ライフサイエンスコーパス: pestivirus

1 ne fever virus (CSFV), a devastating porcine pestivirus.

2 diarrhea virus (BVDV), a positive-sense RNA pestivirus.

3 , but did not amplify viral RNA from related pestiviruses.

4 the 5' limit of the IRES in both the HCV and pestivirus 5'NTRs.

5 Notably, replication of pestiviruses, a major threat to milk and meat industries

6 nti-PrP(Sc) activity was independent of anti-pestivirus activity.

7 In 2013, envelope proteins from a pestivirus and hepatitis C virus were found to have two

8 rane fusion machinery of the closely related pestiviruses and hepatitis C virus defines a new structu

9 Y2441 is highly conserved among pestiviruses and is located in a region of NS4B predicte

10 he interface explains the acid resistance of pestiviruses and their requirement for a redox activatio

11 bosome entry site-containing picornaviruses, pestiviruses, and hepatitis C viruses.

12 Thus, the zinc-binding ability of N(pro) in pestiviruses appears to be essential for the virus-media

13 e viral diarrhea virus (BVDV), the prototype pestivirus, are divided into cytopathic (cp) and noncyto

14 port, we show that the NS3 proteinase of the pestivirus bovine viral diarrhea virus (BVDV) (NADL stra

15 the hypothesis that the NS5A protein of the pestivirus bovine viral diarrhea virus (BVDV) is a zinc-

16 rallels the observation made for the related pestivirus bovine viral diarrhea virus.

17 activity, while the IIId2 sub-domains of two pestiviruses, classical swine fever virus (CSFV) and bor

18 miR-17 sequestration by pestiviruses conferred reduced AGO binding and functiona

19 The viral N-terminal protease N(pro) of pestiviruses counteracts cellular antiviral defenses thr

20 947 and similar compounds for the control of pestivirus diseases, and for hepatitis C virus drug disc

21 Despite increasing characterization of pestivirus-encoded proteins, functions for nonstructural

22 Pestiviruses form a genus in the Flaviviridae family of

23 We expect the pestivirus fusion apparatus to be conserved in hepatitis

24 nomes of Flaviviridae of the Hepacivirus and Pestivirus genera contain internal ribosomal entry sites

25 esidues, conserved among the Hepacivirus and Pestivirus genera, fitting the formula of CX17CXCX20C.

26 ement in the NS5A proteins of members of the Pestivirus genus has led to the hypothesis that the NS5A

27 calves persistently infected with HoBi-like pestivirus (HoBi-like PI calves) were generated and samp

28 ism of translation initiation on hepacivirus/pestivirus (HP) IRESs, which involves factor-independent

29 e-strand RNA virus and a member of the genus Pestivirus in the family Flaviviridae.

30 st effective measures for controlling bovine pestiviruses, including bovine viral diarrhea virus (BVD

31 Pestiviruses, including bovine viral diarrhea virus (BVD

32 Pestiviruses, including bovine viral diarrhea virus, are

33 7 inhibits both cytopathic and noncytopathic pestiviruses, including isolates of BVDV-1, BVDV-2, bord

34 a novel antiviral host factor that restricts pestivirus infection.

35 Although pestivirus infections impose an important toll on the li

36 mmunosuppression is a feature of a number of pestivirus infections; our studies suggest type III IFN

37 sheds light on the molecular basis by which pestiviruses interplay with the host cell.

38 unction of this unique viral protease in the pestivirus life cycle remains to be elucidated.

39 Although the pestivirus N-terminal protease, N(pro), has been shown t

40 The pestivirus N-terminal protease, N(pro), is essential for

41 The pestivirus noncytopathic bovine viral diarrhea virus (BV

42 ongly conserved among related Flavivirus and Pestivirus nontranslated regions.

43 We report here the X-ray structure of the pestivirus NS3 helicase domain (pNS3h) at a 2.5-A resolu

44 e site preference, a structural model of the pestivirus NS3 proteinase predicts a highly hydrophobic

45 the similarities between the Hepacivirus and Pestivirus NS5A proteins and suggest that both proteins

46 classical swine fever virus (CSFV), a fatal pestivirus of pigs, remain unknown.

47 n of bovine viral diarrhea virus, a ruminant pestivirus of the family Flaviviridae, but has no apprec

48 Pestivirus particles are composed of an RNA genome, a ho

49 y the single large open reading frame of the pestivirus positive-sense RNA genome and has an autoprot

50 ES domains of several viral RNA genomes: two pestiviruses related to HCV, classical swine fever virus

51 up new questions about pNS3h function during pestivirus replication.

52 e discovery of a small molecule inhibitor of pestivirus replication.

53 ctive NS3 serine proteinase is essential for pestivirus replication.

54 We generated a self-replicating cytopathic pestivirus RNA to enhance production and presentation of

55 ortant for optimal translation initiation of pestivirus RNAs.

56 ing two stem-loops not present in the HCV or pestivirus structures.

57 Pestiviruses, such as bovine viral diarrhea virus and cl

58 Pestiviruses, such as classical swine fever virus (CSFV)

59 These findings suggest dual mechanisms of pestivirus superinfection exclusion, one at the level of

60 Unique to pestiviruses, the N-terminal protein encoded by the bovi

61 lation was multiple logs more resistant than pestivirus to DB772, suggesting that the anti-PrP(Sc) ac

62 eractions, miR-17 and let-7 binding enhanced pestivirus translation and RNA stability.

63 Bovine viral diarrhea virus (BVDV) (genus Pestivirus) was reported to trigger interferon productio