ライフサイエンスコーパス: persistent

1 are metastable and, consequently, temporally persistent.

2 tcomes from clinical trials in children with persistent AA receiving omalizumab therapy and observati

3 e identified and labeled as follows-class 1: persistent, accelerating, rapid growth (5%); class 2: ea

4 ion of TRADD triggers cell death through the persistent activation of JNK and accumulation of reactiv

5 in secondary outcomes were LBP intensity and persistent active discopathy on MRI at 12 months and spi

6 Here, we ask how neural circuits support persistent activity by examining population recordings f

7 was observed in both areas, robust selective persistent activity for motion direction was only observ

8 Persistent activity of hippocampal and amygdala neurons

9 While spatially selective persistent activity was observed in both areas, robust s

10 the brain stores information in patterns of persistent activity, it might use codes that minimize th

11 chanisms that may underlie memory-associated persistent activity.

12 ivity within neural circuits to maintain the persistent activity.

13 nd blocking microvascular thrombosis despite persistent ADAMTS13 deficiency.

14 METHOD: Adult participants (persistent ADHD, N=35; remit-ted ADHD, N=47; never affec

15 ince childhood, contrasting remitted against persistent ADHD.

16 ODS AND In 6 European centers, patients with persistent AF were prospectively randomized.

17 ion can occur, particularly in patients with persistent AF.

18 plasticity is necessary for the induction of persistent AHR after neonatal exposure during rescue ass

19 Asthmatics with persistent airflow obstruction had greater airway smooth

20 tissue inflammation and remodeling, although persistent airflow obstruction in these patients was ass

21 oved for the treatment of moderate-to-severe persistent allergic asthma (AA) that remains uncontrolle

22 Drugs of abuse cause persistent alterations in synaptic plasticity that may u

23 ed and it is unclear how irradiation induces persistent alterations in the brain.

24 Influenza is known to cause persistent alveolitis in animal models; however, little

25 ich is at least partially due to the lack of persistent and homogeneous severe weather observations a

26 The presence of persistent and mobile organic contaminants (PMOC) in aqu

27 Importantly, we observe the development of persistent and non-persistent gastrointestinal carriage

28 ission periods, suggesting the presence of a persistent and potentially progressive pathology.

29 t to antibiotic therapy and a major cause of persistent and recurrent infections.

30 currents revealed proexcitatory increases in persistent and resurgent currents and rightward shifts i

31 tivated MnPO neurons establishes a scalable, persistent, and aversive internal state that dynamically

32 With elevated, persistent, and specific accumulation in TF-positive BXP

33 AF [paroxysmal, persistent or long-standing persistent], and ER-AF = early recurrent AF), had better

34 uted tomographic angiography (CTA) confirmed persistent aneurysmal perfusion due to the incomplete ne

35 developed de novo DSA, and of these, 71% had persistent antibodies.

36 roduction while self-renewing in reaction to persistent antigen; yet, excessive expansion reduces mem

37 mittent AR were significantly lower than for persistent AR (euro1484.98 vs euro2655.86, P < 0.001).

38 ory neuron 2 d after paired stimuli reversed persistent associative LTF.

39 atural disease course in children at risk of persistent asthma (defined as wheeze and presence of air

40 Management of persistent asthma requires avoidance of aggravating envi

41 ldhood is associated with increased risk for persistent asthma, potentially through modulating suscep

42 alizumab for patients with mild to moderate, persistent asthma.

43 he highest BMI being seen among females with persistent asthma.

44 However, the mutants were persistent at skin sites and had similar growth factors

45 nt atrial fibrillation (PeAF), long-standing persistent atrial fibrillation (LPeAF), or paroxysmal at

46 ected "real-world" patients if sources drive persistent atrial fibrillation (PeAF), long-standing per

47 rhythm in patients with both paroxysmal and persistent atrial fibrillation.

48 cterized by extreme genital inflammation and persistent bacterial vaginosis (BV); this subtype could

49 ls are falsely assigned as being potentially persistent based on results from BSTs.

