ライフサイエンスコーパス: peroxyl

1 alpha-Tocopherol acts as a peroxyl and alkoxyl radical scavenger in lipid environme

2 n of supercoiled DNA strand from scission by peroxyl and hydroxyl radicals into the nicked circular f

3 A strand breakage inhibition induced by both peroxyl and hydroxyl radicals.

4 is(3-ethylbenzothiazoline-6-sulphonic acid), peroxyl and NO radicals as well as inhibition of low den

5 n inactivation of PFL revealed protein-based peroxyl and sulfinyl radicals during the manual mixing a

6 Peroxyl and superoxide RSAs of 96.8% and 88.6% were noti

7 ties: (i) radical scavenging activity toward peroxyl and toward ABTS radical (chain-breaking activity

8 y re-addition of oxygen to form the 11-HPETE peroxyl, and they exclude a mechanism proceeding through

9 adical scavenging assays: DPPH, hydroxyl and peroxyl; and Ferrous Ion-chelating Ability Assay).

10 sses of enzymes form quasi-stable C4a-(hydro)peroxyl FAD intermediates.

11 When challenged by hydroxyl or peroxyl free radicals or Abeta(1-42), oxidative stress a

12 lene groups adjoining the carbon bearing the peroxyl group and the protoporphyrin IX.

13 yme 12/15-lipoxygenase (12/15-LO) introduces peroxyl groups in a position-specific manner into unsatu

14 eterolytic bond dissociation energies of the peroxyl groups of small peroxides indicated that they ar

15 hese cross-molecular reactions of fatty acid peroxyls have also important implications for understand

16 ificantly higher TPC, total isoflavones, and peroxyl, hydroxyl, and ABTS(+) radical scavenging abilit

17 ggest that PGG2 binds the POX site through a peroxyl-iron bond, a hydrogen bond with His-207 and van

18 xyl (k approximately 1 x 10(9) M(-1) s(-1)), peroxyl (k approximately 2 x 10(6) M(-1) s(-1)), and thi

19 cals consume molecular oxygen forming either peroxyl or superoxide anion radicals.

20 d free radical scavenging activities against peroxyl (ORAC) and 2,2-diphenyl-1-picrylhydrazyl radical

21 1,1-Diphenyl-2-picryl-hydrazyl (DPPH-RS), peroxyl (PRS), and hydroxyl radical scavenging (HRS) and

22 The major reaction pathways for the peroxyl radical (1) derived from 5,6-dihydro-2'-deoxyuri

23 olecular hydrogen atom abstraction by the C6-peroxyl radical (14) and suggests that gamma-radiolysis

24 Under aerobic conditions, the peroxyl radical (2) derived from 1 reacts approximately

25 The reaction of the allyl group with a peroxyl radical (C-H hydrogen abstraction) proceeds with

26 we have clearly identified the generation of peroxyl radical (ROO(*)) by the unmodified SWCNT and the

27 spectrum that we assign to the alpha-carbon peroxyl radical (ROO*) of the active-site glycine, G734.

28 turated fatty acids such as oxygen addition, peroxyl radical 5-exo cyclization, and S(H)i carbon radi

29 at lycopene, alpha-tocopherol, selenium, and peroxyl radical absorption capacity are unlikely to be a

30 or lycopene, alpha-tocopherol, selenium, and peroxyl radical absorption capacity.

31 n, lycopene, alpha-tocopherol, selenium, and peroxyl radical absorption capacity.

32 Products that arise from peroxyl radical abstraction at each position of the vari

33 Kinetic studies revealed that peroxyl radical addition to the 5'-thymine was favored b

34 al products and provided direct evidence for peroxyl radical addition to the adjacent thymine bases.

35 chemically activated population of the major peroxyl radical adduct (*)O2CH2CH(OH)2 is predicted to u

36 ins with a hydrogen atom transfer, forming a peroxyl radical and a Compound II-like species.

37 imolecular beta-fragmentation (k(beta)) of a peroxyl radical and its bimolecular reaction with a hydr

38 ed by H-bond formation between the attacking peroxyl radical and the 3beta-OH.

