ライフサイエンスコーパス: perturbation

1 and returning to that orbit after transient perturbation.

2 lex structures following massive ontogenetic perturbation.

3 te matrix-rich atheromata in regions of flow perturbation.

4 nize the membrane aberrancy wrought by lipid perturbation.

5 s necessary to predict microbial response to perturbation.

6 es not abolish their responsiveness to lipid perturbation.

7 uld otherwise be a deleterious environmental perturbation.

8 that is proportional to the strength of the perturbation.

9 efinition for robustness under thermodynamic perturbation.

10 w the gut microbiota recovers following this perturbation.

11 portions of the tree most influenced by the perturbation.

12 g an attenuated anticipatory response to the perturbation.

13 gatively correlated with molecular degree of perturbation.

14 ponse of multicellular organisms to deguelin perturbation.

15 n pattern recovery following auxin transport perturbation.

16 ross various loci and following experimental perturbation.

17 ns reflect an increased ability to withstand perturbations.

18 immune system and their response to several perturbations.

19 these shape fluctuations, we use biochemical perturbations.

20 t against environmental and cellular context perturbations.

21 trated during artificial and/or pathological perturbations.

22 tep to respond to exogenous and/or endogenic perturbations.

23 s that are highly sensitive to different FLC perturbations.

24 irectional modulation by relevant pathologic perturbations.

25 stantly re-calibrated to adapt to systematic perturbations.

26 e Sabrina Coast, may be sensitive to climate perturbations.

27 ein interactome changes across environmental perturbations.

28 MD & MSMs in predicting effects of chemical perturbations.

29 idating the modes of actions of the profiled perturbations.

30 n carbon stocks in response to environmental perturbations.

31 onding to both stabilizing and destabilizing perturbations.

32 e under diverse genetic and/or environmental perturbations.

33 he conserved loop sequence tolerated minimal perturbations.

34 ll-permeable drugs that preclude single-cell perturbations.

35 stem, we include symmetric alpha-stable Levy perturbations.

36 temporal response that is robust to external perturbations.

37 ratify phenotypic similarities among genetic perturbations.

38 and temporal structure of the environmental perturbations.

39 l-time image analysis, and automated optical perturbations.

40 cle activities, respectively, in response to perturbations.

41 such as pharmacologic modulators and genetic perturbations.

42 , exhibiting the most dramatic translational perturbations.

43 ; and build molecular annotations of network perturbations.

44 ed by physiological demands and pathological perturbations.

45 at were based on dose and time series of FLC perturbations.

46 to study forelimb adaptation to force field perturbations.

47 pond to genetic, environmental or phenotypic perturbations?

48 treatment resulted in greater mitochondrial perturbation, activation of caspase-9 and -3 and cleavag

49 sceptibility of ceRNAs to different types of perturbations affecting their competitors (and hence the

50 These maps, complemented with genetic perturbations, allowed us to uncover TRUB1 and PUS7 as t

51 on of three conceptual levels imitating drug perturbation allows these pathways to be realistically r

52 ting exposure to predation and environmental perturbation, allows for larger more fit young, and faci

53 simulations (Antibodyomics7) and free energy perturbation analyses (Antibodyomics8) providing informa

54 Mechanistically, network perturbation analyses showed eIF2A-phosphorylation-media

55 Chemical shift perturbation analysis by (1)H-(15)N heteronuclear single

56 ere we describe ShootingStar, a platform for perturbation analysis in vivo, which combines live imagi

57 nnels possess a high degree of resilience to perturbation and invariance with respect to the launch c

58 ey permit to characterize cells with minimal perturbation and manipulation, at the benefit of sample

59 Both perturbation and response profiles are stratified into s

60 may not be regular in the presence of those perturbations and (ii) optimizing those flexibilities ca

61 nimizes artificially induced transcriptional perturbations and allows for faithful detection of both

62 onal subjects on these combined motion-state perturbations and confirmed the predictions of the model

