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1 entral bridges drug-target interactions with pharmacological action and indications.
2 he anti-proliferative effects of TP53 during pharmacological activation in vitro.
3                                        While pharmacological activation of AMPK is anticipated to imp
4                                              Pharmacological activation of transcription factor Nrf2
5                          We also report that pharmacological activation of TRPV4 with GSK1016790A red
6 rotein coupled receptors to screen for novel pharmacological active peptides.
7 erable commercial interest due to its strong pharmacological activities and functional low-calorie sw
8      This group of molecules, having diverse pharmacological activities, may be the basis for future
9                                     Although pharmacological administration of oxytocin has implicate
10 n CX3CL1 levels in male mice through central pharmacological administration or virally mediated hypot
11                          Alcohol is a potent pharmacological agent when consumed acutely at sufficien
12  investigations of garcinol as a therapeutic pharmacological agent.
13 y function as a downstream mediator of newer pharmacological agents currently under investigation for
14                               Development of pharmacological agents like NACA may eventually prevent
15 r specialization of axoglial signalling, how pharmacological agents may promote or impede such signal
16 rational basis for the development of future pharmacological agents targeting PPARgamma with advantag
17 ressing Hh signaling, with genetic models or pharmacological agents used in cancer treatments, disrup
18 ted insulin release such as in diabetes with pharmacological agents, which boost the secretory capaci
19 gates with fluorophore, affinity handle, and pharmacological agents.
20 allenges, pathophysiological conditions, and pharmacological agents.
21  hematologic malignancies) or c-MPL-targeted pharmacological agents.
22 nt options and should be considered as a non-pharmacological alternative for these disorders.
23                    Metabolomic, genetic, and pharmacological analyses confirm increased trehalose syn
24 ide that led to two compounds with optimized pharmacological and antiparasitic properties.
25 des to compounds based on their therapeutic, pharmacological and chemical characteristics as well as
26 active ingredients but also its therapeutic, pharmacological and chemical properties, thereby substan
27 dies could facilitate the development of new pharmacological and dietary therapies for epilepsy and o
28 ellular signatures.Despite the importance of pharmacological and functional genomic screens the reado
29 s that are difficult to probe using standard pharmacological and genetic approaches.
30 fection-induced transepithelial signaling by pharmacological and genetic approaches.
31 ne, suggesting an opioid-mediated mechanism; pharmacological and genetic data suggest the importance
32                                        Using pharmacological and genetic experiments, we also determi
33                                              Pharmacological and genetic inhibition of either mitopha
34 mination microscopy in conjunction with both pharmacological and genetic manipulation, we show that c
35 nt for prefrontal executive function because pharmacological and genetic manipulations that affect pr
36 e found that inhibition of RIPK1, using both pharmacological and genetic means, reduced amyloid burde
37 chymal sub-populations highly susceptible to pharmacological and genetic perturbation of the cellular
38                                              Pharmacological and molecular biology results support a
39                          Convergent genetic, pharmacological and neuroimaging evidence implicating ne
40            The capabilities include wireless pharmacological and optical intervention for dissecting
41        This is achieved with combinations of pharmacological and physical therapies that maximize cor
42 ly thought and may be treated by an array of pharmacological and surgical techniques.
43 Using a combination of electrophysiological, pharmacological, and behavioral approaches, this study e
44 Improved understanding of basic mycological, pharmacological, and immunological processes has led to
45 TG2 inhibition by either a viral particle or pharmacological approach attenuated behavioral deficits
46 et for a potentially clinically translatable pharmacological approach that can block T1D development
47 tiation in neonatal mouse retinas, we used a pharmacological approach that showed that inhibition of
48                                      Using a pharmacological approach to inhibit TNT formation, we ab
49      This discovery reveals an unprecedented pharmacological approach to MMP inhibition, providing an
50 ional potential of these findings, we used a pharmacological approach.
