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1 n were enrolled onto this single-institution phase I study.
2 antitumor activity were demonstrated in this phase I study.
3 nd gemcitabine has been evaluated in a prior phase I study.
4 therapy enrolled in this 28-day, open-label, phase I study.
5 /IV NSCLC were enrolled to this multicenter, phase I study.
6 previously entered at least one child into a phase I study.
7 d granulocyte-colony-stimulating factor in a phase I study.
8     Twenty-four patients were treated in the phase I study.
9 refractory solid tumors were enrolled onto a phase I study.
10 bstantial clinical activity was seen in this phase I study.
11 ified the process of dose escalation in this phase I study.
12 stinal graft-versus-host disease (GVHD) in a phase I study.
13     Eighteen patients are assessable on this phase I study.
14 an cancer patients that was noted during the phase I study.
15 afe, well tolerated, and immunogenic in this phase I study.
16 center, randomized, double-blind, controlled phase I study.
17 maximum-tolerated dose derived in a previous phase I study.
18  in a patient with ACC who was enrolled in a phase I study.
19 ent glioblastoma multiforme (GBM) in a prior phase I study.
20 ouble-blinded, placebo-controlled, crossover phase I study.
21 or activity in taxane-refractory patients in phase I studies.
22 ncer treated in two ongoing, dose-escalating phase I studies.
23  ( P =.01 and.004, respectively) was seen in phase I studies.
24 UC, SUV, and Cmax were observed in tumors in phase I studies.
25 l development, with the majority still being phase I studies.
26  and inflexible study designs of traditional Phase I studies.
27 mising candidate for evaluation in pediatric phase I studies.
28 riguing clinical safety and efficacy data in phase I studies.
29 double-blind, randomised, placebo-controlled phase I studies.
30  of FAPbI3 between the alpha-phase and delta-phase is studied.
31                                         In a phase I study, 12 patients with proliferative lupus neph
32 ulticenter, double-blind, placebo-controlled phase I study, 13 subjects were randomized to single-dos
33                                 Based on the phase I study, 525 mg/day is the recommended dose for or
34                                      In this phase I study, 90 patients with unresectable stage III o
35                               We conducted a phase I study administering BMS-247550 as a 1-hour intra
36                                         This phase I study aimed to describe the toxicity and to dete
37 citabine has shown some promising results in phase I studies and is being investigated in phase II tr
38   PH-797804 has met safety criteria in human phase I studies and is under clinical development for se
39  factors associated with multi-institutional phase I studies and OBD determination.
40 clinical toxicology, human pharmacokinetics, phase I studies, and activity against gastric carcinoma
41 lete and partial responses were seen in this phase I study, and clinical response appears related to
42                          This first-in-human phase I study assessed safety, tolerability, pharmacokin
43                                         This phase I study assessed the safety, clinical feasibility,
44                                         This phase I study assessed the safety, optimally tolerated r
45                                            A phase I study assessed the safety, tolerability, pharmac
46                               We performed a phase I study assessing the safety and clinical effects
47                                         This phase I study attempted to report the initial safety and
48 e or a lot of pressure to participate in the phase I study because their cancer was growing, whereas
49                                           In phase I studies, brentuximab vedotin demonstrated signif
50   Patients are aware of many alternatives to phase I studies, but do not seriously consider them.
51                                      In this phase I study, capecitabine was administered twice daily
52 he Children's Cancer Group (CCG) undertook a phase I study (CCG-0922) to determine a tolerable dose o
53                                         In a phase I study, compound 1 eyedrops were well tolerated a
54                     This review of completed phase I studies confirms the safety and generalizability
55                             Conclusion: This phase I study defined the following two MTDs for clofara
56                                         This phase I study defined the MTD and recommended phase II d
57                                     Previous phase I studies demonstrated that a branched peptide con
58                                         This Phase I study demonstrated the feasibility, safety, and
59                                         This Phase I study demonstrated the feasibility, safety, and
60                                         This Phase I study demonstrated the feasibility, safety, and
61                                         This phase I study demonstrates that photoangioplasty with mo
62                                          The Phase I study described here represents the first gene t
63                                   The unique phase I study design allowed early identification of imp
64 sed therapy, three of whom were treated in a phase I study designed to establish the maximum tolerate
65                   Patients were treated in a phase I study designed to establish the maximum-tolerate
66                                         This phase I study determined the maximum-tolerated dose (MTD
67                          Multi-institutional phase I studies do not decrease the time to study comple
68 made one of three decisions (enrollment on a phase I study, do not resuscitate status, or terminal ca
69                                         This phase I study evaluated elotuzumab, lenalidomide, and de
70                                         This phase I study evaluated the maximum-tolerated dose (MTD)
71                                         This phase I study examined whether a heat shock protein (Hsp
72                                   This was a phase I study examining a once-weekly dosing schedule of
73                                           In phase I studies FAHF-2 was found to be safe and well tol
74                          In pre-clinical and phase I studies, flurpiridaz F 18 has shown characterist
75                          We have completed a phase I study, followed by three phase I/II studies, in
76          For the RRMS studies, an open-label phase I study found that rituximab reduced the annualize
77                                      In this phase I study, FP-21399 was administered intravenously o
78                                              Phase I studies have explored the safety and pharmacokin
79                                              Phase I studies have shown the dose-limiting toxicity to
80                                    Completed phase I studies have shown these combinations to be both
81                                      In this phase I study, HRG was administered intravenously as a s
82                                          Two Phase I studies in healthy human subjects evaluated safe
83 alysis of outcomes from select, single-agent phase I studies in patients with HGG.