63 nalysis, transcriptome profiling, functional perturbations and mathematical simulations, we find that

64 structural information, high-throughput drug perturbation, and drug sensitivity profiles, enabling dr

65 a highly heterogeneous landscape of genetic perturbations, and transcriptome analysis of transformed

66 Similar solitary perturbations are also frequently observed before the on

67 bacteria, suggesting that these biochemical perturbations are independent of concurrent changes in t

68 Perturbations are observed in vesicular trafficking, lip

69 We show that gravity perturbations are particularly well observed with broadb

70 the microbiological changes induced by many perturbations are stochastic, and therefore lead to tran

71 These temperature-induced perturbations are strongly correlated with hydration sur

72 sity of the response of forest trees to such perturbations are unknown, especially given the lack of

73 However, these perturbations are weak and, so far, their detection has

74 t Nrf2 can reflect highly-localised cellular perturbations associated with relevant toxicological mec

75 ity, most likely by causing an electrostatic perturbation at the active site.

76 psid during virion maturation and results in perturbations at a specific protein-protein interface in

77 ression changes of the landmark genes into a perturbation barcode that reveals important features of

78 ays have been predicted previously using the perturbation-based Markovian transmission model.

79 tworks to respond and adapt to environmental perturbations, but the nature of the signaling hub(s) in

80 cifically, it was shown that the hemodynamic perturbation by AF considered led to substantial increas

81 We have previously shown that a hemodynamic perturbation by AF or reduced cardiac output and cycle l

82 stnatal period, which are thus vulnerable to perturbation by anesthetic exposure.

83 Fetal perturbations by OSA during pregnancy impose long-term d

84 leation renders the reactions susceptible to perturbations by other molecules.

85 model so that the influence of time varying perturbation can be theoretically analyzed.

86 ts shed some light on how SP-C-induced lipid perturbations can alter membrane structure to sustain LS

87 ers lay in the suboptimal region where their perturbations can improve both speed and accuracy.

88 ness and composition driven by environmental perturbations can work in concert or antagonistically to

89 anipulating the magnetic interaction through perturbations caused by chemical substitutions.

90 We suggest that structural perturbations caused by chiral inversions of amino acid

91 Here we present a novel approach, called perturbation clustering for data integration and disease

92 al fibre-based readout ensures minimal field perturbations compared to conductive probes and greatly

93 on did not impair basic motor patterns, post-perturbation completion of the action, or their performa

94 genes affect adipocyte biology and how their perturbations contribute to systemic metabolic disease.

95 exes are important for responding rapidly to perturbations, correcting limb trajectory, and strengthe

96 ly tailored to analyze high-dimensional gene perturbation data, to incorporate logical functions that

97 We used pressure perturbation differential scanning calorimetry (PPC) tha

98 ) can be cumulative in cells exposed to both perturbations-drug and mutation-compared with cells expo

99 tatistical analysis to investigate metabolic perturbations due to EA treatments at different meridian

100 hich people converge when exposed to a novel perturbation during locomotion is also energetically opt

101 Perturbations during adolescence can alter the developme

102 aorta matures and upon genetic and chemical perturbations during embryonic development.

103 ouse intestine, with luminal flow to control perturbations (e.g., microbes, drugs).

104 mputational predictions of a larger membrane perturbation effect by PGPC correspond to greater stiffn

105 w model does not take into consideration the perturbation effect, we modify the power flow model so t

106 tive to the temporal structure of a movement perturbation even at the earliest stage in learning.

107 This order is remarkably stable to perturbations, even in the presence of slow thermalizati

108 This revealed that perturbation-evoked responses were initially restricted

109 might lead to catastrophic events when those perturbations exceed certain intensity thresholds.

