ライフサイエンスコーパス: persistently

1 incubation of cocaine craving was decreased persistently.

2 stence increases with the distance travelled persistently.

3 ated Na(+) channels and enables them to open persistently.

4 irreversibly, with several pathways that are persistently abnormal during effective ART.

5 ific kinds of human speech sounds, occurring persistently across continents and linguistic lineages (

6 rnative "notch-pre-patterns-growth" model, a persistently acting growth regulator whose distribution

7 tors of transcription 3 (STAT3) signaling is persistently activated and could contribute to tumorigen

8 by a malfunction of CD8(+) T cells that are persistently activated and/or exhausted.

9 ering the release of a paracrine signal from persistently activated beta-cells.

10 lear factor kappaB (NF-kappaB) (p52/RelB) is persistently activated in a subset of BRCA1-deficient ma

11 3 inhibitor resistance, MEK/ERK signaling is persistently activated in AML cells even when FLT3 phosp

12 The type I interferon (IFN) system is persistently activated in systemic lupus erythematosus (

13 hat in hypercaloric diet-induced obese mice, persistently activated microglia in the MBH hypersecrete

14 Because of the pervasive importance of persistently activated STAT3 in many human cancers and t

15 Here, we show that TBI persistently activates the integrated stress response (I

16 Persistently active eyes were excluded, as were eyes wit

17 We found persistently active neurons in both areas.

18 direct evidence for a distributed network of persistently active neurons supporting working memory ma

19 PKMzeta is a persistently active PKC isoform proposed to maintain lat

20 The persistently active protein kinase Mzeta (PKMzeta) has b

21 Yet, recombinant, persistently active Rab3A halts calcium-triggered secret

22 In conclusion, persistently active STAT5 can recruit normal p53, like i

23 The Jovian moon Io hosts the most powerful persistently active volcano in the Solar System, Loki Pa

24 enes or their regulators render RAS proteins persistently active.

25 h seasonal photoperiods may dramatically and persistently alter the function of serotonin neurons.

26 cells and granule cells in the cerebellum is persistently altered by the activity of glutamatergic sy

27 This study demonstrated a persistently altered ERP signature in patients with a re

28 Our results show that PE persistently alters eCB signaling and impairs eCB-LTD at

29 ults suggest that transient Notch activation persistently alters ion channel gene expression and atri

30 that aversive fear conditioning rapidly and persistently alters spontaneous single-unit activity in

31 Once assembled, Num1 clusters persistently anchor mitochondria to the cell cortex.

32 crobiome and nitrogen metabolism in bacteria persistently associated with Azolla ferns were character

33 years or older with systolic blood pressure persistently at or above 150 mm Hg to achieve a target s

34 Notably, SHIVs replicated persistently at titers comparable to HIV-1 in humans and

35 ated inhibition of CXCL13 in the spinal cord persistently attenuated SNL-induced neuropathic pain.

36 In contrast, these responses were persistently augmented in Nrf2-null mice suggesting that

37 low-up, 9 patients with baseline AB remained persistently bacteriuric, whereas 11 were intermittently

38 ion settings, excess cumulative incidence is persistently biased.

39 Four weekly doses persistently blocked complement for 5 to 6 weeks.

40 In particular, PD325901 persistently blocks cocaine-induced place preference and

41 rds opened for adults decreased abruptly and persistently by 13.4% (95% CI, -16.0% to -10.8%; P < .00

42 we succeeded in generating monoclonal cells persistently carrying tau aggregates without obvious cyt

43 e we show in rats that the sleep pattern was persistently changed long after withdrawal from cocaine

44 No persistently chimeric subject has developed donor-specif

45 ution and immunocompetence are maintained in persistently chimeric subjects.

46 viruses South Asia genotype (WPV1-SOAS) have persistently circulated in southern Israel and intermitt

47 culated into naive wild-type (WT) mice, this persistently circulating CHIKV strain displayed a capaci

48 ment (NaVAb/FY: T206F and V213Y) generates a persistently closed form of the activation gate in which

49 of large-scale data sets, which can identify persistently co-occurring species.

50 provides insight as to how an RNA virus can persistently coexist in a protozoan with RNAi activity a

51 opulation is asymptomatically, naturally and persistently colonised by Staphylococcus aureus.

