ライフサイエンスコーパス: pharmacologically

1 hort-hairpin RNAs or proteins were inhibited pharmacologically.

2 e NAD(+) redox balance either genetically or pharmacologically.

3 c or synaptic glutamate release and isolated pharmacologically.

4 ve X (Xi) is robust and difficult to reverse pharmacologically.

5 at surgery 13.8 years), 11 were treated only pharmacologically.

6 eovessels when the Erk pathway was inhibited pharmacologically.

7 t to discover mechanisms that increase GLP-1 pharmacologically.

8 e where IFNAR was inactivated genetically or pharmacologically.

9 itive metabolic properties when administered pharmacologically.

10 on and ask whether they can be distinguished pharmacologically.

11 and cytochrome P450 that could be activated pharmacologically.

12 These findings identified a new pharmacologically accessible pathway that may be relevan

13 L6, a gene downstream of SMAD2/3, as a novel pharmacologically accessible target of our transformed H

14 epletion of HSP90 and its client proteins at pharmacologically achievable concentrations of CPX, and

15 atients harbor a unique somatic profile with pharmacologically actionable alterations, justifying the

16 Here we identify a pharmacologically actionable pathway that controls cellu

17 ssion and PIK3 reactivation), revealed novel pharmacologically actionable targets, and confirmed the

18 d that the anti-HIV drug efavirenz (EFV) can pharmacologically activate CYP46A1 in mice.

19 We pharmacologically activated SERCA2b in a genetic model o

20 ach and in the reduced mass of administered, pharmacologically active (19)F-DOPA.

21 these compounds allowed access to a range of pharmacologically active 5-amino-2,3,4,5-tetrahydro-1-be

22 of the obtained structures allows access to pharmacologically active 5-amino-substituted 2,3,4,5-tet

23 Medicine relies on the use of pharmacologically active agents (drugs) to manage and tr

24 lternative pharmaceutical use of polymers as pharmacologically active agents known as polymeric drugs

25 On screening with >2100 pharmacologically active agents, we identified 24 small

26 ic excess, thereby producing motifs found in pharmacologically active agents.

27 ns as excipients and inert carriers of other pharmacologically active agents.

28 ed the therapeutic effect of cryptolepine, a pharmacologically active alkaloid derived from the roots

29 population of venom peptides containing the pharmacologically active C-C-CC-C-C inhibitor cystine kn

30 effectively generate preliminary data before pharmacologically active candidate compounds are process

31 Two pharmacologically active catabolites were identified wit

32 Two such exposures with pharmacologically active components are coffee and tea c

33 The screening yielded a pharmacologically active compound, N-(2,4-difluorophenyl

34 n annotated chemical library, the library of pharmacologically active compounds (LOPAC), was screened

35 creened the LOPAC (Sigma-Aldrich) Library of Pharmacologically Active Compounds and discovered that G

36 gly, most hits from a screened collection of pharmacologically active compounds are agents that eleva

37 Global production of pharmacologically active compounds exceeds 100000 tons a

38 fying REL1 inhibitors in a library of small, pharmacologically active compounds.

39 g, characterizing, and optimizing innovative pharmacologically active compounds.

40 ed drugs, clinical trial drug candidates and pharmacologically active compounds; we identified compou

41 ement of several administrations to obtain a pharmacologically active concentration.

42 ergotamine, which is chemically identical to pharmacologically active dihydroergotamine.

43 ion between the "human equivalent dose" and "pharmacologically active dose" can lead to inappropriate

44 In vivo, OSU-T315 attains pharmacologically active drug levels and significantly p

45 sm more rapidly than target cells convert to pharmacologically active drug.

46 ck feeding is facilitated by a collection of pharmacologically active factors in tick saliva.

47 have various side effects, investigating new pharmacologically active molecules is important for trea

48 ts presented here will assist the search for pharmacologically active molecules that can potentially

49 The pharmacologically active nucleoside triphosphate (NTP) i

50 Naturally occurring, pharmacologically active peptides constrained with coval

51 Animal venoms represent a rich source of pharmacologically active peptides that interact with ion

52 ic biodegradation, and can be decorated with pharmacologically active peptides, proteins, and small m

53 d to invert stereoselectivity, producing the pharmacologically active pravastatin form.