51 ediated mtDNA damage, using both genetic and pharmacological approaches in cultured neurons and PD pa
52  Here we show using electrophysiological and pharmacological approaches that human RBCs display circa
53 r the development of more effective targeted pharmacological approaches toward variants of mutant p53
54                                        Using pharmacological approaches, we found that an interferon-
55 animal models, together with biochemical and pharmacological approaches, we provide a high-resolution
56 es and melanoma cells, suggesting a limit of pharmacological ascorbate in treating cancer.
57  liver profibrotic role for ATX/LPA, whereas pharmacological ATX inhibition studies suggested ATX as
58 behaviors, which was normalized by selective pharmacological augmentation of AEA signaling and via di
59                                              Pharmacological block of IA completely abolished rebound
60  visceral pain processing, and advocate that pharmacological block of NaV 1.7 alone in the viscera ma
61 esent in Disc1 deficiency and was rescued by pharmacological blockade of adenylate cyclase.
62 this genotypic difference is normalized with pharmacological blockade of CRF1 receptors.
63 g human myocardium, and the highly selective pharmacological blockade of either iPLA2gamma or lipoxyg
64  by carotid chemoreceptor denervation and by pharmacological blockade of either sympathetic - propran
65                                              Pharmacological blockade of gap junctions or genetic abl
66                                              Pharmacological blockade of GH signaling prevented the d
67                                              Pharmacological blockade of LDTg GLP-1Rs with exendin-(9
68                                              Pharmacological blockade of lymphangiogenesis via VEGFR-
69 nction in vivo, whereas genetic knockdown or pharmacological blockade of microRNA-146a blunted the hy
70 intestinal inflammation, genetic deletion or pharmacological blockade of OSM significantly attenuates
71                                              Pharmacological blockade of TRPM7 with NS8593 or waixeni
72 ive DRG neurons recapitulated the effects of pharmacological CaN inhibition on the Kv3.4 current and
73                                     Finally, pharmacological cardiolipin stabilization reverted the e
74 s in cardiac repolarization in response to a pharmacological challenge with sotalol.
75 Spraque Dawley rats at baseline, followed by pharmacological challenge with unlabeled yohimbine (0.3
76 of relatives and systematic tests, including pharmacological challenges, greatly increases the likeli
77                                     In vitro pharmacological characterization of 5-HT6 receptor antag
78 describe the design, synthesis, and in vitro pharmacological characterization of these DcpS inhibitor
79 acellular organelles that are correctable by pharmacological CK2 inhibition.
80        Here, we show that treatment with the pharmacological colony stimulating factor 1 receptor inh
81  as an adjunctive therapy for SRSE requiring pharmacological coma for seizure control.
82                            We propose that a pharmacological compound that abates TGF-beta signalling
83            Here, we characterize AUT00063, a pharmacological compound that modulates Kv3.1, a high-th
84 analysis of cells exposed to three different pharmacological compounds known to elicit Golgi fragment
85                         Our data reveal that pharmacological concentration of ATRA effectively downre
86 s or the RGD peptide ligand-or by genetic or pharmacological correction of ceramide levels-normalizes
87 o more critically analyze the time course of pharmacological data.
88                                              Pharmacological depletion of MCs granules or prevention
89 B277011A (2) whose structural similarity and pharmacological disparity provided the perfect templates
90                    We showed that genetic or pharmacological disruption of alphavbeta3/Src signaling
91 ly regulated not only by genetic but also by pharmacological disruption of oxidative phosphorylation
92                                  Genetic and pharmacological disruption of the EDN3 receptor EDNRB in
93 ntribute significantly to the biological and pharmacological diversity of small molecule metabolites.
94                 Both the actr10 mutation and pharmacological dynein inhibition in zebrafish result in
95 use partial agonism, leading to the opposite pharmacological effect.
96         Natural flavonoids exert innumerable pharmacological effects in humans.
97 work for understanding the physiological and pharmacological effects of H2S.
98  the present study, we compared the possible pharmacological effects of PDE4B and PDE4D selective inh
99 n of the PIP4Ks generates a phenocopy of the pharmacological effects of PIP4K inhibition by a131.
