ライフサイエンスコーパス: person

1 per 100000 persons (95% CI, 97-99 per 100000 persons).

2 ation by state (range, 3.1-47.6 cases/100000 persons).

3 heart disease: 4.3 vs 17.9 deaths per 100000 persons).

4 een formally compared with diagnoses made in person.

5 enotype measurements originate from the same person.

6 ed below around pound200 per fully protected person.

7 tter predictor of HD and HCC in HCV-positive persons.

8 n between 1981 and 2005, including 1 472 762 persons.

9 thing (SDB) and cognitive decline in elderly persons.

10 Results were similar among uninfected persons.

11 was 9.1% in black persons and 8.3% in white persons.

12 was 7.1% in black persons and 5.8% in white persons.

13 serostatus (2 of 93), and 0% of seronegative persons (0 of 43).

14 ests that occurred from 2009 through 2014 in persons 12 to 45 years of age during participation in a

15 l diseases (IBD) is increasing among elderly persons (60 years or older).

16 reased with age; the risk was greatest among persons 75 years.

17 opulation sample was 0.10%, or 98 per 100000 persons (95% CI, 97-99 per 100000 persons).

18 rval: 10.0, 14.5)-approximately 17.1 million persons aged >/=21 years.

19 al {CI}, .23-.85]; P = .014), and highest in persons aged >/=65 years (RR, 1.72 [95% CI, 1.25-2.35];

20 ated with excess hospitalizations in elderly persons aged >/=80 years, with an excess hospitalization

21 2010-2012, with the greatest increases among persons aged >60 years (40%) and in southern states (32%

22 l treatment of seasonal allergic rhinitis in persons aged 12 years or older, routinely prescribe mono

23 rate to severe seasonal allergic rhinitis in persons aged 12 years or older, the clinician may recomm

24 a total of 10033 Chinese, Malay, and Indian persons aged 40 to 80 years residing in the general comm

25 oscopy to prevent colorectal cancer (CRC) in persons aged 70 to 74 and those aged 75 to 79 years.

26 104 black persons and 104 white persons aged 8 years or older who had had type 1 diabete

27 e cohort, co-relative, co-spouse, and within-person analyses of registration for drug abuse during pr

28 Income per person and outcomes in ARDS are independently associated

29 ments was correlated positively with GDP per person and the share of GDP spent on health, and inciden

30 104 black persons and 104 white persons aged 8 years or older who

31 ecent multi-site, mega-analysis of 1713 ADHD persons and 1529 controls.

32 RC by the end of follow-up was 7.1% in black persons and 5.8% in white persons.

33 The mean HbA1c level was 9.1% in black persons and 8.3% in white persons.

34 nal emboli were most commonly seen in Indian persons and associated with conventional cardiovascular

35 accuracy of screening tests in asymptomatic persons, and optimal screening strategies.

36 Females, black persons, and residents of the South had higher SLE ASMRs

37 gible 497 subjects, 51% were male, 77% white persons, and the median age at last follow-up date was 1

38 nd 7.8 (95% CI, 7.6 to 8.0) cases per 100000 persons (annual percentage change [APC], -0.06%; 95% CI,

39 The first context is the person, as attitudes change in connection to values, gen

40 rt the use of rVSVDeltaG-ZEBOV-GP vaccine in persons at risk for Ebola virus disease.

41 ables rapid, point-of-care identification of persons at risk for serious adverse events.

42 62% (from 335 to 543 colonoscopies per 1000 persons) at an additional cost of euro68 000, for an inc

43 network to support the flexible retrieval of person attributes.

44 Further, we found no between-person (B=-0.2; P=0.744) or within-person (B=0.4; P=0.49

45 o between-person (B=-0.2; P=0.744) or within-person (B=0.4; P=0.497) associations between depressive

46 human immunodeficiency virus (HIV)-infected persons be tested at least annually for syphilis, chlamy

47 This single-cohort design included all persons born in Denmark (N = 1683385) between January 1,

48 source settings yields 0.008 fewer QALYs per person, but saves US$204 compared to monitoring every 3

49 f LTFU patients who were alive, contacted in person by the tracer, and out of care.

50 roups, and this was most pronounced in black persons (by 5.7% per year among men and 5.0% among women

51 different intensity or frequency from a mute person can be detected and converted into controllable s

52 Survival analysis of persons carrying either the 22q11.2 deletion or duplicat

53 xamine between-person differences and within-person changes over time in the use of tobacco products.

