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   1 n were enrolled onto this single-institution phase I study.                                          
     2 antitumor activity were demonstrated in this phase I study.                                          
     3 nd gemcitabine has been evaluated in a prior phase I study.                                          
     4 therapy enrolled in this 28-day, open-label, phase I study.                                          
     5 /IV NSCLC were enrolled to this multicenter, phase I study.                                          
     6 previously entered at least one child into a phase I study.                                          
     7 d granulocyte-colony-stimulating factor in a phase I study.                                          
     8     Twenty-four patients were treated in the phase I study.                                          
     9 refractory solid tumors were enrolled onto a phase I study.                                          
    10 bstantial clinical activity was seen in this phase I study.                                          
    11 ified the process of dose escalation in this phase I study.                                          
    12 stinal graft-versus-host disease (GVHD) in a phase I study.                                          
    13     Eighteen patients are assessable on this phase I study.                                          
    14 an cancer patients that was noted during the phase I study.                                          
    15 afe, well tolerated, and immunogenic in this phase I study.                                          
    16 center, randomized, double-blind, controlled phase I study.                                          
    17 maximum-tolerated dose derived in a previous phase I study.                                          
    18  in a patient with ACC who was enrolled in a phase I study.                                          
    19 ent glioblastoma multiforme (GBM) in a prior phase I study.                                          
    20 ouble-blinded, placebo-controlled, crossover phase I study.                                          
    21 or activity in taxane-refractory patients in phase I studies.                                        
    22 ncer treated in two ongoing, dose-escalating phase I studies.                                        
    23  ( P =.01 and.004, respectively) was seen in phase I studies.                                        
    24 UC, SUV, and Cmax were observed in tumors in phase I studies.                                        
    25 l development, with the majority still being phase I studies.                                        
    26  and inflexible study designs of traditional Phase I studies.                                        
    27 mising candidate for evaluation in pediatric phase I studies.                                        
    28 riguing clinical safety and efficacy data in phase I studies.                                        
    29 double-blind, randomised, placebo-controlled phase I studies.                                        
    30  of FAPbI3 between the alpha-phase and delta-phase is studied.                                       
  
    32 ulticenter, double-blind, placebo-controlled phase I study, 13 subjects were randomized to single-dos
  
  
  
  
    37 citabine has shown some promising results in phase I studies and is being investigated in phase II tr
    38   PH-797804 has met safety criteria in human phase I studies and is under clinical development for se
  
    40 clinical toxicology, human pharmacokinetics, phase I studies, and activity against gastric carcinoma 
    41 lete and partial responses were seen in this phase I study, and clinical response appears related to 
  
  
  
  
  
  
    48 e or a lot of pressure to participate in the phase I study because their cancer was growing, whereas 
  
  
  
    52 he Children's Cancer Group (CCG) undertook a phase I study (CCG-0922) to determine a tolerable dose o
  
  
  
  
  
  
  
  
  
  
  
    64 sed therapy, three of whom were treated in a phase I study designed to establish the maximum tolerate
  
  
  
    68 made one of three decisions (enrollment on a phase I study, do not resuscitate status, or terminal ca
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
    84 linositol 3-kinase-delta, was evaluated in a phase I study in 64 patients with relapsed indolent non-
  
  
    87 controlled, sequential, rising multiple-dose phase I study in patients with moderate-to-severe psoria
  
    89 m an open-label, dose-finding, seven-cohort, phase I study in which patients with symptomatic, multic
    90 lticenter, double-blind, placebo-controlled, phase I study included adults who had been maintained on
  
  
  
  
    95 ly by an overall reduction in recruitment to phase I studies of 20%, more than half of whom would in 
  
    97 A criteria have routinely been enrolled onto phase I studies of antineoplastics without clinically me
    98 dynamic biomarkers in cancer patients in two phase I studies of MLN8054, a small-molecule inhibitor o
  
  
   101 sistent with previously reported values from phase I studies of the drug given as a 24-hour IV infusi
  
   103 aneously) on mast cells and melanocytes in a phase I study of 10 patients with advanced breast carcin
  
   105 d radiation dose estimates of this tracer, a Phase I study of 62Cu-PTSM was performed using whole-bod
  
  
  
  
   110 ising results have been reported in an adult phase I study of ABT-510, a peptide derivative of the na
  
   112  Early observations of clinical benefit in a phase I study of cabozantinib, which included patients w
   113 siency for this upregulation, we performed a phase I study of capecitabine in combination with weekly
  
   115 mporary chemotherapy regimen, we conducted a phase I study of docetaxel and samarium-153 ((153)Sm) le
   116 patients with advanced melanoma treated in a phase I study of dose escalation of vemurafenib (PLX06-0
  
  
  
  
  
  
  
  
  
  
   127 ies that required RT were enrolled onto this phase I study of standard chest radiation (30 daily 2-Gy
  
  
  
  
   132 edly with prolonged exposure, we performed a phase I study of weekly XR5000 by 120-hour continuous in
  
   134 or currently under investigation in multiple phase I studies on various malignancies, and its clincal
   135 ated clinically relevant improvement in this phase I study on this small group of patients with activ
  
  
  
   139  1.46 L x min(-1) x m(-2) in pre-phase I and phase I studies, respectively) with the production of se
  
  
  
  
  
  
  
   147 bial activity, and clinical response in this Phase I study suggest that this tetracycline-containing 
  
  
  
  
  
  
  
  
  
  
   158 cademia often partner for the performance of phase I studies, their administrative processes are gene
  
   160  conducted a first-in-man (to our knowledge) phase I study to determine the dose-limiting toxicities 
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   193 afenib was observed in sarcoma patients in a phase I study, we performed a multicenter phase II study
  
   195 Serum levels of flavopiridol obtained during phase I studies were sufficient to inhibit in vitro canc
  
  
   198 inal illnesses who enroll as participants in phase I studies, which assess the toxicity and dosing of
   199 teria may be good candidates for solid tumor phase I studies with single-agent molecular or cytotoxic
  
  
   202 ificantly decrease the duration of pediatric phase I studies without increasing the risk of toxicity.
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