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1 nt leukocytes and investigated the effect of pharmacologic 5-LO inhibition by zileuton and LTB4 inhib
2 We find that TRC regeneration following such pharmacologic ablation requires neuronal expression of S
3 tegrates structure, bioactivity, regulatory, pharmacologic actions and indications for active pharmac
10 f Nr1d1(-/-) mice and human macrophages with pharmacologic activation of NR1D1, we found NR1D1 to reg
12 cancer prevention or treatment based on its pharmacologic activity as a Rac1 and Cdc42 inhibitor.
14 Scientists have recently discovered a novel pharmacologic agent that combines a NEP inhibitor and an
19 ema syndromes, with an emphasis on the novel pharmacologic agents that have recently become available
21 ting that SPMs are physiologic mediators and pharmacologic agonists that stimulate resolution of infl
27 tion draws on computational neuroscience and pharmacologic and genetic studies in animals and humans,
29 tions for eligibility criteria that focus on pharmacologic and immunologic considerations in this pat
31 sed flow cytometry, confocal microscopy, and pharmacologic and molecular targeting to address these g
32 atient shared decision making for the use of pharmacologic and nonpharmacologic approaches to diminis
33 safety and effectiveness of a broad range of pharmacologic and nonpharmacologic depression treatments
34 published through April 2015 on noninvasive pharmacologic and nonpharmacologic treatments for low ba
35 t-activity monitors were used to examine the pharmacologic and rapid antidepressant effects of ketami
41 target for preventing retinopathy, we used a pharmacologic approach (SM16, a selective inhibitor of t
42 inhibits the GC-B mutants, indicating that a pharmacologic approach could reduce GC-B dependent human
44 potentially effective and readily accessible pharmacologic approach to fertility preservation during
46 d in HAAF's development and suggesting novel pharmacologic approaches for safer intensive glycemic co
48 2017 Standards of Care about monitoring and pharmacologic approaches to glycemic management for type
49 ecommendations from the 2017 Standards about pharmacologic approaches to glycemic treatment of type 2
57 iron pools and reactive oxygen species drive pharmacologic ascorbate's selective toxicity to cancer c
59 er, they are also vulnerable to many in vivo pharmacologic barriers limiting their clinical translati
60 gulation of MYC function and suggest a novel pharmacologic basis to target histone demethylases as an
61 ctivity, and they raise the possibility that pharmacologic BET inhibitors can influence gene expressi
62 anipulation of ambient thermal environment), pharmacologic (beta-blockers), and genetic (beta2-AR kno
63 results suggest that AT1R knockdown and AT1R pharmacologic blockade by losartan may differently contr
64 rther, protection from injury is achieved by pharmacologic blockade of FcRn-albumin interactions with
66 letion of CCR2(+) inflammatory monocytes and pharmacologic blockade of IL-1beta or NLRP3 abrogated th
68 r data suggest that prolonged but reversible pharmacologic blockade of the CXCR4/CXCL12 axis represen
69 de accelerates CCM formation, and genetic or pharmacologic blockade of TLR4 signalling prevents CCM f
70 of Notch signaling that was more potent than pharmacologic blockage of Notch activation via gamma-sec
72 d melanocyte stimulating hormone (MSH) or by pharmacologic cAMP induction by forskolin enhanced clear
74 onhuman animal models, psychiatric genetics, pharmacologic challenge) to elucidate brain-based pathwa
76 such as disease progression and response to pharmacologic, cognitive, behavioral, and neuromodulatio
77 findings provide preclinical evidence for a pharmacologic combination of Bax activation and mTOR inh
78 the meta-analytically determined efficacy of pharmacologic combination strategies of antipsychotic dr
79 Overall, our database provides a resource of pharmacologic data that can reinforce known therapeutic
84 of TrkB in neural stem/progenitor cells, or pharmacologic disruption of ERK signaling, or inhibition
87 s discrimination in this task was rescued by pharmacologic disruption of the NRG3 receptor, ErbB4.