54 erencing clinic (TMVC) and a conventional in-person clinic (CIC).

55 HIV-infected persons compared with HIV-uninfected persons were are at

56 mate the mean glucose concentration in black persons compared with white persons, possibly owing to r

57 clinical studies of high-risk, HIV-negative persons conducted in Botswana and Thailand.

58 able range (<5 mum), and most reported inter-person contact with suboptimal protective mask usage.

59 laboratory data, we found 80% of 29382 young persons currently infected with hepatitis C virus lived

60 higher risk for death (18 vs. 8 deaths/1,000 person-days of extracorporeal membrane oxygenation; p =

61 tment from 73.5 to 3.0 days compared with in-person dermatology visits.

62 HIV/CMV co-infected persons despite prolonged viral suppression often experi

63 We created a longitudinal cohort of 2995 persons diagnosed with giardiasis (International Classif

64 RP (formerly American Association of Retired Persons) Diet and Health Study.

65 ll serve as baseline data to examine between-person differences and within-person changes over time i

66 ing poor but no causal association of within-person differences in working poverty status with SRH.

67 ect future development and implementation of person-directed mealtime care programs and dining enviro

68 Persons dying of opioid-related causes, particularly tho

69 The near-person emissions associated with PCP may contribute to e

70 Forty percent of transgender persons endorse suicidality, and the rate of self-injuri

71 the onset of parkinsonism through serial in-person examinations and complete access to medical recor

72 pecific CD8(+) effector cells in vitro Among persons expressing protective HLA class I alleles, carri

73 cognitive control of emotion and (2) within-person expression of a distributed brain pattern associa

74 ported higher convenience scores than the in-person follow-up care group (incidence rate ratio, 1.39;

75 obile app group, and 33 (51%) were in the in-person follow-up care group.

76 Majority of the excess deaths occurred in persons >/=65 y of age.

77 hogenic gene variants in families in which a person had multiple congenital malformations.

78 Elderly persons have the highest influenza-associated hospitaliz

79 In single-person households, dog ownership was inversely associate

80 ecent advancements in the investigation of 2-person human social interaction to investigate interacti

81 age might provide sufficient information for person identification.

82 nt information for social interaction (e.g., person identity).

83 an astroviruses (HAstVs) infect nearly every person in the world during childhood and cause diarrhea,

84 Persons in California within driving distance of gun sho

85 as also detected by NGMS in 4 samples from 2 persons in the clinical trial.

86 When comparing persons in the highest intake quartiles with those in th

87 After 6 weeks of treatment, persons in the multiple-dose groups had reductions in le

88 t Population: The approximately 17.3 million persons in the United States with diabetes diagnosed at

89 y (how much an action is directed to another person) in proximity to person knowledge.

90 contributing to mental health in transgender persons include community attitudes, societal acceptance

91 Of the 10189 persons included in the study, 6838 were men (67%) and 3

92 Target Population: Persons initially presenting for publicly funded treatme

93 rality of protection; (2) integrate affected persons into national health systems by addressing the h

94 ind (ToM), the ability to infer what another person is thinking, may contribute to these social defic

95 to international training (electronic or in-person)-is a growing trend.

96 linical trial (Lutein Influence on Macula of Persons Issued From AMD Parents [LIMPIA]) with a 6-month

97 directed to another person) in proximity to person knowledge.

98 central hub for representing and retrieving person knowledge.

99 and an extended system for the retrieval of person-knowledge and other nonvisual information.

100 ions, life expectancy (LE, in years) and per-person lifetime HIV-related healthcare costs.

101 In the US population, a higher proportion of persons living at latitudes of 35 degrees North or great

102 ter have celiac disease or avoid gluten than persons living south of this latitude, independent of ra

103 s with primary data on botulism in children (persons <18 years of age) or botulinum antitoxin adminis

104 During an in-person meeting, evidence was reviewed, research gaps wer

105 pressure in HealthLNK in comparison with in-person MESA examinations, and body mass index in HealthL

106 tidepressants (absolute risk, 0.89 per 10000 person-months vs 0.48 per 10000 person-months; RR, 2.15;

107 SRIs or SNRIs (absolute risk, 1.29 per 10000 person-months vs 0.64 per 10000 person-months; adjusted

108 tidepressants (absolute risk, 1.15 per 10000 person-months vs 1.12 per 10000 person-months; RR, 0.99;

109 ers who attempted suicide and 151526 control person-months, most were male (86.4%), 29 years or young

110 ll incidence rate of PEx was 521.9 per 10000 person-months.