110 Combining field observations, high-CO2 perturbation experiment results, and retrospective ocean

111 Transcription perturbation experiments further indicate that R-loop in

112 We independently validated 15 of them by perturbation experiments in several cancer cell lines.

113 Furthermore, various perturbation experiments indicated that they are organiz

114 Using live-imaging and perturbation experiments we show that leaf orientation,

115 Perturbation experiments with a miR-218-5p mimic or inhi

116 is of gene expression datasets from chemical perturbation experiments, with the goal of elucidating t

117 o prove the concept, we employed free energy perturbation (FEP) coupled with lambda-exchange molecula

118 nt (DeltaG+/-) will not affect the energetic perturbation from a mutation in a tertiary contact (Delt

119 biomolecules because of strong and ultrafast perturbations from biomolecule-solvent interactions.

120 Phenomena such as perturbation growth, necking and budding of offspring dr

121 hat occurs in the absence of pharmacological perturbation has remained elusive.

122 Local perturbations have therefore revealed unexpected feature

123 onse of colloids subject to a small external perturbation in a dense bath of motile E. coli bacteria.

124 itical developmental period due in part to a perturbation in BDNF-TrkB signaling, and could contribut

125 nal proliferation and developmental splicing perturbation in Chd8(+/del5) mice.

126 nd of ongoing glacier response to an earlier perturbation in driving ice-sheet loss.

127 The main cause of obesity is a perturbation in energy homeostasis, whereby energy intak

128 lar basis underlying lignin biosynthesis and perturbation in grasses.

129 s, the Gly1629Glu mutation causes structural perturbation in the A2 domain and thereby destabilizes t

130 antly, that estrogen treatment reverses this perturbation in the population of interneuron progenitor

131 A screening process ranked the effect of perturbations in 223 inputs, isolating the 30 most influ

132 sociated with profound myeloid expansion and perturbations in B and T cells.

133 Perturbations in cellular chloride concentrations can af

134 TRMT1-associated ID are likely to have major perturbations in cellular homeostasis due to the lack of

135 r in excitatory synaptic scaling that senses perturbations in firing through changes in calcium influ

136 Proteomics results indicated broad perturbations in four signaling pathways, Rho GTPases, a

137 In pollen, the perturbations in LD biogenesis and turnover are coupled

138 These results suggest that perturbations in lipid metabolism associated with late e

139 sis, consistent with NMR-detected structural perturbations in localized regions of KRAS important for

140 ution in the interpretation of mitochondrial perturbations in models where APP is overexpressed, and

141 We create point-like strain perturbations in mono- and bi-layer WSe2 which locally m

142 gated the global transcriptional response to perturbations in O-GlcNAcylation.

143 Furthermore, the significant perturbations in PBMC transcriptome may help determine t

144 uter model also predicts powerful effects of perturbations in plasma and ER calcium pump rates and th

145 ibrary of mutants to quantify the effects of perturbations in protein structure and protein-protein a

146 alterations in global protein synthesis, and perturbations in redox homeostasis, including increased

147 ear these points and suggests specific timed perturbations in signals that can lead to additional une

148 tions show that relatively small temperature perturbations in the back-arc result in vigorous inflow

149 graphy, laser-mediated ablation, and genetic perturbations in the Caenorhabditis elegans oocyte, we s

150 d by local and global structural and dynamic perturbations in the double helix.

151 aumatic brain injury (TBI) is known to cause perturbations in the energy metabolism of the brain, but

152 Perturbations in the environment lead to distinctive gen

153 Climate change-induced perturbations in the hydrologic regime are expected to i

154 This revealed significant perturbations in the lipid profile following CA-diet fee

155 ch as type-1 diabetes may lead to detectable perturbations in the molecular composition of residual s

156 Pulsatory volcanism, and associated perturbations in the ocean-atmosphere system, likely had

157 em follows a cube-root dependence on induced perturbations in the refractive index.