39 e results also support the proposal that the peroxyl radical and the sulfinyl radical are intermediat

40 leads to accumulation of a substrate-derived peroxyl radical as a result of off-pathway trapping of t

41 ls at tyrosine and tryptophan residues and a peroxyl radical at an unknown location have been reporte

42 the energetic cost required to reorient the peroxyl radical at the rate-determining step.

43 We suggest that peroxyl radical beta-scission depends on solvent polarit

44 The peroxyl radical can serve as the seed for the production

45 This peroxyl radical clock methodology has been successfully

46 yrylperacetate as a precursor to a versatile peroxyl radical clock with the present paper, wherein we

47 benzene, as determined by a newly developed peroxyl radical clock.

48 A series of peroxyl radical clocks has been developed and calibrated

49 Recently described peroxyl radical clocks offer a simple, convenient, and i

50 base modifications induced as a function of peroxyl radical concentration was determined by quantita

51 ased in a log linear fashion with respect to peroxyl radical concentration.

52 pproximately 10(6) s(-1)) of the bis-allylic peroxyl radical decreased on going from the cis,cis to t

53 ition of the adjacent 2'-deoxyuridine by the peroxyl radical derived from 1 (3) is observed under aer

54 andem lesions resulting from addition of the peroxyl radical derived from 1 to the 5'-adjacent nucleo

55 hydrogen atom abstraction by an intermediate peroxyl radical derived from linoleic acid that leads to

56 ation involving beta-fragmentation of the 15-peroxyl radical followed by re-addition of oxygen to for

57 Peroxyl radical formation was not prevented by site-dire

58 contrast, mutation of tryptophan 14 prevents peroxyl radical formation, implicating tryptophan 14 as

59 histidinyl radical consumed oxygen, implying peroxyl radical formation.

60 ine flanks drastically reduced the extent of peroxyl radical G oxidation.

61 xidation system (ascorbate/Fe(II)/H2O2) or a peroxyl radical generating system, 2,2'-azobis(2-amidino

62 zobis-2,4-dimethyl valeronitrile (AMVN) as a peroxyl radical generator, and 6-hydroxy-2, 5,7,8-tetram

63 s-2-amidinopropane hydrochloride (AAPH) as a peroxyl radical generator; 6-hydroxy-2,5,7, 8-tetramethy

64 The minor peroxyl radical HOCH2C(OO(*))HOH is even less stable and

65 Reorientation of the peroxyl radical in the active site, concomitant with the

66 The sequence-specific distribution of peroxyl radical induced base damage was mapped for 803 n

67 Peroxyl radical induced tandem mutations were also obser

68 C-9 and C-11 of AA so that the incipient 11-peroxyl radical intermediate is able to add to C-9 to fo

69 [bond]oxygen bond dissociation enthalpies of peroxyl radical intermediates (R[bond]OO*) have been cal

70 cate that reactions of .NO with lipoxygenase peroxyl radical intermediates will result in modulation

71 t/KM(16,16O2)/kcat/KM(18,16O2) reveal that a peroxyl radical is formed in or before the first kinetic

72 The peroxyl radical is shown here to be localized on tryptop

73 the reduced catalytic tyrosine to a terminal peroxyl radical is the first irreversible step that cont

74 chanism starts with a 4-exo cyclization of a peroxyl radical leading to an intermediate dioxetane, a

75 dical in the active enzyme and the resulting peroxyl radical may react further with the sulfhydryl gr

76 esis and carcinogenesis, the contribution of peroxyl radical mediated DNA base damage is less well un

77 ngly suggests that H atom abstraction by the peroxyl radical occurs with substantial quantum mechanic

78 This new radical could be either a peroxyl radical of BH(4) or an amino acid radical was in

79 al oxidations depends on the position of the peroxyl radical on the 18-carbon chain.

80 a hydroperoxide activator and the incipient peroxyl radical oxidizes Tyr385, or (2) ferric enzyme re

81 uminate the physiological relevance of lipid peroxyl radical production during cell homeostasis and d

82 luorescence assay for monitoring kinetics of peroxyl radical reactions in liposomes is subsequently d

83 cular oxygen addition, and a factor of 5 for peroxyl radical reactions.

84 Reducing power (RP), DPPH and peroxyl radical scavenging (PRS) evaluated indirect anti

85 Employing this method, the relative peroxyl radical scavenging activities of Trolox, alpha-t

86 tribution of epigallocatechin gallate in the peroxyl radical scavenging of green tea extracts.