50 nesis in offspring at weaning accompanied by persistent beneficial effects in protecting against HFD-

51 ll molecules could have a dramatic impact on persistent, biofilm-associated bacterial infection treat

52 may have chronic genital inflammation due to persistent BV, which may place them at a particularly hi

53 lly dead mutant stabilizes IP3R3 and induces persistent Ca(2+) mobilization and apoptosis.

54 These results suggest that persistent cardiorespiratory abnormalities caused by LT-

55 exaggerated recovery from anemic stress and persistent cell cycling consistent with a role for KLF3

56 d in the local observational record remain a persistent challenge.

57 al robustness, they could be used to address persistent challenges in membrane separations.

58 tissue of AIE-exposed rats further revealed persistent changes in the expression of DA-related prote

59 Periods of abrupt warming can trigger persistent changes in the state of ecosystems, also call

60 ar and molecular mechanisms underlying these persistent changes were determined in F1 and F2 adult of

61 ammonium chloride causes more extensive and persistent changes, including membrane depolarization, p

62 he last 50-80 years, indicating that CPs are persistent chemicals regardless of alkane-chain lengths.

63 luoroalkyl substances (PFAS) are ubiquitous, persistent chemicals that have been widely used in the p

64 Persistent childhood asthma is mainly atopy driven.

65 ltiple allergic sensitizations are common in persistent childhood asthma, and thorough assessment of

66 tween-type variation, and identify distinct, persistent click types.

67 is given continuously for 3 years, there is persistent clinical benefit for several years after its

68 gG4 binding have been found in children with persistent CMA beyond 5 years of age compared to patient

69 sm through which intermittent seizures drive persistent cognitive deficits in conditions accompanied

70 admissions, prolonged ICU and hospital stay, persistent cognitive problems, and higher mortality rate

71 pL cysteine protease activity contributes to persistent colonization of mice by the EPEC-like mouse p

72 Persistent congestion is associated with worse outcomes

73 Persistent congestion trumps serum creatinine increases

74 iologic signature of the melanopsin-mediated persistent constriction phase of the pupillary light ref

75 vascular smooth muscle (VSM) cells, causing persistent constriction.

76 pply of energy in the form of ATP to support persistent contractile function.

77 els exposed to activated CaMKII had enhanced persistent current and depolarized channel inactivation

78 Persistent currents in non-molecular rings switch direct

79 ic infection with T. gondii by targeting the persistent cysts of the parasite.

80 SEM reveals persistent damage to some surviving outer hair cell ster

81 orubicin and trastuzumab resulted in modest, persistent declines in LVEF at 3 years.

82 nce with transcriptional responses, we found persistent degradation of protective ECM structures call

83 Persistent delivery by the filomicelle formulation was e

84 Tetraphenylmethane-ethynylene-based shape-persistent dendrimers are a new class of nanoobjects wit

85 d by an imbalance of two opposing processes: persistent destruction of myelin and myelin repair by di

86 by the end of learning, some significant and persistent differences appeared to persist.

87 n which remyelination failure contributes to persistent disability.

88 ed proinflammatory cytokines, did not induce persistent disease in MPTP-insulted mice.

89 Explanations for these persistent disparities in cardiovascular disease are mul

90 n mPer2 Our findings show that CSDS produces persistent disruptions in sleep and circadian rhythmicit

91 Persistent DNA damage induces profound alterations in ge

92 for gene expression reprogramming induced by persistent DNA damage remains poorly understood.

93 -/-) mice contain hepatocytes with a notable persistent DNA damage response (gammaH2AX, 53BP1) due to

94 p38alpha- and NMD-dependent manner following persistent DNA damage.

