ライフサイエンスコーパス: pexophagy

1 bers is through an autophagic process called pexophagy.

2 peroxisomal and is required specifically for pexophagy.

3 ks pexophagy, and its overexpression induces pexophagy.

4 (PEX2) is the causative agent for mammalian pexophagy.

5 e is necessary but not sufficient to trigger pexophagy.

6 s sequestered within vacuoles as a result of pexophagy.

7 heir delivery to the autophagy machinery for pexophagy.

8 pAtg30, mediates peroxisome selection during pexophagy.

9 tions, at least one of which is required for pexophagy.

10 Cvt pathway and efficient autophagy but not pexophagy.

11 oxisomes in the process of being engulfed by pexophagy.

12 d the targeted degradation of peroxisomes by pexophagy.

13 storis, Gsa9 is required for glucose-induced pexophagy.

14 appears to be required for an early event in pexophagy.

15 (TbHK1) protein levels are maintained during pexophagy, acidification inactivates the activity.

16 e shown that these proteins are required for pexophagy and autophagy in P. pastoris and the Cvt pathw

17 y, including cytoplasm-to-vacuole targeting, pexophagy and mitophagy, and mammalian genetic screens h

18 of cellular recycling mechanisms (autophagy, pexophagy and ribosome breakdown) in maintaining cell vi

19 verlap of macroautophagy with the process of pexophagy and with the biosynthetic cytoplasm-to-vacuole

20 ame this protein Atg36 as its absence blocks pexophagy, and its overexpression induces pexophagy.

21 Autophagy, pexophagy, and the Cvt pathway are processes that delive

22 l membrane protein required specifically for pexophagy at the stage of phagophore formation.

23 During pexophagy, Atg30 undergoes phosphorylation, a prerequisi

24 ignal transduction pathway are necessary for pexophagy but not for pexophagosome formation or other n

25 It is necessary for pexophagy, but not for other selective and nonselective

26 study, we investigated the role of Sar1p in pexophagy by expressing dominant-negative mutant forms o

27 suggesting that the mTORC1 pathway regulates pexophagy by regulating PEX2 expression levels.

28 of Atg26 and Vac8 functions under different pexophagy conditions demonstrates that not only pexophag

29 ains also displayed defects in autophagy and pexophagy, degradative pathways that share protein machi

30 PpAtg30 overexpression stimulates pexophagy even under peroxisome-induction conditions, im

31 Pexophagy (fusion of glycosomes with acidic lysosomes) h

32 ion of peroxisomal membrane proteins signals pexophagy; however, the E3 ligase responsible for mediat

33 However, the role of this protein in pexophagy in other yeast remained unclear.

34 eling, provide evidence for the existence of pexophagy in plants, and indicate that peroxisome destru

35 peroxisome pool, and establishes its role in pexophagy in S. cerevisiae.

36 pastoris and the Cvt pathway, autophagy, and pexophagy in S. cerevisiae.

37 nd that its interaction with Atg30 regulates pexophagy in the yeast P. pastoris.

38 s, determine the requirements for subsequent pexophagy in yeast.

39 nases in selective autophagy of peroxisomes (pexophagy) in Saccharomyces cerevisiae.

40 ophagy conditions demonstrates that not only pexophagy inducers, such as glucose or ethanol, but also

41 PpAtg30 is required for formation of pexophagy intermediates, such as the micropexophagy appa

42 Pexophagy is a process that selectively degrades peroxis

43 For example, pexophagy is a selective process for the regulated degra

44 hat the function of sterol glucoside (SG) in pexophagy is both species and peroxisome inducer specifi

45 ne via interaction with peroxins, and during pexophagy it colocalizes transiently at the preautophago

46 r hydrolase, aminopeptidase I (API), whereas pexophagy mediates the delivery of excess peroxisomes fo

47 ls that activate this pathway do not trigger pexophagy on their own, suggesting that this MAPK cascad

48 ential for Cvt vesicle formation but not for pexophagy or induction of autophagy.

49 stinct from endoplasmic reticulum-autophagy, pexophagy, or mitophagy, despite the close association b

50 Both the Cvt and pexophagy pathways are selective processes that specific

51 During pexophagy, PpAtg30 undergoes multiple phosphorylations,

52 Autophagy (Apg) and pexophagy, processes that use the majority of the same p

53 The Pichia pastoris pexophagy receptor Atg30 is recruited to peroxisomes und

54 We conclude that Pex3 recruits the pexophagy receptor Atg36.

55 We propose that pexophagy requires the simultaneous activation of this M

56 Additionally, the pexophagy-specific phagophore assembly site, organized b

57 ome turnover by autophagy-related processes (pexophagy), termed micropexophagy and macropexophagy, is

58 solated pex3 alleles blocked specifically in pexophagy that cannot recruit Atg36 to peroxisomes.

59 size of peroxisomes before their turnover by pexophagy, the selective autophagy of peroxisomes, and f

60 rols the selective autophagy of peroxisomes (pexophagy) through the assembly of a receptor protein co

61 rgo rapid, selective autophagic degradation (pexophagy) when the metabolic pathways they contain are

62 on of both mitochondria and peroxisomes (via pexophagy), whereas Hog1 functions specifically in mitop