ライフサイエンスコーパス: pharmaceutically

1 tion, or as medical problems to be addressed pharmaceutically.

2 dentify focal mutations that are potentially pharmaceutically actionable in rare cancers.

3 It provides a practical access to pharmaceutically active 3-aminoquinoxalinone derivatives

4 work has facilitated expedient syntheses of pharmaceutically active compounds currently in clinical

5 Preliminary screening of a library of 1280 pharmaceutically active compounds identified inhibitors

6 at chlorination may increase the toxicity of pharmaceutically active compounds in surface water.

7 Modification of nucleosides to give pharmaceutically active compounds, mutagenesis models, a

8 ailable structures, and present in nearly 30 pharmaceutically active compounds.

9 tance derives from the observation that many pharmaceutically active natural products contain a chlor

10 Many biologically and pharmaceutically active natural products contain chlorin

11 folds for the insertion and stabilization of pharmaceutically active peptides.

12 ed ring, allowing rapid access to a range of pharmaceutically and agrochemically relevant polycyclic

13 We compare the separation of pharmaceutically and biologically important stereoisomer

14 es have been made in red biotechnology using pharmaceutically and medically relevant applications, gr

15 ction provides a straightforward approach to pharmaceutically and synthetically useful 2-aminobenzoxa

16 ised using a simple dip-coating process from pharmaceutically approved materials using a gelatin drug

17 ds induce melanogenesis is of great interest pharmaceutically (as therapy for pigmentary diseases) an

18 catalyst, thus allowing for the synthesis of pharmaceutically attractive alpha-diarylesters through a

19 ful transformations, exploitable to generate pharmaceutically attractive molecular targets.

20 that myofibrillar CK energy delivery can be pharmaceutically augmented in the failing human heart.

21 Dilation was induced pharmaceutically by the addition of 2.5% phenylephrine a

22 e clinical use of this highly promising, but pharmaceutically challenging biotherapeutic.

23 We captured this pharmaceutically critical process in atomic detail using

24 In the cosmopolitan and pharmaceutically highly relevant genus Euphorbia L., ide

25 These pharmaceutically highly-relevant channels contain struct

26 ction of numerous secondary metabolites with pharmaceutically important activities.

27 a single target is sufficient to elicit the pharmaceutically important antioxidant response element

28 spp. plants have the capacity to synthesize pharmaceutically important APGs using dual functional CH

29 are a class of natural products that include pharmaceutically important aromatic compounds such as th

30 class of natural products that include many pharmaceutically important aromatic compounds.

31 h-catalyzed direct arylation of a variety of pharmaceutically important azoles with aryl bromides is

32 the doors to studies on their widespread and pharmaceutically important bacterial signaling mechanism

33 provides a straightforward synthesis of the pharmaceutically important benzo[c]quinolizinium cation

34 iosynthetic pathways, including a variety of pharmaceutically important beta-hydroxylated antibiotics

35 Ozonolysis of the pyrazole moiety affords pharmaceutically important beta-phenethylamines.

36 re commonly used in the biosynthesis of many pharmaceutically important compounds and industrially us

37 o[1,2-a]indoles are known as medicinally and pharmaceutically important compounds, but there is a lac

38 d for the synthesis of (R)-phenylalanine and pharmaceutically important drug intermediate (R)-3-pheny

39 formational changes during catalysis of this pharmaceutically important enzyme.

40 e the recent solution of X-ray structures of pharmaceutically important G protein-coupled receptors (

41 le cells, causing the membrane assay to miss pharmaceutically important inverse agonists.

42 Coffee seeds also contain caffeine, a pharmaceutically important methylxanthine.

43 ies elucidate the lifestyle of a unique, and pharmaceutically important microorganism and highlight t

44 ts used in the production of a wide range of pharmaceutically important molecules.

45 receptor modulators are an emerging class of pharmaceutically important molecules.

46 ssential components of many biologically and pharmaceutically important molecules.

47 The synthesis of a series of pharmaceutically important N-protected methyl-substitute

48 gs and is representative of a broad class of pharmaceutically important natural products with five-me

49 omain enzymes that biosynthesize a number of pharmaceutically important natural products.

50 A novel, efficient route to biologically and pharmaceutically important o-(dimethylamino)aryl ketones

51 its use in the synthesis of biologically and pharmaceutically important organic molecules.

52 col in a simple one-step high-yield route to pharmaceutically important polyarylated pyridopyrimidino

53 for combinatorial biosynthesis of unnatural pharmaceutically important polyketides.

54 ed to investigate aggregate formation in the pharmaceutically important protein, recombinant human fa

55 Many extracellular proteins and most pharmaceutically important proteins contain disulfide bo

56 They play pharmaceutically important roles, at least in telomere h

57 this constitutes a novel disconnection of a pharmaceutically important scaffold.

58 synthetic transformations, the resolution of pharmaceutically important small molecules including pol

59 n manipulation of the opiate pathway in this pharmaceutically important species.

60 can be readily extended to a large number of pharmaceutically important targets.

61 It affords an efficient access to pharmaceutically important versatile 3-aryl-pyrido[1,2-a

62 t operons in E. coli and the 'more complex', pharmaceutically important, Streptomyces coelicolor.

63 A facile synthetic route toward pharmaceutically interesting 1-aminoisoquinoline derivat

64 ient information about a molecule to predict pharmaceutically interesting properties directly from th

65 a wide range of potentially biologically and pharmaceutically interesting substituted indazoles in go

66 This allowed for the deuteration of complex pharmaceutically interesting substrates, including examp

67 al development of kinase inhibitors aimed at pharmaceutically modulating network behavior.