111 29 per 10000 person-months vs 0.64 per 10000 person-months; adjusted relative risk [RR], 1.88; 95% CI

112 15 per 10000 person-months vs 1.12 per 10000 person-months; RR, 0.99; 95% CI, 0.66-1.50).

113 89 per 10000 person-months vs 0.48 per 10000 person-months; RR, 2.15; 95% CI, 1.06-4.36), but not of

114 the Measuring Your Health (MY-Health) study, persons newly diagnosed with cancer (prostate, colorecta

115 We did not include detainees and missing persons, nor deaths from siege conditions or insufficien

116 RDS identified 4,051 HIV-infected persons, of whom 2,325 (57.4%) were unaware of their HIV

117 disorder measure could substitute for the in-person one with little to no loss of precision.

118 Person-to-person or hospital-based epidemiologic links were identi

119 eople unaware of their HIV infection was 0.5 persons per day, and the detection rate of HIV-infected

120 s, biases, and self-fulfilling prophecies in person perception are real, reliable, and occasionally q

121 Person perception is inaccurate as it is insufficient wh

122 s, biases, and self-fulfilling prophecies in person perception were generally weak, fragile, and flee

123 excellent model of how to integrate data on person, place, and time of a major public health problem

124 tration in black persons compared with white persons, possibly owing to racial differences in the gly

125 le to students who participate in similar in-person programs.

126 Assessment of Cardiac Events (PEACE) Million Persons Project from Sept 15, 2014, to June 20, 2017, a

127 major bleeding events occurred during 447037 person-quarters with NOAC prescriptions.

128 he performances of questionnaires as patient/person-reported outcome measures; 3) describe prescribed

129 A person's apparent confidence in the likely reward of an

130 orm of distressing images that emerge into a person's awareness, unbidden.

131 standing of the impact this disease has on a person's life.

132 Among 5278 persons screened, 13 (0.2%) were positive by RDT and 123

133 Study 1 demonstrated that third-person self-talk reduced an ERP marker of self-referenti

134 tical affiliation, can cue a rich cascade of person-specific knowledge.

135 s, communication has remained impossible for persons suffering from complete motor paralysis but inta

136 r mortality were significantly reduced among persons taking aspirin.

137 he risk for interval CRC was higher in black persons than in white persons; the difference was more p

138 RC was higher in black persons than in white persons; the difference was more pronounced for cancer o

139 April 2015), we estimated event rates during person-time spent in key strata of age (7-12, 13-17, and

140 We analyzed data from 68.5 million persons to assess the trends in the prevalence of overwe

141 ortic aneurysm: 3.5 vs 5.1 deaths per 100000 persons) to 4.2 (hypertensive heart disease: 4.3 vs 17.9

142 Person-to-person or hospital-based epidemiologic links w

143 onal studies (n = 39211) included cohorts of persons treated for well-differentiated thyroid cancer a

144 s providing similar levels of efficiency per person vaccinated.

145 s (r), corrected for attenuation from within-person variation in the recalls, were calculated between

146 line visit, participants had 4 additional in-person visits, for a total of 5 in-person visits, hospit

147 tional in-person visits, for a total of 5 in-person visits, hospitalization surveillance, telephone c

148 High gross national income per person was associated with increased survival in ARDS; h

149 nfected persons compared with HIV-uninfected persons were are at higher risk for subsequent new SCC b

150 HIV-infected persons who achieve undetectable viral loads on antiretr

151 The proportion of persons who died was higher in the untreated group compa

152 for baseline low-density lipoprotein levels, persons who filled prescriptions for statins continuousl

153 After adjustment, persons who had ever used tenofovir disoproxil fumarate

154 mmunodeficiency virus (HIV) infections among persons who inject drugs (PWID) was recognized in rural

155 To explore the plasma virome of persons who inject drugs and to characterize the sensiti

156 in 17 (10.9%) of 156 members of a cohort of persons who injected drugs.

157 ughout the 5-year study period but not among persons who moved.

158 ffects, including increased mortality, among persons who receive stored red blood cells (RBCs) have r

159 This relationship held for persons who remained in the same location throughout the

160 iet and Health Study, which enrolled 566,407 persons who were 50-71 y old at baseline (1995-1996).

