ライフサイエンスコーパス: peroxy

1 es may proceed through the generation of a 6-peroxy-2,4-cyclohexadienone intermediate.

2 ctivated human phagocytes converted 17-hydro(peroxy)-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid to th

3 red formation of 5-H(p)ETE (5-hydroxy- and 5-peroxy-6-trans-8,11,14-cis-eicosatetraenoic acid) by the

4 ter plates with two species of oxidized A2E, peroxy-A2E, and furano-A2E, followed by incubation with

5 d in serum incubated in wells precoated with peroxy-A2E, the lipofuscin pigment all-trans-retinal dim

6 (OVOCs) in the atmosphere are precursors to peroxy acetyl nitrate (PAN), affect the tropospheric ozo

7 2O2 was observed for all investigated linear peroxy acids but not for carboxylic acids and could ther

8 the ionization and fragmentation behavior of peroxy acids in mass spectrometers.

9 step toward unambiguous characterization of peroxy acids in the atmosphere.

10 ds, the identification and quantification of peroxy acids is often highly uncertain.

11 Peroxy acids might play a significant role in particle t

12 The MS/MS spectra of the peroxy acids showed fragmentation patterns clearly diffe

13 The peroxy acids were separated using liquid chromatography,

14 ir fragmentation patterns, we synthesized 12 peroxy acids with C8 to C10 carbon backbones and mono- o

15 lpha,beta-unsaturated acids, tertiary acids, peroxy acids, esters, ketones, and alpha,beta-unsaturate

16 ould therefore serve as a diagnostic ion for peroxy acids.

17 ntermediate compound P (P), presumed to be a peroxy adduct.

18 mechanisms for flavin oxidation in which C4a-peroxy and -hydroperoxy flavin intermediates accumulate

19 ) = 790 cm(-1) transition (P-->F, where P is peroxy and F is ferryl) is triggered not only by electro

20 des unequivocal evidence for the presence of peroxy and ferryl species during dioxygen reduction by c

21 d observations of NO(3), N(2)O(5), nighttime peroxy and OH radicals, and related compounds.

22 oxidase and generate the well-characterized "peroxy" and "ferryl" forms.

23 ts, the subsequent reactions of alkyl, alkyl peroxy, and alkoxy radical intermediates, and the compos

24 tates that are tentatively assigned as C(4a)-peroxy- and C(4a)-hydroperoxyflavin intermediates and th

25 istidine during the initial formation of the peroxy anion/heme iron complex is not simply base cataly

26 owed by treatment with an aqueous mixture of peroxy anions buffered at pH 9.6.

27 of water that has been proposed to assist in peroxy bond cleavage.

28 her intermediate followed by cleavage of the peroxy bond to form two ester molecules, releasing stoic

29 of enzymes with equivalent mu-eta(2):eta(2) peroxy bridged coupled binuclear copper active sites.

30 between PCA and O(2) in the formation of the peroxy-bridged ESO2 intermediate.

31 sign, synthesis, and in vivo applications of Peroxy Caged Luciferin-1 (PCL-1), a chemoselective biolu

32 o establish this approach, we have developed Peroxy Caged Luciferin-2 (PCL-2), a H(2)O(2)-responsive

33 Here we report Peroxy-Caged-[(18)F]Fluorodeoxy thymidine-1 (PC-FLT-1),

34 at pH >/= 6.0, spontaneous decomposition of peroxy carboxylic acids, generated from H(2)O(2) and org

35 dium, and (2) reacting with H(2)O(2) to form peroxy carboxylic acids, which are extremely strong oxid

36 Ultraviolet light (UV) combined with peroxy chemicals, such as H2O2 and peroxydisulfate (PDS)

37 f atmospheric reactions that proceed through peroxy complexes.

