ライフサイエンスコーパス: pharmacology

1 ug treatments, including with regard to drug pharmacology.

2 le new avenues of exploration in imaging and pharmacology.

3 TRP channel structure-function analysis and pharmacology.

4 omplement direct intervention by genetics or pharmacology.

5 ional states, and often show state-dependent pharmacology.

6 ng opportunities to better understand opioid pharmacology.

7 te after cleaning did not affect ion channel pharmacology.

8 increased investigation of their behavioral pharmacology.

9 ing data in crystal structures and molecular pharmacology.

10 ividual contributions to voltage sensing and pharmacology.

11 le of this domain on A1AR orthosteric ligand pharmacology.

12 propriate model system for the study of GPCR pharmacology.

13 romising candidates for in-depth preclinical pharmacology.

14 so been established with the IUPHAR Guide to Pharmacology.

15 ve our understanding of human physiology and pharmacology.

16 and support its functional mGlu2 antagonist pharmacology.

17 dominant forces in research and training in pharmacology.

18 r an era spanning over 40 years in molecular pharmacology.

19 (SMs) and some play a role in agriculture or pharmacology.

20 nation with viral-mediated gene delivery and pharmacology.

21 y published compendium, the Concise Guide to PHARMACOLOGY.

22 ic force microscopy and toxin (i.e., apamin) pharmacology.

23 t tumors becomes an important goal in cancer pharmacology.

24 erred linker length dependency in allosteric pharmacology.

25 s expressed functional nAChRs with different pharmacology.

26 brane as a modulator of channel function and pharmacology.

27 onidation metabolic liability and off-target pharmacology.

28 ls by a combination of electrophysiology and pharmacology.

29 can expose fragments with purely allosteric pharmacology.

30 rameworks were revealed which may have novel pharmacology.

31 he underlying molecular basis of this unique pharmacology.

32 genetic methods and the temporal control of pharmacology.

33 rstanding and emerging opportunities for new pharmacology.

34 ime in vivo GPCR imaging to the forefront of pharmacology.

35 r the most important emerging trends in GPCR pharmacology.

36 determination of drug uptake for single-cell pharmacology.

37 hes that may derive from understanding aGPCR pharmacology.

38 ighlights a role for RAMP2 in regulating its pharmacology.

39 mutations vital for the second conformation pharmacology.

40 ove useful in future studies of MOR receptor pharmacology.

41 us potential for systems biology and network pharmacology.

42 gated channel function, ion selectivity, and pharmacology.

43 arch of chemical biology and is essential in pharmacology.

44 to search for Gs- and Golf-specific receptor pharmacology.

45 and uncovers an alternative endocannabinoid pharmacology.

46 compound in both chemical structure and AHR pharmacology.

47 d to identifying new molecules with a select pharmacology.

48 plications in drug development and molecular pharmacology.

49 new and improved drugs with less off-target pharmacology.

50 tivity at the MC5R, the first report of this pharmacology.

51 kotriene CysLT1) to reconstitute the elusive pharmacology.

52 ty in determination of Kir channel inhibitor pharmacology.

53 as such as medical science, diagnostics, and pharmacology.

54 on Kv1.1 (KCNA1) gating, ion selectivity, or pharmacology.

55 ate AMPAR assembly, trafficking, gating, and pharmacology.

56 D3-preferring radioligand [(11)C]-(+)-PHNO, pharmacology, a novel three-choice probabilistic discrim

57 ng inhibition of human FLAP but differential pharmacology across species and was completely inactive

58 ility for medicinal purposes, and comparable pharmacology against insulin-induced hypoglycemia in rat

59 Over the past 50 years in pharmacology, an understanding of seven transmembrane (7

60 inding to a given target, detailed molecular pharmacology analysis accurately predicts utility of lig

61 atabase was successfully applied for systems pharmacology analysis of a complicated herbal formula in

62 asis chemopreventive, we performed a systems pharmacology analysis of mifepristone-related molecules

63 The novel pharmacology and aqueous humor dynamic effects of this m

64 facilitated by a better understanding of the pharmacology and behavioral effects of opioids that unde

65 cle, we review the available evidence on the pharmacology and behavioral interactions of THC and CBD

66 Specifically, using behavioral pharmacology and biochemistry in adult rats, we determin

67 has implications for CRAC channel function, pharmacology and disease-causing mutations.