161 is not well established in African Americans persons whose cardiac comorbidities and structural abnor

162 gions that consider the zygote to be a human person with an immortal soul.

163 f Life Alzheimer's Disease [QoL-AD]) for the person with dementia and general health status (Short Fo

164 We included >50000 persons with >250000 person-years of follow-up.

165 Supporting persons with a chronic illness to take an active role in

166 Persons with a family history of CRC or a documented adv

167 Persons with a single first-degree relative diagnosed at

168 duals, including both elite controllers (ie, persons with a viral load of </=40 copies/mL) and noncon

169 For persons with asthma, influenza vaccination may be effect

170 We identified persons with celiac disease based on results of serum te

171 gh the ACA increased coverage and access for persons with chronic disease, substantial gaps remain, p

172 A total of 18 372 persons with commercial health insurance and 3394 Medica

173 The proportions of persons with commercial health insurance with newly diag

174 A reference group comprised all persons with CRC diagnosed in the Netherlands general po

175 graphic and photobiological features between persons with darker and lighter skin types who have CAD.

176 was 1.4 +/- 0.3 vs. 2.2 +/- 0.44 kg/m(2) in persons with fasting glucose levels below and above the

177 and oropharyngeal swabs were collected from persons with influenza-like illness and tested for influ

178 s who were household contacts of symptomatic persons with laboratory-confirmed influenza, to identify

179 Persons with Lynch syndrome (LS) have high lifetime risk

180 d 5) identify measures that best distinguish persons with ME/CFS from those in the comparison groups

181 he comparison groups and detect subgroups of persons with ME/CFS who may have different underlying ca

182 tools used by expert clinicians to care for persons with ME/CFS; 4) collect biospecimens for future

183 and nonaccidental mortality were elevated in persons with moderate fibrosis (adjusted hazard ratio [a

184 LRD compared with 1.0% (95% CI, 0.2-7.5) of persons with moderate fibrosis, 4.7% (95% CI, 1.5-14.1)

185 hether similar benefits would be observed in persons with NAFLD remains largely unstudied.

186 HCV or ALD and a small increase in HCC among persons with NASH).

187 d for well-differentiated thyroid cancer and persons with no surgery or surveillance; however, these

188 % (95% confidence interval [CI]: 0.4-6.8) of persons with no/mild fibrosis developed ESLD compared wi

189 ars after biopsy, 0.0% (95% CI, 0.0-14.8) of persons with no/mild fibrosis had suffered an LRD compar

190 The mortality among persons with Parkinson disease is only moderately increa

191 homologous to bacteria in the microbiome in persons with previous TB disease may reflect long-term e

192 ted considerable dendritic pathologies among persons with schizophrenia and to some extent among thos

193 in in special populations of PLWH, including persons with substance use and mental health disorders.

194 on associated with cognitive fatigue between persons with traumatic brain injury (TBI) and healthy co

195 utcomes have not been extensively studied in persons with type 1 diabetes or type 2 diabetes.

196 biotic prescription fills did not differ for persons with versus without risk factors for development

197 day, and the detection rate of HIV-infected persons with viremia (regardless of their awareness stat

198 al incidence rate (IR) was 11.4 cases/100000 persons, with substantial variation by state (range, 3.1

199 Persons without prior screening should be considered for

200 ssive disease with a prevalence of 1 million persons worldwide.

201 th healthy microbiota (incidence 0.6 per 100 person years in PrEP group and 2.5 per 100 person-years

202 onia declined from 2.9 to 1.2 cases per 1000 person-years (58% decline, 22-77) in children aged 2-11

203 11 months and from 2.6 to 0.7 cases per 1000 person-years (75% decline, 47-88) in children aged 12-23

204 ing to a cumulative incidence of 71 per 1000 person-years (95% CI 56.5-89.3) and an incidence proport

205 .2 [11.2] years) in the study, during 485322 person-years (median, 6.7 years) of observation, 5750 (8

206 ce of VF on second-line ART was 12.9 per 100 person-years (n = 23), and prevalence of VF at censoring

207 1 per 100000 person-years to 99.7 per 100000 person-years (P < .001 for trend).

