ライフサイエンスコーパス: peroxynitrite

1 dose-dependently nitrated and inactivated by peroxynitrite.

2 DA) increased the Fe-SODB sensitivity toward peroxynitrite.

3 ed probe, pnGFP, which can selectively sense peroxynitrite.

4 y active protein that was not susceptible to peroxynitrite.

5 ed as a probe for the selective detection of peroxynitrite.

6 ing is due to increases in the production of peroxynitrite.

7 synthase mRNA and produced higher levels of peroxynitrite.

8 ) synthesis and scavenging of superoxide and peroxynitrite.

9 )O(2)), 3-morpholinosydnonimine (SIN-1), and peroxynitrite.

10 known to be driven by the overproduction of peroxynitrite.

11 A exposed to ultraviolet (UV) irradiation or peroxynitrite.

12 and the generation of nitric oxide (NO) and peroxynitrite.

13 ger, prevented hyperoxia-induced increase in peroxynitrite.

14 of many other genes that are up-regulated by peroxynitrite.

15 vels were also elevated after treatment with peroxynitrite.

16 he hairpin is susceptible to modification by peroxynitrite.

17 proving the balance between nitric oxide and peroxynitrite.

18 ation of NO(2) as a decomposition product of peroxynitrite.

19 ared by reaction of the resting enzymes with peroxynitrite.

20 oth the NO donor 3-morpholinosydnonimine and peroxynitrite.

21 with the release of reactive species such as peroxynitrite.

22 he toxicity is mediated by microglia-derived peroxynitrite.

23 drogen peroxide, organic hydroperoxides, and peroxynitrite.

24 a previously unrecognized source of NO(*)and peroxynitrite.

25 reaction of PDI with the biological oxidant peroxynitrite.

26 beta can be nitrated at tyrosine 10 (Y10) by peroxynitrite.

27 ydrogen peroxide, organic hydroperoxide, and peroxynitrite.

28 e nitrogenous intermediates (RNI), including peroxynitrite.

29 ation of dityrosine, suggesting formation of peroxynitrite.

30 s and in the extracellular space, generating peroxynitrite.

31 ysteines made the enzyme more susceptible to peroxynitrite.

32 reduce peroxides, lipid hydroperoxides, and peroxynitrites.

33 none intermediate (2OHCBZ) and nitration via peroxynitrite (2OHCBZ and 3OHCBZ) as well as formation o

34 Peroxynitrite, a key cytotoxic and oxidizing effector bi

35 Peroxynitrite, a reactive short-lived peroxide with a pK

36 Blocking the production of peroxynitrite abrogated the SDR-induced increase in micr

37 trite production, nitroso product formation, peroxynitrite accumulation, and cell death in wild-type

38 ely neutralized by the pro-death activity of peroxynitrite after UVB radiation.

39 optimizations for methyl nitrite and methyl peroxynitrite, along with various protonated isomers for

40 al oxidants, including hydrogen peroxide and peroxynitrite, also produce only the corresponding sulfo

41 retinal neuro/vascular injury is mediated by peroxynitrite-altered Trx antioxidant defense, which in

42 tyrosine nitration of chlamydial protein by peroxynitrite, an NO metabolite.

43 Thus, the cellular responses to peroxynitrite and hydrogen peroxide are distinct.

44 angiogenic function in BMECs is mediated by peroxynitrite and involves c-src and MT1-MMP activation.

45 uction of P450 compound I through the use of peroxynitrite and laser flash photolysis.

46 Peroxynitrite and products of the autooxidation of NO in

47 ad increased production rates of superoxide, peroxynitrite and total reactive oxygen species (ROS) in

48 e, which is formed from the reaction between peroxynitrite and tyrosine (Try).

49 SH levels (scavenging of reactive oxygen and peroxynitrite)-and by supporting the mitochondrial energ

50 itroxidative species), including superoxide, peroxynitrite, and hydrogen peroxide.

51 roxynitrite scavengers or pH inactivation of peroxynitrite, and mass spectroscopy confirmed nitration

52 tion of hydrogen peroxide, superoxide anion, peroxynitrite, and nitric oxide.