68 processes and it is of tremendous value for pharmacology and drug design.

69 We describe the clinical pharmacology and drug interaction potential of the DAAs,

70 e potential to impact regenerative medicine, pharmacology and electronic therapeutics.

71 27g, and 27n were selected based on in vitro pharmacology and evaluated in murine pharmacokinetic and

72 An integrated network pharmacology and experimental verification approach was

73 to guide meaningful investigations into the pharmacology and function of individual receptors.

74 cence-based Ca(2+) flux assays combined with pharmacology and gene knock-out methods, we discovered a

75 resolution STED imaging, force measurements, pharmacology and gene knockout, we show that dynamic ass

76 A unique resource for systems pharmacology and genomic studies is the NCI-60 cancer ce

77 and expanded classical concepts of receptor pharmacology and have begun to illuminate the distinct m

78 histamine, with a thorough evaluation of its pharmacology and interaction with histamine H1 -receptor

79 ke defect, including timed injection series, pharmacology and ion replacement, and optogenetic activi

80 age activated transient Ca(2+) current whose pharmacology and kinetics corresponded to a CaV3.1 T-typ

81 ted transient Ca(2+) current developed whose pharmacology and kinetics corresponded to a T-type CaV3.

82 It has rich pharmacology and largely accounts for the recreational u

83 ay be important determinants in defining the pharmacology and mechanism(s) of action of the S1R.

84 rk analysis by integrating data from network pharmacology and metabolomics to identify targets of act

85 aken in consideration in NHP models of human pharmacology and microbiology.

86 This article focuses on novel aspects of the pharmacology and molecular mechanisms of histamine recep

87 nt roles in the development of the fields of pharmacology and neurobiology, nicotinic receptors are i

88 In vivo pharmacology and optogenetics hold tremendous promise fo

89 tofluidic neural probes for advanced in vivo pharmacology and optogenetics in freely moving rodents.T

90 modifications on myricetin might improve its pharmacology and pharmacokinetics.

91 LR-RAMP interactions yield discrete receptor pharmacology and physiological effects.

92 e 1950s, when understanding of antimicrobial pharmacology and regulatory requirements for approval of

93 ructural modifications profoundly impact its pharmacology and result in large numbers of useful pharm

94 Herein, we report the pharmacology and SAR studies both in vitro and in vivo o

95 ndole-2-carboxamide (3) displayed allosteric pharmacology and sensitivity to mutations of the same re

96 ics, whole-cell electrophysiology, molecular pharmacology and single cell RT-PCR in mice.

97 Moving from general aspects of aspirin pharmacology and specific issues in diabetes mellitus, t

98 monstrate that drug design affected receptor pharmacology and suggest that the MMC scaffold is a usef

99 unoresolvents as agonists to test resolution pharmacology and their role in catabasis for their thera

100 North West England MRC Clinical Pharmacology and Therapeutics Clinical Research Fellowsh

101 molecules that display bitopic or allosteric pharmacology and those that are simply competitive antag

102 er highlights the importance of RAMPs to CLR pharmacology and to bias in general, as well as identify

103 Pharmacology and toxicology of these compounds are discu

104 rent scientific fields, such as biomedicine, pharmacology and toxicology.

105 on and expansion study evaluated the safety, pharmacology, and activity of varlilumab in patients wit

106 e and non-invasive routes of administration, pharmacology, and adverse effects.

107 lights the powerful combination of genetics, pharmacology, and biochemistry used to study energy bala

108 nation of cell-type-specific gene deletions, pharmacology, and chemogenetics, we found that systemic

109 pulations of neuronal and muscular activity, pharmacology, and genetic perturbations to uncover circu

110 hnology, such as target engagement, receptor pharmacology, and high-throughput screening.