100            Litchi seed extracts have diverse pharmacological effects, including anticancer.
101   Finally, we use these new tools to monitor pharmacological engagement of Bcl-2 protein inhibitors,
102          Herein, we report the synthesis and pharmacological evaluation of a new family of multitarge
103                                              Pharmacological evidence suggests a role for glucagon-li
104                                              Pharmacological experiments confirmed that the effects d
105                              Biochemical and pharmacological experiments further indicate that the to
106                         In vivo and in vitro pharmacological experiments suggest that PKA dysregulati
107                    Here, we used genetic and pharmacological experiments to determine whether the pol
108                                        These pharmacological findings were corroborated by showing th
109 nducted a systematic search for post-mortem, pharmacological, functional magnetic resonance and molec
110 diomyocytes coupled to myofibroblasts during pharmacological gap junctional uncoupling.
111 eduction of ER stress or Xbp1 splicing using pharmacological, genetic, and RNAi approaches demonstrat
112               However, ex vivo expansion and pharmacological/genetic modification of human cardiac pr
113                                 In a 6-month pharmacological hormone manipulation protocol, healthy,
114           Increasing efforts have focused on pharmacological hypothermia as a treatment option for st
115 e results form the basis for a molecular and pharmacological identification of IK,L .
116  secondary metabolites, many of which are of pharmacological importance.
117 ocking motor cortical output with lesions or pharmacological inactivation has identified movements th
118  fear conditioning and extinction paradigms, pharmacological inactivation of area 25 decreased the au
119                miR-217-mediated, genetic, or pharmacological inactivation of EHMT1/2 was sufficient t
120 ection task and combined it with fMRI-guided pharmacological inactivation of ML to test whether ML is
121 STATEMENT We recently reported that an acute pharmacological increase in protein O-GlcNAcylation indu
122                                              Pharmacological inducers of ER stress, tunicamycin and t
123             Pan-PI3K and p110alpha-selective pharmacological inhibition effectively blocks transforma
124 athogenesis of inflammatory disease, and its pharmacological inhibition has been shown to exert thera
125                        Genetic knockdown and pharmacological inhibition in vascular smooth muscle cel
126 utophagic activity in human trophoblasts and pharmacological inhibition limited ZIKV infectivity.
127 tion, and neuronal survival, suggesting that pharmacological inhibition of aberrantly accumulated Roc
128 othelial cells in vitro, which is blocked by pharmacological inhibition of acid sphingomyelinase.
129 sidases, were unaltered in L-G6pc(-/-) mice, pharmacological inhibition of alpha-glucosidase activity
130                                              Pharmacological inhibition of CaMK4 recapitulated the ob
131                  In cultured H9c2 myoblasts, pharmacological inhibition of cathepsin K, or treatment
132                                          The pharmacological inhibition of CYP4A reduced lung pre-met
133             Interestingly, DDR2 knockdown or pharmacological inhibition of DDR2 also inhibited the MT
134                                         Upon pharmacological inhibition of dynamin-2 or clathrin term
135                                    Moreover, pharmacological inhibition of either IKKbeta or the seri
136  and in vivo Moreover, genetic disruption or pharmacological inhibition of eNOS attenuates angiogenes
137            Importantly, both loss of MYC and pharmacological inhibition of ERRalpha attenuated bone l
138 ic screen, we found that partial genetic and pharmacological inhibition of fatty acid synthase (FASN)
139                                              Pharmacological inhibition of folate action by methotrex
140 on occurred in GCase-deficient mice or after pharmacological inhibition of GCase and was associated w
141                                     In vivo, pharmacological inhibition of HDAC6 improved established
142                                              Pharmacological inhibition of IL-1R activation by Anakin
143                                              Pharmacological inhibition of liver RetSat may represent
144                                              Pharmacological inhibition of MAOA enzymatic activity ef
145 ic toxicity; this effect can be abolished by pharmacological inhibition of Mek to restore tumour grow
146                                     By acute pharmacological inhibition of mitochondrial fission prot
147                                              Pharmacological inhibition of mTOR resulted in a proport
148                                              Pharmacological inhibition of mTOR signaling resulted in
149 nomic mechanisms, by individual and combined pharmacological inhibition of muscarinic and/or beta-adr
150              Together, our data suggest that pharmacological inhibition of necroptosis with Nec-1s st
151                                              Pharmacological inhibition of NLRP3 inflammasome activat
152                                  METHODS AND Pharmacological inhibition of phosphodiesterase 2 (BAY 6
153 d RPE cells was almost completely blocked by pharmacological inhibition of phosphorylation of Akt.