90 prolonged heart allograft survival, whereas pharmacologic downregulation of kidney-derived EPO reduc
93 ence from their off-target anti-inflammatory pharmacologic effects, an understanding of the role of t
101 The human VE cell line (EA.hy926 cells) and pharmacologic (imatinib) and genetic (short hairpin RNA
102 however, requires treatment with nonspecific pharmacologic immunosuppressants that carry both systemi
103 quired, and the median durations of systemic pharmacologic immunosuppression for the BuCy MRD, BuFlu
111 , we found that genetic deficiency of p53 or pharmacologic inhibition by pifithrin impairs thrombus r
112 MCL survival because its downregulation and pharmacologic inhibition induced cytotoxicity in all MCL
116 osteolysis releases DAMPs from bone matrix, pharmacologic inhibition of bone resorption by zoledrona
119 s contributed to graft-versus-tumor effects, pharmacologic inhibition of Cdk5 preserved leukemia-free
120 tent with their essential role in Ph(+) ALL, pharmacologic inhibition of CDK6 and BCL2 markedly suppr
124 Collectively, this study demonstrates that pharmacologic inhibition of CypA offers a potential ther
132 Exposure of H9c2 cardiomyocytes to H2O2 or pharmacologic inhibition of H2S production increased PYK
135 4beta1 expression and CNS migration, whereas pharmacologic inhibition of integrin alpha4beta1 reduced
137 respective of HIF-1 Conversely, silencing or pharmacologic inhibition of LOX activity blocked dissemi
139 ity lipoprotein secretion through genetic or pharmacologic inhibition of microsomal triglyceride tran
140 al ureteral obstruction, genetic deletion or pharmacologic inhibition of MIF aggravated fibrosis and
144 hen presented with planktonic organisms, and pharmacologic inhibition of NADPH-oxidase partially impa
154 ht to determine the metabolic effects of the pharmacologic inhibition of STRs in response to an oral
155 ted the effects of lactisole on the OGTT.The pharmacologic inhibition of STRs in the gastrointestinal
156 tative and quantitative effects of long-term pharmacologic inhibition of the CXCR4/CXCL12 axis on the
160 etastatic cancer cells in vitro Silencing or pharmacologic inhibition of the two-pore channel TPC2 re
161 se 1 that was also beta2-integrin dependent; pharmacologic inhibition of these kinases completely pre
164 nes, and CRC growth can be mitigated through pharmacologic inhibition or genome editing of these loci
173 ls activated in the presence of rapamycin, a pharmacologic inhibitor of mTORC1, we were able to ident
176 hat elevated MYC levels confer resistance to pharmacologic inhibitors of BCR signaling, which has sig
177 elevance of our findings was confirmed using pharmacologic inhibitors of cyclooxygenase 2 and peroxis
179 Our findings raise the possibility that pharmacologic inhibitors of MCT1-mediated lactic acid tr
181 development and testing of HDAC11-selective pharmacologic inhibitors, and may ultimately provide new
182 mbination with integrin blocking antibodies, pharmacologic inhibitors, phosphoproteomics, and Western
183 mTOR inhibition displayed highly synergistic pharmacologic interactions almost exclusively in PTEN-lo
184 to MALT1, as its inhibition by either RNA or pharmacologic interference induced cytotoxicity both in
186 s that reducing DC activation could be a new pharmacologic intervention to treat patients with severe
187 kidney diseases, raising the possibility of pharmacologic intervention with MIF pathway agonists, wh
188 istration of both established and more novel pharmacologic interventions based on disease pathology.
189 serotonin reuptake inhibitors as first-line pharmacologic interventions for OCD; however, more recen
190 urrent evidence on the efficacy and harms of pharmacologic interventions to prevent or delay cognitiv
191 olling adults without dementia and comparing pharmacologic interventions with placebo, usual care, or
194 hymal and related stem cell transplantation, pharmacologic manipulation of endogenous stem cells to e
199 e 150 genes, so we used reverse genetics and pharmacologic methods to explore regulation of gene expr
203 he canonical Wnt signaling pathway directly, pharmacologic modulation of beta-catenin activity throug
208 ymerase II activity in postmortem brain, and pharmacologic modulation of RNA polymerase II activity a
212 cell culture models to perturbations such as pharmacologic modulators and genetic perturbations.