111 nation of molecular and behavioral analyses, pharmacology, and in vivo amperometry to assess the role

112 Using a combination of electrophysiology, pharmacology, and light/electron microscopy, we show tha

113 ical trials; seminal articles on physiology, pharmacology, and neuroimanging; and listings from clini

114 , infectious diseases, dermatology, clinical pharmacology, and pharmacogenomics discussed the current

115 ng details surrounding SAR, in vitro/in vivo pharmacology, and pharmacokinetics, is reported herein.

116 ceptor complex with altered gating kinetics, pharmacology, and pore properties.

117 lessly from systems pharmacology to cellular pharmacology, and the revealed hub genes may be the prom

118 al application fields, including toxicology, pharmacology, and therapeutics.

119 rings matched outcomes predicted by in vivo pharmacology, and were supported by immunohistochemistry

120 Third, we provide an example of cross-over pharmacology antiepileptic drug testing.

121 We illustrate how a systems pharmacology approach combining experimental and computa

122 ific chemogenomics databases and our systems pharmacology approach TargetHunter to explore synergisti

123 we have developed a novel structural systems pharmacology approach to elucidate metformin's molecular

124 Using a systems pharmacology approach, we have extended an existing PK-P

125 lecular Pharmacology has had on the field of pharmacology as well as on biomedical science is discuss

126 Molecular- and pharmacology-based analyses revealed that LATS1 inactiva

127 resent systemsDock, a web server for network pharmacology-based prediction and analysis, which permit

128 es KCNQ channel ion selectivity, gating, and pharmacology by direct physical interaction with the por

129 ting the vagus nerve with neuromodulation or pharmacology can be used as a therapeutic treatment of o

130 ation, demonstrating that cell type-specific pharmacology can be used to dissect signaling pathways w

131 tial applications including systems biology, pharmacology, cancer diagnosis and stem cell biology.

132 Inhaled dual-pharmacology compounds, combining muscarinic antagonism

133 n showed acceptable safety and tolerability, pharmacology consistent with its intended mechanism of a

134 vity, sensitivity to extracellular K(+), and pharmacology, consistent with an impact on conformation

135 we combined double-blind, placebo-controlled pharmacology [D2 receptor (D2R) antagonist amisulpride]

136 sed to marry the wealth of existing receptor pharmacology data with the expanding repertoire of struc

137 Together with multichannel pharmacology data, this model predicts that compounds wi

138 APD and Q-T intervals as criteria for safety pharmacology decisions.

139 Further, GABAA receptor pharmacology determined an excitatory effect of the PH o

140 framework helped to interpret JAK1 blockade pharmacology, different clusters being affected under to

141 ly, an integrative approach of optogenetics, pharmacology, electrophysiology, and behavior is used to

142 sensitivity, unitary current magnitude), and pharmacology (enhancement and inhibition by 2-aminoethox

143 solution and have great promise in molecular pharmacology, especially in the context of mapping the b

144 Our aim was to investigate the receptor pharmacology, expression pattern, and in vivo function o

145 n for the possible future development in the pharmacology field.

146 over cell-type-specific neural circuitry and pharmacology for appetite control within the DRN.

147 Peptide toxins represent a rich source of pharmacology for ion channels, and we recently reported

148 atocyte hopping"-a novel concept in clinical pharmacology-for detoxification of targeted cancer drugs

149 In this study, we present a systems pharmacology framework which draws on genetic data from

150 , we addressed this question in humans using pharmacology, functional magnetic resonance imaging, and

151 The substantial impact that Molecular Pharmacology has had on the field of pharmacology as wel

152 n of Arg side chains to protein function and pharmacology has proven to be exceedingly difficult in s

153 molecules, along with the issues relating to pharmacology, has left integrin therapeutics in need of

154 sed cardiovascular procedures and adjunctive pharmacology have an inherent risk of neurological compl

155 n, we consider how evolving concepts of GPCR pharmacology have shaped understanding of the complex ph

156 Network pharmacology helps to overcome target-based bottlenecks

157 G channel interactions and multi-ion channel pharmacology improves the prediction of torsadogenic ris

158 was performed at the Department of Clinical Pharmacology in cooperation with the Center for Medical

159 hlights the significant potential of systems pharmacology in elucidating the mechanism of synergy and

160 ging interpretations of NAADP physiology and pharmacology in heart.

