1 entral bridges drug-target interactions with
pharmacological action and indications.
2 he anti-proliferative effects of TP53 during
pharmacological activation in vitro.
3 While
pharmacological activation of AMPK is anticipated to imp
4 Pharmacological activation of transcription factor Nrf2
5 We also report that
pharmacological activation of TRPV4 with GSK1016790A red
6 rotein coupled receptors to screen for novel
pharmacological active peptides.
7 erable commercial interest due to its strong
pharmacological activities and functional low-calorie sw
8 This group of molecules, having diverse
pharmacological activities, may be the basis for future
9 Although
pharmacological administration of oxytocin has implicate
10 n CX3CL1 levels in male mice through central
pharmacological administration or virally mediated hypot
11 Alcohol is a potent
pharmacological agent when consumed acutely at sufficien
12 investigations of garcinol as a therapeutic
pharmacological agent.
13 y function as a downstream mediator of newer
pharmacological agents currently under investigation for
14 Development of
pharmacological agents like NACA may eventually prevent
15 r specialization of axoglial signalling, how
pharmacological agents may promote or impede such signal
16 rational basis for the development of future
pharmacological agents targeting PPARgamma with advantag
17 ressing Hh signaling, with genetic models or
pharmacological agents used in cancer treatments, disrup
18 ted insulin release such as in diabetes with
pharmacological agents, which boost the secretory capaci
19 gates with fluorophore, affinity handle, and
pharmacological agents.
20 allenges, pathophysiological conditions, and
pharmacological agents.
21 hematologic malignancies) or c-MPL-targeted
pharmacological agents.
22 nt options and should be considered as a non-
pharmacological alternative for these disorders.
23 Metabolomic, genetic, and
pharmacological analyses confirm increased trehalose syn
24 ide that led to two compounds with optimized
pharmacological and antiparasitic properties.
25 des to compounds based on their therapeutic,
pharmacological and chemical characteristics as well as
26 active ingredients but also its therapeutic,
pharmacological and chemical properties, thereby substan
27 dies could facilitate the development of new
pharmacological and dietary therapies for epilepsy and o
28 ellular signatures.Despite the importance of
pharmacological and functional genomic screens the reado
29 s that are difficult to probe using standard
pharmacological and genetic approaches.
30 fection-induced transepithelial signaling by
pharmacological and genetic approaches.
31 ne, suggesting an opioid-mediated mechanism;
pharmacological and genetic data suggest the importance
32 Using
pharmacological and genetic experiments, we also determi
33 Pharmacological and genetic inhibition of either mitopha
34 mination microscopy in conjunction with both
pharmacological and genetic manipulation, we show that c
35 nt for prefrontal executive function because
pharmacological and genetic manipulations that affect pr
36 e found that inhibition of RIPK1, using both
pharmacological and genetic means, reduced amyloid burde
37 chymal sub-populations highly susceptible to
pharmacological and genetic perturbation of the cellular
38 Pharmacological and molecular biology results support a
39 Convergent genetic,
pharmacological and neuroimaging evidence implicating ne
40 The capabilities include wireless
pharmacological and optical intervention for dissecting
41 This is achieved with combinations of
pharmacological and physical therapies that maximize cor
42 ly thought and may be treated by an array of
pharmacological and surgical techniques.
43 Using a combination of electrophysiological,
pharmacological,
and behavioral approaches, this study e
44 Improved understanding of basic mycological,
pharmacological,
and immunological processes has led to
45 TG2 inhibition by either a viral particle or
pharmacological approach attenuated behavioral deficits
46 et for a potentially clinically translatable
pharmacological approach that can block T1D development
47 tiation in neonatal mouse retinas, we used a
pharmacological approach that showed that inhibition of
48 Using a
pharmacological approach to inhibit TNT formation, we ab
49 This discovery reveals an unprecedented
pharmacological approach to MMP inhibition, providing an
50 ional potential of these findings, we used a
pharmacological approach.