208 s-associated diarrhea incidence was 37.2/100 person-years (PY) (95% confidence interval [CI], 33.2-41

209 We followed participants for 35353 person-years (PY).

210 ly increased disease incidence (28.0 per 100 person-years [95% CI 14.9-45.7]) compared with non-conve

211 f autism spectrum disorder was 4.51 per 1000 person-years among children exposed to antidepressants v

212 ed complications were 123.95 events per 1000 person-years among patients actively exposed to antithro

213 tithrombotic agents vs 80.17 events per 1000 person-years among patients not exposed to these drugs (

214 dysplasia (95% CI 1.5-7.2), and 7.3 per 100 person-years among patients with baseline high-grade dys

215 -years overall (95% CI 3.3-8.2); 3.3 per 100 person-years among patients with baseline low-grade dysp

216 exposed to antidepressants vs 2.03 per 1000 person-years among unexposed children (between-group dif

217 nual incidence rates of MA-NGE were 4.9/1000 person-years and 0.7/1000 person-years for episodes invo

218 rate of anaphylaxis was 26 cases per 100 000 person-years and the one-year period prevalence was 0.04

219 Participants contributed 22,576 person-years at risk.

220 2012; the annual incidence rates per 10 000 person-years declined among older individuals (rates in

221 es as the number of hospitalizations per 100 person-years for all causes, AIDS-defining illnesses, an

222 -NGE were 4.9/1000 person-years and 0.7/1000 person-years for episodes involving primary care or hosp

223 of fatal and non-fatal self-harm per 100 000 person-years in adolescents aged 12-17 years in England.

224 incidence of HCC after SVR (1.82 vs 0.34/100 person-years in patients without cirrhosis; adjusted haz

225 33, 45, 52, and 58 was 0.5 cases per 10 000 person-years in the 9vHPV and 19.0 cases per 10 000 pers

226 rson-years in the PrEP group and 3.5 per 100 person-years in the placebo group; efficacy 62.72% [95%

227 rson-years in the PrEP group and 3.5 per 100 person-years in the placebo group; efficacy 72.50% [95%

228 0 person years in PrEP group and 2.5 per 100 person-years in the placebo group; efficacy 76.55% [95%

229 ediate microbiota (HIV incidence 1.8 per 100 person-years in the PrEP group and 3.5 per 100 person-ye

230 cterial vaginosis (HIV incidence 0.9 per 100 person-years in the PrEP group and 3.5 per 100 person-ye

231 years in the 9vHPV and 19.0 cases per 10 000 person-years in the qHPV groups, representing 97.4% effi

232 h an excess hospitalization rate per 100,000 person-years of 242.7 for IHD (P = 0.02), 271.8 for CHF

233 During 1,190,170 person-years of follow-up (1982-2012), there was no asso

234 During 873,376 person-years of follow-up (1990-2012), longer durations

235 Over 401 person-years of follow-up (mean, 3.6 years per patient;

236 HRs and 95% CIs of diabetes risk.In 494,741 person-years of follow-up, 5207 participants developed T

237 cident cancers and 8956 deaths during 267145 person-years of follow-up, and 11.9% of decedents had a

238 of 233 HCC cases were reported after 26,163 person-years of follow-up, indicating an incidence of 8.

239 During more than 185,000 person-years of follow-up, there were 6834 cases of inci

240 We included >50000 persons with >250000 person-years of follow-up.

241 participants followed prospectively (1644.5 person-years of observation [PYO]), 371 HCV incident inf

242 For the entire cohort, with >163,772 person-years of observation, there were 9,373 deaths (5.

243 rate of dysplasia recurrence was 5.2 per 100 person-years overall (95% CI 3.3-8.2); 3.3 per 100 perso

244 fold from 2001 to 2014 (from 0.26 per 100000 person-years to 1.51 per 100000 person-years).

245 experienced an increase from 55.1 per 100000 person-years to 99.7 per 100000 person-years (P < .001 f

246 with 95% confidence intervals (CI) per 1,000 person-years were as follows: non-biologic, 14.2 (11.5-1

247 Age-standardized incidence rates per 100,000 person-years were calculated by country and sex.

248 Incidence rates per 1000 person-years were calculated, and crude and adjusted haz

249 When the analysis was restricted to person-years with exposure to PM2.5 of less than 12 mug

250 of 7356 patients (11.4%; 3.7 events per 100 person-years) in the exenatide group and in 905 of 7396

251 of 7396 patients (12.2%; 4.0 events per 100 person-years) in the placebo group (hazard ratio, 0.91;

252 appendicitis or appendectomy (in per 100,000 person-years) was 100 (95% CI: 91, 110) in Northern Amer

253 llowed on average for 8.3 years (3.9 million person-years) with a mean age of 21 years, 6,999 first s

254 neys followed for a median of 1.9 years (408 person-years), a greater proportion of recipients with D

255 in high-poverty neighborhoods (47.4 per 100 person-years), and people with a history of injection dr

256 es were observed among females (46.8 per 100 person-years), Black and Latino/Hispanic people (41.8 an

257 ncidence rate, 8.2; 95% CI, 6.8-9.6 per 1000 person-years).