38 Many peroxy-containing secondary metabolites have been isolat

39 Bimolecular peroxy decomposition is promoted by the red-light or nea

40 age 12-lipoxygenase (hm12-LOX) gave 14-hydro(peroxy)-docosahexaenoic acid (14-HpDHA), as well as seve

41 , and nuclear H2O2, as measured with nuclear peroxy emerald 1 (NucPE1).

42 Peroxy-fatty acids such as 13-hydroperoxydodecanoeic aci

43 ation of the previously characterized 1,2-mu peroxy Fe(III)Fe(III) (P) intermediate to a 1,1-mu hydro

44 3HB complex reacts with oxygen to form a C4a-peroxy flavin with a rate constant of 1.13 +/- 0.01 x 10

45 Tyr(71) , along with nearby Glu(70) and a peroxy flavin, facilitates a keto-enol transition of the

46 ated with the absence of any detectable C4a-(peroxy)flavin formation in stopped-flow kinetic studies.

47 The resulting SNAP-Peroxy-Green (SNAP-PG) probes consist of appropriately d

48 The simulation indicates a prevalence of peroxy groups, with hydroxyl and ether groups being the

49 rp] dioxygenase complexes generates a ferric peroxy heme species with very similar EPR and (1)H ENDOR

50 through a dynamic kinetic resolution of the peroxy hemiacetal intermediate.

51 e nighttime production and cycling of OH and peroxy (HO(2) + RO(2)) radicals.

52 Peroxy (HO2 and RO2) radicals are important intermediate

53 reaction with dioxygen to form the so-called peroxy intermediate (compound P).

54 sequential two-electron steps generating the peroxy intermediate (PI) and the native intermediate (NI

55 e premature O-O bond cleavage, such that the peroxy intermediate can perform a nucleophilic addition

56 ecause of the amidine methyl group, the heme peroxy intermediate cannot be protonated, thereby preven

57 laboratory have indicated that the putative peroxy intermediate formed during the reduction of dioxy

58 acts with oxygen to form a flavin-C4a-(hydro)peroxy intermediate, which we show has a maximum absorba

59 th the proximal oxygen of the catalytic iron-peroxy intermediate, yielding efficient production of de

60 ical role in determining the fate of the key peroxy intermediate.

61 d created by rearrangement of the postulated peroxy intermediate.

62 The "peroxy" intermediate (P form) of bovine cytochrome c oxi

63 me oxidase have indicated that the putative "peroxy" intermediate in the catalytic cycle (P(R)) is a

64 absence of any external electron donor, the "peroxy" intermediate of cytochrome c oxidase (CcO-607) i

65 s also possible that breakdown of a putative peroxy-intermediate controlled TPQ formation.

66 ry study of the structures and energetics of peroxy intermediates arising from reaction of nitrosamin

67 only provides the first direct detection of peroxy intermediates in cofactor biogenesis but also ind

68 p, presumably arising from the reaction of a peroxy-iron species with the aldehyde to give a peroxyhe

69 Over 20 new, cyclic, peroxy ketals have been prepared via a two-step protocol

70 prior to DNA cleavage is a low spin Fe(III) peroxy level species, termed activated bleomycin (ABLM).

71 OR spectra in which protonation of the basic peroxy ligand does not occur at 77 K.

72 , properties, and biological applications of Peroxy Lucifer 1 (PL1), a new fluorescent probe for imag

73 rates support the radical formation of alpha-peroxy malononitrile species, which can cyclize to dioxi

74 iological and medicinal chemistry studies of peroxy natural products.

75 We investigate the formation of hydroxy peroxy nitrites (ROONO) and nitrates (RONO(2)) from the

76 ith a hydrogen peroxide (H2O2)-specific dye, peroxy orange 1 (PO1), and nuclear H2O2, as measured wit

77 ing one of the new H(2)O(2)-specific probes, Peroxy Orange 1 (PO1), in conjunction with the green-flu

78 tretching modes at 790 and 804 cm(-1) at the peroxy oxidation level (PM).