161 Using occlusion experiments and pharmacology in patched pairs of coupled neurons in vitr

162 Using pharmacology in Peromyscus and chemogenetics in Mus, we

163 rphology, discharge properties, and synaptic pharmacology in semi-intact in vitro preparations of lar

164 of human heart morphology, biochemistry and pharmacology in vitro, offering a promising alternative

165 Finally, by combining recordings and pharmacology in vivo, in slices, and in human embryonic

166 Here, we used classical pharmacology, in situ hybridization, immunohistochemistr

167 Using a combination of behavior, pharmacology, in vivo surface sensing of translation (SU

168 rotonin transporter (SERT/SLC6A4) has a rich pharmacology including inhibitors, releasers (amphetamin

169 Then, we employed network pharmacology including text mining and molecular docking

170 derstanding peripheral nerve homeostasis and pharmacology, including targeted drug delivery and the m

171 he reach of opioid-receptor neurobiology and pharmacology into a new era of analgesic discovery.

172 uantitative approaches to translate in vitro pharmacology into functionally relevant cellular setting

173 A novel translational pharmacology investigation was conducted by combining an

174 drugs with well-characterized toxicology and pharmacology is a novel way to reduce the time, cost, an

175 cannabinoids, unique natural products, whose pharmacology is going to gain increasing interest in the

176 -permeant neutral CB1 antagonist, though its pharmacology is still unclear.

177 agonists in the same assay, and their unique pharmacology is the subject of increasing interest and d

178 In the brain, AMPAR trafficking, gating, and pharmacology is tightly controlled by transmembrane AMPA

179 phasic and tonic glycine receptors suggests pharmacology is unlikely to be able to selectively targe

180 he International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological So

181 viously reported the first discovery of dual pharmacology MABA bronchodilators, exemplified by 1.

182 The resulting immune-cell pharmacology map is used to predict how five drugs influ

183 chemistry, medicinal science, biochemistry, pharmacology, material science, and catalysis.

184 By pharmacology, mathematical modelling, and intracellular

185 ve overview of the basics of GPCR allosteric pharmacology, medicinal chemistry, drug metabolism, and

186 This computational systems pharmacology model captures the ability of the ECM to re

187 Quantitative pharmacology models that integrated cellular PTX pharmac

188 evelop computational predictive quantitative pharmacology models.

189 Here, we used selective pharmacology, molecular and genetic approaches to implic

190 cell proliferation assays are widely used in pharmacology, molecular biology, and drug discovery.

191 and beta-arrestin signaling pathways in D2R pharmacology, neurobiology, and associated pathologies.

192 Accumulating evidence from pharmacology, neuroimaging, and genetics indicates that

193 molecular biology, biochemistry, physiology, pharmacology, neuroscience, cardiology, endocrinology, n

194 Finally, we applied SYSMOLE to study the pharmacology of a new class of glutamate antipsychotic d

195 ciation of the molecular determinants of the pharmacology of a NR pathway in a given tissue.

196 of this disulfide bond, the observed in vivo pharmacology of AMG 416 showed readily reversible pharma

197 ally influence the distribution, gating, and pharmacology of AMPARs, but the contribution of these au

198 identification and the in vitro and in vivo pharmacology of an antigen-binding fragment (Fab) antido

199 Increased knowledge of the pharmacology of antithrombotic drugs and the mechanisms

200 provides new insights into the function and pharmacology of both the CAN and the TRPM families.

201 orking team summarized the literature on the pharmacology of central neuromodulators and their effect

202 vides additional elements for the design and pharmacology of clinically relevant nonsteroidal GR anta

203 ribe the discovery, synthesis, and molecular pharmacology of delta-opioid receptor-selective positive

204 and, and venous sinuses as expected from the pharmacology of dihydroergotamine.

205 molecular structure, general physiology, and pharmacology of distinct Na(v) channel subtypes.