53 By reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides, peroxiredoxin

54 he peculiar ability to neutralize peroxides, peroxynitrite, and phospholipid hydroperoxides.

55 with superoxide results in the generation of peroxynitrite, and this powerful oxidant has been sugges

56 alter the activity of LKB1(S), but abolished peroxynitrite- and metformin-induced activation of AMPK.

57 *)NO rapidly react to form a potent oxidant, peroxynitrite anion (ONOO(-)).

58 The activation of the peroxynitrite anion (PN) by hemoproteins, which leads to

59 l three extracts scavenged superoxide anion, peroxynitrite anion, and peroxyl radicals, but with diff

60 shes the NO bioavailability by forming toxic peroxynitrite anion.

61 itrogen species (ROS/RNS; hydrogen peroxide, peroxynitrite anions, and peroxyl radicals) were measure

62 transport and AMPK activation in response to peroxynitrite are markedly reduced by pharmacological in

63 ts survival, induces apoptosis, and promotes peroxynitrite as a novel therapeutic target for the impr

64 of C5a in spleens of septic mice, indicating peroxynitrite as a possible cause for CPB1 functional al

65 stently thiol-modified in cells treated with peroxynitrite as follows: AsnB, FrmA, MaeB, and RidA.

66 ue, our findings highlight oxLDL, LOX-1, and peroxynitrite as important therapeutic targets in EPE.

67 n of TRPA1 cysteine residues, most likely by peroxynitrite, as a novel mechanism of action of STZ.

68 hich led to the formation of highly reactive peroxynitrite, as shown by 3-nitrotyrosine formation in

69 effect of iNOS on TIMP-2 may be mediated by peroxynitrite, as the latter reversed TIMP-2 expression

70 lly introduced into mammalian cells to image peroxynitrite at physiologically relevant concentrations

71 , and Kupffer cell activation while blocking peroxynitrite-attenuated NASH symptoms.

72 nthetic molecule having high reactivity with peroxynitrite, attenuates inflammatory pathogenesis in N

73 Scavenging the peroxynitrite avoids the inactivation of cellular enzyme

74 likely due to the imbalance of nitric oxide/peroxynitrite because treating the cells with lower (50

75 hought to proceed through an iron(III)-bound peroxynitrite before homolytic cleavage of the O-O bond

76 ancements and the challenges in the field of peroxynitrite biosensors and probes for in vivo and in v

77 the levels of fatty acid hydroperoxides and peroxynitrite, both of which are involved in host-pathog

78 Homocysteine treatment elevated peroxynitrite by approximately 85% after 9 hours.

79 Reduction of peroxynitrite by Ohr was also determined to be in the or

80 Although peroxynitrite caused a fairly indiscriminate nitration o

81 eases the generation of hydroxyl radical and peroxynitrite close to the cell nucleus, inflicting DNA

82 erization of the long sought after ferriheme peroxynitrite complex has been accomplished.

83 be required to detect the putative iron(III) peroxynitrite complex.

84 sis for assigning them to the six-coordinate peroxynitrite complexes (NH(3))Co(Por)(OONO).

85 A discrete peroxynitrite-copper(II) complex, [(TMG3tren)CuII(-OONO)

86 ntrast, at 313 nm we observe no formation of peroxynitrite, corresponding to Phi(ONOO(-)) < 0.26%.

87 -deficient mice and from mice treated with a peroxynitrite decomposition catalyst [iron(III) tetrakis

88 he CypD-regulated mPT, we coadministered the peroxynitrite decomposition catalyst Fe-TMPyP (10 mg/kg,

89 tate (NMDA) in rats, which also received the peroxynitrite decomposition catalyst FeTPPs.

90 ion of SP-D dodecamers or murine lavage with peroxynitrite decreased the SP-D-dependent aggregation o

91 d phenomenon was NADPH oxidase, p47phox, and peroxynitrite dependent, as liver from p47phox-deficient

92 tosis of motor neurons through a copper- and peroxynitrite-dependent mechanism.