79 The redox states of the "peroxy" (P) and "ferryl" (F) intermediates formed during

80 In this scheme, the presence of the "peroxy" ("P") intermediate does not build up a sufficien

81 h is believed to be formed directly from the peroxy precursor and not via elimination of superoxide.

82 irst step of the mechanism is formation of a peroxy-pterin species, which subsequently reacts with th

83 the second-generation dihydroxy hydroperoxy peroxy radical (C5H11O6.) must undergo an intramolecular

84 icture of a formation mechanism advancing by peroxy radical (RO2) isomerization through intramolecula

85 cations and strand break densities caused by peroxy radical (ROO*) oxidation were measured by glyoxal

86 ize the electronic excitations of the phenyl peroxy radical as well as other hydrocarbon substituted

87 In this work, the peroxy radical chemical amplification (PERCA) method was

88 Laboratory characterizations of the peroxy radical chemical ionization mass spectrometer (Pe

89 In this review, laboratory studies of this peroxy radical chemistry are detailed, as they pertain t

90 The peroxy radical concentration was obtained from the ampli

91 t of CAPS baseline offsets on the calculated peroxy radical concentrations.

92 experimental work has shown that the phenyl peroxy radical exhibits a transition in the visible regi

93 Gas-phase autoxidation-regenerative peroxy radical formation following intramolecular hydrog

94 , only one isomeric pathway via the bicyclic peroxy radical is accessible to lead to ring cleavage.

95 In this regime, beta hydroxy peroxy radical isomers comprise approximately 95% of the

96 H-shift isomerization of the Z-delta hydroxy peroxy radical isomers produced from OH addition to C4 i

97 In addition, the Z-delta hydroxy peroxy radical isomers undergo unimolecular 1,6 H-shift

98 or beta to the OH group forming six distinct peroxy radical isomers.

99 difference in the relative stability of the peroxy radical isomers.

100 The peroxy radical mixing ratio is determined by the differe

101 8-oxo-dG by HPLC/electrochemical analysis of peroxy radical oxidation of dG, suggesting that the G --

102 ISOP(OOH)2(C5H12O6), a major product of the peroxy radical reacting with HO2.

103 tion of DNA exposed to micromolar amounts of peroxy radical resulted in a 30-fold increase in mutatio

104 The peroxy radical substituent is also compared against isoe

105 TDDFT calculations of the phenyl peroxy radical support an excitation in the visible spec

106 d in Escherichia coli upon transfection with peroxy radical treated DNA carrying the lacZ alpha gene

107 Electrophoretic analysis of peroxy radical treated DNA exposed to NaOH, Nth, and Fpg

108 + oxidizes a peroxide to yield an initiating peroxy radical.

109 ts, such as ozone (O3) and hydroxyl (OH) and peroxy radicals (HO2 + RO2), determines the lifetimes of

110 Peroxy radicals (HO2 and RO2) within this air are detect

111 rument for the quantification of atmospheric peroxy radicals (HO2, CH3O2, C2H5O2, etc.) using the che

112 OH) and molecular oxygen to produce isoprene peroxy radicals (ISOPOO).

113 Organic peroxy radicals (often abbreviated RO(2)) play a central

114 rce of reactive species such as hydroxyl and peroxy radicals (OH and HO2, "HOx") indoors.

115 The reaction of hydroxy peroxy radicals (RO(2)) with NO represents one of the mo

116 In HO2-dominant experiments, organic peroxy radicals (RO2) primarily react with HO2.

117 stigate the rate of autoxidation for organic peroxy radicals (RO2) produced in the oxidation of a pro

118 Hydroxy, alkoxy, and peroxy radicals all have the potential to react with DNA

119 by an increase in the level of intracellular peroxy radicals and lipid peroxidation products, two ind

120 ttachment/detachment density diagrams of the peroxy radicals and present a qualitative picture of the

121 between intramolecular hydrogen migration of peroxy radicals and their bimolecular termination reacti

122 ns are unaffected by formation of stabilized peroxy radicals and to estimate atmospheric pressure yie

123 ation and bimolecular reactions with organic peroxy radicals are also possible.

