ライフサイエンスコーパス: peroxisome biogenesis

1 two AAA-ATPases that play a crucial role in peroxisome biogenesis.

2 al membrane proteins, which are required for peroxisome biogenesis.

3 pastoris is characterized by a deficiency in peroxisome biogenesis.

4 or, one of at least 15 peroxins required for peroxisome biogenesis.

5 t PpPas2p is involved in the early stages of peroxisome biogenesis.

6 of Pex1/Pex6 and dynamin-related proteins in peroxisome biogenesis.

7 n are induced in oleate and coordinated with peroxisome biogenesis.

8 f the phosphoprotein ScPex11p coincides with peroxisome biogenesis.

9 ction, YCL056c, and Pex proteins involved in peroxisome biogenesis.

10 at indicate a defect in lipid metabolism and peroxisome biogenesis.

11 eins in addition to their canonical roles in peroxisome biogenesis.

12 tion is independent of its role at the ER in peroxisome biogenesis.

13 n of genes required for lipid metabolism and peroxisome biogenesis.

14 the requirements of early and late events of peroxisome biogenesis.

15 r peroxisome-induction conditions, impairing peroxisome biogenesis.

16 enetically defined as proteins necessary for peroxisome biogenesis.

17 ional assays to identify genes with roles in peroxisome biogenesis.

18 g peroxisomal proteins and genes involved in peroxisome biogenesis.

19 61-related gene, SSH1, also has no effect on peroxisome biogenesis.

20 hat loss of Sec61p activity has no effect on peroxisome biogenesis.

21 respiratory deficiency dramatically induces peroxisome biogenesis.

22 more than 20 PEX genes that are required for peroxisome biogenesis.

23 roxisomes and does not inhibit PEX3-mediated peroxisome biogenesis.

24 PBD cell lines are shaping current models of peroxisome biogenesis.

25 a peroxisomal protein (peroxin) involved in peroxisome biogenesis.

26 l enzyme abnormalities as well as defects of peroxisome biogenesis.

27 hat Pex4p and Pex22p act at the same step in peroxisome biogenesis.

28 g that Pex19p functions at an early stage of peroxisome biogenesis.

29 vel and implies a role for these vesicles in peroxisome biogenesis.

30 chloroplast biogenesis, SP1 plays a role in peroxisome biogenesis.

31 f genes required for glycerol metabolism and peroxisome biogenesis.

32 in growth on fatty acids, one is involved in peroxisome biogenesis and at least two are required for

33 drome, and with car1, a protein required for peroxisome biogenesis and caryogamy in the filamentous f

34 ion of the PEX12 transcript exhibit impaired peroxisome biogenesis and function, inhibition of plant

35 Both are implicated in genetic disorders of peroxisome biogenesis and function.

36 glycerol metabolism, and genes required for peroxisome biogenesis and function.

37 In this review we focus on the genetics of peroxisome biogenesis and on how defects in this process

38 disorder characterized by severe defects in peroxisome biogenesis and peroxisomal protein import.

39 psis thaliana) PEX12 protein is required for peroxisome biogenesis and plays an essential role throug

40 epithelial cell differentiation upregulates peroxisome biogenesis and promotes robust type III inter

41 ta demonstrate an important role for PEX1 in peroxisome biogenesis and suggest that mutations in this

42 PEX6 form a complex of central importance to peroxisome biogenesis and that mutations affecting this

43 In the absence of both proteins, peroxisome biogenesis and the intra-ER sorting of Pex2 a

44 In humans, defects in peroxisome biogenesis are the cause of lethal diseases t

45 s a protein required for the early stages of peroxisome biogenesis, but its precise function and site

46 (RCDP) is an autosomal recessive disease of peroxisome biogenesis characterized by deficiencies in s

47 sicle coat-assembly, centrosomes, autophagy, peroxisome biogenesis, cytoskeleton, ribosome maturation

48 pared to wild-type PEX6 c.2578C results in a peroxisome biogenesis defect and thus constitutes the ca

49 In peroxisome biogenesis-defective (pex) mutants of the yea

50 wo novel schemes for the direct selection of peroxisome-biogenesis-defective (pex) mutants of the met

51 PEX7 mutations cause the peroxisome biogenesis disorder (PBD) rhizomelic chondrod

52 odysplasia punctata (RCDP), a severe, lethal peroxisome biogenesis disorder characterized by aberrant

53 3 or [1-14C]22:5n-3 to DHA as did cells from peroxisome biogenesis disorder patients comprising eight

54 at comprises complementation group 11 of the peroxisome biogenesis disorders (PBD).

55 The peroxisome biogenesis disorders (PBDs) are a group of ge

56 The peroxisome biogenesis disorders (PBDs) are a group of le

57 defects in peroxisome assembly result in the peroxisome biogenesis disorders (PBDs), a group of genet

58 l matrix proteins and are referred to as the peroxisome biogenesis disorders (PBDs).

59 s in a group of neurological diseases termed peroxisome biogenesis disorders (PBDs).

60 sponsible for complementation group 8 of the peroxisome biogenesis disorders and showed that it encod

61 for the majority of the most severe forms of peroxisome biogenesis disorders in humans.