95 Persistent downregulation of methyltransferase DNMT3b an

96 mates were subjected to reaction with (*)OH, persistent DPPH(*) and galvinoxyl radical, as well as in

97 longer HF duration were associated with more persistent dyspnea at 24 h (>1 to 12 months, odds ratio

98 Mechanisms that allow for a persistent E. coli infection are not fully understood.

99 Persistent EAV infection is associated with moderate, mu

100 in rhesus monkeys could serve as a model for persistent EBOV infection in humans, and we demonstrate

101 In conclusion, our data suggest that persistent EBOV infection in rhesus monkeys could serve

102 Here, we detect persistent EBOV replication coinciding with systematic i

103 The effect of persistent EBV infection remained significant even after

104 These results demonstrate the persistent ecosystem retention of N deposition even as i

105 erotype A (BoNT/A) has the most prolonged or persistent effects, which can last several months, and e

106 We show that infants with persistent egg allergy exhibit a unique innate immune si

107 ered unsafe if more than 25% of patients had persistent elevation in estradiol (E2), defined as E2 gr

108 cificity of 100% in identifying recurrent or persistent EMPD.

109 Persistent episodes of extreme weather in the Northern H

110 In many chronic diseases persistent fibrogenesis results in the accumulation of s

111 d mouse model of lung fibrosis to a model of persistent fibrosis in an S100A4-dependent manner.

112 es to assess the ionic mechanisms supporting persistent firing modes triggered by depolarizing stimul

113 ircuits underlying working memory, where the persistent firing of 'Delay cells' is mediated by N-meth

114 d a left shift of the input/output curve and persistent firing.

115 resistance, two critical elements generating persistent firing.

116 the same direction, and the association was persistent for exposure from >/=6 procedures in all sens

117 estigate whether this pathway contributes to persistent fungal infection and to determine whether ant

118 Without Brca2, forks with persistent gaps are converted by Smarcal1 into reversed

119 bserve the development of persistent and non-persistent gastrointestinal carriage states in genetical

120 The most persistent gene repression required the action of severa

121 n-like compounds (DLCs) are highly toxic and persistent global pollutants with extremely large differ

122 A persistent goal of vaccine development is the enhancemen

123 ributed across East Africa could function as persistent groundwater hydro-refugia through orbital-sca

124 Polychlorinated biphenyls (PCBs) are persistent hazardous chemicals that are still detected i

125 with time-averaged proteinuria >0.75 g/d and persistent hematuria had significantly worse renal survi

126 2 or greater lesions in biopsy specimens or persistent high levels of tTGA.

127 Persistent high-risk genus human Alphapapillomavirus (HP

128 nvironmental contaminant that is refractory, persistent, highly mobile in soils and aquifers, and yet

129 e assays could be used to indirectly measure persistent HIV replication in individuals receiving anti

130 ality reduction and topological analysis via persistent homology as the main tools.

131 Persistent homology with graph filtration on alpha-gamma

132 We identified a persistent hotspot, not associated with study arm, where

133 Persistent hotspots have been described after mass drug

134 aginal microbiota (VM) may influence risk of persistent Human Papillomavirus (HPV) infection and cerv

135 Among patients with persistent hypercapnia following an acute exacerbation o

136 Persistent hypercholesterolemia leads to immune response

137 aemia is the most common cause of severe and persistent hypoglycaemia in neonates and children.

138 in astrocytes and oligodendrocytes, caused a persistent hypomyelination, as did deletion from astrocy

139 any cellular stresses activate senescence, a persistent hyporeplicative state characterized in part b

140 BI's) Sequence Read Archive (SRA) via unique persistent identifiers.

141 In this study, we present evidence that persistent immune activation causes impairment of lympho

142 prolonged viral suppression often experience persistent immune activation, have an increased frequenc

143 of 6 months or less in patients with chronic/persistent immune thrombocytopenia (ITP) increased plate

144 layer 5 pyramidal neurons and underscore the persistent impact of MD on synapse loss in the developin

145 arrhythmia pattern was paroxysmal in 62.3%, persistent in 28.2%, and permanent in 9.5%.

146 H) secretory profiles-pulsatile in males and persistent in females-regulate the sex-biased, STAT5-dep

147 oxyethanol) were found to be both mobile and persistent in groundwater under a range of redox conditi

148 bal burden of measles, but the virus remains persistent in much of the world.

149 from C18 to C36, as well as C8-C17 CPs, are persistent in sediments over the last 50-80 years, indic

150 lyethylene terephthalate (PET) are extremely persistent in the environment, where they undergo very s

151 A persistent increase in excitatory transmission can also

152 Long-term potentiation (LTP) is a rapid and persistent increase in synaptic transmission that is tho

153 entiation (LTP) is an activity-dependent and persistent increase in synaptic transmission.

