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1 directly measured positions of alaninol and phenethylamine.
2 e slowly and bound 75-fold more tightly than phenethylamine.
3 lass of 5-HT(2A) receptor agonists, N-benzyl phenethylamines.
4 iety affords pharmaceutically important beta-phenethylamines.
5 rimethamine with substituted benzylamines or phenethylamines.
6 y restricted analogues of the hallucinogenic phenethylamine 1 (2,5-dimethoxy-4-bromophenethylamine, 2
7 , and a series of substituted tryptamine and phenethylamine 5-HT(2A) receptor agonists, we found that
8 g affinities of a series of para-substituted phenethylamine analogues to MAO A show an increase in af
9 nd isotopic characterization of alaninol and phenethylamine, analogues of alanine and phenylalanine,
10 ding site for the aryl ring is identical for phenethylamine and for benzylamine analogues and that st
12 nd further allows the simulation analysis of phenethylamine and tyramine, which are major monoamine c
14 a-selective C-H arylation of nosyl-protected phenethylamines and benzylamines is disclosed using a co
17 strated on amides derived from benzylamines, phenethylamines and phenylpropylamines; amine-containing
19 benzyl analogs, whereas most N-unsubstituted phenethylamines and traditional agonists were only weakl
20 zamide, homologation of the benzylamine to a phenethylamine, and incorporation of a methyl group at t
21 ic study of the nitrosation of ethylbenzene, phenethylamine, and tyramine was carried out, using UV-v
22 mides prepared from readily available chiral phenethylamines, and allows easy variation of the stereo
23 ctional assays confirmed that these N-benzyl phenethylamines are potent and highly efficacious agonis
25 P450 2D6 discriminated between the various phenethylamines, as evidenced by binding and steady-stat
28 hrine, and epinephrine, as well as for other phenethylamines, but not for imidazolines, a class of st
29 phenylalanine were converted to tyramine and phenethylamine by tyrosine and phenylalanine decarboxyla
30 implies, therefore, that the hallucinogenic phenethylamines cannot be directly superimposed on LSD i
33 eral approach for (13)C(2)- and (2)H-labeled phenethylamine derivatives has been developed, based on
34 ence, we prepared nearly two dozen different phenethylamine derivatives, attached them to the C termi
38 tes, such as tyrosine, tryptamine, tyramine, phenethylamine, dopamine, 3-methoxytyramine, serotonin,
40 e a higher potency and intrinsic activity of phenethylamines for polyphosphoinositide turnover but no
44 phetamine (DOM; 0.6 mg/kg, i.p.), which is a phenethylamine hallucinogen, increased glutamate to 206%
46 nt with the proposed mechanism of action for phenethylamine hallucinogens, that such compounds must b
47 terium exchange (HDX) in aqueous droplets of phenethylamine has been determined with submillisecond t
49 it enhanced inhibitory activity (relative to phenethylamine), including para-substituted sulfonamide
50 We selected naphthylpropane-2-amines of the phenethylamine library (PAL) including the partial subst
51 ses concerning the bioactive conformation of phenethylamine ligands upon binding to the 5-HT(2A) rece
52 reproducibility of delta15N of tyramine and phenethylamine measured by GCC-IRMS averaged SD(delta15N
53 sitized, and internalized on exposure to the phenethylamines norepinephrine (NE), epinephrine, or phe
55 e-3-acetic acid (5-HIAA), tryptophane, and 2-phenethylamine (PEA) in rat brain using liquid chromatog
56 urthermore, Mg2(olz) was used to encapsulate phenethylamine (PEA), a model drug for a broad class of
57 ynthetic cannabinoids, synthetic cathinones, phenethylamines, piperazines, ketamine and phencyclidine
58 interacting with Phe339((6.51)), whereas the phenethylamine portion was likely to be interacting with
59 of medetomidine conformations with those of phenethylamines provided a tentative explanation for the
62 monoamine oxidase A (MAO A) with a series of phenethylamine substrate analogues has been investigated
65 effects similar to DisA overexpression, and phenethylamine, the product of phenylalanine decarboxyla
68 this class of ligand binds differently than phenethylamine-type agonists and may be more antagonist-
69 hylurapidil, with no changes in affinity for phenethylamine-type agonists such as epinephrine, methox
71 of sophorolipid ethyl ester in dry THF with phenethylamine, tyramine, p-methoxyphenethylamine, 2-(p-
72 analogues, such as ascorbic acid, catechol, phenethylamine, tyrosine, epinephrine, and norepinephrin
73 ffects for para-substituted benzylamines and phenethylamines, unlike native AADH for which a poor cor
75 is method delivers valuable beta-substituted phenethylamines via a challenging reductive elimination
76 incorporation of two carbon-13 isotopes into phenethylamines was accomplished using a palladium-catal
79 In contrast to the 2,5-dimethoxy-substituted phenethylamines, where rigidification of the methoxy gro
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