51 ediated mtDNA damage, using both genetic and
pharmacological approaches in cultured neurons and PD pa
52 Here we show using electrophysiological and
pharmacological approaches that human RBCs display circa
53 r the development of more effective targeted
pharmacological approaches toward variants of mutant p53
54 Using
pharmacological approaches, we found that an interferon-
55 animal models, together with biochemical and
pharmacological approaches, we provide a high-resolution
56 es and melanoma cells, suggesting a limit of
pharmacological ascorbate in treating cancer.
57 liver profibrotic role for ATX/LPA, whereas
pharmacological ATX inhibition studies suggested ATX as
58 behaviors, which was normalized by selective
pharmacological augmentation of AEA signaling and via di
59 Pharmacological block of IA completely abolished rebound
60 visceral pain processing, and advocate that
pharmacological block of NaV 1.7 alone in the viscera ma
61 esent in Disc1 deficiency and was rescued by
pharmacological blockade of adenylate cyclase.
62 this genotypic difference is normalized with
pharmacological blockade of CRF1 receptors.
63 g human myocardium, and the highly selective
pharmacological blockade of either iPLA2gamma or lipoxyg
64 by carotid chemoreceptor denervation and by
pharmacological blockade of either sympathetic - propran
65 Pharmacological blockade of gap junctions or genetic abl
66 Pharmacological blockade of GH signaling prevented the d
67 Pharmacological blockade of LDTg GLP-1Rs with exendin-(9
68 Pharmacological blockade of lymphangiogenesis via VEGFR-
69 nction in vivo, whereas genetic knockdown or
pharmacological blockade of microRNA-146a blunted the hy
70 intestinal inflammation, genetic deletion or
pharmacological blockade of OSM significantly attenuates
71 Pharmacological blockade of TRPM7 with NS8593 or waixeni
72 ive DRG neurons recapitulated the effects of
pharmacological CaN inhibition on the Kv3.4 current and
73 Finally,
pharmacological cardiolipin stabilization reverted the e
74 s in cardiac repolarization in response to a
pharmacological challenge with sotalol.
75 Spraque Dawley rats at baseline, followed by
pharmacological challenge with unlabeled yohimbine (0.3
76 of relatives and systematic tests, including
pharmacological challenges, greatly increases the likeli
77 In vitro
pharmacological characterization of 5-HT6 receptor antag
78 describe the design, synthesis, and in vitro
pharmacological characterization of these DcpS inhibitor
79 acellular organelles that are correctable by
pharmacological CK2 inhibition.
80 Here, we show that treatment with the
pharmacological colony stimulating factor 1 receptor inh
81 as an adjunctive therapy for SRSE requiring
pharmacological coma for seizure control.
82 We propose that a
pharmacological compound that abates TGF-beta signalling
83 Here, we characterize AUT00063, a
pharmacological compound that modulates Kv3.1, a high-th
84 analysis of cells exposed to three different
pharmacological compounds known to elicit Golgi fragment
85 Our data reveal that
pharmacological concentration of ATRA effectively downre
86 s or the RGD peptide ligand-or by genetic or
pharmacological correction of ceramide levels-normalizes
87 o more critically analyze the time course of
pharmacological data.
88 Pharmacological depletion of MCs granules or prevention
89 B277011A (2) whose structural similarity and
pharmacological disparity provided the perfect templates
90 We showed that genetic or
pharmacological disruption of alphavbeta3/Src signaling
91 ly regulated not only by genetic but also by
pharmacological disruption of oxidative phosphorylation
92 Genetic and
pharmacological disruption of the EDN3 receptor EDNRB in
93 ntribute significantly to the biological and
pharmacological diversity of small molecule metabolites.
94 Both the actr10 mutation and
pharmacological dynein inhibition in zebrafish result in
95 use partial agonism, leading to the opposite
pharmacological effect.
96 Natural flavonoids exert innumerable
pharmacological effects in humans.
97 work for understanding the physiological and
pharmacological effects of H2S.
98 the present study, we compared the possible
pharmacological effects of PDE4B and PDE4D selective inh
99 n of the PIP4Ks generates a phenocopy of the
pharmacological effects of PIP4K inhibition by a131.
100 Litchi seed extracts have diverse
pharmacological effects, including anticancer.