154 posite of death, the need for dialysis, or a persistent increase of at least 50% from baseline in the

155 Finally, SS/SS patients with persistent increased percentages of blood MDSCs had incr

156 mal disease at cutaneous sites but developed persistent infection at the mucosal sites including thos

157 work in the murine norovirus (MNV) model of persistent infection demonstrates that innate immunity c

158 DeltacheY2-infected ticks did not develop a persistent infection in the murine host.

159 full MCMV infectivity in macrophages and for persistent infection in the salivary gland.

160 that plays an essential role in establishing persistent infection in their respective host species.

161 that is consistent with the establishment of persistent infection in tissue macrophages.

162 Thus, establishment of persistent infection in vitro involves viral genetic cha

163 murine cytomegalovirus (MCMV) was used as a persistent infection model to study heterologous immunit

164 In contrast, persistent infection was asymptomatic and led to establi

165 Persistent infection was observed in all cases.

166 viral genome into the host cell, leading to persistent infection wherein HIV-1 can remain transcript

167 Whereas immune-compromised mice developed persistent infection, immune-competent mice cleared the

168 Using the J-Lat 10.6 model of persistent infection, we demonstrate that proliferation

169 letion of genes from the wca operon caused a persistent-infection E. coli strain to become sensitive

170 Because repeated or persistent infections are correlated with serious compli

171 coma-associated herpesvirus (KSHV) establish persistent infections in B cells.

172 Despite this, SCVs are associated with persistent infections of the bloodstream, bones, and pro

173 comes a more complex issue in the context of persistent infections.

174 eposited within the wound area, resulting in persistent inflammation and resultant fibrosis.

175 t rostral ventromedial medulla is altered in persistent inflammation.

176 ities and challenges in achieving effective, persistent inhibition of polymerization of hemoglobin S.

177 thelial cells can result in the formation of persistent intracellular reservoirs that are refractory

178 Although both persistent itch and inflammation are commonly associated

179 Our results demonstrate that persistent itch and inflammation are mediated by distinc

180 Studies on persistent KSHV infection in vivo and the role of EBV co

181 d an infection with mouse cytomegalovirus, a persistent-latent virus that elicits different cytotoxic

182 re to blood-stage malaria infection is often persistent, leading to generation of CD4 effector and ef

183 Bioamplification means the liberation of persistent lipophilic organic pollutants (PLOPs) into bl

184 takotsubo cardiomyopathy, patients develop a persistent, long-term heart failure phenotype.

185 with a low CD4 cell count or re-present with persistent low CD4 cell counts because of poor adherence

186 ypic seroresponses observed between PIVs and persistent low-level AdV shedding may account for the hi

187 d stimuli did not disrupt the maintenance of persistent LTF.

188 h include impaired chloride permeability and persistent lung inflammation, a multidrug approach is re

189 ult was driven primarily by the new onset of persistent macroalbuminuria, which occurred in fewer par

190 lected from biodegradable to environmentally persistent materials, all formulated under a credit card

191 llectively, the results provide evidence for persistent MDD effects across current episodes or remiss

192 Twenty-one (68%) had persistent medical issues, mainly ongoing immunoglobulin

193 e key prediction is that this should produce persistent memory erasure even after the inhibitory agen

194 n important primer for metaflammation is the persistent metabolic overloading of the endoplasmic reti

195 Together, the results provide evidence of persistent microglial HMGB1-RAGE expression that increas

196 nt (C5a), for which a stable gradient led to persistent migration.

