ライフサイエンスコーパス: perturb

1 as the water monomer becomes electronically perturbed.

2 third the binding events are only minimally perturbed.

3 ortions of the inhibitory population must be perturbed.

4 ex, where regulation of fibrinolysis appears perturbed.

5 sine-1-phosphate signaling was not obviously perturbed.

6 usters even when the parameters are strongly perturbed.

7 ar-native crystallographic poses after being perturbed.

8 n of condensin along the chromosome axes was perturbed.

9 hat are mobilized when muscle homeostasis is perturbed.

10 migration is affected when proliferation is perturbed.

11 of the bacterial population to cooperate is perturbed.

12 he population average to that range if it is perturbed [1, 2].

13 As expected, ongoing hand action was perturbed 25-30 ms after TMS, but our results fail to sh

14 chemical strategy is described to precisely perturb a specific molecular interaction between adeno-a

15 that regulates reovirus disassembly and how perturbing a metastable capsid can compromise replicativ

16 Standard methods that rely on perturbing a polypeptide's sequence and evaluating impac

17 amyloid during the seeding stage, likely by perturbing Abeta clearance and enhancing Abeta aggregati

18 S was found to induce Sertoli cell injury by perturbing actin cytoskeleton through changes in the spa

19 dings may have potential general utility for perturbing actin-mediated cellular activities and biolog

20 s is involved in UFM1 binding and if mutated perturbs activation of UFM1.

21 rrant strict safety monitoring of gut-homing perturbing agents used in treating intestinal inflammati

22 d fibroblast-derived collagen synthesis, and perturbed alignment of myofibroblast arrays in the infar

23 c buffers, and thermal processing of peanuts perturbed allergen quantification in ELISAs, probably vi

24 We additionally examined whether perturbed amygdala subregional connectivity coincides wi

25 M1-activation could be an interesting way to perturb an MM subgroup identified by our method.

26 g that sensory neuron identity is prenatally perturbed and that a critical developmental insult is ke

27 -Trcp2, the balance of PERIOD degradation is perturbed and the clock becomes dramatically unstable, p

28 lative subtlety by which neural circuits are perturbed, and the limited understanding of how basic ci

29 the liver and fibroblasts, resulting in the perturbed assembly of the holoenzyme at the 830 kDa stag

30 ersible-change trend-most were significantly perturbed at 3 or 7 dpi and returned to control levels a

31 lation, which impairs H2A ubiquitylation and perturbs ATM signaling.

32 tions of loop 2 mutations and dNTP effectors perturbed ATP's role as an allosteric activator.

33 nique insights into a putative mechanism for perturbed attention-emotion interactions, which could bi

34 g calls of another bat, timed to selectively perturb audiovocal feedback or echo feedback.

35 phage-derived small protein to specifically perturb bacterial RNAP activity in exponentially growing

36 that adaptation to conditions that directly perturb bacterial RNAP performance can result in a bipha

37 in levels were markedly diminished, and this perturbed behavior as well as autonomic function in muta

38 binding to complement receptor 1 but did not perturb binding to factor H.

39 at enable toxic alpha-synuclein oligomers to perturb biological membranes and disrupt cellular functi

40 The ability to experimentally perturb biological systems has traditionally been limite

41 ks that allow recording of brain activity or perturbing brain regions while monkeys simultaneously ma

42 te that PCSK9 proteolysis acts as a commonly perturbed but critical switch in controlling lipid homeo

43 ther established or assumed, of the pathways perturbed by a specific clinical or experimental conditi

44 Splicing is perturbed by a variety of mechanisms in cancer.

45 ation and phosphorylation, a process that is perturbed by Abeta, in regulating the membrane sorting d

46 d genes may cause target gene silencing when perturbed by activation probes.

47 g endocytic and lipid metabolic pathways was perturbed by benzo[a]pyrene.

48 highly structurally conserved and which are perturbed by crystal lattice contacts.

49 cture and mechanics of tissues is constantly perturbed by endogenous forces originated from cells.

50 trained subjects to make reaching movements perturbed by force patterns dependent upon either limb p

51 When homeostasis is perturbed by neurohormonal activation in heart failure,

52 ted by weak Brownian forces that are readily perturbed by protein-protein interactions, we anticipate

53 owing to the fact that the IR responses are perturbed by PyH(+) adsorption.