54 eine, a naturally occurring, bitter-tasting, pharmacologically active secondary compound whose main p

55 hod for the simultaneous determination of 22 pharmacologically active substances (antibacterials, non

56 plied to the screening of a small library of pharmacologically active substances, and the effect of c

57 Key to the concept was the identification of pharmacologically active zwitterions designed to be reta

58 e, and as a source of numerous under-studied pharmacologically-active compounds, a precise understand

59 of drug safety and efficacy, to identifying pharmacologically-altered networks in zebrafish models o

60 roved therapeutic responses in other complex pharmacologically amenable pathways.

61 e assays; cells and tissues were manipulated pharmacologically and by RNA interference.

62 xone (BUP-NX), a partial opioid agonist, are pharmacologically and conceptually distinct intervention

63 The Ang-II effect can be reversed pharmacologically and genetically by inhibiting Ang-II p

64 of lysosomal enzymes enhances autophagy, and pharmacologically and genetically enhancing autophagy im

65 We induced RPE injury pharmacologically and genetically in transgenic mouse mo

66 ly, increasing mitochondrial proteostasis by pharmacologically and genetically targeting mitochondria

67 role for the metal transporter ZIP14 during pharmacologically and high-fat diet-induced ER stress us

68 brain stiffness, blocked mechanotransduction pharmacologically and knocked down the mechanosensitive

69 t for Cav-3 expression in protection against pharmacologically and pressure overload-induced cardiac

70 l for protecting the signaling mechanisms in pharmacologically and pressure overload-induced cardiac

71 e, a known nonorganified hNIS tracer, and is pharmacologically and radiobiologically safe in humans.

72 exposure to an HIV-1 protein can be reversed pharmacologically and that loss and recovery of dendriti

73 e latencies, manipulating synaptic responses pharmacologically, and tracing the pathway transynaptica

74 eripheral microOR activation indicating that pharmacologically antagonizing TRPM3 may be a useful ana

75 pigenetic mechanism, and these events can be pharmacologically attenuated with either AR antagonists

76 isopropylsulfonamide and biphenyl group, was pharmacologically augmented by converting it to a confor

77 e successful, has shifted emphasis away from pharmacologically based studies.

78 petitive allosteric inhibitors, were used to pharmacologically blockade CXCR1/2.

79 expression was inhibited when melanopsin was pharmacologically blocked by AA92593 as well as when its

80 Induction of the plasticity can be pharmacologically blocked by antagonists of either the p

81 Intracellular protein trafficking was pharmacologically blocked in vivo and in vitro.

82 hyperpolarization-activated current, Ih, as pharmacologically blocking it prevented the long- and mi

83 In addition, we found that pharmacologically boosting either mTORC2 or actin polyme

84 difficult neuropsychiatric diseases to treat pharmacologically, but respond to cognitive therapies.

85 as ATG5, p62/SQSTM1, or inhibiting autophagy pharmacologically by chloroquine, also induced the expre

86 We further validated these results pharmacologically by demonstrating similar reductions in

87 osphatase 2A (PP2A) activity can be enhanced pharmacologically by PP2A-activating drugs (PADs).

88 uption of these interactions can be achieved pharmacologically by small molecule kinase domain inhibi

89 lzheimer disease because it can be activated pharmacologically by some marketed drugs, as exemplified

90 Pharmacologically, CaV1.1e behaves like other L-type cal

91 We sequenced the MC4R from 20 cetaceans, and pharmacologically characterized 17 of these protein prod

92 a set of 48 tetrapeptides were designed and pharmacologically characterized at the mouse melanocorti

93 ediated endocytosis of LGR5 could be used to pharmacologically control cell behavior.

94 ion of KARs in vivo and may prove useful for pharmacologically controlling the activity of neuronal n

95 el mice and that targeting mitochondrial ROS pharmacologically could benefit individuals with AS.

96 lectrode arrays left in place, the ears were pharmacologically deafened and electrical stimulation wa

97 growth inhibitory effects of genetically or pharmacologically decreasing CaMKK2 activity; collective

98 t the tip of the axon and can be reversed by pharmacologically decreasing Gsk3beta activity during po

99 ractory to oxaliplatin unless genetically or pharmacologically depleted of B cells.