101 Finally, we use these new tools to monitor
pharmacological engagement of Bcl-2 protein inhibitors,
102 Herein, we report the synthesis and
pharmacological evaluation of a new family of multitarge
103 Pharmacological evidence suggests a role for glucagon-li
104 Pharmacological experiments confirmed that the effects d
105 Biochemical and
pharmacological experiments further indicate that the to
106 In vivo and in vitro
pharmacological experiments suggest that PKA dysregulati
107 Here, we used genetic and
pharmacological experiments to determine whether the pol
108 These
pharmacological findings were corroborated by showing th
109 nducted a systematic search for post-mortem,
pharmacological,
functional magnetic resonance and molec
110 diomyocytes coupled to myofibroblasts during
pharmacological gap junctional uncoupling.
111 eduction of ER stress or Xbp1 splicing using
pharmacological,
genetic, and RNAi approaches demonstrat
112 However, ex vivo expansion and
pharmacological/
genetic modification of human cardiac pr
113 In a 6-month
pharmacological hormone manipulation protocol, healthy,
114 Increasing efforts have focused on
pharmacological hypothermia as a treatment option for st
115 e results form the basis for a molecular and
pharmacological identification of IK,L .
116 secondary metabolites, many of which are of
pharmacological importance.
117 ocking motor cortical output with lesions or
pharmacological inactivation has identified movements th
118 fear conditioning and extinction paradigms,
pharmacological inactivation of area 25 decreased the au
119 miR-217-mediated, genetic, or
pharmacological inactivation of EHMT1/2 was sufficient t
120 ection task and combined it with fMRI-guided
pharmacological inactivation of ML to test whether ML is
121 STATEMENT We recently reported that an acute
pharmacological increase in protein O-GlcNAcylation indu
122 Pharmacological inducers of ER stress, tunicamycin and t
123 Pan-PI3K and p110alpha-selective
pharmacological inhibition effectively blocks transforma
124 athogenesis of inflammatory disease, and its
pharmacological inhibition has been shown to exert thera
125 Genetic knockdown and
pharmacological inhibition in vascular smooth muscle cel
126 utophagic activity in human trophoblasts and
pharmacological inhibition limited ZIKV infectivity.
127 tion, and neuronal survival, suggesting that
pharmacological inhibition of aberrantly accumulated Roc
128 othelial cells in vitro, which is blocked by
pharmacological inhibition of acid sphingomyelinase.
129 sidases, were unaltered in L-G6pc(-/-) mice,
pharmacological inhibition of alpha-glucosidase activity
130 Pharmacological inhibition of CaMK4 recapitulated the ob
131 In cultured H9c2 myoblasts,
pharmacological inhibition of cathepsin K, or treatment
132 The
pharmacological inhibition of CYP4A reduced lung pre-met
133 Interestingly, DDR2 knockdown or
pharmacological inhibition of DDR2 also inhibited the MT
134 Upon
pharmacological inhibition of dynamin-2 or clathrin term
135 Moreover,
pharmacological inhibition of either IKKbeta or the seri
136 and in vivo Moreover, genetic disruption or
pharmacological inhibition of eNOS attenuates angiogenes
137 Importantly, both loss of MYC and
pharmacological inhibition of ERRalpha attenuated bone l
138 ic screen, we found that partial genetic and
pharmacological inhibition of fatty acid synthase (FASN)
139 Pharmacological inhibition of folate action by methotrex
140 on occurred in GCase-deficient mice or after
pharmacological inhibition of GCase and was associated w
141 In vivo,
pharmacological inhibition of HDAC6 improved established
142 Pharmacological inhibition of IL-1R activation by Anakin
143 Pharmacological inhibition of liver RetSat may represent
144 Pharmacological inhibition of MAOA enzymatic activity ef
145 ic toxicity; this effect can be abolished by
pharmacological inhibition of Mek to restore tumour grow
146 By acute
pharmacological inhibition of mitochondrial fission prot
147 Pharmacological inhibition of mTOR resulted in a proport
148 Pharmacological inhibition of mTOR signaling resulted in
149 nomic mechanisms, by individual and combined
pharmacological inhibition of muscarinic and/or beta-adr
150 Together, our data suggest that
pharmacological inhibition of necroptosis with Nec-1s st
151 Pharmacological inhibition of NLRP3 inflammasome activat
152 METHODS AND
Pharmacological inhibition of phosphodiesterase 2 (BAY 6
153 d RPE cells was almost completely blocked by
pharmacological inhibition of phosphorylation of Akt.