52 ify a single strain of S. aureus found to be persistently colonising the gastrointestinal tract of BA

53 Its ability to persistently colonize the intestinal tract of a broad ra

54 Approximately 20% of the population is persistently colonized by Staphylococcus aureus in the n

55 nversely, mice not treated with FMT remained persistently colonized with high levels of C. difficile,

56 sponse is suboptimal and may account for the persistently compromised function of surviving axons.

57 uding tolerance and protective immunity, are persistently compromised.

58 Moreover, the females persistently continued to alarm call until their own mal

59 Persistently culture-positive fungal endophthalmitis was

60 e found that a history of alcohol dependence persistently decreased the expression of Prdm2, a histon

61 endon reflexes, extrapyramidal symptoms, and persistently deficient myelination on MRI.

62 ted and high-density lipoprotein cholesterol persistently depressed.

63 The MND-ADA vector was persistently detected in PBMCs (vector copy number [VCN]

64 bmGT was persistently detected only in CGD lungs.

65 vioral control over an aversive stimulus can persistently diminish threat responses, and that these e

66 nce may be more effective than extinction in persistently diminishing threat responses.SIGNIFICANCE S

67 rological response patients all MCS symptoms persistently disappeared (36 patients, 57%); in only two

68 at the H2A-H2B interface of nucleosomes and persistently displaces DNA from the surface of H2A-H2B.

69 red in conjunction with memory reactivation, persistently disrupted the memory that underlies the cap

70 es expression of many genes also known to be persistently downregulated in the ASD cortex later in li

71 g Scn5a (Nav1.5) and Gja5 (connexin 40), are persistently downregulated long after a transient Notch

72 +) T cells, at the peak of clonal expansion, persistently downregulated their TCR expression in propo

73 k shows that obesity during puberty leads to persistently dysregulated patterns of sleep and wakefuln

74 RNA construct was sufficient to markedly and persistently elevate ingestive behavior and body weight

75 ed by day 2, whereas interleukin-10 remained persistently elevated and high-density lipoprotein chole

76 d trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, b

77 to later escalated cocaine taking, and that persistently elevated CRF tone in the VTA may drive late

78 A persistently elevated CRP level but not an elevated CRP

79 A persistently elevated CRP level in plasma (defined as >/

80 of acute erythema nodosum leprosum (ENL) and persistently elevated during reaction.

81 Persistently elevated eosinophil granulocytes in the per

82 nitial phenotyping, the high-BI group showed persistently elevated freezing during a 30-min 'recovery

83 Stressed animals displayed persistently elevated freezing during extinction.

84 eart failure, reduced ejection fraction, and persistently elevated heart rate despite otherwise maxim

85 KMO expression was persistently elevated in brain regions of both newborn a

86 Chemokines Ccl5 and Ccl8 were persistently elevated in inflamed islets and the influx

87 ly regulated by nutrient status but is often persistently elevated in nutrient-excessive obesity cond

88 Furthermore, persistently elevated KLK5 could induce AD-like skin arc

89 n type 9 (PCSK9) inhibitors in patients with persistently elevated low-density lipoprotein cholestero

90 suggested that dynorphin A mutations lead to persistently elevated mutant peptide levels that are cyt

91 However, some statin-treated patients have persistently elevated residual cardiovascular risk due t

92 IBD are chronic risk factors that lead to a persistently elevated risk of thrombosis, although the t

93 eas animals transplanted with SCS grafts had persistently elevated serum creatinine and blood urea ni

94 This was associated with persistently elevated T2 values in the surrounding infar

95 Using a murine model with persistently elevated type I IFNs in the absence of exog

96 This chronic ISR program is characterized by persistently elevated uORF mRNA translation and concurre

97 clinically recognized events had dynamic or persistently elevated values and were at high risk of re

98 scribes "a distinct period of abnormally and persistently elevated, expansive, or irritable mood and

99 activity-dependent intrinsic plasticity that persistently eliminates the burst firing potential of Re

100 In most cases, clinicians should gently but persistently engage adolescents directly in conversation

101 ence of GADD34, eIF2alpha phosphorylation is persistently enhanced and the UPR translational program

102 of SSFO at mPFC-to-NAc projection terminals persistently enhanced the action potential-dependent glu

103 Platelet activation is persistently enhanced, and its inhibition by low-dose as

104 tubules adjacent to the periclinal wall were persistently enriched at the convex side of lobes during

105 Subjects with the persistently eosinophilic phenotype had a significantly

106 pe 1 (HIV-1) invades, amplifies, and becomes persistently established, and cell-to-cell transmission

107 aviorally too, unmated males but not females persistently exchanged mild punishments in return for so

108 bout intracellular signaling mechanisms that persistently excite neurons in pain pathways.

