ライフサイエンスコーパス: peroxisome

1 which in vivo fluoresces selectively inside peroxisomes.

2 Peroxin (PEX) proteins generate and maintain peroxisomes.

3 e characterized by the absence of functional peroxisomes.

4 dimer facilitates co-transport of Pnc1 into peroxisomes.

5 a-ketoglutarate (alphaKG) in the cytosol and peroxisomes.

6 soprenoid intermediates between plastids and peroxisomes.

7 r NAD(+)-dependent reaction performed inside peroxisomes.

8 ring the cellular requirement for functional peroxisomes.

9 to cell surfaces; instead, it accumulates in peroxisomes.

10 peroxisome size, suggesting that increasing peroxisome abundance can compensate for the deficiencies

11 n remain poorly understood because measuring peroxisome abundance is technically challenging.

12 e present a simple technique for quantifying peroxisome abundance using the small probe Nitro-BODIPY,

13 equires the known peroxisome division factor PEROXISOME AND MITOCHONDRIAL DIVISION FACTOR1 (PMD1).

14 s including cytosol, plastid, mitochondrion, peroxisome and vacuole.

15 Peroxisomes are eukaryotic organelles that posttranslati

16 Peroxisomes are highly dynamic and metabolically active

17 hage inflammatory responses and suggest that peroxisomes are involved in the physiological cessation

18 Peroxisomes are metabolic organelles necessary for anabo

19 We show that chloroplasts and peroxisomes are physically tethered through peroxules, a

20 Peroxisomes are proposed to play an important role in th

21 By contrast, Pex15 molecules at peroxisomes are rapidly converted from an initial Msp1-s

22 Peroxisomes are small organelles that house many oxidati

23 In Saccharomyces cerevisiae, peroxisomes are the sole site of fatty acid beta-oxidati

24 Peroxisomes are thought to have played a key role in the

25 Peroxisomes are tiny organelles that control important a

26 In sharp contrast, genes for peroxisome-associated functions are absent, suggesting B

27 that epidermal progenitors deficient in the peroxisome-associated protein Pex11b failed to segregate

28 Three peroxisome-associated ubiquitin-protein ligases in the R

29 teasome inhibitor or by combining pex26 with peroxisome-associated ubiquitination machinery mutants,

30 We compared this pex12-1 mutant to other peroxisome-associated ubiquitination-related mutants and

31 at least some PTS1-containing monomers enter peroxisomes before they assemble into oligomers.

32 In the absence of both proteins, peroxisome biogenesis and the intra-ER sorting of Pex2 a

33 pared to wild-type PEX6 c.2578C results in a peroxisome biogenesis defect and thus constitutes the ca

34 the most commonly affected peroxin in human peroxisome biogenesis disorders.

35 sive disorders that are caused by defects in peroxisome biogenesis due to bi-allelic mutations in any

36 lipids, the trafficking of cholesterol, and peroxisome biogenesis in mammalian cells.

37 which the model can be used to conclude that peroxisome biogenesis is dominated by de novo production

38 During de novo peroxisome biogenesis, importomer complex proteins sort

39 our studies reveal a novel role for Lrp1 in peroxisome biogenesis, lipid homeostasis, and OPC differ

40 Further, proliferation of peroxisomes blocked the TLR4 ligand LPS-induced proinfla

41 Msp1 also resides on peroxisomes but it remains unknown how native TA protein

42 oxisomal membrane proteins (PMPs) traffic to peroxisomes by two mechanisms: direct insertion from the

43 we show that targeting synthetic pathways to peroxisomes can increase the production of fatty-acid-de

44 We found peroxisomes clustered around persisting oil bodies in pe

45 tion of peroxisomes through the cytoskeleton-peroxisome connection.

46 ety of metabolic pathways are sequestered in peroxisomes, conserved organelles that are essential for

47 biogenesis, function, and regulation of the peroxisome contain Msn2/4-binding sites.

