ライフサイエンスコーパス: phenocopy

1 ause a phenotype resembling HCM (genocopy or phenocopy).

2 ated by pharmacological rescue and molecular phenocopy.

3 r DSB repair pathway genes produce molecular phenocopies.

4 racellular concentrations of this amino acid phenocopied a TbAAT2-4 genetic defect.

5 r is locked in the most active output state, phenocopies a DeltarpaA strain.

6 Moreover, a loss of DLX3 phenocopies a loss of KDM4B.

7 One way to design a drug is to attempt to phenocopy a genetic variant that is known to have the de

8 Here we report that SMS mutations phenocopy a mutation that allows ATP binding but prevent

9 sites in human embryonic stem cells, thereby phenocopying a more primitive cellular state.

10 Huntington disease phenocopies accounted for 12.4%, and their mean (SD) age

11 and induction of inflammation in young mice phenocopied aging-associated B lymphopoiesis.

12 Hif2a knockdown phenocopied all effects of ITPP, including the mitotic d

13 f the secreted neurotrophin Spatzle 3 (Spz3) phenocopied alphaSNAP phenotypes, which included loss of

14 iation, enhanced mesenchymal transition, and phenocopying alterations that occur with high D-2HG leve

15 ce of dAmph and impaired T-tubule formation, phenocopying amph-null mutants.

16 n functional experiments, LDH overexpression phenocopied AMPKalpha1(-/-) phenotype, that is shifted M

17 The diagnostic rate of HD phenocopies and frequency of other etiologies using deep

18 rent clusters, high-risk BRCA1 mutations and phenocopies and low-risk, fully sequenced controls and v

19 It contained genes responsible for HD phenocopies and other neurodegenerative conditions, as w

20 ns to discriminate FTD more effectively from phenocopies and to identify factors that determine progr

21 l was to improve the genetic diagnosis of HD phenocopies and to identify new HD related genes.

22 Zac1 loss- and gain-of-function presented as phenocopies, and overexpression of Pac1 rescued the Zac1

23 onverts dextral snail embryos to a sinistral phenocopy, and in frogs, drug inhibition or overexpressi

24 110alpha, beta, and delta, yet APDS2 largely phenocopies APDS1 without dramatic effects outside the i

25 In conclusion, the etiologies of HD phenocopies are heterogeneous, and clinical evolution sh

26 5%) from the PSEN1 A79V family are potential phenocopies as they also developed AD dementia (median a

27 test human craniocardiac candidate genes for phenocopy as a critical first step towards understanding

28 isease and severe ocular surface damage that phenocopied aspects of human pseudohypoaldosteronism-1 M

29 asing SA promoted growth in some hybrids and phenocopied aspects of hybrid vigor in parental lines.

30 This phenocopies aspects of Lamp1/2 knockdowns and Dppa3 (KO)

31 involving ABL1, ABL2, CSF1R, and PDGFRB that phenocopy BCR-ABL1 and alterations of CRLF2, JAK2, and E

32 helial- and lymphatic-specific Hk2 knockouts phenocopy blood and/or lymphatic vascular defects seen i

33 pproximately 363, miR-106b approximately 25) phenocopied both increased TGF-betaRII expression and si

34 orresponding rise in Nanog mRNA and protein, phenocopying BRG1 knockdown embryos and ESCs.

35 suppression of individual or multiple Hdacs phenocopied broad-acting HDACis in 3 genetically distinc

36 uced phagocytosis capability and this can be phenocopied by adding monomeric alphaS to the cell cultu

37 Effects of PTEN deficiency were phenocopied by beta-Arrestin1 KD or inhibition of beta-A

38 me fusion in these cells, and this defect is phenocopied by depletion of the Ca(2+) pump SERCA, a sec

39 This effect is phenocopied by downregulation of either ZEB1 or the ZEB1

40 The proapoptotic effects of S1PR2 are phenocopied by ectopic expression of the small G protein

41 The suppression of mRNA encoding BiP was phenocopied by ectopic overexpression of BiP protein, an

42 tially redundant Cdk1 inhibitory kinase) and phenocopied by expression of a Cdk1F mutant defective fo

43 This effect was phenocopied by genetically inhibiting copper import in t

44 nic defects caused by pericyte depletion are phenocopied by intraocular injection of VEGF-A or pericy

45 ucers were rescued by inhibition of ROCK and phenocopied by JAM-A, JACOP, or p114RhoGEF down-regulati

46 y low appetite and extreme leanness; this is phenocopied by mice carrying similar mutations and can b

47 induced neuronal differentiation, an effect phenocopied by miR-143-3p overexpression.