154 Pharmacological inhibition of PKA activity reduced prote
155 Finally, we observed that
pharmacological inhibition of PPARgamma is therapeutical
156 The
pharmacological inhibition of PPP canceled the UCHL1-med
157 Pharmacological inhibition of Rpn11 with O-phenanthrolin
158 Pharmacological inhibition of SirT-1 activity decreased
159 Genetic or
pharmacological inhibition of SRPK2 blunts de novo lipid
160 eloid cells, which were reversed by siRNA or
pharmacological inhibition of STAT3.
161 high altitude after individual and combined
pharmacological inhibition of sympathetic and/or parasym
162 As such,
pharmacological inhibition of the ISR emerges as a promi
163 Pharmacological inhibition of the MAPK pathway abrogates
164 a role in porcine atrial repolarization, and
pharmacological inhibition of these with AP14145 demonst
165 Pharmacological inhibition of this enzyme blocked S. pne
166 tment incorporating soluble CD40 agonist and
pharmacological inhibition of Trx-1 was functionally equ
167 Either genetic or
pharmacological inhibition of v-ATPase in cardiomyocytes
168 Pharmacological inhibition or deletion of NLRP3, ASC (ap
169 Here we show that
pharmacological inhibition or gene ablation of the Ep3 r
170 Accordingly,
pharmacological inhibition or genetic reduction of Hck a
171 Pharmacological inhibition or knockdown of any one of th
172 Genetic knockdown of Glo1 or
pharmacological inhibition using two structurally distin
173 Through
pharmacological inhibition we observed that the response
174 ne editing, RNA interference, morpholinos or
pharmacological inhibition) can have a major effect on p
175 ibroblast-specific knockout of STAT3, or its
pharmacological inhibition, ameliorate skin fibrosis in
176 Utilizing
pharmacological inhibition, genetic loss of function and
177 el, with involvement of MMPs confirmed using
pharmacological inhibition.
178 lts were obtained with the p38gamma-specific
pharmacological inhibitor pirfenidone.
179 We have tested the effects of new
pharmacological inhibitors of MRTF/SRF signalling in a p
180 7, is critical to pain sensation in mammals,
pharmacological inhibitors of Nav1.7 have not yet fully
181 which were partially corroborated using the
pharmacological inhibitors wortmannin, a phosphatidyl in
182 The treatment of cells with
pharmacological inhibitors, such as nonsteroidal anti-in
183 lerates hepatocellular carcinoma, genetic or
pharmacological interference with IgA(+) cell generation
184 Optogenetic, chemogenetic, genetic, and
pharmacological interrogation suggested that downregulat
185 Using
pharmacological intervention and ion replacement, we sho
186 f CXCL12/CXCR4 has only been implied through
pharmacological intervention, in particular, because the
187 terleukin-1 (IL-1) signaling as a target for
pharmacological intervention.
188 of novel structural hot spots as targets for
pharmacological intervention.
189 Robust
pharmacological interventions that promote healthy agein
190 We conducted a series of
pharmacological interventions to interrogate 5-HT1B rece
191 C couplons in beating cardiomyocytes without
pharmacological interventions.
192 Our results highlight promising
pharmacological leads and demonstrate the importance of
193 Pharmacological levels of ascorbate have long been sugge
194 asurements of sympathetic nerve activity and
pharmacological manipulation of blood pressure, we show
195 BRS was tested using
pharmacological manipulation of BP via the Modified Oxfo
196 This may prompt the consideration for
pharmacological manipulation of Cav1.2 in neuropsychiatr
197 Pharmacological manipulation of PKM2 activity with TEPP-
198 t that may be more amenable to behavioral or
pharmacological manipulation.
199 o elucidate APP-related targets suitable for
pharmacological manipulation.