48 This work revealed that peroxisome could be engineered as a compartmentalized or

49 ompartmentalized, involving the chloroplast, peroxisome, cytosol, and mitochondria.

50 Specifically, induction of peroxisomes did not affect the upregulation of COX-2 at

51 ion of technologies capable of investigating peroxisomes directly in the cell.

52 fficient for early endosome localization and peroxisome distribution and motility.

53 These findings expand our understanding of peroxisome division and potentially identify factors con

54 division in a manner that requires the known peroxisome division factor PEROXISOME AND MITOCHONDRIAL

55 thaliana) MAP KINASE17 (MPK17) in affecting peroxisome division in a manner that requires the known

56 Moss PEX11 functions in peroxisome division similar to PEX11 in other organisms

57 in cytoskeleton is required for NaCl-induced peroxisome division.

58 o found that N-BODIPY detects aggregation of peroxisomes during final stages of programmed cell death

59 pex1-3 displayed symptoms of peroxisome dysfunction when heterozygous; this semidomin

60 proteins and molecular mechanisms governing peroxisome emergence from the ER are poorly characterize

61 In this issue, Costello et al. identify a peroxisome-ER contact site in human cells held together

62 n how native TA proteins on mitochondria and peroxisomes evade Msp1 surveillance.

63 for storage and transport, mitochondria and peroxisomes for beta-oxidation, and lysosomes for lipid

64 AP-ACBD5-mediated contact between the ER and peroxisomes for organelle maintenance and lipid homeosta

65 d for cell growth in conditions that require peroxisomes for the metabolism of certain carbon sources

66 In contrast, disturbing peroxisome function by knockdown of peroxisomal gene Pex

67 id, ethylene, and brassinosteroid signaling, peroxisome function, disease resistance, protein phospho

68 n import processes play an essential role in peroxisome functionality.

69 ng of peroxisomes to the ER is necessary for peroxisome growth, the synthesis of plasmalogen phosphol

70 crotubule-based organelle transport in which peroxisomes hitchhike on early endosomes and identify Px

71 ncompass identification of genes controlling peroxisome homeostasis and capturing stress-tolerant gen

72 Furthermore, accumulation of peroxisomes in an autophagy-deficient Arabidopsis mutant

73 Abundance of peroxisomes in cells is dynamic; however mechanisms cont

74 Counting peroxisomes in individual cells of complex organs by ele

75 identify a previously unidentified role for peroxisomes in macrophage inflammatory responses and sug

76 in peroxisomal biogenesis factor-2 and fewer peroxisomes in OL processes.

77 ique reported here enables quantification of peroxisomes in plant material at various physiological s

78 enyl butyric acid is an efficient inducer of peroxisomes in various models of murine macrophages, suc

79 ere increased in the conditioned medium from peroxisome-induced macrophages, which blocked LPS-induce

80 e demonstrate that vMIA is also localized at peroxisomes, induces their fragmentation and inhibits th

81 her, production and localization of CD33m in peroxisomes is a way of diminishing the amount of CD33M

82 e between the endoplasmic reticulum (ER) and peroxisomes is necessary for the synthesis and catabolis

83 20% of these cells show import-incompetent, peroxisome-like structures (peroxisome remnants).

84 e for mitochondrial damage in consequence of peroxisome loss in Pex19 mutants.

85 e-specific autophagy can clear mitochondria, peroxisomes, lysosomes, ER, chloroplasts, and the nucleu

86 Plant peroxisomes maintain a plethora of key life processes in

87 The PEX1 ATPase facilitates recycling of the peroxisome matrix protein receptor PEX5 and is the most

88 nes, revealing the ability of BAK to control peroxisome membrane integrity and the release of soluble

89 Immunofluorescence microscopy with anti-peroxisome membrane protein antibodies disclosed that th

90 lastid protein import locus 1 (ppi1) 1] as a peroxisome membrane protein with a regulatory role in pe

91 henotype and interacted with Fission1 on the peroxisome membrane.