197 ed in two different cancer mouse models with persistent mitotic chromosomal instability, observing a

198 a fundamental property of the brain, causing persistent modifications of neuronal communication thoug

199 Systemic inflammation through persistent monocyte activation and microbial translocati

200 One such feature is persistent mood instability, and efforts are underway to

201 D diffusive exploration, and super-diffusive persistent motion.

202 Focal cortical stroke often leads to persistent motor deficits, prompting the need for more e

203 that tics are exaggerated, maladaptive, and persistent motor habits reinforced by aberrant, increase

204 Tardive dyskinesia is a persistent movement disorder induced by dopamine recepto

205 cophylogenies of languages and genes reveal persistent movements between stable speech communities f

206 rs (early transient [n = 96; 9.2%] and early persistent [n = 67; 6.5%]), the late phenotype with onse

207 resistance protein (BCRP/ABCG2), there is a persistent need for studies of inhibitors of ABCG2.

208 y input into functional circuits to generate persistent neural activity, which interacts with both th

209 er, the neural circuit mechanisms underlying persistent neuronal encoding within this network remain

210 of nicotine taking, nicotine withdrawal, and persistent nicotine seeking even after prolonged abstine

211 me-varying satellite data for a composite of persistent nighttime illumination at approximately 1 km(

212 mune modulation and resistance contribute to persistent, nonhealing wounds.

213 reproductive tract disease, characterized by persistent, often asymptomatic, infection.

214 New persistent opioid use represents a common but previously

215 on was used to identify risk factors for new persistent opioid use.

216 eft atrium >/=47 mm, Type of AF [paroxysmal, persistent or long-standing persistent], and ER-AF = ear

217 plant (LTx) recipients and those with either persistent or no DM.

218 These data raise the possibility that persistent or occult neurologic and lymphoid disease may

219 of the surviving patients had no evidence of persistent or recurrent infections.

220 Advancing age, shock severity, and persistent organ dysfunction are predictive of chronic c

221 Multielemental stable isotope analysis of persistent organic pollutants (POPs) has the potential t

222 Fish are a source of persistent organic pollutants (POPs) in the human diet.

223 dibenzo-p-dioxins and -furans (PCDD/Fs) are persistent organic pollutants whose main removal process

224 of the 2L+(a) allele may form reservoirs of persistent outdoor malaria transmission requiring novel

225 Purpose Persistent pain after breast cancer surgery is a well-re

226 reen for patients at high risk of developing persistent pain after breast cancer surgery.

227 The outcome variable was moderate to severe persistent pain at 1 year from surgery in the Finnish an

228 tes to the hyperexcitability associated with persistent pain induced by spinal cord injury (SCI).

229 Results Moderate to severe persistent pain occurred in 13.5%, 13.9%, and 20.3% of t

230 o the emergency department for evaluation of persistent pain over the volar portion of his right fift

231 Previously persistent papillomas disappeared within 2 months after

232 Nonetheless, because persistent parasite numbers remain roughly constant over

233 oxy records of sea-ice variability, and show persistent patterns of co-variability broadly consistent

234 The persistent peroxides on the powder further explain previ

235 Nevertheless, persistent PFOS treatment in mice finally led to a failu

236 iding evidence from experimental, acute, and persistent phenomena to demonstrate the advantages of ad

237 exposure of cells to 0.1 g/L nZVI induced a persistent phenotype of P. putida F1 as indicated by sma

238 To determine if there are persistent phenotypic distinctions between SA (as define

239 H exposure during early development produces persistent phenotypic, metabolic and molecular changes t

240 f temperature-directed behaviors elicited by persistent PKC-2 activation or inhibition in AFD (or int

241 nd black carbon at 30 m-scale reveal stable, persistent pollution patterns with surprisingly sharp sm

242 polyesters have a large potential to replace persistent polymers in numerous applications and to ther

243 way, which may be responsible for ensuring a persistent pool of GPRC6A receptors at the cell surface

244 provided limited insight into the causes of persistent postoperative seizures in patients with tempo

245 stress in mental illness, rearing rodents in persistent postweaning social isolation has been establi

246 al/venous thrombosis and miscarriages in the persistent presence of autoantibodies against phospholip

247 tree model to predict the probability of the persistent presence of CWD in a region of northern Illin

248 ctions in these patients are associated with persistent pro-inflammatory T-helper (TH)2 and TH17 resp

249 hat ST-SPI diet early in life has modest but persistent programming effects on bone formation to prev

250 The persistent protection from autoimmune destruction was pa

251 threatening appraisals might protect against persistent psychotic experiences becoming clinically rel

252 of appraisals by comparing individuals with persistent psychotic experiences without a need for care

253 for extracellular metabolism, microbes face persistent public goods dilemmas.