68 ir cytokine/Ig production in vitro, and that pharmaceutically or genetically blocking the interaction

69 ver, the produced compounds are valuable and pharmaceutically quite relevant.

70 addition products were readily converted to pharmaceutically relevant 3,5-disubstituted pyrrolidinon

71 catalyzes the atroposelective bromination of pharmaceutically relevant 3-arylquinazolin-4(3H)-ones (q

72 tility of this approach, 10 biologically and pharmaceutically relevant alkaloids were prepared using

73 provides access to synthetically useful and pharmaceutically relevant alpha-amino boronic acid deriv

74 s and sulphides, which are commonly found in pharmaceutically relevant architectures.

75 synthesis (dehalogenation, deoxygenation) of pharmaceutically relevant building blocks.

76 luorescein (5-BMF) for the quantitation of a pharmaceutically relevant carboxyl-containing analyte in

77 which facilitate the divergent synthesis of pharmaceutically relevant compound libraries from a sing

78 Applying VCD to pharmaceutically relevant compounds has been handled in

79 be adapted to (13)C-isotope labeling of six pharmaceutically relevant compounds starting from Ba(13)

80 biquitous among living organisms and include pharmaceutically relevant compounds such as antibiotics

81 ines and -piperidines, an important class of pharmaceutically relevant compounds that contain a quate

82 Several pharmaceutically relevant compounds, including widely us

83 lockers of protein-protein interactions into pharmaceutically relevant compounds.

84 (11)CO to produce structurally challenging, pharmaceutically relevant compounds.

85 gy for converting peptidic compounds to more pharmaceutically relevant compounds.

86 The model systems studied include pharmaceutically relevant compounds: griseofulvin and ch

87 but show that its main inhibitory action at pharmaceutically relevant concentrations results from st

88 High-resolution structural studies of pharmaceutically relevant derivatives have been limited

89 linic, high-resolution structural studies of pharmaceutically relevant derivatives have been limited

90 nd enantioselective cross-coupling to afford pharmaceutically relevant diarylmethane products.

91 inity and in vivo blood pressure lowering at pharmaceutically relevant doses.

92 nisms of allosteric control of this class of pharmaceutically relevant enzymes, and provides a new pa

93 nstrate the synthetic utility of our method, pharmaceutically relevant examples of both product class

94 novel methodology and present results for 21 pharmaceutically relevant examples.

95 As one of the best studied members of the pharmaceutically relevant family of G-protein-coupled re

96 timization for the A2A adenosine receptor, a pharmaceutically relevant G protein-coupled receptor.

97 he contribution of the sugar constituents of pharmaceutically relevant glycosylated natural products,

98 radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecul

99 -MS excipient screening data collected for a pharmaceutically relevant IgG4 mAb being characterized t

100 useful for investigating the large number of pharmaceutically relevant kinases.

101 sets lends itself well to the prediction of pharmaceutically relevant molecular parameters for which

102 blishing structure-activity relationships of pharmaceutically relevant molecules.

103 is demonstrated in the synthesis of several pharmaceutically relevant molecules.

104 etection of intramolecular hydrogen bonds in pharmaceutically relevant molecules.

105 incorporating motifs readily encountered in pharmaceutically relevant molecules.

106 tial mimetics of the hormone somatostatin, a pharmaceutically relevant natural peptide, which contain

107 native secondary amine substrates, including pharmaceutically relevant nitrogen heterocycles, is demo

108 l understanding and potential replacement of pharmaceutically relevant PEGs by alternative macromolec

109 programs identified active compounds from a pharmaceutically relevant pool of decoy compounds; howev

110 he first time, genetic accessibility of this pharmaceutically relevant producer strain by intergeneri

111 rovide a new approach for the preparation of pharmaceutically relevant products possessing tetrasubst

112 ational methods on 150 crystal structures of pharmaceutically relevant protein-ligand complexes.

113 hodology is demonstrated by the synthesis of pharmaceutically relevant quinolines.

114 monitor molecular dynamic transitions in the pharmaceutically relevant solids Ambroxol and Ibuprofen.

115 tases (KREDs), enantioselectively reduce the pharmaceutically relevant substrates 3-thiacyclopentanon

116 ed yields for challenging cross-couplings of pharmaceutically relevant substrates compared with those

117 nd biocatalysis can have on the synthesis of pharmaceutically relevant target molecules.

118 support the tenet that active compounds for pharmaceutically relevant targets can be successfully id

119 ng biological activity over a broad range of pharmaceutically relevant targets.

120 d with the synthesis of natural products and pharmaceutically relevant targets.

121 thodology provides easy access to a class of pharmaceutically significant molecules and their precurs

122 y for the rapid assembly of biologically and pharmaceutically significant molecules, such as benzoxaz

123 being used in catalysis, green chemistry and pharmaceutically significant reactions are summarized in

124 chanisms of FXR regulation and in developing pharmaceutically suitable synthetic FXR ligands that mig

125 ing C3aR/C5aR activity either genetically or pharmaceutically suppressed OC generation, while stimula

126 and memory consolidation, and they have been pharmaceutically targeted for pain therapies, smoking ce

127 of MaCSCs in breast cancer and suggest that pharmaceutically targeting these kinases may hold promis

128 phenotypically screen, and thereby validate pharmaceutically tractable genes for drug development.

129 lls to enhance the yield of industrially and pharmaceutically useful products.

130 The pharmaceutically valuable monoterpene indole alkaloids (

131 atharanthus roseus that produces a number of pharmaceutically valuable, bioactive terpenoid indole al

132 The latter is critical for having pharmaceutically viable nano-drugs.