92 Phypa_PEX11 targeted to peroxisome membranes could rescue the knock out phenotyp

93 al. find that loss of VDAC2 diverts BAK into peroxisome membranes, revealing the ability of BAK to co

94 ized, the reactions present in the primitive peroxisomes (microbodies) of algae are poorly understood

95 les (endoplasmic reticulum, Golgi, lysosome, peroxisome, mitochondria and lipid droplet) and show how

96 ACBD5 or VAP expression results in increased peroxisome mobility, suggesting that VAP-ACBD5 complex a

97 VI to various organelles in vivo and hinders peroxisome motion in a light-controllable manner.

98 n contrast with this view, we show here that peroxisomes move by hitchhiking on early endosomes, an o

99 whereas neither structural difference of the peroxisome network, nor alteration of the respiratory ma

100 various oxidative pathways operating in the peroxisomes of higher plants are fairly well characteriz

101 sing enzymes were targeted to the cytoplasm, peroxisome, or endoplasmic reticulum to generate fatty a

102 t peroxules have a novel role in maintaining peroxisome-organelle interactions in the dynamic environ

103 Most eukaryotic cells require peroxisomes, organelles housing fatty acid beta-oxidatio

104 This fatty acid breakdown occurs in peroxisomes, organelles that sequester oxidative reactio

105 to the many metabolic functions fulfilled by peroxisomes, PBD pathology is complex and incompletely u

106 n be enhanced up to 3-fold by increasing the peroxisome population.

107 Even distribution of peroxisomes (POs) and lipid droplets (LDs) is critical t

108 Peroxisomes (POs) and the endoplasmic reticulum (ER) coo

109 metabolic interference with mitochondria and peroxisomes produce an intricate ROS and redox signature

110 ful system in which to address mechanisms of peroxisome proliferation and division.

111 f cochlear origin by affecting noise-induced peroxisome proliferation in auditory hair cells and neur

112 MPK17 and PMD1 are involved in peroxisome proliferation in response to NaCl stress.

113 Peroxisome proliferation is induced under multiple stres

114 s is dynamic; however mechanisms controlling peroxisome proliferation remain poorly understood becaus

115 While significant peroxisome proliferation was observed in wild-type Arabi

116 tarting with peroxule formation, followed by peroxisome proliferation, and finally returning to the n

117 Pex36 is not an essential protein for peroxisome proliferation, but in the absence of the func

118 actors connecting the actin cytoskeleton and peroxisome proliferation.

119 strated using salinity as a known inducer of peroxisome proliferation.

120 ited the key adipogenic transcription factor peroxisome proliferative activated receptor gamma (PPARg

121 nd their metabolites activate members of the peroxisome proliferative-activated receptor (PPAR) famil

122 rticle, we demonstrate that the nonclassical peroxisome proliferator 4-phenyl butyric acid is an effi

123 essed the hypothesis that variability in the Peroxisome Proliferator Activated Receptor (PPAR) pathwa

124 e glutathione-S-transferase 4-4 (Gsta4(-/-))/peroxisome proliferator activated receptor alpha (Ppara(

125 esponsive element binding protein 1 (CREB1), peroxisome proliferator activated receptor alpha (PPARA)

126 f human chorionic gonadotropin (hCGbeta) and peroxisome proliferator activated receptor gamma (PPARga

127 chain amino acids (BCAA), and regulation of peroxisome proliferator activated receptor gamma (PPARga

128 ty to activate the nuclear hormone receptor, peroxisome proliferator activated receptor gamma (PPARga

129 The nuclear receptor peroxisome proliferator activated receptor gamma (PPARga

130 e dismutase, mitochondrial KATP channels and peroxisome proliferator activated receptor gamma coactiv

131 Peroxisome proliferator activated receptor gamma, coacti

132 ect of PERC on bodyweight loss, induction of peroxisome proliferator activated receptor-alpha (PPARal

133 ificant alterations in pathways regulated by peroxisome proliferator activated receptor-gamma (PPARga