87 eroxidation products to perflubron or by the peroxyl radical scavenging properties of perflubron.

88 ioxidants, is shown herein to exhibit potent peroxyl radical scavenging properties that are controlle

89 droxyl radical scavenging, 279.02 mug mL(-1) Peroxyl radical scavenging).

90 epoxyallylic radical, giving an epoxyallylic peroxyl radical that does not further react with Fe(III)

91 alkoxyamine that subsequently reacts with a peroxyl radical to eventually re-form the nitroxide.

92 substituents on the rearrangement of the C-3 peroxyl radical to give conjugated diene products.

93 cid-catalyzed reaction of a nitroxide with a peroxyl radical to yield an oxoammonium ion followed by

94 l has more than an order of magnitude better peroxyl radical trapping activity than alpha-tocopherol

95 Plasma total peroxyl radical trapping potential values did not change

96 ycopene and vitamin concentrations and total peroxyl radical trapping potential, a measure of antioxi

97 In the first mechanism, a peroxyl radical undergoes successive 5-exo cyclizations

98 PFL was mixed with oxygenated solution, the peroxyl radical was also observed at 10 ms but in this c

99 ng from C1'-hydrogen atom abstraction by the peroxyl radical, could not be detected.

100 irreversible step, subsequent to forming the peroxyl radical, is also discussed in the context of the

101 due to reaction with the enzyme-bound lipid peroxyl radical, rather than impairment of (13S)-HPODE-d

102 PPH and ABTS), reactive oxygen species (ROS; peroxyl radical, superoxide radical, hypochlorous acid),

103 l radical yields a strand break containing a peroxyl radical, which initiates opposite strand cleavag

104 gen atom and the internal oxygen atom of the peroxyl radical, which is nominally better for the more

105 cells, fibroblasts and lymphocytes) against peroxyl radical-induced apoptosis, necrosis and mitotic

106 ay, which measures antioxidant inhibition of peroxyl radical-induced oxidations and is a measure of t

107 Furthermore, since the assay has a Q(10) for peroxyl radical-scavenging of about 3, elevation of the

108 of H(2)B-PMHC consistent with unprecedented peroxyl radical-trapping activity in lipid bilayers.

109 results support formation of a transient SOD-peroxyl radical.

110 al (g = 2.034, 2.007) is characteristic of a peroxyl radical.

111 ed selectively by the 5S-diastereomer of the peroxyl radical.

112 ne results in the accumulation of the carbon peroxyl radical.

113 formed after abstraction of H-9 or H-14 by a peroxyl radical.

114 umn fractions permitted the determination of peroxyl-radical-scavenging profiles, demonstrating the r

115 established rate constants for reaction with peroxyl radicals (k(H-tocopherol) = 3.5 x 10(6) M(-1) s(

116 eaction between nitric oxide (*NO) and lipid peroxyl radicals (LOO*) has been proposed to account for

117 the transformation, that only the 12- and 8-peroxyl radicals (those leading to 12-HPETE and 8-HPETE)

118 Here, the reaction between linoleate peroxyl radicals and *NO was examined using 2, 2'-azobis

119 with more lipophilic compounds trapping two peroxyl radicals and more hydrophilic compounds trapping

120 own to undergo an irreversible reaction with peroxyl radicals and other radical oxidants to generate

121 romise between H-atom transfer reactivity to peroxyl radicals and stability to one-electron oxidation

122 romise between H-atom transfer reactivity to peroxyl radicals and stability to one-electron oxidation

123 he ability of NO to react with lipid-derived peroxyl radicals and terminate the propagation of lipid

124 e short-lived organic species are similar to peroxyl radicals appears most consistent with our experi

125 The reactions of peroxyl radicals are at the center of the oxidative degr

126 Gas phase peroxyl radicals are central to our chemical understandi

127 (5) Lipophilic peroxyl radicals are scavenged with the same efficiency

128 Nucleobase peroxyl radicals are the major reactive intermediates fo

129 r substitutes since they often do not employ peroxyl radicals as the oxidant and do not account for b

130 from the liposome oxidations that linoleate peroxyl radicals at different positions on the eighteen-