109 ients with chronic, drug-refractory epilepsy persistently expressed the acetylated, disulfide HMGB1 i

110 ple, strong, and direct, yet ecologists have persistently failed to perceive generality in Paine's re

111 moment fragments into an ordered part and a persistently fluctuating one.

112 etween HEN and HINT domains, HEN domains are persistently found at one specific site in inteins, indi

113 accurately identifies patients who will have persistently frequent severe exacerbations in the future

114 unfavorable long-term disease trajectory and persistently frequent severe exacerbations need to be id

115 npersistently frequent"), and 9.5% exhibited persistently frequent severe exacerbations, with the hig

116 depression (+1 point) was predictive of the "persistently frequent" trajectory (area under the receiv

117 the highest incidence of near-fatal asthma ("persistently frequent").

118 o demonstrate that these birds were acquired persistently from Mesoamerica between A.D. 900 and 1150.

119 rgue that the perception that mutant KRAS is persistently frozen in its active GTP-bound form may not

120 lateral attachment of the second sister can persistently generate this metaphase-like tension before

121 1- and 4-year models, respectively); and (5) persistently good adherence (20.0% and 15.0% of persons

122 n IgA nephropathy (IgAN) when proteinuria is persistently >/=1 g/d despite 3-6 months of supportive c

123 and 0.58 [95% CI, 0.36-0.94] for uninsured) persistently had lower rates of hypertension control com

124 tigated the RBV resistance mechanism using a persistently HCV-infected cell culture system.

125 the impairment of RBV antiviral activity in persistently HCV-infected cell cultures and suggests tha

126 or why RBV antiviral activity is impaired in persistently HCV-infected cell cultures and suggests tha

127 ly stage phase of the allostasis model, with persistently heightened reward sensitivity and stimulati

128 ncreased as collagen fibers remodeled, and a persistently high degree of polarization.

129 Conclusion The findings demonstrate persistently high detection rates of high-grade DCIS in

130 Although no classes were characterized by persistently high disorder risk, for those in the increa

131 episodic exposure, while concentrations were persistently high in golden tilefish.

132 In vitro, ISG15 deficiency also leads to persistently high levels of type I IFN-stimulated gene e

133 Conclusions and Relevance: Persistently high mental health disorder risk across 3 d

134 wing prevalence of chronic diseases, and the persistently high prevalence of overweight and obesity,

135 After the chronic phase, IL-33 levels were persistently high, and rhinovirus challenge exacerbated

136 t ages 6 years; n=72 at young adulthood) had persistently higher rates than UK controls of symptoms o

137 Under high airway pressure, CVP was persistently higher than pneumoperitoneum pressure.

138 ect was more pronounced using ELISA-B due to persistently higher values compared to ELISA-A.

139 nse was more prevalent in those who remained persistently HIV-1-negative for Gag (P = 0.007), Integra

140 specific binding against native antigens on persistently HIV-infected cells and recombinant antigens

141 The impact of proteinuria was highest in persistently hypertensive patients between years 1-3.

142 e plaque structures, whereas Cx43 GJs remain persistently immobile for more than 2 min after bleachin

143 rate Galleria mellonella model and also in a persistently immunosuppressed murine model of invasive a

144 ferentiation toward cartilage and bone, with persistently impaired function.

145 Escaping ejecta persistently imprint Phobos with linear, low-velocity cr

146 LKB1 in beta cells, GSIS is dramatically and persistently improved.

147 le cells group into a collective and migrate persistently in a directed manner.