134 Computational analysis identified three peroxisome proliferator response elements (PPREs) within

135 The peroxisome proliferator, WY 14,643 exhibits a pure non-c

136 Peroxisome proliferator-activated gamma coactivator 1-al

137 We investigated the role of peroxisome proliferator-activated receptor (PPAR) beta/d

138 The peroxisome proliferator-activated receptor (PPAR) family

139 bound by the adipocytic transcription factor peroxisome proliferator-activated receptor (PPAR) gamma,

140 a models, we report that CD8(+) TILs enhance peroxisome proliferator-activated receptor (PPAR)-alpha

141 nt receptor potential vanilloid (TRPV)-1 and peroxisome proliferator-activated receptor (PPAR)-alpha.

142 ipogenesis (+30% Oil Red O stain [ORO], +50% peroxisome proliferator-activated receptor (PPAR)-gamma

143 Peroxisome proliferator-activated receptor (PPAR)-gamma

144 chanistic target of rapamycin (mTOR) and the peroxisome proliferator-activated receptor (PPAR)-gamma

145 into lipid-laden adipocytes by upregulating peroxisome proliferator-activated receptor (PPARgamma) a

146 to a putatively advantageous allele for the peroxisome proliferator-activated receptor A (PPARA) gen

147 receptor type 1 (CB1) or type 2 (CB2) or via peroxisome proliferator-activated receptor alpha (PPAR-a

148 adipocytes by controlling the expression of peroxisome proliferator-activated receptor alpha (Ppara)

149 CREBH interacts with peroxisome proliferator-activated receptor alpha (PPARal

150 n, Acot1 knockdown reduced the expression of peroxisome proliferator-activated receptor alpha (PPARal

151 igated whether Astragaloside IV can activate peroxisome proliferator-activated receptor alpha (PPARal

152 Peroxisome proliferator-activated receptor alpha (PPARal

153 such as bezafibrate, known activators of the peroxisome proliferator-activated receptor alpha (PPARal

154 ific DRE that overlaps binding sequences for peroxisome proliferator-activated receptor alpha (PPARal

155 and stabilizes the ligand-binding domain of peroxisome proliferator-activated receptor alpha (PPARal

156 ecular analysis unraveled that inhibition of peroxisome proliferator-activated receptor alpha activit

157 gene is an AMP-activated protein kinase and peroxisome proliferator-activated receptor alpha respons

158 Peroxisome proliferator-activated receptor alpha target

159 Falpha (3.0-fold), whereas the expression of peroxisome proliferator-activated receptor alpha target

160 ment binding protein-hepatocyte specific and peroxisome proliferator-activated receptor alpha, which

161 Nuclear receptor co-activator peroxisome proliferator-activated receptor co-activator

162 We found that peroxisome proliferator-activated receptor delta (PPAR-d

163 Mechanistically, a HFD induces a robust peroxisome proliferator-activated receptor delta (PPAR-d

164 Peroxisome proliferator-activated receptor delta (PPARde

165 Peroxisome proliferator-activated receptor delta (PPARde

166 Moreover, FAs from higher lipolysis activate peroxisome proliferator-activated receptor delta to indu

167 with markedly diminished ability to activate peroxisome proliferator-activated receptor gamma (MSDC-0

168 We studied interactions between polar bear peroxisome proliferator-activated receptor gamma (pbPPAR

169 Peroxisome proliferator-activated receptor gamma (PPAR-g

170 ng through the intracellular butyrate sensor peroxisome proliferator-activated receptor gamma (PPAR-g

171 CL10 and IL-6 transcript levels, and induced peroxisome proliferator-activated receptor gamma (PPAR-g

172 action between OmpA and Ecgp96 downregulates peroxisome proliferator-activated receptor gamma (PPAR-g

173 restored expression of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-g

174 on of several of its target genes, including peroxisome proliferator-activated receptor gamma (PPARG)

175 een in a Pten-null background, we identified peroxisome proliferator-activated receptor gamma (Pparg)