48 Moreover, uhrf1 mutants are phenocopied by mutation of dnmt1, and Dnmt1 knockdown in

49 ease or Glu receptor expression and could be phenocopied by mutations that disrupt the function of pl

50 n single-SF mechanics may be correspondingly phenocopied by overexpression of mono- and diphosphomime

51 These features were phenocopied by pharmacological blockage of Arf6 activati

52 This was phenocopied by raising intracellular adenosine levels wi

53 ges, which depend on RhoA activation and are phenocopied by Rap1 inhibition, permit subsequent entosi

54 Surprisingly, this is not phenocopied by rapid rapamycin-dependent relocalization

55 anoma cell invasion, an effect that could be phenocopied by RNAi-mediated silencing of MCL1.

56 These behavioral phenotypes could be phenocopied by selective inactivation of synaptic transm

57 These effects were phenocopied by the Aurora A phosphomimetic mutation, S71

58 ro-Myc lymphoma in vitro and in vivo and was phenocopied by the HDAC1/2-specific agent RGFP233.

59 Furthermore, rover foraging scores can be phenocopied by transgenically reducing pr4 expression in

60 Finally, effects of PTK6 downregulation were phenocopied by treatment with a recently developed PTK6

61 l and molecular synaptogenic defects are all phenocopied by Wg overexpression, suggesting that Notum

62 cued by loss of one copy of Yap and Taz, and phenocopied by YAP overexpression.

63 ysiology of T. gondii tachyzoites appears to phenocopy cancer cells, which holds promise for developi

64 ces endocannabinoid levels in the offspring, phenocopies CB1R(-/-) islet microstructure and improves

65 irst, although CCBE1DeltaCollagen mice fully phenocopy CCBE1 knock-out mice, CCBE1DeltaEGF knock-in e

66 integrin alpha6beta1-binding defective CCN1 phenocopied Ccn1(DeltaHep) mice, indicating that CCN1 ac

67 prompts a collapse of global elongation that phenocopies CDK9 inhibition.

68 mpaired Pseudomonas aeruginosa phagocytosis, phenocopying CF MPhis.

69 KLF6 overexpression partially phenocopied chaetocin treatment in DDLPS cells and induc

70 ordingly, the promoter activity, which could phenocopy changes in Habp2 mRNA in response to TGF-beta,

71 utgrowth, whereas suppression of other exons phenocopied collagen deposition mutants.

72 of Lkb1 protein, and rapid tumor growth that phenocopied Cre-mediated genetic deletion of Lkb1.

73 Phenocopying Ctbp2 deletion, both Ctbp inhibitors caused

74 is sufficient to impair locomotor activity, phenocopying DA depletion models of Parkinson's disease,

75 Opitz syndrome, a human genetic disease that phenocopies deficient Hedgehog signaling and is caused b

76 ed DENND1B variants express less DENND1B and phenocopy Dennd1b(-/-) TH2 cells.

77 the actin cortex, as actin depolymerization phenocopies dynein depletion, and direct recruitment of

78 DeltakhpA and DeltakhpB mutants phenocopy each other exactly, consistent with a direct i

79 Depletion of MEF2B, EBF1, or IL6R partially phenocopies EBNA1 depletion by decreasing the cell growt

80 re, c-Myc knockdown in prostate cancer cells phenocopied effects of JMJD1A knockdown, and c-Myc re-ex

81 RNA-mediated knockdown of Card10 expression phenocopied effects of miR-181b on NF-kappaB signaling a

82 Selective loss of SHP1 in CD11c(+) cells phenocopies enhanced adaptive immunity to Leishmania.

83 rtion, and transgenic overexpression of GDF6 phenocopies evolutionary changes in armor-plate size.

84 Two separate exoc5 mutant zebrafish lines phenocopied exoc5 morphants and, strikingly, exhibited a

85 f SpGAI expression in females to male levels phenocopied exogenous GA application with respect to flo

86 ry incisors in K5-Ikkbeta mice were found to phenocopy extra incisors in mice with mutations of Wnt i

87 neuronal death and axonal rarefaction, which phenocopy fetal brain abnormalities in humans.