54 DFT calculation is used to generate orbitals perturbed by the excitonic state, and then a second line

55 ures represent biological processes that are perturbed by the experiment.

56 t for the paraoxonase activity is negatively perturbed by up to 100-fold, suggesting greater mutation

57 KEY POINTS: Reaching movements can be perturbed by vestibular input, but the function of this

58 ients with anti-C3b Abs stabilized C3bBb and perturbed C3b binding to complement receptor 1 but did n

59 Such events have been attributed to perturbed Ca2+ handling in cardiac myocytes leading to s

60 r functions which suggest a central role for perturbed calcium signalling in DYT2 dystonia.

61 tion of the mutant allele and a signature of perturbed cardiac metabolism.

62 Finally, in O-I mode, we cyclically perturbed cells at constant strain of varying duration t

63 system with small molecules to specifically perturb cellular functions is commonly referred to as ch

64 uggest that ALS-linked mutations in PFN1 may perturb cellular microtubule dynamics and/or the coordin

65 res technologies for disrupting RREs without perturbing cellular homeostasis.

66 Loss of Trpm6 in mice also perturbs cellular magnesium homeostasis but additionally

67 roteins often leads to growth inhibition and perturbs central metabolism and this burden varies with

68 The dual problem of perturbed cholesterol metabolism and mitochondrial dysfu

69 These findings identify perturbed chromatin acetylation in irinotecan resistance

70 Previous studies have shown that perturbing chromosome movement leads to pairing defects

71 e knockdown or knockout of retromer does not perturb CI-MPR transport, the targeting of the retromer-

72 n these two experiments and a suite of other perturbed climate simulations, we argue that this puzzle

73 l (Littorina saxatilis), re-established with perturbed colour morph frequencies and followed for >20

74 We further found that lncRNA knockdown can perturb complex transcriptional networks in a cell type-

75 ce potentially pro-arrhythmic dynamics under perturbed conditions, pertaining to calcium-transient al

76 ce changes during interphase under minimally perturbed conditions.

77 ex by HYSCORE spectroscopy validate that the perturbed conformation of Y731 in R411A-alpha2 is dynami

78 These results offer new insights into the perturbed cortical topology in CP, which may serve as th

79 he gastrointestinal tract that are driven by perturbed cytokine pathways.

80 y contribute to risk for disorders linked to perturbed DA signaling.

81 nd existing immobilization techniques either perturb development or are unsuited for young larvae.

82 about how the carboxymethylated DNA lesions perturb DNA replication in human cells.

83 pothesis, mutations and drug treatments that perturb dNTP pool levels disproportionately influence th

84 ors can influence gene expression in part by perturbing domain boundary function.

85 We perturbed dopamine in healthy individuals using dopamine

86 show that the pathway that is vibrationally perturbed during UV-induced electron transfer is dramati

87 force generation in embryos with a partially perturbed dynein function, indicating the existence of t

88 Perturbed parameter sets were generated by perturbing each parameter independently.

89 vestigate signaling mechanisms of normal and perturbed EC function without the need for clonal expans

90 hat OligoG CF-5/20 had virtually no membrane-perturbing effects.

91 Puf118 and its target mRNAs to the cell rear perturbs efficient chemotaxis in shallow cAMP gradients,

92 We spatiotemporally perturbed electrical activity in beta-cells of channelrh

93 both steady-state and nascent RNA levels and perturbed embryonic stem cell differentiation.

94 Resulting from perturbed endolysosomal degradation, Plaa mutant neurons

95 ract with aberrant DNA methylation and cause perturbed enhancer activity in cytogenetically normal AM

96 We develop Mosaic-seq to systematically perturb enhancers and measure their endogenous activitie

97 the loss of contractile actin filaments and perturbed epithelial packing geometry.

98 n when the biochemical activity of PBP 2B is perturbed evolved prior to the clinical use of beta-lact

99 Perturbing exogenous hepatic FA use modulates both hepat

100 DGCs during novel environmental exploration perturbed experience-induced neuronal addition.

101 l transport of organic and inorganic carbon, perturbing feedbacks to regional and global marine carbo

102 highly actionable functional information by perturbing-for example, with cancer therapies-viable pri

103 in which cation and anion concentrations are perturbed from their bulk values.