93 intramolecular electron transfer, preventing peroxynitrite-dependent nitration and consequent inactiv

94 The reaction of purified PP2A with peroxynitrite dissociated the A subunit, and 3-nitro-Tyr

95 om rat primary cardiomyocytes treated with a peroxynitrite donor.

96 s compound is able to inhibit the effects of peroxynitrite-driven toxicity, including the formation o

97 strongly suggest that NADPH oxidase-mediated peroxynitrite drove TLR4 recruitment into hepatic lipid

98 ratiometric and calorimetric response toward peroxynitrite due to ONOO(-)-triggered oxidative reactio

99 The mechanisms by which peroxynitrite exerts its protective effect may include i

100 altered transcription factors in response to peroxynitrite exposure, including OxyR and ArgR.

101 ggest S-nitrosylation to be a consequence of peroxynitrite exposure.

102 tress was suppressed and malondiladehyde and peroxynitrite expressions were absent.

103 Malondiladehyde and peroxynitrite expressions were present.

104 Treatment of N2a cells with peroxynitrite for 5 min followed by recovery of cells fo

105 est the viability of biological CuI/O2/(*NO) peroxynitrite formation and chemistry, that is, not comi

106 APAP alone caused severe liver injury with peroxynitrite formation and DNA fragmentation, all of wh

107 NMDA-induced peroxynitrite formation caused RGC loss, which was assoc

108 nduce the increases in eNOS activity, NO and peroxynitrite formation in COS-7 cells transfected with

109 We hypothesized that excess peroxynitrite formation in diabetic ischemia/reperfusion

110 The increase in peroxynitrite formation is accompanied by increases in n

111 and attenuates eNOS-beta-actin association, peroxynitrite formation, endothelial apoptosis, and pulm

112 formation, mitochondrial oxidant stress and peroxynitrite formation, mitochondrial dysfunction (asse

113 5% O(2)) for 24 h resulted in an increase in peroxynitrite formation.

114 g motor neurons required copper and involved peroxynitrite formation.

115 econditioning, the protection is mediated by peroxynitrite formed by the reaction of NO with superoxi

116 ied LOX-1 activation by oxLDL and subsequent peroxynitrite generation as a novel mechanism by which d

117 on of Nox4 abolishes the increase in ROS and peroxynitrite generation as well as eNOS uncoupling trig

118 demonstrate that cytokines fail to stimulate peroxynitrite generation by rat islets and insulinoma ce

119 on of Nox4 abrogates the increase in ROS and peroxynitrite generation, as well as the eNOS uncoupling

120 r blood pressure, but blocked superoxide and peroxynitrite generation, reversed the decline in RBF, c

121 1 promotes inducible NOS (iNOS)-dependent NO-peroxynitrite generation, which leads in turn to LDL oxi

122 s through blockade of Nox4-dependent ROS and peroxynitrite generation, with subsequent eNOS uncouplin

123 itric oxide-producing macrophages results in peroxynitrite generation.

124 The peroxynitrite generator 3-morpholinosydnonimine stimulat

125 Likewise, exposure to the peroxynitrite generator SIN-1 degraded the mechanical pr

126 rpholinosydnonimine hydrochloride (SIN-1 , a peroxynitrite generator).

127 c levels in neural stem cells treated with a peroxynitrite generator, Sin-1, revealed an immediate de

128 A fraction of peroxynitrite, however, decayed to radicals that hydroxy

129 , pyrophosphate, bicarbonate, hydrosulphide, peroxynitrite, hypochlorite and hypobromite) a comprehen

130 f oxidants including H2O2, hydroxyl radical, peroxynitrite, hypochlorous acid, hypobromous acid, and

131 trated the utility of 4-MB for intracellular peroxynitrite imaging.

132 In the present study, the role of peroxynitrite in altering the antioxidant and antiapopto

133 hyperoxia increases the formation of NO and peroxynitrite in lung endothelial cells via increased in

134 ce the hyperoxia-induced formation of NO and peroxynitrite in lung endothelial cells.