88 An interaction-defective mutant, dbf4DeltaC, phenocopies fkh alleles in terms of origin firing.

89 We show that Syngap(+/-) mice phenocopy Fmr1(-/y) mice in the alterations in mGluR-dep

90 mission block show that elevated PN activity phenocopies FMRP-null defects, whereas PN silencing caus

91 ummary, AgRP neuron-specific Gpr17 knockouts phenocopy FOXO1 knockouts in the same cell type, thus su

92 o FVA assays distinguish BRCA1 mutations and phenocopies from benign variants and categorize most VUS

93 s, but it is unknown whether these mutations phenocopy gain-of-function mutations in the CTNNB1 gene

94 ated macrophages from CSL/RBP-Jkappa KO mice phenocopied gamma-secretase inhibitor treatment for redu

95 ly reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh rece

96 CTTN silencing in human MKs phenocopies HDAC6 inactivation and knockdown leads to a

97 O1 as truncation of the HMO1 C-terminal tail phenocopies hmo1 deletion.

98 of JH4 to LmnaG609G/G609G-mutant mice, which phenocopy human HGPS, resulted in a marked improvement o

99 ntaneous mutations in the murine Eda (Tabby) phenocopy human X-linked hypohidrotic ectodermal dysplas

100 -treated RDEB mice developed invasive tumors phenocopying human RDEB-cSCC, whereas wild-type mice for

101 urine more often than did wild-type organs, phenocopying human UFS.

102 f WT recipients of Id cDKO bone marrow cells phenocopied Id cDKO cardiac fibrosis 4 months post-trans

103 ed clinical and genetic exploration of 28 HD phenocopies identified the underlying cause in 35.7% (10

104 These mice phenocopied Ifnlr1-null animals, exhibiting increased in

105 ically spliced intron of Sxl, as its absence phenocopies Ime4 mutants.

106 The Neb cKO phenocopies important aspects of NEM (muscle weakness, o

107 ifferentiation observed in col mutant is not phenocopied in Antp mutant.

108 These findings were phenocopied in healthy human ECs after SHIP2 silencing.

109 cement at the virus entry step, a phenomenon phenocopied in HIV-1 infections of IFN-alpha-treated pri

110 The effects of antibiotics were phenocopied in Stat1-deficient mice, with no additional

111 ing of embryonic and adult zebrafish that is phenocopied in zebrafish deficient in Ltk.

112 e-limiting enzyme in polyamine biosynthesis, phenocopies inhibition or knockdown of the enzyme deoxyh

113 MYH9-RD mutants phenocopy inhibition, revealing a dominant negative effe

114 ived cells rescued all placental defects but phenocopied intraembryonic defects observed in global Gr

115 The 4 phenocopy is associated with the deregulation of Ci cont

116 RK inhibition in mice lacking epidermal RAF1 phenocopies it.

117 e further show that genetic UbcH7 deficiency phenocopies ITCH phosphorylation in regulating RIPK2 ubi

118 l knockout of both Hif-1alpha and Hif-2alpha phenocopied key aspects of these HSC phenotypes, demonst

119 We found that NANOS2 knockout pigs phenocopy knockout mice with male specific germline abla

120 Knockdown of phb-2 partially phenocopied loss of mec-2 in touch neurons of the nemato

121 required for actin disassembly, and its loss phenocopies loss of actin disassembly proteins.

122 Silencing of TEAD phenocopies loss of YAP1, implicating transcriptional tr

123 vivo, and mutations in the Cas10 Palm domain phenocopy loss of Csm6.

124 vation results in developmental defects that phenocopy loss of miRISC cofactors and enhances the loss

125 with delayed Nanog promoter methylation and phenocopying loss of Eprn or Lin28a.

126 odelling and DSB-repair via HRR; effectively phenocopying loss of TIP60.

127 repression of these three targets completely phenocopies major dysfunctions produced by miR-101 block

128 ltured in conventional serum plus LIF medium phenocopy male ES cells cultured in 2i/L.