154                                              Pharmacological inhibition of PKA activity reduced prote
155                    Finally, we observed that pharmacological inhibition of PPARgamma is therapeutical
156                                          The pharmacological inhibition of PPP canceled the UCHL1-med
157                                              Pharmacological inhibition of Rpn11 with O-phenanthrolin
158                                              Pharmacological inhibition of SirT-1 activity decreased
159                                   Genetic or pharmacological inhibition of SRPK2 blunts de novo lipid
160 eloid cells, which were reversed by siRNA or pharmacological inhibition of STAT3.
161  high altitude after individual and combined pharmacological inhibition of sympathetic and/or parasym
162                                     As such, pharmacological inhibition of the ISR emerges as a promi
163                                              Pharmacological inhibition of the MAPK pathway abrogates
164 a role in porcine atrial repolarization, and pharmacological inhibition of these with AP14145 demonst
165                                              Pharmacological inhibition of this enzyme blocked S. pne
166 tment incorporating soluble CD40 agonist and pharmacological inhibition of Trx-1 was functionally equ
167                            Either genetic or pharmacological inhibition of v-ATPase in cardiomyocytes
168                                              Pharmacological inhibition or deletion of NLRP3, ASC (ap
169                            Here we show that pharmacological inhibition or gene ablation of the Ep3 r
170                                 Accordingly, pharmacological inhibition or genetic reduction of Hck a
171                                              Pharmacological inhibition or knockdown of any one of th
172                 Genetic knockdown of Glo1 or pharmacological inhibition using two structurally distin
173                                      Through pharmacological inhibition we observed that the response
174 ne editing, RNA interference, morpholinos or pharmacological inhibition) can have a major effect on p
175 ibroblast-specific knockout of STAT3, or its pharmacological inhibition, ameliorate skin fibrosis in
176                                    Utilizing pharmacological inhibition, genetic loss of function and
177 el, with involvement of MMPs confirmed using pharmacological inhibition.
178 lts were obtained with the p38gamma-specific pharmacological inhibitor pirfenidone.
179            We have tested the effects of new pharmacological inhibitors of MRTF/SRF signalling in a p
180 7, is critical to pain sensation in mammals, pharmacological inhibitors of Nav1.7 have not yet fully
181  which were partially corroborated using the pharmacological inhibitors wortmannin, a phosphatidyl in
182                  The treatment of cells with pharmacological inhibitors, such as nonsteroidal anti-in
183 lerates hepatocellular carcinoma, genetic or pharmacological interference with IgA(+) cell generation
184      Optogenetic, chemogenetic, genetic, and pharmacological interrogation suggested that downregulat
185                                        Using pharmacological intervention and ion replacement, we sho
186 f CXCL12/CXCR4 has only been implied through pharmacological intervention, in particular, because the
187 terleukin-1 (IL-1) signaling as a target for pharmacological intervention.
188 of novel structural hot spots as targets for pharmacological intervention.
189                                       Robust pharmacological interventions that promote healthy agein
190                     We conducted a series of pharmacological interventions to interrogate 5-HT1B rece
191 C couplons in beating cardiomyocytes without pharmacological interventions.
192              Our results highlight promising pharmacological leads and demonstrate the importance of
193                                              Pharmacological levels of ascorbate have long been sugge
194 asurements of sympathetic nerve activity and pharmacological manipulation of blood pressure, we show
195                         BRS was tested using pharmacological manipulation of BP via the Modified Oxfo
196        This may prompt the consideration for pharmacological manipulation of Cav1.2 in neuropsychiatr
197                                              Pharmacological manipulation of PKM2 activity with TEPP-
198 t that may be more amenable to behavioral or pharmacological manipulation.