104 tation of data from synapses with normal and perturbed function, as well as for modeling the dynamics

105 These mutants perturb fungal development and accumulation of emblemati

106 Furthermore, we found that chemically perturbing Fus3 dynamics with a specific inhibitor could

107 Here we perturbed genes in human melanoma cells to mimic loss-of

108 human health, and the association between a perturbed gut microbiome with human diseases has been es

109 he IL10(-/-) offspring that had received the perturbed gut microbiota developed markedly increased co

110 The toxins perturb host cell function through a multistep process o

111 neurin are potent antifungal agents but also perturb human immunity thereby negating their use as ant

112 expresses the Ir68a gene, and Ir68a mutation perturbs humidity preference.

113 The structurally and dynamically perturbed hydration shells that surround proteins and bi

114 disrupted muscle proteostasis, and severely perturbed IFM structure.

115 ustrate several molecular processes that are perturbed in Amish GMS patients.

116 I3K and MAPK signaling pathways are commonly perturbed in cancer.

117 In this study, we report that mitophagy is perturbed in CL-deficient yeast cells.

118 and motivation, and how these processes are perturbed in clinical or at-risk populations, we must fi

119 ch cannot phosphorylate H2A at T121, are not perturbed in cohesin protection as long as Mps1 is funct

120 respiratory homeostatic networks that may be perturbed in congenital pathophysiologies.

121 These pathways have been shown to be perturbed in different ways in different subjects who ha

122 the concentrations of signaling proteins are perturbed in disease states, such as cancer, and are mod

123 ulin response to glycemic challenge were not perturbed in Gpr119(betacell-/-) mice on RC and high-fat

124 In parallel, autophagic flux was perturbed in HSALR muscle and in cultured human DM1 myot

125 We first show that MT dynamics are perturbed in mutant progenitor cells in vitro.

126 Forty metabolic pathways were perturbed in patients with T1R, with 71 dysregulated met

127 oading of RPA from sites of ICL induction is perturbed in RFWD3-deficient cells.

128 at endocytosis is a major cellular mechanism perturbed in SMA and emphasize the power of protective m

129 These genes are perturbed in T2D and have a similar expression pattern t

130 The BDNF surge in response to THC is perturbed in the presence of mutant DISC1, suggesting DI

131 nown to be key nuclear mechanical components perturbed in these diseases, but their distinct mechanic

132 ods have been developed to identify pathways perturbed in tumors, the results are often not generaliz

133 nit, selective for the unmethylated tail and perturbing/inactivating the phosphatase active site.

134 all function is difficult without a means of perturbing individual cells or subpopulations.

135 ioamidation has the potential to selectively perturb interactions with proteases while preserving int

136 erified cholesterol, that is consistent with perturbed intracellular cholesterol trafficking.

137 to maintain insulin secretion in the face of perturbed ionic signals.

138 d host iron with malaria susceptibility, and perturbed iron handling has been hypothesized to contrib

139 nables STAT3 binding at some enhancers while perturbing it at others.

140 e the beam's thermally driven vibrations and perturb its motion with optical force fluctuations at a

141 nonintuitive dynamic effects that ensue from perturbing its components.

142 CdGAP expression potently perturbs junctions and Ajuba binding inhibits CdGAP acti

143 idermis, and altered AP1 factor function can perturb keratinocyte proliferation and differentiation.

144 Disruption of the keratin cytoskeleton by perturbing Krtap5-5 function broadly altered the express

145 softer nucleus and nuclear blebbing, without perturbing lamins.

146 diverse biology of these cells is that when perturbed, macrophages are the primary contributors to p

147 at increased ER-mitochondrial apposition and perturbed MAM function lie at the heart of AD pathogenes

148 flammatory cytokines, which could ultimately perturb maternal-fetal tolerance during pregnancy.