135 We have previously shown a causal role of peroxynitrite in mediating retinal ganglion cell (RGC) d

136 microglial release of soluble mediators (and peroxynitrite in particular), which induced neuronal exp

137 the effect of hyperoxia on the production of peroxynitrite in pulmonary artery endothelial cells (PAE

138 ployed to visualize exogenous and endogenous peroxynitrite in RAW264.7 macrophages, EAhy926 cells, ze

139 of cytokines, (ii) beta-cells do not produce peroxynitrite in response to cytokines, and (iii) when f

140 quently, many efforts are underway to detect peroxynitrite in the biomedical field.

141 lysis of 3-NT-containing proteins exposed to peroxynitrite in the total protein lysate of cultured C2

142 In experimental settings, peroxynitrite incubation of serum samples and isolated p

143 sGC stimulation prevented peroxynitrite-induced apoptosis of alveolar and endothel

144 ne thiol oxidation may be operant in vivo in peroxynitrite-induced FeOxI activity inhibition.

145 Reduced glutathione prevented peroxynitrite-induced FeOxI drop, tyrosine nitration, an

146 ut not cysteine oxidation, partially impeded peroxynitrite-induced FeOxI drop.

147 present studies tested the mechanism for the peroxynitrite-induced inactivation and subsequent reacti

148 h, we identified specific target proteins of peroxynitrite-induced modifications in Escherichia coli.

149 (Y284F) expressed in cells was resistant to peroxynitrite-induced nitration and reduction of A subun

150 In this study, we identified peroxynitrite-induced post-translational modifications (

151 Mechanistically, peroxynitrite-induced TLR4 recruitment was linked to inc

152 ing mitochondrial dysfunction, generation of peroxynitrite, induction of apoptosis, and oxidative str

153 Peroxynitrite inhibited purified KGDHC activity in a dos

154 ur results provide evidence that I/R-induced peroxynitrite inhibits survival, induces apoptosis, and

155 A peroxynitrite intermediate complex is implicated; if 2,4

156 rmation of both Fe(III)-superoxo and Fe(III)-peroxynitrite intermediates and takes into account the e

157 Peroxynitrite is a highly reactive chemical species with

158 Peroxynitrite is a highly reactive molecule involved in

159 Peroxynitrite is a powerful nitrating and oxidizing agen

160 Peroxynitrite is a short-lived oxidant species that is a

161 Peroxynitrite is an endogenous toxicant but is also a cy

162 Peroxynitrite is believed to contribute to pathogenesis

163 Peroxynitrite is formed in macrophages by the diffusion-

164 The biological chemistry of peroxynitrite is modulated by endogenous antioxidant mec

165 s reactive oxygen species, and the generated peroxynitrite is responsible for significant bacterial i

166 Peroxynitrite is the product of the diffusion-controlled

167 roduct of the oxidation of guanine in DNA by peroxynitrite, is an excellent substrate of BER only.

168 est that heme/O(2)/*NO chemistry may lead to peroxynitrite leakage and/or exogenous substrate oxidati

169 betic cells by AVE3085 resulted in increased peroxynitrite levels and, therefore, did not enhance NO-

170 eased mitochondrial superoxide formation and peroxynitrite levels.

171 O2 species through O-O bond homolysis of the peroxynitrite ligand.

172 eory (DFT) calculations, reveal that M(III) -peroxynitrite (M=Fe and Mn) species, generated in the re

173 mitochondrial 3-nitrotyrosine adduct levels (peroxynitrite marker) were decreased.

174 ta suggest that AMPK activation by statin is peroxynitrite-mediated but PKC-zeta-dependent.

175 ed that GIT-27NO but not Saq-NO acts through peroxynitrite-mediated cell destruction.

176 bition or genetic depletion of CypD and that peroxynitrite-mediated cell injury predominates in the a

177 ent of Tyr(350) with phenylalanine abolished peroxynitrite-mediated eNOS translocation to mitochondri

178 t mass spectrometry analysis indicating that peroxynitrite-mediated inactivation of T. cruzi Fe-SODs

179 A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1

180 resistant to both streptococcus/nitrite- and peroxynitrite-mediated killing.