206 Herein, we profiled the pharmacology of histamine receptor agonists at the two m

207 The signature pharmacology of IK1, blockade by TRAM-34, was reported f

208 ntriguing behavior on cardiac physiology and pharmacology of KACh channels.

209 However, the molecular pharmacology of ligand binding to CXCR3 alternative spli

210 , we have analysed postsynaptic function and pharmacology of neuronal nicotinic ACh receptors (nAChRs

211 ur results provide key information about the pharmacology of newly emerging mephedrone analogs, and g

212 The pharmacology of OCT3 is distinct from that of other OCTs

213 expert consensus provides an overview of the pharmacology of P2Y12 inhibitors, different modalities a

214 The spinal pharmacology of pathways that subserve DNIC are complica

215 The pharmacology of PGE2 in isolated human small airways was

216 Here we develop a system to isolate the pharmacology of precisely defined GPCR dimers, trapped b

217 This emerging pharmacology of receptor-associated proteins provides a

218 ogy have shaped understanding of the complex pharmacology of receptors that recognize and are activat

219 pound 27 may be a useful tool to explore the pharmacology of selective PDE2a inhibition.

220 tion of receptor signaling contribute to the pharmacology of super agonism.

221 demonstrated to be involved in the distinct pharmacology of the alpha4-alpha4 versus alpha4-beta2 bi

222 For example, the predicted systems pharmacology of the cholesterol-lowering agent ezetimibe

223 aminergic cells, which explains the peculiar pharmacology of the DA reuptake activity previously note

224 pharmacological tools to probe the molecular pharmacology of the delta receptor and to explore the th

225 purpose of this article is to (1) review the pharmacology of the DOACs, (2) describe the advantages o

226 tions between Y1 and Y5 receptors modify the pharmacology of the heterodimer, with implications for p

227 extensive characterization of the molecular pharmacology of the most widely used CB2R ligands to dat

228 Finally, the pharmacology of the NMDAR requirement is consistent with

229 Here, we investigate the pharmacology of the orthosteric binding site in GluD2 by

230 In this study, we further define the pharmacology of the previously reported NLRP3 inflammaso

231 In this study, we characterized the pharmacology of the recently identified hydroxysuccinic

232 orted assay system faithfully replicates the pharmacology of the receptor in response to known agonis

233 responsible for generating the low-affinity pharmacology of the secondary beta1-adrenoceptor conform

234 In recent times it has become clear that the pharmacology of these receptors is far more complex than

235 Further understanding of the complex pharmacology of these receptors will be critical to unlo

236 gress has been achieved in understanding the pharmacology of this fourth opioid receptor/peptide syst

237 e also review insights into the function and pharmacology of voltage-gated ion channels that have eme

238 Using a combination of pharmacology, optogenetics, and linear regression method

239 in ortholog HSP-16.48 Using a combination of pharmacology, optogenetics, and phenotypic analyses we d

240 Here, we use pharmacology, optogenetics, genetics, and electrophysiol

241 frequently published in the subject areas of pharmacology, pharmacy, oncology, and medicinal chemistr

242 tes, we use an integrated structural systems pharmacology pipeline which combines proteome-scale liga

243 RELN levels using transgenesis or prefrontal pharmacology prevents the pHFD-induced prefrontal cognit

244 ble applications in bioscience, medicine and pharmacology previously not possible.

245 n to be clinically safe and has a well-known pharmacology profile.

246 The IUPHAR/BPS Guide to PHARMACOLOGY provides expert-curated molecular interacti

247 mental results of suramin using quantitative pharmacology (QP) modeling indicated the major cause of

248 Quantitative Systems Pharmacology (QSP) is a drug discovery approach that int

249 the body's own cell therapy, particularly by pharmacology rather than genetics, is likely to become a

250 The current state of pharmacology research for CUD highlights the need to con

251 olled, phase 1 study at the PAREXEL Clinical Pharmacology Research Unit (Harrow, Middlesex, UK), we s

252 ng countries are inadequately represented in pharmacology research, and postmarketing pharmacovigilan

253 research settings for cancer prevention and pharmacology research.