84 linositol 3-kinase-delta, was evaluated in a phase I study in 64 patients with relapsed indolent non-
85                               We conducted a phase I study in chemotherapy-naive patients with advanc
86                             We constructed a phase I study in patients with locally advanced cervix c
87 controlled, sequential, rising multiple-dose phase I study in patients with moderate-to-severe psoria
88                  Our institution conducted a phase I study in relapsed chronic lymphocytic leukemia.
89 m an open-label, dose-finding, seven-cohort, phase I study in which patients with symptomatic, multic
90 lticenter, double-blind, placebo-controlled, phase I study included adults who had been maintained on
91 tion of BAY 1187982 in cancer patients and a phase I study (NCT02368951) has been initiated.
92                                      In this phase I study, no significant toxicity was observed.
93                                           In phase I (studies of myocardial stunning), conscious rabb
94                                           In phase I (studies of myocardial stunning), rabbits were s
95 ly by an overall reduction in recruitment to phase I studies of 20%, more than half of whom would in
96                                              Phase I studies of antidepressants should incorporate ne
97 A criteria have routinely been enrolled onto phase I studies of antineoplastics without clinically me
98 dynamic biomarkers in cancer patients in two phase I studies of MLN8054, a small-molecule inhibitor o
99        Physicians involved in the conduct of phase I studies of novel anticancer agents have raised c
100                   Both preclinical and human phase I studies of recombinant human endostatin (rhEndos
101 sistent with previously reported values from phase I studies of the drug given as a 24-hour IV infusi
102                                              Phase I studies of volunteers not infected with human im
103 aneously) on mast cells and melanocytes in a phase I study of 10 patients with advanced breast carcin
104                               We conducted a phase I study of 38 patients with solid tumors who faile
105 d radiation dose estimates of this tracer, a Phase I study of 62Cu-PTSM was performed using whole-bod
106                               We conducted a phase I study of a 30-minute hepatic artery infusion of
107                               We conducted a phase I study of a 7-day oral administration of PSC 833
108                               We performed a phase I study of a day (D) 1 and D4 bortezomib administr
109                                            A phase I study of a pharmacokinetically derived schedule
110 ising results have been reported in an adult phase I study of ABT-510, a peptide derivative of the na
111                                         In a phase I study of cabozantinib, five of eight patients wi
112  Early observations of clinical benefit in a phase I study of cabozantinib, which included patients w
113 siency for this upregulation, we performed a phase I study of capecitabine in combination with weekly
114                       PATIENTS AND METHODS A phase I study of dasatinib in pediatric patients with re
115 mporary chemotherapy regimen, we conducted a phase I study of docetaxel and samarium-153 ((153)Sm) le
116 patients with advanced melanoma treated in a phase I study of dose escalation of vemurafenib (PLX06-0
117                               We conducted a phase I study of flavopiridol, fludarabine, and rituxima
118 minary antitumor efficacy were assessed in a phase I study of MK-0752.
119                                 We present a phase I study of N901-bR in relapsed SCLC.
120                                            A phase I study of navitoclax, a novel inhibitor of Bcl-2
121          Patients and Methods We performed a phase I study of oral Z-endoxifen to determine its toxic
122                                            A phase I study of patients with metastatic malignant mela
123                                            A phase I study of PEG-IFN with pharmacokinetic and pharma
124                                      In this phase I study of relapsed/refractory NHL, continuous inf
125                               We conducted a phase I study of single-agent AZD1775 in adult patients
126                                            A phase I study of SIR-Spheres therapy with modified FOLFO
127 ies that required RT were enrolled onto this phase I study of standard chest radiation (30 daily 2-Gy
128                                         This phase I study of the Innovative Therapies for Children w
129            These findings led to the present phase I study of the intravenous infusion of VNP20009 to
130                             In March 2006, a phase I study of the superagonistic anti-CD28 antibody T
131 y subcutaneous (SC) injections of rhSCF in a phase I study of this cytokine.
132 edly with prolonged exposure, we performed a phase I study of weekly XR5000 by 120-hour continuous in
133                        We conducted initial (Phase I) studies of acute safety and efficacy of aerosol
134 or currently under investigation in multiple phase I studies on various malignancies, and its clincal
135 ated clinically relevant improvement in this phase I study on this small group of patients with activ
136 py Evaluation Program-sponsored single-agent phase I studies over three decades (1979 to 2010).