176 Peroxisome proliferator-activated receptor gamma (PPARga

177 miR-503 expression is directly regulated by peroxisome proliferator-activated receptor gamma (PPARga

178 und that this defect is because of defective peroxisome proliferator-activated receptor gamma (PPARga

179 Peroxisome proliferator-activated receptor gamma (PPARga

180 We have recently shown that peroxisome proliferator-activated receptor gamma (PPARga

181 In contrast, the master adipogenic TF peroxisome proliferator-activated receptor gamma (PPARga

182 Peroxisome proliferator-activated receptor gamma (PPARga

183 ancer-binding protein alpha (C/EBPalpha) and peroxisome proliferator-activated receptor gamma (PPARga

184 The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARga

185 A class of small molecules-peroxisome proliferator-activated receptor gamma (PPARga

186 pha), C/EBPbeta, C/EBPdelta, KLF5, KLF9, and peroxisome proliferator-activated receptor gamma (PPARga

187 Peroxisome proliferator-activated receptor gamma (PPARga

188 d the extracellular matrix, particularly the peroxisome proliferator-activated receptor gamma (Pparga

189 Peroxisome Proliferator-Activated Receptor Gamma (PPARga

190 lipid droplet formation and the induction of peroxisome proliferator-activated receptor gamma (PPARga

191 gh levels of TNF and IL-12 but low levels of peroxisome proliferator-activated receptor gamma (PPARga

192 anoparticle (NP) platforms to deliver either Peroxisome Proliferator-Activated Receptor gamma (PPARga

193 their direct action on the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARga

194 ich was recruited to the promoter of Nox1, a peroxisome proliferator-activated receptor gamma (PPARga

195 iated macrophage differentiation by cleaving peroxisome proliferator-activated receptor gamma (PPARga

196 tion depends on interactions between Sp1 and peroxisome proliferator-activated receptor gamma (PPARga

197 The expression of placental peroxisome proliferator-activated receptor gamma (r = -0

198 ver development by suppressing expression of peroxisome proliferator-activated receptor gamma 2 and l

199 ented the inflammatory response dependent on peroxisome proliferator-activated receptor gamma activit

200 N-terminal kinase inhibitor SP600125 and the peroxisome proliferator-activated receptor gamma agonist

201 lta-prostaglandin J2-dependent activation of peroxisome proliferator-activated receptor gamma and mac

202 ated protein 2 expression and suppression of peroxisome proliferator-activated receptor gamma and p27

203 s, including uncoupling protein 1 (Ucp1) and peroxisome proliferator-activated receptor gamma co-acti

204 Erk5 regulation of peroxisome proliferator-activated receptor gamma co-acti

205 Here we demonstrate that the coactivator peroxisome proliferator-activated receptor gamma coactiv

206 tably, the mitochondrial DNA copy number and peroxisome proliferator-activated receptor gamma coactiv

207 ouse, these UCP1(+) cells also expressed the peroxisome proliferator-activated receptor gamma coactiv

208 Peroxisome proliferator-activated receptor gamma coactiv

209 The transcriptional regulator peroxisome proliferator-activated receptor gamma coactiv

210 evels and the expression of four isoforms of peroxisome proliferator-activated receptor gamma coactiv

211 chondrial transcription factor A (TFAM), and peroxisome proliferator-activated receptor gamma coactiv

212 idrug resistance-associated protein 2 and 4, peroxisome proliferator-activated receptor gamma coactiv

213 ated the role of ERK1/2 on the expression of peroxisome proliferator-activated receptor gamma coactiv

214 uction and ATP levels, reduced expression of peroxisome proliferator-activated receptor gamma coactiv

215 ssion, potentially through the regulation of peroxisome proliferator-activated receptor gamma coactiv

216 nd ZR75.1 breast cancer cells, IGF-1 induces peroxisome proliferator-activated receptor gamma coactiv

217 Here we demonstrate, unexpectedly, that peroxisome proliferator-activated receptor gamma coactiv

218 Peroxisome proliferator-activated receptor gamma coactiv

219 gnature genes uncoupling protein (UCP)-1 and peroxisome proliferator-activated receptor gamma coactiv