62 utations in PEX5 or 12 other PEX genes cause peroxisome biogenesis disorders, collectively named the

63 e our understanding of the etiology of human peroxisome biogenesis disorders.

64 the most commonly affected peroxin in human peroxisome biogenesis disorders.

65 The peroxisome-biogenesis disorders (PBDs) are a genetically

66 The peroxisome-biogenesis disorders (PBDs) are a group of ge

67 The peroxisome-biogenesis disorders (PBDs) are a set of ofte

68 causes of a spectrum of autosomal-recessive peroxisome-biogenesis disorders (PBDs), including Zellwe

69 cking protein for other proteins that affect peroxisome biogenesis, division, and segregation.

70 sive disorders that are caused by defects in peroxisome biogenesis due to bi-allelic mutations in any

71 ons, including membrane fusion, proteolysis, peroxisome biogenesis, endosome sorting and meiotic spin

72 on between PpPex1p and PpPex6p in regulating peroxisome biogenesis events.

73 Seed 1 (SSE1) gene encodes a homolog of the peroxisome biogenesis factor Pex16p, and a loss-of-funct

74 Inactivation of the peroxisome biogenesis gene PEX10 was crucial in obtainin

75 mutants, we isolated a viable allele of the peroxisome biogenesis gene PEX13 with striking peroxisom

76 this report we demonstrate the induction of peroxisome biogenesis genes in both plant and animal cel

77 tor, Mxr1 activates methanol utilization and peroxisome biogenesis genes in the methylotrophic yeast,

78 The molecular mechanisms of peroxisome biogenesis have begun to emerge; in contrast,

79 s involved in peroxisomal protein import and peroxisome biogenesis) have become clearer.

80 During de novo peroxisome biogenesis, importomer complex proteins sort

81 Their expression also restores peroxisome biogenesis in cells that are deficient in the

82 lipids, the trafficking of cholesterol, and peroxisome biogenesis in mammalian cells.

83 s occurs via a process that is homologous to peroxisome biogenesis in other eukaryotes.

84 cytosolic location, PEX26- delta ex5 rescues peroxisome biogenesis in PEX26-deficient cells as effici

85 EX26-Mito retains the full ability to rescue peroxisome biogenesis in PEX26-deficient cells.

86 We have cloned PEX15 which is required for peroxisome biogenesis in Saccharomyces cerevisiae.

87 es the progress made in our understanding of peroxisome biogenesis in the last few years, during whic

88 rt the cloning of PER6, a gene essential for peroxisome biogenesis in the methylotrophic yeast Pichia

89 amily, PpPex1p and PpPex6p, are required for peroxisome biogenesis in the yeast Pichia pastoris.

90 ral membrane peroxins (proteins required for peroxisome biogenesis) in Saccharomyces cerevisiae, Pex2

91 Refsum disease, and five of the disorders of peroxisome biogenesis, including rhizomelic chondrodyspl

92 d growth on oleic acid, but had no effect on peroxisome biogenesis, indicating a role for YLR284C in

93 which the model can be used to conclude that peroxisome biogenesis is dominated by de novo production

94 which the model can be used to conclude that peroxisome biogenesis is dominated by de novo production

95 This may sound familiar, but in fact, peroxisome biogenesis is proving to be surprisingly uniq

96 udy of phosphatases and kinases required for peroxisome biogenesis is the first genome-wide analysis

97 of peroxisomal matrix proteins, crucial for peroxisome biogenesis, is mediated by the cytosolic rece

98 our studies reveal a novel role for Lrp1 in peroxisome biogenesis, lipid homeostasis, and OPC differ

99 , none are known, leading us to propose that peroxisome biogenesis may not require protein import int

100 Peb1 is a peroxisome biogenesis mutant isolated in Saccharomyces c

101 nce increases considerably in the Deltapex14 peroxisome biogenesis mutant.

102 f the approximately 20 proteins required for peroxisome biogenesis, only four have been implicated in

103 Among peroxins involved in peroxisome biogenesis, only Pex8p is predominantly intra

104 Several peroxisome biogenesis PEROXIN (PEX) genes encode protein

105 nol pathway enzymes and proteins involved in peroxisome biogenesis (PEX proteins) are induced in resp

106 A recent model for peroxisome biogenesis postulates that peroxisomes form d

107 Mutations in peroxisome biogenesis proteins (peroxins) can lead to de

108 e anomalies associated with the disorders of peroxisome biogenesis remains unknown.

109 In yeast and mammals, various steps in peroxisome biogenesis require the function of peroxin (P

110 Peroxisome biogenesis requires that proteins be transpor

111 ic reticulum (ER) plays an important role in peroxisome biogenesis; some peroxisomal membrane protein

112 me fission factors, leading us to infer that peroxisome biogenesis switches from de novo synthesis to

113 elated yeast peroxins (proteins required for peroxisome biogenesis) that are partially redundant in f

114 proteins (mostly peroxins) are required for peroxisome biogenesis, the role of only a few of these h

115 sing on transcriptional networks that induce peroxisomes biogenesis, the model-guided experiments all

116 s of evidence support a function for SSE1 in peroxisome biogenesis: the peroxisomal localization of a

117 has permitted categorization of disorders of peroxisome biogenesis, their molecular basis and mutatio