149 HFHS feeding perturbed maternal insulin sensitivity in late pregnancy

150 An understanding of how perturbed mechanical properties impact mitotic rounding

151 abolites were identified, and the underlying perturbed metabolic pathways are quite similar to the pa

152 The major perturbed metabolic pathways included purine and pyrimid

153 However, tuning proton adsorption without perturbing metallicity remains a challenge.

154 However, urea efficiently perturbs metastable states induced by cold and CD4Ms and

155 A PAT-perturbed microbial community is necessary for host effe

156 asked whether the transfer of an antibiotic-perturbed microbiota from mothers to their children coul

157 ped by antibiotic exposure transmitted their perturbed microbiota to their offspring with high fideli

158 Increased MEL-46 levels also restored perturbed microRNA (miR-2) function in smn-1(lf) animals

159 describe emerging strategies for selectively perturbing microscopic interaction parameters, which can

160 Furthermore, laminin alpha2 knockdown also perturbed microtubule (MT) organization by considerable

161 Furthermore, perturbing microtubule and actin cytoskeletal dynamics h

162 e TDP-43 phosphorylation and ubiquitination, perturb mitochondria, and initiate degenerative inflamma

163 , our results demonstrate that E9591 and LMT perturb mitochondrial Fe-S cluster biosynthesis; thus, t

164 tion are defects in beta-cell metabolism and perturbed mitochondrial structure.

165 and Ag(100) surfaces, with the most strongly perturbed mode being that associated with the largest vi

166 at small molecules can inhibit maturation by perturbing molecular motions.

167 These findings support the possibility that perturbed morphological differentiation of cells within

168 al disruption of Rev-Rev interactions should perturb multiple Rev activities, both Rev-RNA binding an

169 Our results suggest that increases in ShcA perturb nephrin phosphosignaling dynamics, leading to ab

170 gical data analysis (TDA) to interrogate two perturbed networks.

171 Perturbing networks is one strategy for identifying modu

172 t oxidative stress response to hyperglycemia perturbs neutrophil cytoskeletal stability leading to MP

173 emicals induce endoplasmic reticulum stress, perturb NF-kappaB, and p53 signaling, and diminish mitoc

174 and tumours share metabolomic signatures of perturbed nitrogen handling.

175 ping brain, yet little is known about how Pb perturbs NSC functions and whether such perturbation con

176 rrelated with directionality alterations and perturbed nucleus-centrosome (N-C) coupling.

177 ctor, contribute to remyelination failure by perturbing oligodendrocyte progenitor cell (OPC) maturat

178 Glyoxal molecules, on the other hand, perturb only slightly the surface of ice and do not expe

179 TB treatment does not perturb overall diversity, but nonetheless dramatically

180 Perturbed parameter sets were generated by perturbing ea

181 mice and that hepatocyte glucose uptake was perturbed, partly accounting for the HCV-induced glucose

182 d by somatic genomic alterations (SGAs) that perturb pathways regulating metastasis-relevant activiti

183 measures specificity-the degree to which the perturbed pathways identified by a particular method to

184 Recall measures the consistency of the perturbed pathways identified by applying a particular a

185 platform/batch effects and able to identify perturbed pathways in individual samples.

186 in a RIM2alpha mutant mouse only marginally perturbs photoreceptor synaptic transmission.

187 that generates a partially buried group with perturbed physico-chemical properties.

188 e demonstrate that loss of PO-ER association perturbs PO membrane expansion and increases PO movement

189 al cells or local forced expression of Wnt5a perturbed polarization of neighboring wild-type cells.

190 es properly and entered a mitotic delay that perturbed polarized divisions and skewed daughter fates.

191 ohol during adolescence has been reported to perturb prefrontal cortical development, yet the mechani

192 ometry, are limited in three aspects: 1) The perturbing preparation procedures often alter the molecu

193 a unique class of free oscillations that are perturbed primarily by velocity and density variations a

194 Here we introduce a method to identify perturbed processes.

195 emonstrates a possible link between PGD2 and perturbed proliferation dynamics in epithelial stem cell

196 o characterisation show that these mutations perturb protein folding, assembly or polarity of secreti

197 use neural tube defects (NTDs) in embryos by perturbing protein activity, causing cellular stress, an

198 13-HODE also perturbed proteins related to lipid metabolism.

199 t approaches to identify antimalarial agents perturbing redox equilibrium.

200 rates and extracellular fluxes from a set of perturbed reference strains (RSs) and a parental strain

201 Here, we developed PRISM (Perturbing Regulatory Interactions by Synthetic Modulato

202 ns and linewidths for samples near 100 K are perturbed relative to those near 273 K.