131 inary work, we showed that TEMPO reacts with peroxyl radicals at diffusion-controlled rates in the pr

132 der these conditions wastage reactions among peroxyl radicals become important, and this translates i

133 t of cells with scavengers of superoxide and peroxyl radicals blocked adriamycin-induced oxidation of

134 The quenching of peroxyl radicals by ortho-(alkyltelluro)phenols occurs b

135 By changing the [O2]/[I] ratio, we show that peroxyl radicals can be detected and quantified preferen

136 iterature data for reactions of phenols with peroxyl radicals clearly reveals that diarylamines have

137 xidation, and the carbon[bond]oxygen BDEs of peroxyl radicals correlate with rate constants for beta-

138 measurements of the reactions of RSeOH with peroxyl radicals demonstrate that it readily undergoes H

139 e modifications at guanines and cytosines by peroxyl radicals depends on the exact specification of 5

140 -classical" RTA activity, where they trap >2 peroxyl radicals each, at ambient temperatures.

141 to different rates of beta-fragmentation of peroxyl radicals formed from oxygen addition at differen

142 e oxidation of organic amines by NH2Cl and N-peroxyl radicals from the reaction of aminyl radicals wi

143 eroxidizing arachidonic acid (20:4omega6) or peroxyl radicals generated by thermolysis of ABIP in the

144 minary applications include the detection of peroxyl radicals generated thermally in soybean phosphat

145 tions of linoleate in which the C-9 and C-13 peroxyl radicals have similar reactivities.

146 activities of lipophilic antioxidants toward peroxyl radicals in a lipophilic medium (octane:butyroni

147 nic solutions of different polarity and with peroxyl radicals in a micellar system mimicking the amph

148 ne (kinh = 3.8 x 10(4) M(-1) s(-1)) and four peroxyl radicals in acetonitrile (kinh = 9.5 x 10(3) M(-

149 al and prevent macrophage lysis, implicating peroxyl radicals in both mitochondrial dysfunction and m

150 1) in acetonitrile, and honokiol trapped two peroxyl radicals in chlorobenzene (kinh = 3.8 x 10(4) M(

151 ndicate that the rate of production of lipid peroxyl radicals in HeLa cells under basal conditions is

152 ties of the pyridinols toward chain-carrying peroxyl radicals in homogeneous organic solution were ex

153 and the polarity of the local environment of peroxyl radicals in liposomal oxidations depends on the

154 have mapped oxidative base damage induced by peroxyl radicals in the supF tRNA gene and correlated th

155 We find that the intermediate peroxyl radicals in these cases have negative C[bond]OO*

156 Detection of photochemically produced peroxyl radicals is achieved by employing 3-amino-2,2,5,

157 nce intensity enhancement upon reaction with peroxyl radicals is reported.

158 her than expected reactivity of RSeOH toward peroxyl radicals is the strongest experimental evidence

159 us micelles, with rate constant for trapping peroxyl radicals kinh=(3.8 +/- 0.7) x 10(4)M(-1)s(-1) at

160 ompounds 9-11 quenched linoleic-acid-derived peroxyl radicals much more efficiently than alpha-tocoph

161 We propose that cellular lipid peroxyl radicals or lipid hydroperoxides induce an apopt

162 bservation of steady concentrations of lipid peroxyl radicals produced in live cell imaging condition

163 Perflubron did not serve as a sink for peroxyl radicals produced in the aqueous phase during se

164 Each molecule trapped a number n of peroxyl radicals ranging from 4 to 7.

165 Scavengers of peroxyl radicals restore mitochondrial membrane potentia

166 tom transfer from pzH to alkyl, alkoxyl, and peroxyl radicals reveals that BDEs are not a good predic

167 (4) Lipophilic peroxyl radicals show reduced discrimination between ant

168 provides a steady source of free amphiphilic peroxyl radicals that efficiently initiates oxidation of

169 gen incorporation on their reactivity toward peroxyl radicals was comparatively small (a decrease of

170 reactivity of DNA bases toward oxidation by peroxyl radicals was found to be G >> C > T.

171 f dialkylamino-substituted diarylamines with peroxyl radicals were found to be >10(7) M(-1) s(-1), wh

172 ary orbital interactions in the reactions of peroxyl radicals with good H-atom donors.