100 Blocking K(ATP) channels pharmacologically depolarizes the beta-cell plasma membr

101 Pharmacologically difficult targets, such as MYC transcr

102 peripheral B cells in cGVHD patients can be pharmacologically directed from hyperactivation toward m

103 These studies demonstrate that three pharmacologically distinct classes of drugs, clinically

104 The 6TM isoform was pharmacologically distinct from the canonical 7TM mu-opi

105 support the presence of physiologically and pharmacologically distinct functional subgroups of extra

106 Furthermore, this IL-8 response could not be pharmacologically downregulated without affecting IFN-be

107 brain hemodynamics provide information about pharmacologically driven downstream CNS drug effects; th

108 ver, silencing IL neurons optogenetically or pharmacologically during the retrieval of extinction 1 d

109 cation that mechanosensing could be modified pharmacologically during the transition to heart failure

110 Pharmacologically elevating brain endocannabinoids (eCBs

111 We anticipate that pharmacologically elevating the function of 14-3-3sigma

112 econd-line antiretroviral therapy (ART) of a pharmacologically enhanced (boosted) protease inhibitor

113 loss of SMS is suppressed by genetically or pharmacologically enhanced antioxidant activity.

114 Decreasing the number of MSC pharmacologically enhanced cancer cell homing to the bon

115 Studies showing that spindles can be pharmacologically enhanced in SZ and that increasing spi

116 enethylamines was designed, synthesized, and pharmacologically evaluated.

117 ase in beta-cells, and show that this can be pharmacologically exploited to boost insulin secretion.

118 s at an important juncture, with the current pharmacologically focused model having achieved modest b

119 n adolescents and adult mice that is induced pharmacologically from a more severe model and demonstra

120 lkaloids was achieved resulting isolation of pharmacologically important alkaloids: magnoflorine and

121 y a missing step in the biosynthesis of this pharmacologically important class of plant natural produ

122 controlling the central branch point of this pharmacologically important group of compounds.

123 eptides, which extend the panel of potential pharmacologically important Kv1 ligands.

124 s of therapeutics, can functionally modulate pharmacologically important proteins by inhibiting prote

125 roduction or action, genetically in mice and pharmacologically in humans, respectively, has not produ

126 tive methods to reverse pharyngeal hypotonia pharmacologically in sleeping humans.

127 we increased the frequency of retinal waves pharmacologically in the ferret (Mustela putorius furo)

128 e of (52)Mn(2+) was successfully manipulated pharmacologically in vitro and in vivo using glucose, ni

129 Chronically increasing neuronal activity pharmacologically in vivo led to a normalization of Kv2.

130 Furthermore, genetically depleting or pharmacologically inactivating Skp2 synergistically re-s

131 eted therapies with immunotherapies that are pharmacologically incompatible; (ii) early monitoring of

132 wake animals, we investigated to what extent pharmacologically increased or decreased CN neuron activ

133 lind placebo-controlled crossover design, we pharmacologically increased synaptic catecholamine level

134 We pharmacologically increased synaptic catecholamine level

135 y attenuated when protein O-GlcNAcylation is pharmacologically increased.

136 is dependent on actin depolymerization, and pharmacologically induced actin depolymerization is suff

137 ained into adulthood, and restored following pharmacologically induced degeneration of the olfactory

138 es endocytosis in SMA models and ameliorates pharmacologically induced endocytosis defects in zebrafi

139 tau(-/-) mice abolished the protection from pharmacologically induced excitotoxicity and middle cere

140 We pharmacologically induced focal seizures in primary visu

141 We hypothesized that a pharmacologically induced GABA deficit would create vuln

142 Pharmacologically induced glycosuria elicits adaptive re

143 Using zebrafish with genetic or pharmacologically induced macrophage deficiencies, we fi

144 tives and controlled mechanical ventilation, pharmacologically induced neuromechanical uncoupling of

145 More importantly, the pharmacologically induced Nrf2 overcomes Keap1 regulatio

146 The impact of pharmacologically induced phase III contractions on the

147 Pharmacologically induced phase III contractions were al

148 Pharmacologically induced remission of this condition is

149 rain shift the threshold for spontaneous and pharmacologically induced seizures alongside changes in

150 Furthermore, pharmacologically induced SIRT1-mediated deacetylation c

151 al firing in vitro and increased strength of pharmacologically induced spike and wave discharges in v

152 Here, for the first time, we demonstrate pharmacologically induced, immediate rescue of deficits

153 tates of consciousness, such as psychotic or pharmacologically-induced hallucinations, provide a uniq

154 a-opioid receptor (KORD) is activated by the pharmacologically inert drug salvinorin B (SalB; Vardy e

155 a-opioid receptor (KORD) is activated by the pharmacologically inert drug salvinorin B.