124 the case of reaction with oxygen, persistent peroxy radicals are formed in high yield.

125 Peroxy radicals are mixed with high concentrations of NO

126 calibration method: peroxyacetyl and methyl peroxy radicals are produced by the photolysis of aceton

127 Aromatic peroxy radicals arising from initial OH and subsequent O

128 Dimerization of the peroxy radicals by recombination and cross-combination r

129 venging of reactive oxygen species and lipid peroxy radicals by tocopherols can result in the formati

130 find that the ratio of delta to beta hydroxy peroxy radicals depends on their bimolecular lifetime (t

131 The chemistry of peroxy radicals derived from limonene upon addition of o

132 Without this rearrangement, peroxy radicals derived from MTbuK and DTbuK cannot unde

133 d kinetic model results suggest that organic peroxy radicals formed by alpha-pinene reacting with sec

134 f the atmospheric fate of the entire pool of peroxy radicals formed via addition of OH at C4 for typi

135 ief discussion of methods used to detect the peroxy radicals in the laboratory is presented.

136 ility of the allylic radical, however, these peroxy radicals lose O2 in competition with bimolecular

137 accurate evaluation of the concentration of peroxy radicals over a variety of atmospheric conditions

138 measurements of the reaction products of the peroxy radicals to diagnose this complex chemistry.

139 In the amplification channel, the peroxy radicals were converted in an excess amount of NO

140 ation of 1-alkenylperoxy radicals, which are peroxy radicals where the OO moiety is bonded to an sp2-

141 > 10 s, the distribution of isoprene hydroxy peroxy radicals will be controlled primarily by the diff

142 e sensitivities of the instrument to organic peroxy radicals with different hydrocarbon groups.

143 u, and sensitive measurements of atmospheric peroxy radicals with fast time response.

144 ently inside the particle by the reaction of peroxy radicals with SO2.

145 In particular, the reaction of organic peroxy radicals with the HO2 radical and the H2 OHO2 rad

146 PerCIMS provides measurements of the sum of peroxy radicals, HO2 + RO2 (HOxROx mode), or the HO2 com

147 ng the formation of both carbon-centered and peroxy radicals.

148 er rates than O(2) addition to form bicyclic peroxy radicals.

149 ssignment of electronic transitions in alkyl peroxy radicals.

150 cal as well as other hydrocarbon substituted peroxy radicals.

151 ibiting the lateral propagation of the lipid peroxy radicals.

152 (NOx) (NMOG:NOx), which affects the fate of peroxy radicals.

153 formed via decomposition of the beta hydroxy peroxy radicals.

154 l instrument for measurements of atmospheric peroxy radicals.

155 It decays to a 1:6 mixture of peroxy species (a3(3+)-O(-)-O-) in which cytochrome a is

156 favors protonation of a cryogenerated ferric peroxy species at 77 K.

157 The peroxy species decay to a ferryl intermediate, with a pe

158 nor in most hydroxylation reactions, an iron-peroxy species is apparently involved in the deformylati

159 presence of a uniquely stable Fe---O---O(H) peroxy species is not detected.

160 tificial oxidants, we conclude that the iron-peroxy species is the direct oxygen donor.

161 lear center which is substantially in the P (peroxy) state, not the well-characterized F (oxyferryl)

162 The initially formed peroxy-type adduct (RO(2)) is found to evolve in a compl

163 Mitochondria peroxy yellow 1 (MitoPY1) is a small-molecule fluorescen

164 and biological applications of mitochondria peroxy yellow 1 (MitoPY1), a new type of bifunctional fl

165 Molecular imaging with Peroxy Yellow 1 Methyl-Ester (PY1-ME), a new chemoselect

166 duction was assayed in arterioles using mito peroxy yellow 1.