158 Early perturbations in tissue-wide gene expression, as observe

159 Paternal environmental perturbations including exposure to drugs of abuse can p

160 tent with our hypotheses, we found that: (1) perturbations increased EMG activity of the gluteus medi

161 ow examine the impact of microbial community perturbations induced by acute ABX exposure exclusively

162 The response to this perturbation is localized due to distinct physico-biogeo

163 ng movement accuracy after introduction of a perturbation, is affected at the pre-clinical and clinic

164 ory force patterns were largely based on the perturbation kinematic (e.g., velocity), but also showed

165 lar dynamics simulations and the free energy perturbation method (MD/FEP) in fragment optimization fo

166 k, we show that FEP+, which is a free energy perturbation method based on all-atom molecular dynamics

167 elop the Optometrist Algorithm, a stochastic perturbation method combined with human choice.

168 very to the shoreline and dampening possible perturbations might lead to catastrophic events when tho

169 f TRIM14 in NSCLC using in vitro and in vivo perturbation model systems.

170 erstand disease conditions and environmental perturbations, multiomic studies combining proteomic, li

171 Traditionally, a very small perturbation near an optical microcavity introduces eith

172 that a volcanically induced global Hg cycle perturbation occurred at that time.

173 nt mechanisms designed to counteract loss or perturbation of a single member of the network.

174 Here, we demonstrate that perturbation of astroglial networks impairs the sleep-wa

175 model of PDAC, which allows time-restricted perturbation of cell fate, shows that depletion of Smarc

176 is important for cardiovascular health, and perturbation of CL metabolism is implicated in cardiovas

177 Perturbation of CL remodeling leads to the rare X-linked

178 The selective perturbation of complex microbial ecosystems to predicta

179 synthesis, reduced hemoglobin formation, and perturbation of erythroid regulatory systems.

180 structure, Tg exhibits substantially reduced perturbation of G-quadruplex folding.

181 Perturbation of glucose metabolism or disruption of Myc

182 Perturbation of iron homeostasis is a major strategy in

183 We now show, through perturbation of its inherent left-right (L-R) asymmetry

184 dressed this ambiguity using measurement and perturbation of motor cortical activity together with el

185 quality in this environment through thermal perturbation of near surface permafrost and increased mo

186 OS stimulates endothelial sprouting and that perturbation of normal FOS degradation could account for

187 Chemogenetic [clozapine-N-oxide (CNO)-hM4Di] perturbation of Tac1-Pet1 neuron activity blunted the ve

188 nsible for the reduction in antioxidants and perturbation of the ascorbate and aldarate metabolism.

189 fast T-TET is due primarily to a geometrical perturbation of the carotenoid backbone in the triplet s

190 y susceptible to pharmacological and genetic perturbation of the cellular proteostatic machinery and

191 n of P. aeruginosa outer domains without any perturbation of the conserved interior of the filament.

192 Perturbation of the cooperative Tpz1-Poz1-Rap1 assembly

193 in reduced nutrient transport and a profound perturbation of the endocytic machinery, despite preserv

194 Based on perceptual changes following perturbation of the GABAergic system, it is conceivable

195 Perturbation of the gut-associated microbial community m

196 nce with the JAK/STAT3 signaling, leading to perturbation of the host innate and adaptive immune resp

197 The binding competition leads to perturbation of the IAV polymerase complex, thereby limi

198 This strategy enables perturbation of the metabolic and regulatory networks in

199 n appearance presumably due to local thermal perturbation of the nail structure.

200 elated signaling contributed to the observed perturbation of the NETosis pathway by PPTT with AuNRs@R

201 ental disorder, we examined the effects that perturbation of the one-carbon metabolism during gestati

202 sensitive technique to monitor drug-induced perturbation of the PI3K/mTOR pathway in sarcomas.

203 Perturbation of the protein-protein interface has proven

204 ypothesis that Robinow syndrome results from perturbation of the Wnt/PCP pathway, suggest specific re

205 both in silico and in vitro experiments that perturbation of this interface leads to higher phosphory

206 lipases for LD breakdown in hepatocytes, and perturbation of this pathway could be a major consequenc

207 Perturbation of thyroid iodide uptake is a well-document

208 The genome-wide perturbation of transcriptional networks with CRISPR-Cas

209 line corrections in response to inconsistent perturbations of auditory feedback.