214 e first studies in humans demonstrating that pharmacologic opioid receptor activation induces some of
217 ical decision making (additional testing and pharmacologic or dietary management); short-term clinica
220 rebral ischemia in rats in vivo We show that pharmacologic or genetic inhibition of Cdc25A activity p
221 se trachea and in muscle can be prevented by pharmacologic or genetic inhibition, respectively, of ma
222 ys affected by IFN-gamma, demonstrating that pharmacologic or genetic manipulation of MSCs can enhanc
223 l mechanism of action is formulated based on pharmacologic, pharmacogenomic, transcriptomic, and phen
225 ferentiated HepaRG cells in conjunction with pharmacologic PLK1 inhibitors, small interfering RNA (si
226 roaches is documented to be effective, while pharmacologic prevention and treatment of delirium remai
227 to some degree, NO-GC1 as targets for early pharmacologic prevention of auditory fiber loss (synapto
229 ollectively, our results offer a preclinical pharmacologic proof of concept for the coordinate inhibi
231 ed synaptic inputs to motor neurons, but the pharmacologic properties of interneurons varied with the
233 hway correlates with decreased survival, and pharmacologic RANK inhibition reduces tumor growth in pa
234 Genetic perturbation of copper import or pharmacologic reduction of copper with the clinical copp
236 atients achieving complete stable remission, pharmacologic remission, or minimal manifestations based
238 encing, functional disconnection strategies, pharmacologic rescue, and designer receptors exclusively
242 With the use of different physiologic or pharmacologic stimuli, endothelium-dependent (micro)vasc
244 cancer metastasis, our findings suggest that pharmacologic strategies to target FKBP65 and LH2 may ha
245 ing that it may be a suitable alternative to pharmacologic stress or exercise for myocardial perfusio
248 xperiments between WT and CD73(-/-) mice and pharmacologic studies modulating enzymatic activity of C
251 26-mediated NPY axis that has potential as a pharmacologic target to regulate hematopoietic trafficki
253 effects of KRAS activation in cancer cells, pharmacologic targeting of KRAS or its downstream effect
255 tic phenotypes in vitro and in vivo Notably, pharmacologic targeting of SPHK1 or YAP/TAZ was sufficie
256 ged metabolic pathways are common in cancer; pharmacologic targeting of these two pathways could prov
259 n and extraterminal motif (BET) proteins are pharmacologic targets for the treatment of diverse disea
260 ostasis and TXNIP suppression present viable pharmacologic targets to prevent cytokine-mediated beta
263 To review the current evidence on systemic pharmacologic therapies for acute or chronic nonradicula
264 myloid polyneuropathy, there are no approved pharmacologic therapies shown to improve survival in TTR
266 blocker, should generally be included in the pharmacologic therapy for hypertension in patients with
267 formin to patients with type 2 diabetes when pharmacologic therapy is needed to improve glycemic cont
268 ombining metabolic, histologic, physiologic, pharmacologic, thermographic, and molecular techniques,
269 d controlled trials, the clinical benefit of pharmacologic thromboprophylaxis for the prevention of C
271 ohol withdrawal syndrome, clinical outcomes, pharmacologic treatment for alcohol withdrawal syndrome,
272 sphosphonates are the most widely prescribed pharmacologic treatment for osteoporosis and reduce frac
273 inicians consider initiating or intensifying pharmacologic treatment in adults aged 60 years or older
274 inicians consider initiating or intensifying pharmacologic treatment in some adults aged 60 years or
277 a guideline titled "Nonpharmacologic Versus Pharmacologic Treatment of Adult Patients with Major Dep
280 quality evidence does not support the use of pharmacologic treatment of depression in patients with d
282 ance to health care providers on the initial pharmacologic treatment of seasonal allergic rhinitis in
284 and provide clinical recommendations on oral pharmacologic treatment of type 2 diabetes in adults.
285 st bone density monitoring during the 5-year pharmacologic treatment period for osteoporosis in women
287 tion 1: ACP recommends that clinicians offer pharmacologic treatment with alendronate, risedronate, z
288 tion 3: ACP recommends that clinicians offer pharmacologic treatment with bisphosphonates to reduce t
289 apy, clinicians and patients should consider pharmacologic treatment with nonsteroidal anti-inflammat
291 , individualized treatment plans, outpatient pharmacologic treatment, glucose targets for critically
293 Evidence does not support use of the studied pharmacologic treatments for cognitive protection in per
294 e benefits and risks of short- and long-term pharmacologic treatments for low bone density, including
295 h normal cognition and those with MCI, these pharmacologic treatments neither improved nor slowed dec
297 njectable antipsychotic medications were the pharmacologic treatments with the highest rates of preve
298 ated incidence rates, health service burden, pharmacologic treatments, extra-intestinal manifestation
299 regulator of NLRP3 inflammasome activation: pharmacologic (using the US Food and Drug Administration
300 ility to evolve as an alternative to current pharmacologic vasodilators used for cardiac stress testi
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