203 ium experiments show that poly(dA:dT) tracts perturb remodeling reactions if within one and a half he

204 e of extrachromosomal elements, hallmarks of perturbed replication.

205 The centre frequency of the perturbed resonator is inadvertently drifted from its or

206 n targets or systematically designed mutants perturbing RNA sequence and structure.

207 ken together, DBAN may precipitate cancer by perturbing S phase and by blocking the Chk1-dependent re

208 These data collectively argue that mutations perturbing SCO1 function have tissue-specific consequenc

209 cooperative action of deregulated genes that perturb self-renewal, proliferation, and differentiation

210 icocortical computational model representing perturbed signal conduction from myelin.

211 interaction via mutations in the II-III loop perturbs skeletal muscle EC coupling, but preserves the

212 n and colleagues uses sophisticated tools to perturb specific lipids in living cells to assess the co

213 domain with high transfection efficacy would perturb spermatogenesis, in particular, spermatid adhesi

214 the consequences of aneuploidy has relied on perturbing spindle assembly checkpoint (SAC) components,

215 P binding and on GTPase activity and did not perturb stability of the MCM-MeaB complex.

216 ly isolate and sacrifice cells, inflicting a perturbed state and preventing complementary analyses.

217 rea do not affect native Env but destabilize perturbed states induced by cold or CD4Ms and increase t

218 Across 253 minimally perturbed streams in eight ecoregions in the western USA

219 nd capsular serotype but these can be easily perturbed, such as by vaccination.

220 dary structural features in both enzymes are perturbed, suggesting the existence of a common mechanis

221 maps on 63 RNA-seq datasets from normal and perturbed T-cell development to identify functional targ

222 roach, we found that these modifications can perturb telomerase function in hPSCs and cancer cells, r

223 t labels for chemical targeting, which could perturb the biological functionality in living systems.

224 le depletion of polymerase (Pol) eta did not perturb the bypass efficiency of the lesion, the bypass

225 e thermal, chemical, or mechanical stress to perturb the folding equilibrium for examining protein st

226 , we hypothesized that sleep restriction may perturb the gut microbiome to contribute to a disease st

227 er backbone substitutions at Gly77 and Tyr78 perturb the hydrogen bonding involving the buried water

228 poses a significant challenge to selectively perturb the interactions of even the SFK SH2 family agai

229 y the leukocytes and the VECs can separately perturb the junctional tensions of VECs to result in the

230 nonconserved residues (Ser/Thr(296/297)) may perturb the local fold.

231 the extracellular matrix protein fibronectin perturb the maturation of oligodendrocyte progenitor cel

232 lucose, or fatty acid synthase inhibitors to perturb the metabolic alterations, which resulted in dam

233 e antibiotics, when given early in life, can perturb the metabolic and immunological development of l

234 s suggest that antibiotic treatments greatly perturb the native gut community, thereby facilitating p

235 e use of divalent counterions to temporarily perturb the packing features of the ionic groups in a ho

236 containing theaflavins are then predicted to perturb the protonation of His264.

237 entify therapeutically useful compounds that perturb the ratio of GagPol to Gag, and pertinent to the

238 e find that disease-associated mutations may perturb the regulatory network through diverse mechanism

239 POINTS: Omecamtiv mecarbil and blebbistatin perturb the regulatory state of the thick filament in he

240 arison, we find that the spin label does not perturb the signature population of the beta-hairpin for

241 Mutations that perturb the substrate binding site either result in the

242 zone and other respiratory inhibitors, which perturb the transmembrane potential, were equally effici

243 Mutations in the CUE1 domain of SMARCAD1 perturbed the binding to KAP1 in vitro and in vivo Accor

244 Further, nitrogen limitation significantly perturbed the carbon and nitrogen flows in the fungal me

245 Mutations that perturbed the conformational behavior of the beta3-alpha

246 To assess causality, we perturbed the function of Tet2, the second most commonly

247 Diazinon exposure perturbed the gut microbiome community structure, functi

248 mulation (TMS) intervention that transiently perturbed the LPFC.

249 Microstimulation even perturbed the percept of certain objects that did not ac

250 ge, transiently decreased the frequency, and perturbed the phasing of the locomotor-like rhythm.