199 o elucidate APP-related targets suitable for pharmacological manipulation.
200  techniques, such as behavioral responses to pharmacological manipulations and spike timing statistic
201 fMRI) studies performed during site-specific pharmacological manipulations of arousal levels may be u
202    Moreover, in singing birds, we found that pharmacological manipulations of RA's inhibitory circuit
203                            Genetic and acute pharmacological manipulations suggest that prolonged bur
204 ese changes in Mecp2(het) through genetic or pharmacological manipulations targeting the GABAergic ne
205 x, using electrophysiological recordings and pharmacological manipulations.
206                                              Pharmacological MAPK inhibition restores migration and a
207 r selectively targeting MYC transcription by pharmacological means as a potential treatment for MYC-d
208 d with lower circulating hormone levels than pharmacological means due to participation of cells in t
209      Together these studies identify a novel pharmacological mechanism of facilitating the function o
210 , anatomical and physiological features, and pharmacological mechanisms.
211       Most previous studies used genetic and pharmacological methods to modulate enzymes that alter P
212 activators and anticoagulants (including non-pharmacological methods) and might aid in the early non-
213                                            A pharmacological mimetic of TIMP3 blocked the conversion
214 lpha aggregation and both are susceptible to pharmacological modulation of ALP function.
215 secretion and offer potential strategies for pharmacological modulation of its neuronal secretion.SIG
216                                              Pharmacological modulators of TEADs could therefore find
217                                  KEY POINTS: Pharmacological, molecular and genetic data indicate a p
218 though this phenotype could be suppressed by pharmacological neutralization of the phagosome.
219                Despite this effort, however, pharmacological options for ARDS remain scarce.
220                                 Importantly, pharmacological or genetic ablation of innervation prese
221                                              Pharmacological or genetic inhibition of IGF-1R enhanced
222                                              Pharmacological or optogenetic reversal of these adaptat
223 or 1000-fold improvement in a variety of key pharmacological parameters can be realized.
224 eurocognitive events raised by prior trials, pharmacological PCSK9 (proprotein convertase subtilisin/
225                            Our studies using pharmacological PKD inhibitors and PKD1-knockdown macrop
226 agy and mHtt proteolysis, revealing a useful pharmacological point of intervention for the treatment
227                                      Yet, no pharmacological prevention or specific treatment for acu
228            In addition to differences in the pharmacological profile of N-methyl-d-aspartate receptor
229                      Despite its outstanding pharmacological profile, application of riociguat in oth
230 , which mediates opioid actions, have unique pharmacological properties and anatomic distributions th
231 ant traditional Tibetan medicinal plant with pharmacological properties effective in the treatment of
232 rotein-protein interactions, and improve the pharmacological properties of proteins.
233 t up two assays to specifically identify the pharmacological properties of rat mGlu heterodimers comp
234 thesized functional STO-609 and assessed its pharmacological properties through in vitro (kinase assa
235 d insights into the chemical, biological and pharmacological properties, and medical potential of mat
236  in Muscat varieties having also interesting pharmacological properties.
237 ir high affinity, specificity, and favorable pharmacological properties.
238  which are known for their nutraceutical and pharmacological properties.
239 ex, prolongs the clotting time by generating pharmacological quantities of activated protein C and ef
240 tion of alpha2-antiplasmin was comparable to pharmacological r-tPA for dissolving thrombi.
241            In vivo, Rac1 deletion in SMCs or pharmacological Rac1 inhibition by nebulization of NSC23
242                          Interestingly, when pharmacological Rac1 inhibition was combined with either
243 uctural hot-spots in proteins as targets for pharmacological rescue in loss-of-function genetic disea
244 and in vivo arrhythmia models and to measure pharmacological responses.
245 ell survival functions were compromised by a pharmacological SGK1 inhibitor.