181 Redox inhibition of PP2A results from peroxynitrite-mediated nitration of a conserved tyrosine

182 modulators of neuronal excitability, and (2) peroxynitrite-mediated posttranslational nitration and i

183 se in NO bioavailability, demonstrating that peroxynitrite mediates the effects of Ang II on eNOS dys

184 Peroxynitrite mediates the effects of HG on eNOS dysfunc

185 ion and killing of E. coli demonstrates that peroxynitrite mediates the stressor-induced increase in

186 pt to acute oxidative stress (e.g. H(2)O(2), peroxynitrite, menadione, and paraquat) through transien

187 Hydrogen peroxide and peroxynitrite mimicked the inhibitory effect of high glu

188 S) leads to the emergence of highly reactive peroxynitrite molecules with significantly enhanced bioc

189 Treating CD4+ T cells with peroxynitrite nitrated PKCdelta, preventing PKCdelta T(5

190 uring infection, there were higher levels of peroxynitrite (NO(3).(-)) in livers from mice lacking ec

191 Scavengers of reactive oxygen species and peroxynitrite normalized HTRA3 and POLG1 levels in CS ce

192 racetamol often causes hepatotoxicity due to peroxynitrite ONOO(-) .

193 peroxide (H2 O2 ), superoxide (O2(-) ), and peroxynitrite (ONOO(-) ).

194 ide (NO), reactive oxygen species (ROS), and peroxynitrite (ONOO(-)) (spleen).

195 tive stress is associated with resistance to peroxynitrite (ONOO(-)) and hydrogen peroxide (H(2)O(2))

196 is oxidatively and nitrosatively modified by peroxynitrite (ONOO(-)) and hypochlorous acid (HOCl) and

197 ation of a fluorogenic sensor for monitoring peroxynitrite (ONOO(-)) and myeloperoxidase (MPO) mediat

198 ed myocardial superoxide anion (O(2)(-)) and peroxynitrite (ONOO(-)) and their enzymatic sources in s

199 lla, presumably by limiting the formation of peroxynitrite (ONOO(-)) arising from the diffusion-limit

200 t physiological pH leads to the formation of peroxynitrite (ONOO(-)) as a major intermediate.

201 Peroxynitrite (ONOO(-)) contributes to coronary microvas

202 nhibited by 3-morpholinosydnonimine (SIN-1) [peroxynitrite (ONOO(-)) donor]; ONOO(-) can be produced

203 O2showed complex kinetic behavior and led to peroxynitrite (ONOO(-)) formation, which was detected us

204 sive epidermal oxidative stress via H2O2 and peroxynitrite (ONOO(-)) in affected individuals.

205 We also monitored the formation of peroxynitrite (ONOO(-)) in HEK293 cells fluorimetrically

206 stress via hydrogen peroxide (H(2)O(2)) and peroxynitrite (ONOO(-)) in the skin of affected individu

207 stress via hydrogen peroxide (H(2)O(2)) and peroxynitrite (ONOO(-)) in the skin of affected individu

208 Peroxynitrite (ONOO(-)) inactivates eNOS, but questions

209 We found that d-flow-mediated peroxynitrite (ONOO(-)) increased PKCzeta activation, wh

210 Preincubation with antioxidants and peroxynitrite (ONOO(-)) inhibitors improved endothelium-

211 Among these RNOS, peroxynitrite (ONOO(-)) is a well-known inflammatory med

212 Peroxynitrite (ONOO(-)) is an important species involved

213 over, we show the presence of high epidermal peroxynitrite (ONOO(-)) levels via nitrotyrosine togethe

214 n addition, we found that oxidation of TE by peroxynitrite (ONOO(-)) prevented binding of SMCs and WI

215 ng by Ang II, we evaluated the potential for peroxynitrite (ONOO(-)) to mediate CaMKII activation and

216 hat oxidation and release of the zinc ion by peroxynitrite (ONOO(-)), a potent oxidant generated by n

217 ive nitrogen oxide species (RNOx), including peroxynitrite (ONOO(-)), are powerful nitrating agents.