254 diates, and [Cu(II)(carb)3](-) serves as the persistent radical that is responsible for predominant c

255 stent risks are futile and a major source of persistent radiophobia.

256 ine balance between efficient adaptation and persistent reaction.

257 ed LCN stimulations resulted in a robust and persistent recovery on the rotating beam test, even afte

258 ew their role in management of patients with persistent reflux symptoms despite adequate medical or s

259 Persistent remission associated with unadjusted hazard r

260 ears of fully effective antiviral therapy, a persistent reservoir of virus-infected cells remains.

261 extreme, transforming once lush marshes into persistent salt barrens.

262 HS-treated groups revealed persistent scar tissue for 10 weeks, while control group

263 g chronic stroke could improve recovery from persistent sensorimotor impairment.

264 ing pathway and cause death, indicating that persistent signaling supports senescent cell survival.

265 o integrate multiple stimuli and distinguish persistent signals from transient environmental fluctuat

266 CV) is a human-specific poxvirus that causes persistent skin neoplasms.

267 eal forests represent a relatively small but persistent source of carbon to the atmosphere over 30 ye

268 A clear feature is a persistent southward shift of the ITCZ during the Little

269 ferentiate into fruiting bodies that contain persistent spores on top of a cellular stalk.

270 can reversibly transition to a slow-cycling, persistent state in response to targeted kinase inhibito

271 nt, a convenient model that rapidly enters a persistent state without inducing pathology due to loss

272 doctoral and professional education, we find persistent stratification, including pronounced educatio

273 ch as ingrowth of RPE/drusenoid material and persistent subretinal fluid (SRF), but also a RPE-indepe

274 a survivors has highlighted the frequency of persistent symptoms and the possibility of virus persist

275 ld be consider for patients with bacteremia, persistent symptoms despite anticoagulation, and if the

276 nt for acute rhinosinusitis in patients with persistent symptoms for more than 10 days, high fever an

277 piratory tract, characterized by episodic or persistent symptoms of wheezing, dyspnea, and cough.

278 otypes (within age 2 years), especially with persistent symptoms.

279 Persistent T2 hyperintensity was associated with all-cau

280 Persistent T2 hyperintensity was associated with the ini

281 The mechanisms that regulate maintenance of persistent TH2 cells and potentiate allergic inflammatio

282 nous/arterial events, amputations, recurrent/persistent thrombocytopenia, skin lesions) and bleedings

283 are subject to a periodic drive, can exhibit persistent time correlations at an emergent subharmonic

284 eningitis virus chronic infections display a persistent type I IFN signature.

285 er dysfunction in asthma is characterized by persistent underlying de-differentiation program with co

286 vivo biodistribution data confirmed high and persistent uptake of (177)Lu-3BP-227 in HT29 tumors (19.

287 low sensitivity (below 50%) in detection of persistent villous atrophy.

288 g of heterologous immunity in the context of persistent viral infection.

289 In acute and persistent viral infections, IL-22 deficiency resulted i

290 ymphoid and lymphoid organs during acute and persistent viral infections.

291 t innate immunity can control both early and persistent viral replication independently of adaptive i

292 ollicle of the LN, predicted the size of the persistent viral reservoir during ART, and significantly

293 une cells to brain atrophy in a system where persistent virus infection and demyelination are not fac

294 sanctuaries to help eliminate this source of persistent virus.

295 n of these weeds by little characterised and persistent viruses and their potential evolutionary role

296 tions caused by a variety of pathogens, from persistent viruses to parasites.

297 emotherapy, and disease status (recurrent or persistent vs metastatic).

298 weaker in mice that initially presented with persistent warts than in those that spontaneously cleare

299 he fully turbulent environment, and they are persistent with a systematic variation of detection thre

300 BPAF was much more persistent with observed half-lives of 32.6 and 24.5 day