173 mined the DNA damage produced by reaction of peroxyl radicals with human fibroblast DNA.

174 data for reactions of the diarylamines with peroxyl radicals with literature data for reactions of p

175 dimethylisovaleronitrile) (AMVN) to generate peroxyl radicals within cellular membranes of HL-60 cell

176 group on the chromanol group can trap lipid peroxyl radicals within the interior and near the surfac

177 hydrogen peroxide, peroxynitrite anions, and peroxyl radicals) were measured with an amine-reactive g

178 ition of DNA damage (induced by hydroxyl and peroxyl radicals), copper-induced LDL-cholesterol peroxi

179 peroxidation induced by an azo-initiator of peroxyl radicals, 2, 2'-azobis(2,4-dimethylvaleronitrile

180 H2B-QH2 is shown to react with peroxyl radicals, a form of reactive oxygen species (ROS

181 ienyl radicals; (3) disproportionation of 10 peroxyl radicals, and (4) unimolecular decay of nine per

182 iologically relevant reactions of ascorbate, peroxyl radicals, and alpha-tocopherol.

183 ent and cyclization of allyl and pentadienyl peroxyl radicals, and homolytic substitution of carbon r

184 d superoxide anion, peroxynitrite anion, and peroxyl radicals, but with different efficiencies; furth

185 We review the thermochemistry of the peroxyl radicals, CH(3)OO and CH(3)CH(2)OO.

186 s in spinach extracts provided resistance to peroxyl radicals, components that did not bind to the HP

187 M) and is sensitive to the presence of lipid peroxyl radicals, effective chain carriers in the lipid

188 ing processes, including reaction with lipid peroxyl radicals, erythrocytes and superoxide ions, were

189 e constants for H-atom transfer reactions to peroxyl radicals, greatly enabling the kinetic and mecha

190 oxidant capacities of 2c, 2f, and 2p against peroxyl radicals, hydroxyl radicals, superoxide anion, s

191 )(TOH), is ~8 in the presence of hydrophilic peroxyl radicals, regardless of the nature of the lipid

192 The respective peroxyl radicals, resulting from O2 trapping, add to 5'-

193 erates free radical intermediates (primarily peroxyl radicals, ROO(*)) and electrophilic aldehydes as

194 pite their remarkably high reactivity toward peroxyl radicals, the phenoxazines were found to be comp

195 cs, scavenging activity against hydroxyl and peroxyl radicals, the reducing power and chelating capac

196 xidative stress is the reactivity of RSSH to peroxyl radicals, where favorable thermodynamics are bol

197 and styrene at 303 K, magnolol trapped four peroxyl radicals, with a kinh of 6.1 x 10(4) M(-1) s(-1)

198 ts and their scavenging capacity on DPPH and peroxyl radicals.

199 s free radicals, particularly oxygen-derived peroxyl radicals.

200 pyrylium was more effective inhibiting lipid peroxyl radicals.

201 ibits apoptosis by scavenging cellular lipid peroxyl radicals.

202 des, we derive the heats of formation of the peroxyl radicals.

203 he individual extract components to scavenge peroxyl radicals.

204 radicals, and (4) unimolecular decay of nine peroxyl radicals.

205 tal dG's are also oxidatively damaged by the peroxyl radicals.

206 ence for electron transfer by the nucleobase peroxyl radicals.

207 quent trapping by O2 leads to the respective peroxyl radicals.

208 heir reactivity toward H-atom abstraction by peroxyl radicals.

209 e suspensions with hydrophilic or lipophilic peroxyl radicals.

210 presence of either hydrophilic or lipophilic peroxyl radicals.

211 -TO. radical reacts with lipid to form lipid peroxyl radicals. (2) Phase transfer: alpha-TOH can tran

212 pids do not efficiently scavenge hydrophilic peroxyl radicals; under these conditions wastage reactio

213 y reacting with them, the resulting protein (peroxyl) radicals can oxidize the bound DNA.

214 omposition and antioxidant potential towards peroxyl, superoxide and hydroxyl radicals.

215 c product and beta-fragmentation of the same peroxyl that gives the trans,trans-product hydroxyoctade

216 ocess involving beta-fragmentation of the 15-peroxyl would give racemic isoprostane products.