148 While mangrove wetlands store C persistently in roots/soils, storage capacity is most va

149 ansive, or irritable mood and abnormally and persistently increased activity or energy" as a primary

150 P on asthma severity in the offspring with a persistently increased airway inflammation up to the F2

151 creased the H3K27 histone demethylase Jmjd3, persistently increased bone marrow Csf2ra expression and

152 ing hormone (TSH), which is dramatically and persistently increased by short photoperiod exposure in

153 The biosynthesis of TXA2 was persistently increased in subjects with T1DM versus matc

154 ethasone is sometimes needed to ameliorate a persistently increased inflammatory response and to redu

155 Women with persistently increased risk were clinically evaluated.

156 elling off recently, while biomass mortality persistently increased throughout, leading to a shorteni

157 d that after sepsis in humans, MDSCs will be persistently increased, functionally immunosuppressive,

158 After SS/SS in humans, circulating MDSCs are persistently increased, functionally immunosuppressive,

159 ntral cytokine systems are significantly and persistently increased.

160 , a gene-product closely related to PKMzeta, persistently increases in LTP maintenance in PKMzeta-nul

161 We find that whereas PKMzeta persistently increases in LTP maintenance in wild-type m

162 hronic administration of isoproterenol (ISO) persistently increases the frequency of mPTP openings fo

163 Persistently infected (PI) cells exhibited resistance to

164 nd in salpingeal pockets and in one of three persistently infected animals inoculated only in the cer

165 t tissues was not detected, even among three persistently infected animals.

166 c antiviral T cells can completely purge the persistently infected brain without causing blood-brain

167 Despite high levels of viral replication, persistently infected carrier hosts show only mildly ele

168 t cleared infection versus those that became persistently infected carriers.

169 redictive statistical models for identifying persistently infected cattle in an endemic setting that

170 dorsal soft palate and dorsal nasopharynx in persistently infected cattle.

171 s to use alongside NSP ELISAs to help target persistently infected cattle.

172 Viruses isolated from persistently infected cells are highly fusogenic, and th

173 ed with emerging immunotherapeutics to clear persistently infected cells will soon allow measurable c

174 infection prior to the creation of a pool of persistently infected cells.

175 We found that HCV replication in persistently infected cultures induces an autophagy resp

176 Here, we used mice persistently infected from birth with lymphocytic chorio

177 rther decreased viral loads, and reduced the persistently infected HIV reservoir compared with ART tr

178 ame 2 (ORF2) gene encoding VP1 that arose in persistently infected mice and tested whether these muta

179 Treatment of persistently infected mice for 4 wk by repetitive admini

180 proper FcgammaR functions were restored when persistently infected mice specifically lacked immune co

181 R-mediated effector functions were normal in persistently infected mice that lacked LCMV-specific ant

182 However, some of these MCMV persistently infected mice with acute LCMV infection (7

183 6 (EP-II) were removed from serum samples of persistently infected patients and vaccinated chimpanzee

184 The majority (93%) of the persistently infected patients were immunocompetent, and

185 further, we isolated CHIKV from the serum of persistently infected Rag1 (-/-) mice at day 28.

186 mania species, and Trichomonas vaginalis are persistently infected with dsRNA viruses, and growing ev

187 naling in humanized mice (hu-mice) that were persistently infected with HIV-1.

188 mounts of immune complexes generated in mice persistently infected with lymphocytic choriomeningitis

189 and unvaccinated CD4-depleted mice remained persistently infected with P. murina.

190 r assay system: neuroblastoma cells that are persistently infected with scrapie prions.

191 Infected macrophages in spinal cords of mice persistently infected with Theiler's murine encephalomye

192 NAs consistent with a targeted processing of persistently infecting virus genomes.

193 stance, the tapeworm Schistocephalus solidus persistently infects 0-80% of threespine stickleback (Ga

194 Interestingly, carry-over effects persistently influenced dynamics in systems with intersp

195 ory channelrhodopsin, SwiChR, can be used to persistently inhibit pain for long periods of time throu

196 n circulating catecholamines in IUGR fetuses persistently inhibits insulin concentrations and secreti

197 ed and 0.81 [95% CI, 0.79-0.84] for insured) persistently initiated hemodialysis with an AVF less fre

198 manner to attenuate adolescent fear memories persistently into adulthood.