156 s a template (KORD) that is activated by the pharmacologically inert ligand salvinorin B (SALB).

157 Likewise, when BRAF(V600E) is pharmacologically inhibited by targeted therapies (e.g.

158 To manipulate Hsp90 acetylation, we pharmacologically inhibited histone deacetylase 6, a kno

159 r, this effect was not observed when ML1 was pharmacologically inhibited or genetically deleted.

160 ouble knockout ApoE(-/-)Trem-1(-/-) mice, we pharmacologically inhibited Trem-1 using LR12 peptide.

161 sed when HIF-prolyl hydroxylase activity was pharmacologically inhibited using deferoxamine or dimeth

162 When TRPML1 is genetically inactivated or pharmacologically inhibited, clearance of damaged mitoch

163 When migration is pharmacologically inhibited, the ATP:ADP ratio decreases

164 When this sliding is pharmacologically inhibited, the leading process becomes

165 wild-type mice in which GCase and C5aR were pharmacologically inhibited, were protected from these a

166 Pharmacologically inhibiting the erratic output of the c

167 Pharmacologically inhibiting the glycolytic pathway dram

168 Pharmacologically inhibiting this pathway substantially

169 and inhibition of this enzyme genetically or pharmacologically inhibits oncogenesis.

170 new synthetic strategy provides a series of pharmacologically interesting 4,6-diarylpicolinates in h

171 Crippling the program genetically or pharmacologically interferes with multiple inhibitory pa

172 inhibitors provide a set of useful tools to pharmacologically interrogate JAK3-dependent biology.

173 We also highlight current efforts to pharmacologically intervene in Notch signaling and discu

174 Surgery is a valuable option for pharmacologically intractable epilepsy.

175 We synthesized and pharmacologically investigated 37 tetrahydro-beta-carbol

176 on balance in pyramidal neurons, we recorded pharmacologically isolated inhibitory responses, compoun

177 leptiform activity and then replayed them in pharmacologically isolated neurons under control conditi

178 MicroRNA-146a was either genetically or pharmacologically knocked out or genetically overexpress

179 (Dnmt1a), Dnmt3, or blocking DNA methylation pharmacologically, largely disrupts the photoperiodic di

180 Reduction of DNA methylation genetically or pharmacologically leads to a decrease of the H3K27ac mar

181 ulates PXR transcriptional activity and that pharmacologically manipulated AMPK activation exhibits a

182 gs of the proximal negative field potential, pharmacologically manipulated to generate a pure NMDA me

183 awake locusts (Schistocerca americana) while pharmacologically manipulating patterns of correlated ne

184 tes mellitus, leading us to hypothesize that pharmacologically mediated reductions in PAI-1 using PAI

185 rgeting the efferent vestibular system (EVS) pharmacologically might prove useful in ameliorating som

186 l's impact on cerebellar processing and that pharmacologically modifying such responses alters alcoho

187 ma1-selective small molecules can be used to pharmacologically modulate protein homeostasis pathways.

188 and provide proof of concept for efforts to pharmacologically modulate the eIF4E-cap interaction as

189 on in the brain as well as how they might be pharmacologically modulated in neurological disorders an

190 lly, the gain-of-function mutations could be pharmacologically modulated in vitro using an existing F

191 and autoimmune diseases, we genetically and pharmacologically modulated ORAI1 function.

192 By pharmacologically modulating the expression of the dystr

193 Pharmacologically, modulating histone acetylation with a

194 Therefore, aGPCRs appear to be pharmacologically more closely related than previously t

195 Pharmacologically, neurons respond either only to capsai

196 as indexed by pupil diameter and manipulated pharmacologically) on the precision of object representa

197 We report the discovery of BTSA1, a pharmacologically optimized BAX activator that binds wit

198 how that administration of an engineered and pharmacologically optimized human cyst(e)inase enzyme me

199 Disrupting this activity either pharmacologically or by electrical stimulation alters th

200 Inhibiting THIK-1 function pharmacologically or by gene knockout depolarizes microg

201 Activation of p53, pharmacologically or by oncogene-induced replication str

202 hat during fictive locomotion induced either pharmacologically or by sacrocaudal afferent stimulation