137                            This open-labeled phase I study provides the first demonstration of the im
138                                            A phase I study recently reported that seviteronel, a CYP1
139  1.46 L x min(-1) x m(-2) in pre-phase I and phase I studies, respectively) with the production of se
140                                              Phase I study results for ABT-510, which inhibits angiog
141        Eleven patients were entered onto the phase I study: seven with AML, three with acute lymphobl
142                                              Phase I study showed that intraventricular rituximab plu
143                                  KEY POINTS: Phase I study showed that intraventricular rituximab plu
144                              Preclinical and phase I studies showing efficacy of antiinsulin-like gro
145                                         This phase I study sought to determine the safety and antitum
146                                         This phase I study sought to determine the safety and tolerab
147 bial activity, and clinical response in this Phase I study suggest that this tetracycline-containing
148                    Patients and Methods This phase I study tested durvalumab doublets in parallel 3 +
149                    Patients and Methods This phase I study tested the combination of M6620 and topote
150                               We conducted a phase I study that examined the biodistribution of (131)
151                      Based on results from a phase I study that showed T-DM1 was well tolerated at th
152   A total of 47 patients were treated in the phase I study that used a classical 3 + 3 design.
153                                       In the phase I study, the dose-limiting toxicities were hand-fo
154                                       In our phase I study, the intravenous formulation of irinotecan
155                                      In this Phase I study, the maximally tolerated doses (MTDs) of i
156                                         In a phase I study, the maximum tolerated dose of AZD1775 in
157                                      In this phase I study, the maximum-tolerated dose (MTD) and safe
158 cademia often partner for the performance of phase I studies, their administrative processes are gene
159                               We performed a phase I study to determine the appropriate dose of PN401
160  conducted a first-in-man (to our knowledge) phase I study to determine the dose-limiting toxicities
161                                              Phase I study to determine the maximum tolerated dose (M
162                               We conducted a phase I study to determine the maximum-tolerated dose (M
163                                   This was a phase I study to determine the maximum-tolerated dose (M
164                               We conducted a phase I study to determine the maximum-tolerated dose an
165                               We conducted a phase I study to evaluate the safety and immunologic act
166                               We conducted a phase I study to investigate the feasibility and safety
167 armacokinetic data derived from our clinical phase I study to set parameter values.
168                                         This phase I study used radiolabeled huA33 in combination wit
169                                            A phase I study using anti-BlyS in SLE demonstrated a sele
170                                            A phase I study using the nonimmunosuppressive MDR1 blocke
171              The most common toxicity in the phase I study was anemia, seen in 66% of patients.
172                                            A phase I study was conducted to determine the maximum-tol
173                                         This phase I study was conducted to determine the recommended
174                                         This phase I study was conducted to determine the toxicities,
175                                            A phase I study was conducted to determine the toxicity, p
176                                         This phase I study was designed to define the maximum-tolerat
177                                         This phase I study was designed to evaluate the safety, pharm
178                                         This phase I study was designed to evaluate the safety, toler
179                                  The present phase I study was devised to determine the toxicity, pha
180                                          The phase I study was extended to a limited phase II study t
181                                         This phase I study was initiated to determine the toxicity an
182                                            A phase I study was performed to determine the maximum-tol
183                                         This phase I study was performed to evaluate the safety and p
184                                            A phase I study was performed to evaluate the safety, in v
185                     The primary goal of this Phase I study was to assess the safety and bioactivity o
186                             The goal of this phase I study was to determine the maximum tolerated dos
187                              The aim of this phase I study was to determine the safety and toxicity p
188                        Our objective in this phase I study was to determine the tolerability of pacli
189                       The aim of the present phase I study was to evaluate the biodistribution and do
190                          The purpose of this phase I study was to evaluate the safety and immunogenic
191                                         This phase I study was undertaken to define the toxicity, pha
192      In addition to the diarrhea observed in phase I studies, we also observed a higher incidence of
193 afenib was observed in sarcoma patients in a phase I study, we performed a multicenter phase II study
194                                          Two phase I studies were conducted of ABR-217620 alone or in
195 Serum levels of flavopiridol obtained during phase I studies were sufficient to inhibit in vitro canc
196                            The goals of this phase I study were to determine the maximum-tolerated do
197                       The objectives of this phase I study were to evaluate radiation dosimetry, biod
198 inal illnesses who enroll as participants in phase I studies, which assess the toxicity and dosing of
199 teria may be good candidates for solid tumor phase I studies with single-agent molecular or cytotoxic
200 ates for chemotherapy, were included in this phase I study with a 3 + 3 dose escalation design.
201  carcinoma (RCC) treated with nivolumab in a phase I study with expansion cohorts.
202 ificantly decrease the duration of pediatric phase I studies without increasing the risk of toxicity.

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