199 The mutant mice became persistently ketotic and tolerated the KD for up to 11 w

200 In contrast, persistently less coherent ACR fibers were observed in m

201 uestionnaire <45 during the year after LVAD (persistently limiting heart failure symptoms and poor qu

202 rogenase and aspartate aminotransferase were persistently low (lactate dehydrogenase < 100 U/L, below

203 ented in sub-Saharan Africa, contributing to persistently low CD4 cell counts at treatment initiation

204 increased clinical failure, compared with a persistently low CRP level, despite achievement of virol

205 r pH-that show that the ocean surface pH was persistently low during the PETM.

206 Our 3000-year record confirms persistently low growth-rates, reflective of positive NA

207 e if there were individuals with a distinct, persistently low lung function trajectory in the CRS (Tu

208 s in a nonselected population demonstrates a persistently low lung function trajectory that may be pa

209 In multivariable models, compared with the persistently low pain trajectory, there was a dose-depen

210 oxygenated water coupled with tidally driven persistently low pH, relative to neighbouring reefs.

211 for second-line management of patients with persistently low platelet counts and bleeding.

212 Individuals with a persistently low trajectory also demonstrated lower lung

213 ith a normal trajectory, participants with a persistently low trajectory were more likely to have a h

214 orted pain trajectories were identified: (1) persistently low, (2) mild, (3) moderate or (4) high tra

215 Persistently low-weight infants consumed significantly m

216 adherence to dietary guidelines has remained persistently low.

217 Tobacco-exposed infants showed persistently lower axial diffusion in the thalamus and i

218 Persistently lower diffusivity in the thalamus and inter

219 ne/tobacco- and tobacco-exposed girls showed persistently lower FA in anterior corona radiata (ACR) (

220 HbA1c concentrations were persistently lower in the sacubitril/valsartan group tha

221 IPSD mass was persistently lower than gravimetric mass by 56-75% over

222 Persistently lowered shear stress appears to be the prin

223 Persistently luminescent nanoparticles have previously b

224 leles, including A*03 (exclusively A*03:01), persistently maintain relatively high CD8 counts followi

225 is stable intermediate of viral infection is persistently maintained in reservoirs of latently infect

226 astroenteritis, to infect a subset of people persistently may contribute to its spread.

227 Persistently misfolded proteins are retained and eventua

228 the 1- and 4-year models, respectively); (4) persistently moderate adherence (48.1% and 37.0% of pers

229 Those with persistently moderate adherence (group 4), the largest g

230 immune deficiency or leukemia WBC should be persistently monitored.

231 creasing tree mortality, while fragmentation persistently offset the sink and turned many edge-affect

232 expression of NKG2D ligands was not induced persistently on normal tissues of allogeneic HSCT-recipi

233 utation of the nexus transforms Orai1 into a persistently open state exactly mimicking the action of

234 viruses that infect the fruit fly acutely or persistently or are vertically transmitted through the g

235 of prostate-cancer recurrence signaled by a persistently or recurrently elevated prostate-specific a

236 d processing in the population can oscillate persistently, or even go extinct in the long run.

237 penetrated the ablation zone, largely along persistently patent vessels.

238 FI1, KLF13 and ATP9A), whereas others showed persistently perturbed patterns (AHRR, MYO1G, CYP1A1 and

239 ence of liver disease progression, even when persistently PN-dependent.

240 hibited one of three lamellipodial dynamics: persistently polarized, random, or oscillatory, with com

241 In patients who have persistently poor control despite optimal medication com

242 Nearly one third of patients die or have a persistently poor quality of life during the year after

243 had a poor outcome, with death in 22.4% and persistently poor quality of life in 7.3%.

244 ns increased the uptake of polio vaccines in persistently poor-performing high-risk communities in no

245 es to create demand for polio vaccination in persistently poor-performing local government areas (LGA

246 Fourteen patients remained persistently positive for HBsAg, all of whom had undetec

247 Children testing persistently positive for tTGAs were further evaluated f

248 and obstetric morbidities in the setting of persistently positive levels of antiphospholipid antibod

249 s), and three quarters of these subjects had persistently positive measures over time.