203 upting cortical activity during this window, pharmacologically or chemogenetically, increases the num

204 f the transient elevation of O-GlcNAcylation pharmacologically or genetically aggravates the ischemia

205 Perturbing filopodium dynamics pharmacologically or genetically disrupts Slit-mediated

206 ltured cells to hypoxia or mimicking hypoxia pharmacologically or genetically increases CA, and HIF-1

207 en mGluR5, NO production, or MMP-2 and MMP-9 pharmacologically or genetically is sufficient to recapi

208 Elevating cAMP pharmacologically or optogenetically produced plasticity

209 Manipulation of braking molecules either pharmacologically or though experiential alteration enha

210 tion that exogenously blunting M1 signaling (pharmacologically or with cortical stimulation) is a the

211 chanically ventilated, deeply sedated and/or pharmacologically paralysed intensive care unit (ICU) pa

212 Blocking T-type currents pharmacologically prevented LTP induced by high-frequenc

213 mmation caused by dysfunctional autophagy is pharmacologically prevented.

214 traightforward approach for the synthesis of pharmacologically privileged disubstituted naphthalene-1

215 We hypothesized that pharmacologically promoting glutamate spillover in the N

216 eyes, these derivatives potently reduce both pharmacologically raised and basal intraocular pressure.

217 erivatives effectively prevented or reversed pharmacologically raised intraocular pressure in rabbits

218 METHODS AND To pharmacologically re-induce HbF by DNMT1 inhibition, thi

219 Strategies to pharmacologically regulate Irx3 function in adult endoth

220 ged structures possessing remarkable diverse pharmacologically relevant activities.

221 able acyclic and cyclic compounds (including pharmacologically relevant carbazoles, delta-lactams, an

222 found to be readily bioavailable to achieve pharmacologically relevant concentrations for CREB inhib

223 Thus, we find that at pharmacologically relevant concentrations, amphetamines

224 range and towards antimalarial compounds at pharmacologically relevant concentrations.

225 Benzothiazine 1,1-dioxides represent pharmacologically relevant derivatives with biological,

226 The method is compatible with pharmacologically relevant functional groups, including

227 ted as inhibitors of six physiologically and pharmacologically relevant human (h) carbonic anhydrase

228 The MTCs effectively inhibited the pharmacologically relevant human (h) hCAs isoforms I, II

229 ics of more complex p38 inhibitors and other pharmacologically relevant inhibitors in general, demons

230 ore detailed description of an enzyme of the pharmacologically relevant lysophosphospholipid acyltran

231 cedure for the quantitative determination of pharmacologically relevant secoiridoids in olive oil, ol

232 e unbinding mechanism of an inhibitor of the pharmacologically relevant target p38 MAP kinase.

233 and thiols has hindered attempts to identify pharmacologically relevant targets and characterize the

234 for identifying site(s) of interaction with pharmacologically relevant targets and informing the con

235 ynamical properties of cryptic sites in four pharmacologically relevant targets, while comparing the

236 well-defined synthetic macromolecules become pharmacologically relevant when bioactive side chains ar

237 Pharmacologically removing horizontal cells from the cir

238 ore whether these hDAT mutants could also be pharmacologically rescued in an intact organism.

239 iven prostate cancer cells via regulation of pharmacologically responsive Sigma1-AR/ARV interactions,

240 on of eIF2α-P activity, genetically or pharmacologically, restores memory and prevents neurodeg

241 Tumour growth can be pharmacologically restrained using autophagy inhibitors,

242 The results are important for strategies to pharmacologically reverse HIV-1 latency.

243 suggest that this state of latency might be pharmacologically reversed, resulting in viral protein e

244 d demonstrating that synaptic defects can be pharmacologically reversed, these data open the possibil

245 c transformation, resulting in what may be a pharmacologically reversible epigenetic field defect in

246 r schizophrenia risk; show that deficits are pharmacologically reversible in adulthood; and further h

247 Epigenetic changes can be pharmacologically reverted; therefore, identification of

248 and calmodulin-dependent kinase were blocked pharmacologically, S1P3 and VEGFR2 expression was decrea

249 n constriction speed and are genetically and pharmacologically separable.