220 but was independent of the activation of the peroxisome proliferator-activated receptor gamma coactiv

221 e Huh7, the coexpression of the coactivators peroxisome proliferator-activated receptor gamma coactiv

222 city are known to regulate and interact with peroxisome proliferator-activated receptor gamma coactiv

223 that fuses paired box gene 8 (PAX8) with the peroxisome proliferator-activated receptor gamma gene (P

224 nase 2, 15-deoxy Delta-prostaglandin J2, and peroxisome proliferator-activated receptor gamma in this

225 Finally, application of a specific peroxisome proliferator-activated receptor gamma inhibit

226 BPD that is not dependent on the decrease in peroxisome proliferator-activated receptor gamma levels.

227 c-Jun N-terminal kinase, thereby inhibiting peroxisome proliferator-activated receptor gamma through

228 Notably, I148M cells display reduced peroxisome proliferator-activated receptor gamma transcr

229 ing STAT3, STAT6, Kruppel-like factor 4, and peroxisome proliferator-activated receptor gamma, and ca

230 he mitochondrial transcriptional coactivator peroxisome proliferator-activated receptor gamma, coacti

231 nd import of the transcriptional coactivator peroxisome proliferator-activated receptor gamma-coactiv

232 e injections in rats were reported to induce peroxisome proliferator-activated receptor gamma-depende

233 gulating macrophage lipid metabolism through peroxisome proliferator-activated receptor gamma-depende

234 lta-prostaglandin J2-dependent activation of peroxisome proliferator-activated receptor gamma.

235 macologic inhibitors of cyclooxygenase 2 and peroxisome proliferator-activated receptor gamma.

236 fects thought to be due to activation of the peroxisome proliferator-activated receptor gamma.

237 adipogenic differentiation was mediated via peroxisome proliferator-activated receptor gamma.

238 phosphatases, and ameliorated activation of peroxisome proliferator-activated receptor gamma/sterol

239 Tfe3, control the regulator of adipogenesis, peroxisome proliferator-activated receptor gamma2 (Pparg

240 of inflammatory mediators and repression of peroxisome proliferator-activated receptor signaling and

241 n metabolic pathways, some linked to altered peroxisome proliferator-activated receptor signaling, mu

242 the first week due to failure to undergo the peroxisome proliferator-activated receptor signaling-dep

243 Activation of the PPAR (peroxisome proliferator-activated receptor)-fatty acid o

244 sepsis and to identify the mechanism whereby peroxisome proliferator-activated receptor-alpha confers

245 We sought to characterize the role of peroxisome proliferator-activated receptor-alpha in seps

246 Peroxisome proliferator-activated receptor-alpha is sign

247 gulation of nhr-49 (an ortholog of the human peroxisome proliferator-activated receptor-alpha), and a

248 These results suggest that altered peroxisome proliferator-activated receptor-alpha-mediate

249 Because peroxisome proliferator-activated receptor-beta/delta (P

250 elpar is a potent, selective agonist for the peroxisome proliferator-activated receptor-delta (PPAR-d

251 growth hormone secretagogue ibutamoren, the peroxisome proliferator-activated receptor-delta agonist

252 wk with rosiglitazone, a specific agonist of peroxisome proliferator-activated receptor-gamma (PPAR-g

253 the upregulation of the transcription factor peroxisome proliferator-activated receptor-gamma (PPAR-g

254 d patients with NAFLD, hepatic expression of peroxisome proliferator-activated receptor-gamma (PPARG)

255 13.1 treatment were associated with enhanced peroxisome proliferator-activated receptor-gamma (PPARga

256 Peroxisome proliferator-activated receptor-gamma (PPARga

257 but improvement of insulin resistance using peroxisome proliferator-activated receptor-gamma (PPARga