246                                              Pharmacological stimulation of mGluR5 in NAcore recapitu
247 as assessed after mechanical conditioning or pharmacological stimulation of the cGMP pathway and by u
248  reduction in atherosclerosis in response to pharmacological stimulation of thermogenesis linked to i
249 QT3 Kir2.1 mutations and highlights possible pharmacological strategies for management of SQT3-linked
250 gating cell regulation events and developing pharmacological strategies for modulating cell decisions
251                             Using genetic or pharmacological strategies to inhibit CCL5 or CCR2, we d
252 hts that could aide in the identification of pharmacological strategies to modulate FZD receptor func
253             Ex vivo and in vitro genetic and pharmacological studies found that the mechanism involve
254                                           As pharmacological studies highlight the hindbrain nucleus
255                                  Genetic and pharmacological studies in human megakaryoblastic MEG-01
256                                              Pharmacological studies showed that AR significantly inc
257                                Evidence from pharmacological studies suggests that the N/OFQ system i
258                                              Pharmacological study revealed that lamellipodia formati
259                                  Genetic and pharmacological suppression of EZH2 inhibited neuroblast
260 ) channel (KCa3.1) constitutes an attractive pharmacological target for immunosuppression, fibroproli
261 ti-apoptotic protein in cancer, represents a pharmacological target for therapy and a Molecular Beaco
262  BDNF signaling represents a potentially new pharmacological target for treatments aimed at rescuing
263  novel function of HIF-1alpha as a potential pharmacological target to improve skeletal muscle insuli
264 gical conditions, which makes it a promising pharmacological target.
265              Here, we report that genetic or pharmacological targeting of the oncogenic MUC1 subunit
266 ogical mechanisms, which are prone to become pharmacological targets for curative strategies in adult
267 ay be revealed and this could serve as novel pharmacological targets for the treatment of mood disord
268 buting to ectopic calcification and identify pharmacological targets for therapeutic development.
269 provide an opportunity to identify potential pharmacological targets, yet their expression patterns a
270 ysiology will aid in developing physical and pharmacological therapeutic interventions.
271 ey to developing more effective behavior and pharmacological therapies for alcoholism.
272                       The lack of success of pharmacological therapies for ARDS, however, presents a
273                                              Pharmacological therapies for cardiovascular diseases ar
274 on and reassurance, analgesic medicines, non-pharmacological therapies, and timely review.
275 ing these disorders and investigate possible pharmacological therapies, here we examined 13 disease-c
276 ed the superiority of catheter ablation over pharmacological therapy for maintenance of sinus rhythm
277                              No decongestive pharmacological therapy has reduced these harmful conseq
278 ajor depressive disorder respond to adequate pharmacological therapy.
279 pate the expected clinical consequences of a pharmacological therapy.
280                        Both cold-induced and pharmacological thermogenic activation enhances HDL remo
281                                 We have used pharmacological tools to explore the chemical space that
282 cology and result in large numbers of useful pharmacological tools, agents with therapeutic potential
283 alysis, calcium imaging, patch clamping, and pharmacological tools, validated by mathematical modelin
284  inhibitors that can provide potential novel pharmacological tools.
285                                              Pharmacological treatment and antiarrhythmic therapy for
286 ecent advances in reperfusion strategies and pharmacological treatment approaches.
287 order (ADHD) and is currently the first-line pharmacological treatment for children.
288  as ketogenic diets, have been used as a non-pharmacological treatment for refractory epilepsy.
289                                              Pharmacological treatment is based on a cycle of assessm
290 lycemic drugs, opens new perspectives in the pharmacological treatment of type 2 diabetes.
291                                      Several pharmacological treatment options are available for type
292        These data open the avenue for a safe pharmacological treatment that may prevent the neurodeve
293                                 Furthermore, pharmacological treatment with a Drd3 agonist, which inc
294 in cell turnover become uncoupled, including pharmacological treatments and disease models.
295                             The surgical and pharmacological treatments of obesity are discussed, and
296 neously or induced by micromanipulations and pharmacological treatments.
297 investigate other tissue pathologies or test pharmacological treatments.
298                        In rabbits subject to pharmacological triggering, plaques that thrombosed exhi
299           Accordingly, the physiological and pharmacological understanding of specific motoneuronal c
300                     SUMMARY BACKGROUND DATA: Pharmacological VTE prophylaxis with LMWH or UH is the c

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