250 microembolus/hr; 95% CI, 1.01-1.05) and with persistently positive transcranial Dopplers over multipl

251 This is because the implied activity is persistently predictable by preceding stimuli, and so ca

252 other (beta) is a "protective" pigment that persistently quenches the excited state of alpha in the

253 Genital cytokine concentrations were persistently raised (for about 1 year before infection),

254 nformation should be gathered to address the persistently raised risk of suicide among service member

255 , there is a need for alternative methods to persistently reduce threat responding.

256 ued impairment in spike repolarization and a persistently reduced BK channel mediated afterhyperpolar

257 ociated with a better survival compared with persistently reduced EF.

258 er HFiEF is clinically distinct from HF with persistently reduced ejection fraction remains to be val

259 not peripheral, tryptophan hydroxlyase (Tph) persistently reduced HSPC number.

260 Both moderate and high levels of PE persistently reduced low-frequency stimulation-induced e

261 We found persistently reduced neuropsychological function followi

262 hyrotropin-releasing hormone, accounting for persistently reduced secretion of thyroid-stimulating ho

263 ion, and clearance of debris was followed by persistently reduced synaptic density at 55 d.

264 o the feed of ruminants in milligram amounts persistently reduces enteric methane emissions from live

265 ase 1 (PP1), requiring NMDARcd movement, and persistently reduces FRET between the NMDARcd and calciu

266 ical response to treatment, patients' marrow persistently remained clonal with rapid outgrowth of fou

267 plant viruses can avoid total clearance but persistently replicate at low levels, thereby modulating

268 llmarks observed across a range of different persistently replicating viruses and host species, the u

269 Persistently replicating viruses outcompete or subvert t

270 ny somatic lineage programs are actively and persistently repressed by Myt1l to maintain neuronal ide

271 y in the first hour after fertilization, but persistently required throughout the rest of the blastod

272 and find strongest warming consistently and persistently seen over driest ecoregions such as the Sah

273 more difficulty with ADLs and patients with persistently severe or worsening difficulty were at an i

274 ding global cause of gastroenteritis, can be persistently shed during infection, but its in vivo cell

275 x-or-elongate (SAFE) model, kinesin-5 motors persistently slide apart antiparallel interpolar microtu

276 ecovery process after illumination stress is persistently slow by virtue of defect states with a broa

277 ed heart rate, atrial conduction velocity is persistently slower than control.

278 ics strongly balance these forces leading to persistently small cell sizes and reduced size diversity

279 confidence interval, 1.64-4.28; P<0.001) or persistently so (22.5% versus 8.8%; adjusted hazard rati

280 intervention, was strongly associated with a persistently suboptimal CD4/CD8 ratio.

281 ant Krt75-specific short hairpin RNA (shRNA) persistently suppressed this phenotype.

282 We show that C. elegans persistently suppresses oviposition at high CO2.

283 Persistently symptomatic PTSD patients had increasing FA

284 that there is deterioration of CA1 volume in persistently symptomatic UHR individuals in proportion t

285 Children who were persistently tall at both age 7 years and age 13 years h

286 South Asian monsoon established and remained persistently thereafter.

287 ells with the hypothesis that bKu would bind persistently to mtDNA DSBs, thereby preventing mtDNA rep

288 a new state should they be substantially and persistently transgressed.

289 Evolution persistently undermines vector control programs through

290 encing (WES) on a cohort of 71 patients with persistently unresolved white matter abnormalities with

291 Cocaine self-administration selectively and persistently up-regulated the presynaptic release probab

292 f neuropathic pain, we found that CXCL13 was persistently upregulated in spinal cord neurons after SN

293 Persistently upregulated KLK5 degraded DSG1 and stimulat

294 e to transient upregulation of KLK5, whereas persistently upregulated KLK5 did not show this effect.

295 Persistently upregulated KLK5 resulted in AD-like skin a

296 the 1- and 4-year models, respectively); (2) persistently very poor adherence (14.9% and 23.4% of per

297 Increased plaque occurred even among persistently virologically suppressed HIV-infected indiv

298 Patients with persistently vitreous culture-positive endophthalmitis h

299 They learned to lick persistently when higher-value rewards were available an

300 planned readmissions were found, pointing to persistently worse outcomes between non-Hispanic Black a