258 X receptors alpha and beta (LXRalpha,beta), peroxisome proliferator-activated receptor-gamma (PPARga

259 Furthermore, we show that peroxisome proliferator-activated receptor-gamma agonist

260 a healthy human (mini-)organ, and show that peroxisome proliferator-activated receptor-gamma agonist

261 Peroxisome proliferator-activated receptor-gamma agonist

262 ented and even partially reversed ex vivo by peroxisome proliferator-activated receptor-gamma agonist

263 In addition, the up-regulated peroxisome proliferator-activated receptor-gamma and -al

264 mediated by the transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactiv

265 cal exercise and thyroid hormone mediate the peroxisome proliferator-activated receptor-gamma coactiv

266 Thyroid hormone promotes expression of peroxisome proliferator-activated receptor-gamma coactiv

267 (-/-) OPCs with cholesterol or activation of peroxisome proliferator-activated receptor-gamma with pi

268 ease of a transferable factor able to induce peroxisome proliferator-activated receptor-gamma-mediate

269 roxynonenal) released from the heart trigger peroxisome proliferator-activated receptor-gamma-mediate

270 Peroxisome proliferator-activated receptors (PPARs) are

271 Peroxisome proliferator-activated receptors (PPARs) regu

272 Peroxisome proliferator-activated receptors (PPARs) regu

273 Bezafibrate (BEZ), a pan activator of peroxisome proliferator-activated receptors (PPARs), has

274 NRs for treating metabolic diseases are the peroxisome proliferator-activated receptors (PPARs), PPA

275 th 14 other nuclear receptors, including the peroxisome proliferator-activated receptors (PPARs).

276 et of hypoxia-inducible factor 1 (Hif-1) and peroxisome proliferator-activated receptors.

277 al LPS exposure led to pre-existing elevated peroxisome proliferators-activated receptor-gamma co-act

278 ssociated protein Pex11b failed to segregate peroxisomes properly and entered a mitotic delay that pe

279 e membrane protein with a regulatory role in peroxisome protein import.

280 ulate the hallmarks of PBDs, like absence of peroxisomes, reduced viability, neurodegeneration, mitoc

281 e alleles: pex1-2 and pex1-3pex1-2 displayed peroxisome-related defects accompanied by reduced PEX1 a

282 ort-incompetent, peroxisome-like structures (peroxisome remnants).

283 that biosynthesis of these chemicals in the peroxisomes results in significantly decreased accumulat

284 Finally, our data reveal subpopulations of peroxisomes showing only weak colocalization between PEX

285 , PEX14, and PEX11 around actively importing peroxisomes, showing distinct differences between these

286 defects, including the restoration of normal peroxisome size, suggesting that increasing peroxisome a

287 Of note, CD33 is the only Siglec with a peroxisome-targeting sequence, and this motif emerged by

288 Peroxisomal matrix proteins carry peroxisome-targeting signals that are recognized by one

289 hat VAP-ACBD5 complex acts as the primary ER-peroxisome tether.

290 that the msn2Deltamsn4Delta strain had fewer peroxisomes than the wild type, and lipid analysis indic

291 Importantly, LPS itself induced peroxisomes that correlated with the regulation of COX-2

292 ing the numbers and cellular distribution of peroxisomes through the cytoskeleton-peroxisome connecti

293 be compartmentalized into the matrix of the peroxisome to hijack the medium chain fatty acyl-CoA gen

294 This rapid and efficient translocation of peroxisomes to microtubule minus ends indicates that mam

295 We also demonstrate that tethering of peroxisomes to the ER is necessary for peroxisome growth

296 o organelles and observed rapid transport of peroxisomes to the perinuclear region of the cell.

297 that the mutant strain had greatly enlarged peroxisomes up to 10 mum in diameter.

298 xisomal membrane and indirect trafficking to peroxisomes via the endoplasmic reticulum (ER).

299 ncies caused by pex1-3 and that the enlarged peroxisomes visible in PEX1/pex1-3 may represent autopha

300 ssociating with core retromer and binding to peroxisomes, which then send the enzyme to LDs via tubul