200 techniques, such as behavioral responses to
pharmacological manipulations and spike timing statistic
201 fMRI) studies performed during site-specific
pharmacological manipulations of arousal levels may be u
202 Moreover, in singing birds, we found that
pharmacological manipulations of RA's inhibitory circuit
203 Genetic and acute
pharmacological manipulations suggest that prolonged bur
204 ese changes in Mecp2(het) through genetic or
pharmacological manipulations targeting the GABAergic ne
205 x, using electrophysiological recordings and
pharmacological manipulations.
206 Pharmacological MAPK inhibition restores migration and a
207 r selectively targeting MYC transcription by
pharmacological means as a potential treatment for MYC-d
208 d with lower circulating hormone levels than
pharmacological means due to participation of cells in t
209 Together these studies identify a novel
pharmacological mechanism of facilitating the function o
210 , anatomical and physiological features, and
pharmacological mechanisms.
211 Most previous studies used genetic and
pharmacological methods to modulate enzymes that alter P
212 activators and anticoagulants (including non-
pharmacological methods) and might aid in the early non-
213 A
pharmacological mimetic of TIMP3 blocked the conversion
214 lpha aggregation and both are susceptible to
pharmacological modulation of ALP function.
215 secretion and offer potential strategies for
pharmacological modulation of its neuronal secretion.SIG
216 Pharmacological modulators of TEADs could therefore find
217 KEY POINTS:
Pharmacological,
molecular and genetic data indicate a p
218 though this phenotype could be suppressed by
pharmacological neutralization of the phagosome.
219 Despite this effort, however,
pharmacological options for ARDS remain scarce.
220 Importantly,
pharmacological or genetic ablation of innervation prese
221 Pharmacological or genetic inhibition of IGF-1R enhanced
222 Pharmacological or optogenetic reversal of these adaptat
223 or 1000-fold improvement in a variety of key
pharmacological parameters can be realized.
224 eurocognitive events raised by prior trials,
pharmacological PCSK9 (proprotein convertase subtilisin/
225 Our studies using
pharmacological PKD inhibitors and PKD1-knockdown macrop
226 agy and mHtt proteolysis, revealing a useful
pharmacological point of intervention for the treatment
227 Yet, no
pharmacological prevention or specific treatment for acu
228 In addition to differences in the
pharmacological profile of N-methyl-d-aspartate receptor
229 Despite its outstanding
pharmacological profile, application of riociguat in oth
230 , which mediates opioid actions, have unique
pharmacological properties and anatomic distributions th
231 ant traditional Tibetan medicinal plant with
pharmacological properties effective in the treatment of
232 rotein-protein interactions, and improve the
pharmacological properties of proteins.
233 t up two assays to specifically identify the
pharmacological properties of rat mGlu heterodimers comp
234 thesized functional STO-609 and assessed its
pharmacological properties through in vitro (kinase assa
235 d insights into the chemical, biological and
pharmacological properties, and medical potential of mat
236 in Muscat varieties having also interesting
pharmacological properties.
237 ir high affinity, specificity, and favorable
pharmacological properties.
238 which are known for their nutraceutical and
pharmacological properties.
239 ex, prolongs the clotting time by generating
pharmacological quantities of activated protein C and ef
240 tion of alpha2-antiplasmin was comparable to
pharmacological r-tPA for dissolving thrombi.
241 In vivo, Rac1 deletion in SMCs or
pharmacological Rac1 inhibition by nebulization of NSC23
242 Interestingly, when
pharmacological Rac1 inhibition was combined with either
243 uctural hot-spots in proteins as targets for
pharmacological rescue in loss-of-function genetic disea
244 and in vivo arrhythmia models and to measure
pharmacological responses.
245 ell survival functions were compromised by a
pharmacological SGK1 inhibitor.