251 small molecule and genetic, for probing and perturbing the assembly of the Corynebacterineae cell en

252 800734 within the promoter region of MLH1 as perturbing the binding of TFAP4 and consequently increas

253 Perturbing the cholesterol/sphingomyelin balance was sho

254 Perturbing the expression levels of FGFs/FGFRs by excess

255 probe the architecture of ribbon synapses by perturbing the function of RIM-binding proteins (RBPs) a

256 show the role of environmental toxicants in perturbing the gut microbiome and its metabolic function

257 protein expression at the membrane and/or by perturbing the intricate gating properties of Kv11.1 cha

258 Perturbing the longitudinal chromosomal organization by

259 n, and therefore allows measurements without perturbing the native cell physiology.

260 rack their physicochemical evolution without perturbing the nonlinear O3 chemistry.

261 ling S. mutans in a rat caries model without perturbing the oral microbiota.

262 Perturbing the plasma membrane cholesterol/sphingomyelin

263 Perturbing the RNA m(5)C methyltransferase TRM4B resulte

264 cept from 1 to 4 hr post-fertilization, when perturbing the spatial extent of Erk pathway activation

265 f the D1 residue at position 87 with alanine perturbs the chloride-binding site in the proton-exit ch

266 domain that packs against the ETS domain and perturbs the conformation of its DNA-recognition helix.

267 However, whether mutp53 directly perturbs the DNA replication checkpoint remains unclear.

268 dent response of DNA as the remodeler ATPase perturbs the duplex at SHL2.

269 We designed a FOXO4 peptide that perturbs the FOXO4 interaction with p53.

270 of RelA in the regenerating neuroepithelium perturbs the homeostasis between proliferation and apopt

271 This bridging motif perturbs the NU-1000 framework structure, drawing the zi

272 roton binding at the intracellular pH sensor perturbs the potassium affinity at the extracellular sel

273 ant increases the propensity to dimerize and perturbs the secondary structure composition.

274 tion of a critical residue, F270, to glycine perturbs the Si site, allowing structural determination

275 pressure, much like increase in temperature, perturbs the thermodynamic equilibrium between native an

276 etween ternary complexes and release factors perturbs the UGA readthrough level.

277 he tetrahedral structure of water is heavily perturbed, the effect being equivalent to pressurizing p

278 ng them in this resting conformation without perturbing their membrane reorganization properties dimi

279 s not been a robust set of methodologies for perturbing these regions.

280 Corticosteroid and antifungal therapy perturb this response, resulting in decreased cytokine p

281 Disease-causing RPGR mutations perturb this RPGR-gelsolin interaction, compromising gel

282 Any factor that perturbs this balance has the potential to block a produ

283 nse to changes in GTP levels while minimally perturbing those levels.

284 ry effects by targeting different aspects of perturbed threat responses and behaviors.

285 ociated R-loops and the genomic domains they perturb to modify gene expression remain unclear.

286 ct with actin, and how this mechanism can be perturbed to cause disease.

287 at pattern the neural tube were sequentially perturbed to identify an optimized combination of small

288 Using CRISPR/Cas9 technology to perturb transcription factors, we demonstrate that, unli

289 ranscription factors (crisprTFs) to globally perturb transcriptional networks.

290 soaking when delivered by XgDeltaavrHah1 By perturbing transcriptional networks and/or modifying the

291 1A, m2G and N6-methyladenosine (m6A) did not perturb translational fidelity, O6-methylguanosine (m6G)

292 bution was modulated with membrane integrity perturbing treatment that resulted into total loss of ly

293 Insulin sensitivity was not significantly perturbed until 11 weeks of HFD feeding.

294 each complex has distinct functions that are perturbed upon BAF47 loss.

295 mobilized and that their chemical shifts are perturbed upon binding to CXCR1, demonstrating that the

296 Conversely, uS7-D215 substitutions, perturbing uS7-eIF2alpha interaction in the closed state

297 rated where a subset of parameter values are perturbed using local and global sensitivity analysis te

298 Furthermore, muscle repair was severely perturbed when Ptpn11 was ablated in stem cells due to a

299 than two shells ( approximately 5.5 A) were perturbed, with dynamics a factor of 2-10 times slower t

300 vergent set of biological pathways that were perturbed within four of five independent T2D case/contr