258 propriate shocks (incidence rate 0.9 per 100 person-years).

259 history of injection drug use (74.9 per 100 person-years).

260 6 per 100000 person-years to 1.51 per 100000 person-years).

261 , 305 cases of HF remained (0.88 per 100,000 person-years).

262 study period (total follow-up, 57.1 million person-years).

263 posed patients (incidence rate [IR] per 1000 person-years, 0.26; 95% CI, 0.23-0.29), 70 in patients e

264 ausal at baseline in 1991; over 1.13 million person-years, 2041 women reported having natural menopau

265 ve incidence of pregnancy was 106.0 per 1000 person-years, corresponding to 28.4% (22.8-35.0) of thes

266 istically significantly increased, per 10000 person-years, for gallbladder disease (30 more cases [95

267 During 24569 person-years, mild cognitive impairment was diagnosed in

268 eptive was 13 (95% CI, 10 to 16) per 100,000 person-years, or approximately 1 extra breast cancer for

269 atino/Hispanic people (41.8 and 39.5 per 100 person-years, respectively), people living in high-pover

270 1.5-5.5) and 7.8 (95% CI, 2.2-13.3) per 1000 person-years, respectively.

271 spitalization rates were 1.3 and 7.2 per 100 person-years, respectively.

272 Risks, per 10000 person-years, were significantly increased for invasive

273 tic events during the study was 1.22 per 100 person-years.

274 developed HCC with total follow-up of 1,363 person-years.

275 .1%), with an incidence rate of 121 per 1000 person-years.

276 these were followed longitudinally for 3939 person-years.

277 d pancreatic adenocarcinoma over 4.2 million person-years.

278 over a 12-year period, encompassing 949,330 person-years.

279 sion rate was 6.4 (95% CI: 1.3-18.7) per 100 person-years.

280 c event was 27.2 (95% CI, 20.3-35.7) per 100 person-years.

281 s per recipient; total follow-up time, 69590 person-years.

282 ears: 6.9 for SVR and 21.6 for NSVR per 1000 person-years.

283 h an overall incidence rate of 2.8 per 1,000 person-years.

284 followed up in a tertiary center for 37 607 person-years.

285 g event was 21.5 (95% CI, 15.4-29.1) per 100 person-years.

286 ries was reduced from 28.9 to 24.3 per 1,000 person-years.

287 (SHRs) and absolute excess risks per 10 000 person-years.

288 e interval [CI], 16.6-19.2) cases per 100000 person-years.

289 271 cases of incident vitiligo over 835,594 person-years.

290 -up, indicating an incidence of 8.9 per 1000 person-years: 6.9 for SVR and 21.6 for NSVR per 1000 per

291 erse events than those without T2MI (per 100 person-years: MACE, 53.7 versus 21.1, P<0.001; all-cause

292 rn California Diabetes Registry (n = 434,806 person-years; 2007-2010).

293 nt rate in the presence of CAC (2.8 per 1000 person-years; 95% CI, 1.5-5.4) relative to without CAC (

294 pisode psychosis (34.0 new cases per 100,000 person-years; 95% CI=31.5-36.6).

295 5-5.4) relative to without CAC (0.8 per 1000 person-years; 95%, CI 0.3-1.7) (P = .03).

296 nd women, by 7% (from 358 to 332 per 100 000 person-years; adjusted incidence ratio 0.93, 95% CI 0.91

297 ifference, 2.48 [95% CI, 2.33-2.62] per 1000 person-years; hazard ratio [HR], 2.16 [95% CI, 1.64-2.86

298 amputation (0.17 versus 0.09 events per 100 person-years; HR, 1.99; 95% CI, 1.12-3.51).

299 e mortality (19.00 vs. 42.89 events per 1000 person-years; p < 0.001) and the incidences of hemorrhag

300 rhagic stroke (1.21 vs. 4.19 events per 1000 person-years; p = 0.006) were lower in the treated cohor