218 oxide (O2 ()), hydrogen peroxide (H2O2), and peroxynitrite (ONOO(-)), the number of false positives w

219 he upstream signaling events responsible for peroxynitrite (ONOO(-))-induced LKB1 activation.

220 We recently reported a genetically encoded peroxynitrite (ONOO(-))-specific fluorescent sensor, pnG

221 (NO2(-)) and oxygen atom (O((3)P)), and (3) peroxynitrite (ONOO(-)).

222 n increase seen with exposure to the oxidant peroxynitrite (ONOO(-)).

223 ere inert to nitric oxide (NO(*)) as well as peroxynitrite (ONOO(-)).

224 f reactive nitrogen species (RNS), including peroxynitrite (ONOO).

225 nitrogen species, which can react to produce peroxynitrite (ONOO-).

226 ous treatment with stable oxidants (H2O2 and peroxynitrite [ONOO(-)]) and dampened the intracellular

227 Peroxynitrite ((-)OON horizontal lineO, PN) is a reactiv

228 myocardium and are thought to be mediated by peroxynitrite (OONO(-)) in vivo.

229 Although there was no effect of peroxynitrite or tyrosine mutations on lectin activity,

230 esis is increased in a spatial manner and 2) peroxynitrite orchestrates vascular endothelial growth f

231 ved unusual chemoselectivity of pnGFP toward peroxynitrite over hydrogen peroxide by using site-direc

232 eceptor, LOX-1, and subsequent generation of peroxynitrite (P<0.001).

233 unsuspected role of the endothelial iNOS-NO-peroxynitrite pathway in lipid peroxidation and eNOS dys

234 ct rapidly with nitric oxide (NO) to produce peroxynitrite (PN) at the heme site.

235 min at -80 degrees C, 3 is converted to the peroxynitrite (PN) complex [Cu(II)2(UN-O(-))((-)OON hori

236 We report that formation of peroxynitrite (PN) in response to activation of nitric o

237 Peroxynitrite (PN, ONOO(-)) is a potent oxidant and nitr

238 such as acrolein (AC), hydroxyquinones (HQ), peroxynitrites (PN), and hydrogen peroxide, on their abi

239 lls (MDSCs) are a source of the free radical peroxynitrite (PNT).

240 simulations, and MS analyses confirmed that peroxynitrite preferentially oxidizes the redox-active C

241 t as a contaminant in commercially available peroxynitrite preparations.

242 ide or nitric oxide production inhibits both peroxynitrite production and killing of E. coli demonstr

243 Peroxynitrite production and tyrosine nitration are pres

244 that the increased microbicidal activity and peroxynitrite production was dependent upon IL-1 signali

245 eta-actin association, eNOS activity, NO and peroxynitrite production, and protein tyrosine nitration

246 a-actin association contributes to increased peroxynitrite production, eNOS-beta-actin interaction we

247 Disturbed flow induces peroxynitrite production, which activates protein kinase

248 Excess peroxynitrite promoted further PDI oxidation, nitration,

249 l other compounds present in food to prevent peroxynitrite reactions in three different test systems,

250 h for drugs and nutraceuticals able to limit peroxynitrite reactions is thus of interest.

251 tment of disulfide-oxidized Prx2 with excess peroxynitrite renders mainly mononitrated and dinitrated

252 also appeared to play a central role in the peroxynitrite response, because the ohr mutant was more

253 xposed to exogenous or endogenous sources of peroxynitrite resulted in nitration and inactivation of

254 or trimeric SP-D lectin domains (NCRDs) with peroxynitrite resulted in nitration and nondisulfide cro

255 reactions with a reporter disulfide and with peroxynitrite revealed that persulfides are better nucle

256 ) tetrakis(p-sulfonatophenyl)porphyrin] or a peroxynitrite scavenger (phenylboronic acid) had markedl

257 onse and were restored by treatment with the peroxynitrite scavenger 5,10,15,20-tetrakis(4-sulfonatop

258 essed using the superoxide dismutase mimetic/peroxynitrite scavenger MnTMPyP [Mn(III)tetrakis(1-methy

259 nd caspase-1 processing that is blocked by a peroxynitrite scavenger or inhibition of NADPH oxidase.