129 that the SCN5A(E558X/+) pig model accurately phenocopies many aspects of human cardiac sodium channel

130 drug-inducible mouse model is sufficient to phenocopy many of the morphological and molecular conseq

131 rgic neurons, predominantly in the striatum, phenocopied Mecp2-null mice in dopamine deregulation and

132 ered to express only SPPL3 D271A in NK cells phenocopy mice deleted for SPPL3, indicating a requireme

133 arin-binding EGF-like growth factor (HB-EGF) phenocopied miR-132 overexpression in keratinocytes.

134 R-219 depletion and forced expression of Shh phenocopied miR-219 deficiency.

135 sirt2 RNAi also phenocopies mir-92a overexpression.

136 embryonic lethal and die around E10.5, which phenocopies Mll4 knockout mice.

137 ession of constitutively active STAT3(S727E) phenocopied muscle cells from strictured intestine.

138 an SRDX (SUPERMAN repressive domain X) motif phenocopied mutants defective in JA signaling.

139 ine degradation pathway and revealed that it phenocopied mutants in the elongator subunit ELO3, essen

140 rp5p, alter branch region specification, and phenocopy mutations in Prp5p.

141 ter and Drosophila simulans are sterile, and phenocopy mutations in the PIWI interacting RNA (piRNA)

142 -4 contribute to polarized root hair growth, phenocopying myosins, whereas MadA1-4 are redundant for

143 n of actin cytoskeleton in wild-type embryos phenocopied MZdchs1b mutant defects in cytoplasmic segre

144 ic ablation of RelA, c-Rel, and RelB did not phenocopy NEMO deficiency, but constitutively active IKK

145 o mice bearing experimental liver metastases phenocopied neutrophil depletion by reducing liver metas

146 beta prior to oHSV therapy was sufficient to phenocopy NK-cell depletion and suppress tumor growth an

147 This result phenocopies NLRC3-deficient macrophages and fibroblasts

148 The mir-279/996 defect phenocopies Notch loss of function during the sheath-neu

149 Ectopically expressed Ank4 blocks ERAD to phenocopy O. tsutsugamushi infection.

150 or cause renal diseases that may manifest as phenocopies of CAKUT.

151 iscussion to genetic syndromes that are rare phenocopies of common diagnoses such as autism spectrum

152 model for hyperdopaminergia that resembles a phenocopy of alcohol-dependent rats during protracted ab

153 Because severe G6PD deficiency can be a phenocopy of chronic granulomatous disease with regard t

154 ulation of the TAK1 complex produces a close phenocopy of FMD caused by FLNA mutations.

155 PPT1-deficient mouse (Cln1(-/-)) is a useful phenocopy of human INCL.

156 exing single guide RNAs (sgRNAs) allowed for phenocopy of known mutants across many phenotypes in emb

157 rgan integration of hormonal signalling as a phenocopy of menstrual cycle and pregnancy-like endocrin

158 stress-induced relapse to alcohol seeking, a phenocopy of postdependent rats.

159 Ablation of the PIP4Ks generates a phenocopy of the pharmacological effects of PIP4K inhibi

160 ntersect, we found that mTOR pathway mutants phenocopied okg and cnj.

161 ll mutations of TMEM219 or IL-13Ralpha2 also phenocopied one another as regards the ability of Chi3l1

162 CIZ1 or deletion of Repeat E in female cells phenocopies one another in causing Xist RNA to delocaliz

163 ith AZD6482, a selective PI3Kbeta inhibitor, phenocopies p110beta deletion in mouse platelets, which

164 Importantly, alpha-synuclein inactivation phenocopies parkin overexpression and suppresses stress-

165 We show that ubr3 mutants phenocopy pathogenic variants of Myosin II and that Ubr3

166 EBER2 knockdown phenocopies PAX5 depletion in upregulating the expressio

167 Thus, the T8I mutation phenocopies PF-46396 treatment in terms of its ability t

168 Over-expression of miR-181 phenocopied PHLDA1 knockdown and significantly impaired

169 An eNOS inhibitor phenocopied PLD2 loss and had no further effect on PLD2

170 m, because genetic ablation of IKZF1 did not phenocopy pomalidomide treatment.

171 Accordingly, kix8 kix9 mutants phenocopied PPD loss-of-function producing larger leaves

172 rmally more broadly distributed in the cell, phenocopies PSEN2 and shifts its localization to late en

173 enuates insulin-induced GLUT4 translocation, phenocopying RAB10 knockdown.