250 We provide evidence for pharmacologically significant interactions between CRF a

251 drug targets into 167 gene sets targeted by pharmacologically similar drugs and examined enrichment

252 Lengthening surface lifetimes by pharmacologically slowing endocytosis was sufficient to

253 progress has been made in characterizing and pharmacologically slowing the progression of AML and LAM

254 iption kinetics are perturbed genetically or pharmacologically splice patterns may change.

255 as mice in which 5-HT synthesis is inhibited pharmacologically, suggesting 5-HT has localized effects

256 Our results identify pharmacologically suitable targets for reactivation of M

257 Building on our previous studies that pharmacologically suppressed dPul activity for several h

258 nes in four groups of women: 73 ECs, 42 with pharmacologically suppressed viremia (ART), 42 with unco

259 In an attempt to pharmacologically target KLF14 as an experimental therap

260 A new wave of treatments that pharmacologically target the synaptic plasticity underly

261 he transcription factor Stat3 as a critical, pharmacologically targetable effector of CD109-driven lu

262 ell homeostasis, offers a rich repertoire of pharmacologically targetable vulnerabilities presenting

263 cal entities have demonstrated that TRPC6 is pharmacologically targetable.

264 t also different because ZAP70 is not easily pharmacologically targetable.

265 xpression in specific cell types, and can be pharmacologically targeted as a therapeutic approach to

266 us to test the possibility that Nurr1 can be pharmacologically targeted by bexarotene, a ligand for t

267 in regulating humoral immunity, which may be pharmacologically targeted during vaccination or patholo

268 elopment and growth, and this pathway can be pharmacologically targeted to inhibit NRAS-mutant melano

269 ill be discussed to explore the potential of pharmacologically targeting mechanotransduction in cance

270 cognate effectors, is a viable approach for pharmacologically targeting riboswitches and other struc

271 tem may contribute to these disturbances and pharmacologically targeting the D3 dopamine receptor (DR

272 Pharmacologically, targeting PDGFRbeta disrupts APC nich

273 Targeting pharmacologically the activity of HIV-1 Vpu, which contr

274 bility to boost placebo effects by targeting pharmacologically the vasopressin system, characterized

275 eosome components were depleted or inhibited pharmacologically, the steady-state levels of circular R

276 Pharmacologically these compounds lead to G2/M phase cel

277 d inflammation could potentially be targeted pharmacologically through BTK.

278 ping is that contraction is usually arrested pharmacologically to prevent motion artifacts from obscu

279 comprehensive workflow for identification of pharmacologically tractable markers of behaviourally cha

280 ulator of glucose transport that regulates a pharmacologically tractable pathway necessary for PDAC t

281 g evidence for the SH2-kinase interface as a pharmacologically tractable site for allosteric inhibiti

282 ways, and this signaling axis may serve as a pharmacologically tractable target during infection and

283 There was suggestive evidence that pharmacologically treated MD is associated with shorter

284 Of these, 1,372 pharmacologically treated patients with diabetes and 10,

285 tantly, these phenotypes could be rescued by pharmacologically unsilencing paternal UBE3A expression.

286 ake inhibitors [SSRIs], and individuals with pharmacologically untreated depression).

287 month for infants with prenatal exposure to pharmacologically untreated maternal depression, selecti

288 ascular adrenergic sensitivity were assessed pharmacologically using intradermal microdialysis.

289 We show effective targeting of this pathway pharmacologically using proteasome inhibitors in TRIB2-p

290 le and bioavailable prodrugs would provide a pharmacologically valuable strategy for the treatment of

291 cent protein were stimulated electrically or pharmacologically (veratridine).

292 We electrochemically and pharmacologically verify the selectivity of the serotoni

293 This manipulation, when tested pharmacologically via systemic administration of group I

294 shutting down polyP synthesis genetically or pharmacologically, we propose that polyP synthesis rathe

295 MAPKs), TAK1 (MAP3K7) and MAP4K2, as well as pharmacologically well interrogated kinases such as p38a

296 ause it is not possible to block NMDA spikes pharmacologically while maintaining NMDA receptors avail

297 s in PDE4B(Y358C) mice, an effect replicated pharmacologically with a non-selective PDE4 inhibitor, i

298 Decreasing NADH pharmacologically with MTOB or genetically blocking CtBP

299 cases of raised IOP, 5 of which were treated pharmacologically with no surgical intervention required

300 on genetically with a mutant IkappaBalpha or pharmacologically with pyrrolidine dithiocarbamate (PDTC