peroxiredoxin (Prx) IV relative to other Prxs due to its

226 ivity in vitro Remarkably, the processing of peroxiredoxin (Prx) proteins by Oct1 appears to be an ev

227 efenses by making changes to the thioredoxin-peroxiredoxin (Prx) system.

228 terioferritin comigratory protein (BCP) is a peroxiredoxin (Prx) that catalyzes the reduction of H(2)

229 tive site cysteine of the antioxidant enzyme peroxiredoxin (Prx) to the sulfinic acid form, Prx-SO(2)

230 estingly, ACHT1 oxidation is driven by 2-Cys peroxiredoxin (Prx), which in turn eliminates peroxides.

231 zymes and reduced formation of hyperoxidized peroxiredoxin (Prx)2.

232 This reaction is unique to the typical 2-Cys peroxiredoxins (Prx) and plays a role in peroxide-mediat

233 Peroxiredoxins (PRX) are a family of antioxidant enzymes

234 Eukaryotic 2-Cys peroxiredoxins (Prx) are abundant antioxidant enzymes wh

235 Peroxiredoxins (PRX) are critical intracellular antioxid

236 Peroxiredoxins (Prx) are efficient thiol-dependent perox

237 Evidence implicates peroxiredoxins (Prx) as providing the main enzymatic act

238 air the inactivated forms of typical two-Cys peroxiredoxins (Prx) implicated in hydrogen peroxide-med

239 Peroxiredoxins (Prx) make up a family of enzymes that re

240 of the active site cysteine in typical 2-Cys peroxiredoxins (Prx) to sulfinic acid during oxidative s

241 Peroxiredoxins (Prx), a family of peroxidases that reduc

242 e proteins, including thioredoxins (Trx) and peroxiredoxins (Prx), with putative copper-binding ligan

243 st Oct1 could cleave the human mitochondrial peroxiredoxin Prx3 when expressed in Saccharomyces cerev

244 ed to oxidative stress resistance, including peroxiredoxin PrxA, in response to hydrogen peroxide.

245 The mitochondrial 2-Cys peroxiredoxin PrxIII serves as a thioredoxin-dependent p

246 Peroxiredoxins (Prxs or Prdxs) are a large protein super

247 nt peroxidases, including 2-cysteine (2-Cys) peroxiredoxins (PRXs) and thylakoid ascorbate peroxidase

248 Peroxiredoxins (Prxs) are a family of peroxidases that r

249 Peroxiredoxins (Prxs) are a ubiquitously expressed famil

250 Peroxiredoxins (Prxs) are highly conserved proteins foun

251 Peroxiredoxins (Prxs) are important peroxidases associat

252 O2H) residues, the sulfinic forms of certain peroxiredoxins (Prxs) are selectively reduced by sulfire

253 Typical 2-Cys peroxiredoxins (Prxs) are ubiquitous peroxidases that ar

254 Peroxiredoxins (Prxs) are vital regulators of intracellu

255 Inactivation of eukaryotic 2-Cys peroxiredoxins (Prxs) by hyperoxidation has been propose

256 ether with thioredoxin reductase 1 (TR1) and peroxiredoxins (Prxs) comprises a key redox regulatory s

257 Peroxiredoxins (Prxs) detoxify peroxides and modulate H2

258 Typical 2-Cys peroxiredoxins (Prxs) have an important role in regulati

259 Peroxiredoxins (Prxs) make up a ubiquitous class (propos

260 Typical 2-Cys peroxiredoxins (Prxs) react rapidly with H2O2 to form a

261 therefore the family of antioxidant enzymes, peroxiredoxins (Prxs) represent a target for antimalaria

262 Cysteine residues of certain peroxiredoxins (Prxs) undergo reversible oxidation to su

263 NTRC efficiently reduces 2-Cys peroxiredoxins (Prxs), thus having antioxidant function,

264 ed to react fast toward reactive thiols from peroxiredoxins (Prxs).

265 ing age-related oxidation of H2O2-scavenging peroxiredoxins (Prxs).

266 In many bacteria, a dedicated peroxiredoxin reductase, alkyl hydroperoxide reductase s

267 Our results present in vivo evidence of a peroxiredoxin regulating DE-cadherin-mediated adhesion.

268 The crystal structure of the mitochondrial peroxiredoxin reveals a fold typical of the 2-Cys class

269 lose structural similarity to atypical 2-Cys peroxiredoxin(s) (Prx).

270 These observations may represent peroxiredoxin sensing and transducing the oxidant signal

271 Human peroxiredoxins serve dual roles as anti-oxidants and reg

272 Because of its evolutionary conservation, peroxiredoxin signaling might underlie a general princip

273 genases and cyclooxygenases may affect 2-Cys peroxiredoxin signaling, analogous to NADPH oxidases in

274 modulate the oligomeric transitions of 2-Cys peroxiredoxins such as redox state, post-translational m

275 provided further support for the thioredoxin/peroxiredoxin system as the major contributor to mitocho

276 H2O2 detoxification through the thioredoxin/peroxiredoxin system.

277 dent manner predominantly by the thioredoxin/peroxiredoxin system.

278 1-Cys peroxiredoxin (TgTrx-Px2), and a 2-Cys peroxiredoxin (TgTrx-Px1) and immunofluorescent studies

279 T. gondii express thioredoxin (TgTrx), 1-Cys peroxiredoxin (TgTrx-Px2), and a 2-Cys peroxiredoxin (Tg

280 Yeast Prx1 is a mitochondrial 1-Cys peroxiredoxin that catalyzes the reduction of endogenous

281 ydroperoxide reductase subunit C (AhpC) is a peroxiredoxin that detoxifies peroxides.

282 P) of Escherichia coli, as an atypical 2-Cys peroxiredoxin that functions through the formation of an

283 es belonging to the class of 1-Cys and 2-Cys peroxiredoxins that play crucial roles in maintaining re

284 For all of the peroxiredoxins, the catalytic cysteine, referred to as t

285 Peroxiredoxins, the enzymes that catalyze the reduction

286 xpressions of those genes encoding catalase, peroxiredoxin, thioredoxin and glutathione were highly i

287 indicate that at high tissue H2O2 levels the peroxiredoxin-thioredoxin antioxidant chain becomes over

288 ivity of the endoplasmic reticulum-localized peroxiredoxin to hyperoxidation compared with either the

289 d that mutation of the TxxC active site in a peroxiredoxin to the CxxC form could lead to coordinatio

290 ctional gain that allows mitochondrial 2-Cys peroxiredoxins to act as molecular chaperones when formi

291 king one, at 1.4 A, one of the best resolved peroxiredoxins to date.

292 The ability of schistosome peroxiredoxins to use alternative electron donors, and t

293 nhibitor-like allergen (Tri a 39), and 1-cys-peroxiredoxin (Tri a 32), produced the maximal area unde

294 y enhances the expression of the thioredoxin/peroxiredoxin (Trx/Prx) system with the greatest effect

295 fungal meningoencephalitis and regulation of peroxiredoxins, Tsa1 and Tsa3, and thioredoxins, Trx1 an

296 regulon) and only one antioxidant gene, the peroxiredoxin TSA2.

297 creased expression of the antioxidant enzyme peroxiredoxin-V, and a non-significant trend towards dec

298 man trophozoites expressing higher levels of peroxiredoxin was associated with higher levels of intes

299 relative abundance of serpins Z1C and 1-Cys peroxiredoxin was increased at e[CO2].

300 the highly abundant eukaryotic typical 2-Cys peroxiredoxin, whose oxidative stress-induced sulfinic a