174 Hook ablation phenocopies Rad50 deficiency in all respects.

175 find that the YHB mutation is sufficient to phenocopy red light input into the circadian mechanism a

176 eficit, but Gfralpha1;Gfralpha2 double nulls phenocopy Ret nulls.

177 The 4 phenocopy reveals multiple compensation mechanisms and d

178 rom either ooDSGCs or interneurons partially phenocopies Satb1 mutants, demonstrating that Satb1-depe

179 The resulting Sil1Gt mouse phenocopies several pathologies associated with MSS, alt

180 The Alpl knockout (Alpl (-/-)) mouse phenocopies severe infantile HPP, including profound ske

181 Knockdown of Arp-1 phenocopies Shot loss universally, whereas chemical disr

182 ronia (fer) receptor kinase mutant partially phenocopied shv3svl1 and exhibited a similar Suc-conditi

183 nd craniofacial mesenchyme ( Prx1-cKO) would phenocopy skeletal and dental manifestations of late-ons

184 s limb initiation, causing limb defects that phenocopy Sonic Hedgehog (Shh) mutants.

185 2b), and loss of Cers2b in sphk2(MZ) embryos phenocopies sphingosine toxicity.

186 d Rab8 as ICMT substrates that when silenced phenocopy ste14 deficiency.

187 nt in the striatum, and Wnt5a knock-out mice phenocopy striatal anterior-posterior defects observed i

188 RNAi-mediated silencing of alpha2beta1 phenocopied SYK depletion in vitro and in vivo, suggesti

189 s gleaned from treatment development in rare phenocopy syndromes may also teach us how to test treatm

190 ific tau phosphorylation is neuroprotective, phenocopying tau ablation, thus highlighting the complex

191 ivity during the 8-cell to morula transition phenocopied TFAP2C knockdown, triggering a loss of posit

192 red cardiac progenitor cell differentiation, phenocopying that of ISL1 depletion.

193 -18R signaling in T cells, but not of IL-1R, phenocopied the absence of the MyD88 pathway, indicating

194 metic mutants were electrically inactive and phenocopied the almt4 mutants.

195 ng site in the NLRP3 3' untranslated region, phenocopied the characteristics of miR-223(-/y) mice.

196 Silencing MYC expression phenocopied the CSC depletion effects of C1572 and induc

197 TCR stimulation in the presence of monensin phenocopied the defects in Napa(hyh/hyh) signaling and T

198 ntrols ROS formation independently of CoQ10, phenocopied the effect of Coq2-RNAi.

199 Silencing these glycogenes phenocopied the effect of miR-200f, inducing mesenchymal

200 d overexpression, whereas silencing of EphA4 phenocopied the effect of miR-519d.

201 d silencing of PI3Kalpha, PI3Kbeta, and mTOR phenocopied the effect of VS-5584, exhibiting the strong

202 Disruption of E2F8's DNA binding activity phenocopied the effects of an E2f8 null allele and led t

203 MHCII deficiency phenocopied the effects of CREBBP loss in spontaneous an

204 ac1 with an Epac specific inhibitor, ESI-09, phenocopied the effects of Epac1 null by suppressing neo

205 utic administration of an anti-CCR7 antibody phenocopied the effects of genetic Ccr7 deficiency in mi

206 xpression in prostate cancer cells inversely phenocopied the effects of miR-23b/-27b overexpression o

207 Notably, SRC depletion in TNBC cell lines phenocopied the effects of miR-34a reintroduction, where

208 encing of both SERINC3 and SERINC5 precisely phenocopied the effects of Nef and glycoGag on HIV-1 inf

209 Furthermore, silencing Jab1/CSN5 phenocopied the function of miR-24 in NPC cells after io

210 collapse of the haematopoietic system, which phenocopied the highly penetrant bone marrow failure see

211 The thyroid tumors closely phenocopied the histological features of human RAS-drive

212 of Mincle protected against oncogenesis and phenocopied the immunogenic reprogramming of the tumour

213 Mouse livers from drug-induced porphyria phenocopied the in vitro findings, and mass spectrometry

214 overexpression of K38R-Rab7 in HEK293 cells phenocopied the increased secretion of exosomes observed