246 Pharmacological stimulation of mGluR5 in NAcore recapitu
247 as assessed after mechanical conditioning or
pharmacological stimulation of the cGMP pathway and by u
248 reduction in atherosclerosis in response to
pharmacological stimulation of thermogenesis linked to i
249 QT3 Kir2.1 mutations and highlights possible
pharmacological strategies for management of SQT3-linked
250 gating cell regulation events and developing
pharmacological strategies for modulating cell decisions
251 Using genetic or
pharmacological strategies to inhibit CCL5 or CCR2, we d
252 hts that could aide in the identification of
pharmacological strategies to modulate FZD receptor func
253 Ex vivo and in vitro genetic and
pharmacological studies found that the mechanism involve
254 As
pharmacological studies highlight the hindbrain nucleus
255 Genetic and
pharmacological studies in human megakaryoblastic MEG-01
256 Pharmacological studies showed that AR significantly inc
257 Evidence from
pharmacological studies suggests that the N/OFQ system i
258 Pharmacological study revealed that lamellipodia formati
259 Genetic and
pharmacological suppression of EZH2 inhibited neuroblast
260 ) channel (KCa3.1) constitutes an attractive
pharmacological target for immunosuppression, fibroproli
261 ti-apoptotic protein in cancer, represents a
pharmacological target for therapy and a Molecular Beaco
262 BDNF signaling represents a potentially new
pharmacological target for treatments aimed at rescuing
263 novel function of HIF-1alpha as a potential
pharmacological target to improve skeletal muscle insuli
264 gical conditions, which makes it a promising
pharmacological target.
265 Here, we report that genetic or
pharmacological targeting of the oncogenic MUC1 subunit
266 ogical mechanisms, which are prone to become
pharmacological targets for curative strategies in adult
267 ay be revealed and this could serve as novel
pharmacological targets for the treatment of mood disord
268 buting to ectopic calcification and identify
pharmacological targets for therapeutic development.
269 provide an opportunity to identify potential
pharmacological targets, yet their expression patterns a
270 ysiology will aid in developing physical and
pharmacological therapeutic interventions.
271 ey to developing more effective behavior and
pharmacological therapies for alcoholism.
272 The lack of success of
pharmacological therapies for ARDS, however, presents a
273 Pharmacological therapies for cardiovascular diseases ar
274 on and reassurance, analgesic medicines, non-
pharmacological therapies, and timely review.
275 ing these disorders and investigate possible
pharmacological therapies, here we examined 13 disease-c
276 ed the superiority of catheter ablation over
pharmacological therapy for maintenance of sinus rhythm
277 No decongestive
pharmacological therapy has reduced these harmful conseq
278 ajor depressive disorder respond to adequate
pharmacological therapy.
279 pate the expected clinical consequences of a
pharmacological therapy.
280 Both cold-induced and
pharmacological thermogenic activation enhances HDL remo
281 We have used
pharmacological tools to explore the chemical space that
282 cology and result in large numbers of useful
pharmacological tools, agents with therapeutic potential
283 alysis, calcium imaging, patch clamping, and
pharmacological tools, validated by mathematical modelin
284 inhibitors that can provide potential novel
pharmacological tools.
285 Pharmacological treatment and antiarrhythmic therapy for
286 ecent advances in reperfusion strategies and
pharmacological treatment approaches.
287 order (ADHD) and is currently the first-line
pharmacological treatment for children.
288 as ketogenic diets, have been used as a non-
pharmacological treatment for refractory epilepsy.
289 Pharmacological treatment is based on a cycle of assessm
290 lycemic drugs, opens new perspectives in the
pharmacological treatment of type 2 diabetes.
291 Several
pharmacological treatment options are available for type
292 These data open the avenue for a safe
pharmacological treatment that may prevent the neurodeve
293 Furthermore,
pharmacological treatment with a Drd3 agonist, which inc
294 in cell turnover become uncoupled, including
pharmacological treatments and disease models.
295 The surgical and
pharmacological treatments of obesity are discussed, and
296 neously or induced by micromanipulations and
pharmacological treatments.
297 investigate other tissue pathologies or test
pharmacological treatments.
298 In rabbits subject to
pharmacological triggering, plaques that thrombosed exhi
299 Accordingly, the physiological and
pharmacological understanding of specific motoneuronal c
300 SUMMARY BACKGROUND DATA:
Pharmacological VTE prophylaxis with LMWH or UH is the c