260 inflammation, whereas the in vivo use of the peroxynitrite scavenger phenylboronic acid, a novel synt

261 In fact, cotreatment with an NO-peroxynitrite scavenger revealed that GIT-27NO but not S

262 ation of the superoxide scavenger Tiron, the peroxynitrite scavenger Urate, or the eNOS inhibitor L-N

263 Peroxynitrite scavenger uric acid did not affect the fir

264 f haemoglobin (a NO scavenger), uric acid (a peroxynitrite scavenger), melatonin (a non-specific anti

265 An antioxidant/peroxynitrite scavenger, ebselen, prevented stress-induc

266 Uric acid, a peroxynitrite scavenger, prevented hyperoxia-induced inc

267 Modifications were blocked by peroxynitrite scavengers or pH inactivation of peroxynit

268 omethenes, 4a-c, as potent and orally active peroxynitrite scavengers.

269 and neutralized by synthetic compounds with peroxynitrite-scavenging capacity.

270 mmonia, and both protonated and deprotonated peroxynitrite (selectivity coefficients of -5.3, -4.2, -

271 andom mutagenesis, we identified a selective peroxynitrite sensor, which is essentially unresponsive

272 y presumed that this species is an iron(III)-peroxynitrite species, but detailed characterization of

273 In addition to the major phenolic products, peroxynitrite-specific minor products of oxidation of bo

274 VEGF-neutralizing antibody and inhibitors of peroxynitrite, src kinase, or MMP blocked the migration.

275 To determine whether APAP-induced peroxynitrite stress might directly activate mitochondri

276 All four were required for peroxynitrite stress tolerance in vivo.

277 NO-dependent formation of S-nitrosothiols or peroxynitrite structurally modifies complex I in its D-f

278 including superoxide, nitric oxide (NO), and peroxynitrite, than LGN neurons with an intact cortical

279 Complexes 4a-c are shown to reduce peroxynitrite through a two-electron mechanism, thereby

280 Uric acid (UA) can scavenge the peroxynitrite to avoid the formation of nitrotyrosine, w

281 For S-nitrosothiols and peroxynitrite to interfere with the activity of mitochon

282 the ability of the body from preventing the peroxynitrite toxicity.

283 Increasing cellular GSH in peroxynitrite-treated cells rescued KGDHC activity to th

284 505) phosphorylation, similar to PKCdelta in peroxynitrite-treated cells.

285 nished the nitrotyrosine immunoreactivity of peroxynitrite-treated KGDHC, restored the activity and t

286 ation of LKB1(S) in response to metformin or peroxynitrite treatment.

287 ive analysis of transcriptional responses to peroxynitrite under tightly controlled chemostat growth

288 as follows: superoxide using hydroethidine, peroxynitrite using boronate-based probes, nitric oxide-

289 When beta-cells are forced to generate peroxynitrite using nitric oxide donors and superoxide-g

290 The reaction of these PDI residues with peroxynitrite was considerably faster (k = (6.9 +/- 0.2)

291 active species superoxide, nitric oxide, and peroxynitrite was measured by electron paramagnetic reso

292 Susceptibility of T. cruzi Fe-SODA toward peroxynitrite was similar to that reported previously fo

293 with superoxide results in the formation of peroxynitrite, we have shown that beta-cells do not have

294 icals, superoxide anion, singlet oxygen, and peroxynitrite were determined by using ORAC, HORAC, SORA

295 intracellular levels of NO, superoxide, and peroxynitrite were evaluated.

296 eroxia-induced increase in the production of peroxynitrite which may cause nitrosative stress in pulm

297 superoxide-dependent cytotoxicity resides on peroxynitrite, which affects mitochondrial function and

298 Peroxynitrite, whose production is increased in heart fa

299 eveloping novel fluorescent probes to detect peroxynitrite with relatively high sensitivity and speci

300 Whereas scavenging of superoxide and/or peroxynitrite with superoxide dismutase, tiron, Mn(III)t