210 m ATPase was tolerant of genetic or chemical perturbations of calcium-mediated signalling, but abolis

211 Functional perturbations of drebrin demonstrate that proximal leadi

212 Raman spectroscopy revealed molecular-level perturbations of fibril conformation by the PD-related m

213 Deficiencies in the PAPs resulted in perturbations of gene expression, with Star-PAP impactin

214 rmational entropy penalty arising from local perturbations of grafted and matrix chains under confine

215 muscle phenotype and function and molecular perturbations of hyperammonemia; these preclinical studi

216 ic foods, and this scenario is compounded by perturbations of insulin metabolism stemming from high a

217 an transcription of Pfn1, is affected by the perturbations of MKL.

218 deletion of NDCBE in mice caused only subtle perturbations of Na(+) homeostasis and provide evidence

219 that the S672R mutation results in extensive perturbations of the dynamics in both apo- and holo-form

220 In this study we review the evidence linking perturbations of the gut microbiome to pancreatic autoim

221 Perturbations of the intestinal microbiome have been obs

222 Studies in mouse models have shown that perturbations of the microbiota during early life can ca

223 tical model simulations predicted that small perturbations of the microenvironmental extracellular pH

224 In addition, the HSA-induced perturbations of the monomer/protofibrils pseudo-equilib

225 We demonstrate that perturbations of this assembly machinery trigger complex

226 Extreme environmental perturbations offer opportunities to observe the effects

227 an be useful to further exploit the external perturbation on large core fiber in various applications

228 and we can simulate the impact of a protein perturbation on the RN behavior to identify therapeutic

229 fy the differential effects of environmental perturbations on microbial growth across a large compend

230 sed to ascertain the effect of these dynamic perturbations on the kinetic profiles of both proteins.

231 etect, process, and respond to environmental perturbations or signals.

232 idual cells and their response to mechanical perturbations, or to make cells take up chemicals that o

233 his peculiar behaviour is lost when external perturbations overcome a critical threshold, i.e. above

234 ervations suggest that intestinal microbiota perturbations precede arthritis, and that modulation of

235 ces, but little is known about the metabolic perturbations preceding fatty liver disease.

236 ubstrate of human eroded plaques, acute flow perturbation promoted downstream endothelial cell activa

237 In the homogeneous system, the electronic perturbation provided by the pyrene functionality transl

238 w computational method, named random circuit perturbation (RACIPE), for interrogating the robust dyna

239 noise, diffusion, or activity, but that such perturbations reduce fluctuations toward their limiting

240 ion, which are naturally occurring intrinsic perturbations reflecting the capability of a given brain

241 o the next within the same block, indicating perturbation response specificity at the single trial le

242 scFv antibodies are characterized by a novel perturbation-response decomposition of molecular dynamic

243 IL17R1 signal perturbation results in reduced expression of several re

244 Genetic perturbation revealed physiological roles for mitochondr

245 Photobleaching and genetic perturbations showed that the BM receptor dystroglycan f

246 Solitary perturbations (SPs) localized both poloidally and radial

247 covariates but tend to be driven by external perturbations such as climate, severe winters, predators

248 erize the response of cell culture models to perturbations such as pharmacologic modulators and genet

249 ompeting phases can be uncovered by external perturbations such as pressure or magnetic field, which

250 Genetic perturbations targeting allostery or key regulatory node

251 or unit cell, is remarkably invariant under perturbations targeting transcription, translation, ribo

252 uthors show a non-intrusive microwave cavity perturbation technique as a powerful tool to determine t

253 repeat-containing RNAs is more sensitive to perturbation than transcription of other RNAs, indicatin

254 ly involved in updating the memory about the perturbation that is essential for forelimb motor adapta

255 and II of NS5BDelta21 and induces long-range perturbations that affect the RNA-binding properties of

256 s dynamic probing of biological systems with perturbations that are computed on-the-fly during experi

257 domain, thereby identifying the direction of perturbations that are more likely to cause extinctions.