254 Validation experiments using behavioral pharmacology revealed that functional Hcn channels in th

255 In vitro pharmacology revealed that the ArPPLNP2-derived neuropep

256 his discovery was validated using behavioral pharmacology, revealing that Hcn channels in the basolat

257 on, depyrogenation, and in the assessment of pharmacology, safety, and efficacy profiles accompany pr

258 e, we report evidence from a study employing pharmacology, scalp electrophysiology and computational

259 id derivatives as GPR40 agonists with unique pharmacology, selectivity, and pharmacokinetic propertie

260 This coupled with electrophysiology and pharmacology showed that HCN1 channels restrict the rate

261 addition, we describe the recent advances in pharmacology, stent designs, and clinical trials relevan

262 orexin antagonists suitable for preclinical pharmacology studies and human clinical trials.

263 Preclinical GLP toxicology and safety pharmacology studies were without major findings and 103

264 eriment 1, a double-blind placebo-controlled pharmacology study, we measured how flanking distractors

265 erning CNS exposure and undesired off-target pharmacology such as hERG interactions.

266 lanocortin signaling motif, which results in pharmacology that is first-in-class for the central mela

267 most recent basic biology, biochemistry, and pharmacology that serve as a foundation for more than 50

268 tural understanding of fundamental topics in pharmacology: the binding of ligands to G protein-couple

269 Phage pharmacology, therapeutic efficacy, and resistance were

270 peptides have severely hampered their use in pharmacology, thus prompting the design of new peptidomi

271 This work opens the way to use epigenetic pharmacology to achieve induction of epithelial antimicr

272 herapeutic potential seamlessly from systems pharmacology to cellular pharmacology, and the revealed

273 We used organ systems pharmacology to define the transcriptomes of mice that w

274 mbined optogenetics with calcium imaging and pharmacology to demonstrate that stimulation of NPVF cel

275 s complicates the translation of preclinical pharmacology to humans.

276 ogy, and in vivo optogenetics with localized pharmacology to identify neural substrates downstream of

277 y support it with data ranging from receptor pharmacology to measures of cognitive function.

278 ng, closed-loop optogenetic stimulation, and pharmacology to show that reduced glutamatergic transmis

279 We used a combination of genetics and pharmacology to simultaneously block output from multipl

280 ERD) with equivalent potency and preclinical pharmacology to the intramuscular SERD fulvestrant is de

281 ing new momentum for developing mGluR1-based pharmacology to treat ataxia.

282 bination of phosphoproteomics, genetics, and pharmacology to unambiguously identify a subset of Rab G

283 he original goals for the journal, Molecular Pharmacology today remains an outstanding venue for work

284 ive, former and current editors of Molecular Pharmacology, together with the guest editors for this 5

285 This optogenetic pharmacology toolkit allows scalable interrogation of en

286 and pharmacodynamic properties, and in vivo pharmacology/toxicology in preclinical species.

287 It then discusses the pharmacology underlying the therapeutic and main adverse

288 at the Department of NEUROFARBA, Section of Pharmacology, University of Florence, Italy.

289 undamentally new receptors, capable of novel pharmacology, unprecedented subtype selectivity, and uni

290 beta2-adrenoceptor), agonist and antagonist pharmacology was explained by independent actions on the

291 To address this hypothesis, GABAA receptor pharmacology was used to locally inhibit or disinhibit t

292 Using HDB electrical stimulation and in vivo pharmacology, we find that increased OB ACh leads to dyn

293 rmore, through biochemical fractionation and pharmacology, we identified the major hUTC-secreted syna

294 e, molecular biology, electrophysiology, and pharmacology, we identify a role for NRG1-IV in learning

295 ing a combination of patch-clamp physiology, pharmacology, Western blot analyses, immunohistochemistr

296 erent aspects involved in histamine receptor pharmacology, which in turn will contribute to increased

297 nonsteroidal anti-inflammatory drug (NSAID) pharmacology with acid-sensing ion channels (ASICs), a s

298 indications by uniquely integrating systems pharmacology with gene expression analysis.

299 bined the speed and molecular specificity of pharmacology with the cell type specificity of genetic t

300 ll models may not be reliable for predicting pharmacology with this protein.