215 Lack of host EphA2 phenocopied the lack of the sporozoite proteins P52 and

216 sing an LBD29-SRDX transcriptional repressor phenocopied the lax3 mutant, resulting in delayed latera

217 T cell-specificPros1knockouts phenocopied the loss ofTyro3 Thus, a PROS1-mediated feed

218 CD68.hMcl-1 AMs phenocopied the microbicidal defect because transgenic m

219 The min7/ben1 mutant phenocopied the mild root developmental defects and latr

220 Germ line Notch2(COIN) inversion phenocopied the Notch2HCS mutant, validating the model.

221 on of PCM1, and knockdown of endogenous PCM1 phenocopied the observed effects of miR-128 overexpressi

222 y, antiserum raised against Chi3l1 or Sema7a phenocopied the reduction produced by genetic deletions.

223 dental mesenchymal-specific deletion of Evc2 phenocopied the tooth abnormalities in Evc2 mutants.

224 doderm displayed head defects that partially phenocopied the truncation defects of Lhx1-null mutants.

225 Plgf-/- mice treated with leukotrienes phenocopied the WT response to allergen exposure; conver

226 Once activated, this MX1 construct phenocopies the antiviral and NP binding activity of wil

227 Remarkably, this mouse phenocopies the blood-lymphatic mixing and lethality of

228 eurotransmission from retinal ganglion cells phenocopies the changes observed after monocular depriva

229 not of other channels affects viability and phenocopies the complex changes in platelets from hemost

230 ming, as their ectopic overexpression partly phenocopies the dedifferentiation phenotype of PRC2 muta

231 Moreover, depletion of PCL1 phenocopies the defects in maintaining cellular quiescen

232 ABC transporter) of Saccharomyces cerevisiae phenocopies the DeltaF508-CFTR folding and trafficking d

233 overexpression of OsMADS58, a C-class gene, phenocopies the dfo1 mutants.

234 s BubR1.Bub3 complexes in human cancer cells phenocopies the effects observed in gene targeting exper

235 e report a dibenzothiazepinone compound that phenocopies the effects of a Bdf1 BD-inactivating mutati

236 Over-expression of the Bre1 ubiquitin ligase phenocopies the effects of mutating either the invadolys

237 iated in vivo depletion of any TCP-1 subunit phenocopies the effects of mutations in mst or the Prefo

238 Increasing neuronal excitability phenocopies the effects of reducing sleep on Abeta, and

239 Overexpression of GA2ox2 in the RM phenocopies the hdt1,2i phenotype.

240 tability and aggressive prostate cancer that phenocopies the human disease at the histologic and geno

241 mutation of Erk2 in neural crest derivatives phenocopies the human Pierre Robin sequence and highligh

242 n (KI) mice expressing an Itgb3 variant that phenocopies the human Pro33 variant to elucidate the con

243 This strain phenocopies the increase in splicing toward the liCTLA4

244 ein NEURL4, and knockdown of HERC2 or NEURL4 phenocopies the inhibition of RNF8/UBC13 signaling on sy

245 her demonstrate that knockdown of keratin 18 phenocopies the loss of Krtap5-5, suggesting that Krtap5

246 ion rates; inhibition of glucose consumption phenocopies the loss of Lrp5 function.

247 f-Notch phenotypes, and misexpression of Erm phenocopies the loss of Notch.

248 Forced-expression of MICU1 in normal cells phenocopies the metabolic aberrations of malignant cells

249 Spectinomycin-treatment of wild-type plants phenocopies the molecular phenotype of plastid proteome

250 ments, resulting in erythroid dysplasia that phenocopies the red blood cell (RBC) defects seen in sam

251 vely active Akt (Akt-CA) in retinal explants phenocopies the reduction in amacrine cell production ob

252 Inhibition of miR-139-5p in vivo partially phenocopies the retinal vascular defects of APLN/APLNR d

253 of TRF2, which eliminates RTEL1 binding and phenocopies the RTEL1(R1264H) mutation, giving rise to a

254 e with terpenoid or LLO synthesis inhibitors phenocopies the stressed UPR seen intrappc11mutants and

255 omain-containing protein that binds H4K12ac, phenocopies the Tip60 depletion with respect to heteroch

256 Furthermore, our molecules phenocopy the ability of genetic ATF6 activation to sele

257 g to identify non-toxic small molecules that phenocopy the ATF6-mediated reprogramming of the ER prot

258 11a enhancer-deleted mice, Bcl11a(Deltaenh), phenocopy the BCL11A-null state with respect to alterati

259 ignaling and overexpression of miR-17-92 can phenocopy the defects observed in Hdac3 null lungs.