258 pecifically targeting the pathophysiological perturbations that develop in this part of the nephron.

259 hing events are associated with a profile of perturbations that include intermittent hypoxia, oxidati

260 ble these highly symmetric structures are to perturbations that may arise from the interplay between

261 lls when subjected to small mechano-chemical perturbations that mimic tumor microenvironments.

262 ivation can lead to long-lasting physiologic perturbations that resemble medical comorbidities often

263 sing the phenotypes that are caused by these perturbations the wild-type function of genes can be elu

264 adaptation and (2) for combined motion-state perturbations, the gain associated to changes in limb po

265 via embedded n-electron valence second-order perturbation theory within the density functional embedd

266 Free energy perturbation theory, employing all-atom and explicit-sol

267 hey require approaches beyond mean-field and perturbation theory.

268 y metabolic processes in response to applied perturbations, they are insufficiently quantified for pr

269 the screening phenotype, as well as genetic perturbation, through analysis of indel rate and transcr

270 However, upon perturbation, TNFalpha exhibits increased conformational

271 ir membrane partitioning, translocation, and perturbation to one of the parent SMTPs, called "TP2".

272 and adaptive form of NMJ plasticity in which perturbation to postsynaptic neurotransmitter receptors

273 f neural lineages out of the CNS and drastic perturbations to CNS structure.

274 Combinatorial perturbations to dietary casein protein and psyllium fib

275 that diabetic dogs have similar metabolomic perturbations to humans with type 1 diabetes (T1D), we a

276 nd As(III) exposure groups, with significant perturbations to intermediates shuttling into and cyclin

277 Perturbations to mammalian SWI/SNF (mSWI/SNF or BAF) com

278 Thermodynamic cycles use factorial perturbations to measure coupling energies between side

279 CRISPR-based knockouts, and pharmacological perturbations to probe the basis of neutrophil adaptatio

280 ntributions of complement-dependent membrane perturbations to prothrombotic TF activation on myeloid

281 n be tuned in real-time by applying external perturbations to the fiber.

282 ses/phosphatases knockouts and time-resolved perturbations to the nitrogen metabolism.

283 Cell fate perturbations underlie many human diseases, including br

284 igate the magnitude of these proposed oxygen perturbations using selenium (Se) geochemistry, which is

285 dependent and position-dependent force-field perturbations (vFFs and pFFs) at the earliest possible s

286 reduced de-adaptation performance after the perturbation was removed in comparison to the control pa

287 e demonstrate that initial adaptation to the perturbation was significantly impaired in the eighteen

288 nervous system is particularly vulnerable to perturbation, we hypothesized that early-life circadian

289 in cell cycle profile patterns upon chemical perturbation, we identified 36 compounds that inhibited

290 docrine disruption, with expected metabolism perturbations, we performed metabolomics on mice serum o

291 used as probes, and thus possible structural perturbations were minimized.

292 le-trial adaptive responses when vFF and pFF perturbations were randomly intermingled from one trial

293 between walking speed and susceptibility to perturbations, when present, were more complex than anti

294 nteraction is highly sensitive to structural perturbations, which has a profound effect on the overal

295 rved in geophysical flows are also robust to perturbations, which suggests a role for topology.

296 ed controls with multidirectional waist-pull perturbations while walking on a treadmill.

297 wn LFY target genes is unaffected by AP1/CAL perturbation, while others appear to require AP1/CAL act

298 Cells react to extracellular perturbations with complex and intertwined responses.

299 properties have been compromised by genetic perturbations within the carboxyl-terminal tail.

300 By buffering offspring against environmental perturbation without jeopardising their own survivorship