260 and sphingolipid biosynthetic inhibitors can phenocopy the defects of the rpl4d mutant, including an

261 neered a novel porcine model of AT to better phenocopy the disease and bridge the gap between human a

262 fter IL-17A gene transfer, was sufficient to phenocopy the disease.

263 As a result, Sod1(D83G/D83G) mice also phenocopy the distal axonopathy and hepatocellular carci

264 Knockdown of PTEN could phenocopy the effect of EBV-miR-BART7-3p, whereas re-exp

265 and that Arabidopsis mtn1 mtn2 mutant plants phenocopy the effect of HopAF1.

266 In addition, AURKA/B inhibitors phenocopy the effects of BETi.

267 IRS1 overexpression is sufficient to phenocopy the enhanced activation of the signaling hubs

268 inhibits H3K36 methylation, is sufficient to phenocopy the H3K36M mutation.

269 d induction of EMT by ZEB1 was sufficient to phenocopy the increase in fluvastatin sensitivity; knock

270 However, rocaglate treatment may not phenocopy the loss of eIF4A activity, as these drugs act

271 Neurons ectopically expressing L1 phenocopy the migration and orientation defects caused b

272 increases glycolytic rate, was sufficient to phenocopy the mitochondrial and proliferative deficienci

273 Remarkably, these optix knockouts phenocopy the recurring "black and blue" wing pattern ar

274 ually conserve the tumour heterogeneity, and phenocopy the tumour microenvironment using tumour expla

275 sed Ca(2+) leakage via Sec6 complex, thereby phenocopying the effect of BiP depletion.

276 -induced human platelet aggregation, thereby phenocopying the effect of DUSP3 deficiency in murine ce

277 auses delayed onset of cell differentiation, phenocopying the effects of IYO knockdown at the transcr

278 omoter 12-O-tetradecanoylphorbol-13-acetate, phenocopying the reduced regeneration of older Sod2-defi

279 ant protein that fails to interact with Cdh1 phenocopies, the Cdh1 knockout phenotype of impaired mGl

280 ension of the SAM domain in bpk mutant Bicc1 phenocopied these defects.

281 integrin-alpha subunits inhibition of which phenocopied these effects, suggesting that a specific re

282 ant, and chemical inhibition of the V-ATPase phenocopied this effect.

283 ly WNT ligand overexpressed in glioblastoma, phenocopied this inhibitory effect.

284 Donor DC-restricted deletion of MHC class II phenocopied this Treg deficiency and cGVHD.

285 n in MYC, mutations in this region precisely phenocopy those in MbI in terms of stability, in vitro t

286 rexpression, whereas String/Cdc25 expression phenocopies Tiggrin mutants.

287 P1 mutant that is defective in TOP2A binding phenocopies TOP2A depletion.

288 DRP1(S616) phosphorylation is sufficient to phenocopy transformation-induced mitochondrial dysfuncti

289 sed proliferation and branching, but did not phenocopy transgenic expression of activated smoothened

290 phenotype, whereas mice overexpressing Sox6 phenocopied Trbp(cKO) mice.

291 atic overexpression of C/EBPalpha in WT mice phenocopied Trib1_LSKO livers, and hepatic knockout of C

292 Highly adapted herbivores can phenocopy two-component systems by stabilizing, sequeste

293 l as acquired conditions commonly causing HD phenocopies, were first screened.

294 independent endocytosis in proximal tubules, phenocopying what has been reported for Dent disease cau

295 Surprisingly, these mutants phenocopied wild-type CDC37 overexpression by increasing

296 When cultivated under high-CO2 conditions, 4 phenocopies wild-type metabolic and transcriptomic accli

297 Huntington disease phenocopies without CAG repeat expansions in HTT are not

298 on of midstage CD301b-expressing macrophages phenocopied wound healing defects observed in mice where

299 growth of P falciparum parasites in the EPP phenocopy, X-linked dominant protoporphyria, which has e

300 2-deletion blocked endothelial migration and phenocopied Yap/Taz-deficient mutants.