ライフサイエンスコーパス: phenome

1 S and many behavioral traits, the behavioral phenome.

2 odels of the relationship between genome and phenome.

3 electronic health record (EHR) to define the phenome.

4 viduals and associated across the text-based phenome.

5 tudy provides the first comprehensive genome-phenome analyses of B. cenocepacia infection in cystic f

6 ata can transform understanding of the human phenome and accelerate progress toward precision medicin

7 h, which characterizes phenotypes as a whole phenome and systematically studies the molecular changes

8 ome network, as well as its integration with phenome and transcriptome data sets, lead to numerous bi

9 emerging knowledge about the corresponding "phenomes" and the relevant environmental influences.

10 bgroups, bridging the gap between genome and phenome, and facilitating the identification of genetic

11 Similar integration of interactome, phenome, and transcriptome data should be possible for o

12 Our method implements a whole-phenome approach toward disease gene discovery and can b

13 t for submitting data to the European Genome-phenome Archive (EGA) through SRA, and the launch of a n

14 an Nucleotide Archive (ENA), European Genome-phenome Archive (EGA), ArrayExpress and PRoteomics IDEnt

15 Genome Atlas (TCGA), and the European Genome-Phenome Archive.

16 In conclusion, our phenome-based functional analysis of the C. neoformans T

17 CD9) codes are used frequently to define the phenome, but using ICD9 codes alone misses other clinica

18 efforts to functionally annotate genomes and phenomes by in-house curators.

19 The results demonstrated that the phenome can be further analyzed by a generative model, w

20 noHM server can be accessed freely at http://phenome.cchmc.org.

21 ort, we amassed a deep and broad open-access phenome consisting of approximately 4,500 metabolic, phy

22 s in mice, analyzing the genomes of 42 Mouse Phenome Consortium priority strains.

23 The Mouse Phenome Database (MPD) is an open source, web-based repo

24 The Mouse Phenome Database (MPD; phenome.jax.org) was launched in

25 The Mouse Phenome Database is a repository of phenotypic and genot

26 en the complex traits deposited in the Mouse Phenome Database with our genotypes.

27 A database and website (MPD: Mouse Phenome Database) have been developed to serve as a cons

28 purified from 39 inbred strains of the Mouse Phenome Database.

29 data in a central public database, the Mouse Phenome Database.

30 port on RGD's development towards creating a phenome database.

31 collaborative efforts and accessible genome-phenome databases have partially elucidated the genomic

32 uces latent variables (topics) to govern the phenome distribution.

33 olome data sets--by far the largest coherent phenome for any experimental cohort (www.genenetwork.org

34 PhenoHM is a human-mouse comparative phenome-genome server that facilitates cross-species ide

35 The phenome has been also explored for drug repositioning wi

36 rom advances in genomics, profiling the crop phenome (i.e., the structure and function of plants) ass

37 Member 6 (CYP2A6), we investigated the human phenome in a total of 11,271 individuals.

38 The behavioral phenome included 50 traits from the domains of psychopat

39 We developed our model on the phenome information in Side Effect Resource (SIDER).

40 mpact of one or more genetic variants on the phenome is starting to be characterized both in clinical

41 hasizes that the immune effector and memory "phenome" is a function of the overall infection experien

42 The Mouse Phenome Database (MPD; phenome.jax.org) was launched in 2001 as the data coordi

43 We compared this map to a phenome map of the germline obtained by RNA interference

44 conditions, increasing the possibilities for phenome mapping in C. elegans.

45 mportant new perspective: that the genome-to-phenome mapping of social organisms might be organized t

46 from both large-scale phenotypic analysis ("phenome mapping") and transcriptome profiling.

47 unbiased understanding of the transcriptome-phenome mapping.

48 knockins) under the scope of genome/proteome/phenome, may provide a more complete understanding of th

49 Here, we present the genomes and phenomes of 157 industrial Saccharomyces cerevisiae yeas

50 aradigm takes advantage of a curated medical phenome, often derived from electronic health records, t

51 The Mouse Phenome Project was launched a decade ago to complement

52 rdination center for the international Mouse Phenome Project.

53 of whom were enrolled as part of the Autism Phenome Project.

54 ssociation studies, sequencing and the Mouse Phenome Project.

55 d strains from priority group A of the Mouse Phenome Project.

56 e and environment is a step toward the Human Phenome Project.

57 everse genetic strategy to analyze genome-to-phenome relations in human clinical cohorts.

58 characterization of the complex human genome-phenome relationship.

59 aligning sequences to modeling the genome-to-phenome relationship.

60 The phenome represents a distinct set of information in the

61 markers correlated with the index phenotype (phenome scan).

62 This tool aims to facilitate 'phenome scans', the cross-referencing of genetic variant

63 es to predict the specifics of a given human phenome (set of all expressed phenotypes) encoded by eac

64 Next, we applied the model on the whole phenome to narrow down repositioning candidates and sugg

65 , ADH1B may be a gene relevant for the human phenome via both alcohol metabolism-related mechanisms a

66 an alternative to ICD9 coding, a text-based phenome was defined by 23 384 clinically relevant terms

67 For a comprehensive analysis of the phenome, we assumed that all phenotypes (indications and

68 hallenges in our ability to capture disease "phenomes." We propose a previously unreported method for

69 Phenome-wide application of GLMMs identifies phenotypes

70 An intensive phenome-wide assessment of a single human was performed

71 Phenome-wide association is a novel reverse genetic stra

72 Phenome-wide association scanning showed that CCDC92 lik

73 cal records (EMRs) offers the possibility of phenome-wide association scans (PheWAS) for disease-gene

74 Phenome-wide association studies (PheWAS) have been used

75 clinical and population-based settings using phenome-wide association studies (PheWAS).

76 Phenome-wide association studies (PheWASs) offer an alte

77 We then performed phenome-wide association studies on variants in these 5

78 n studies and gene-environment interactions, phenome-wide association studies, as well as copy number

79 lar, we demonstrate a novel extension to the phenome-wide association study (pheWAS) approach, using

80 to alcohol and nicotine use, we conducted a phenome-wide association study (PheWAS) in a large multi

81 We can interpret the phenome-wide association study (PheWAS) result for a sin

82 A phenome-wide association study (PheWAS) that was perform

83 A phenome-wide association study (PheWAS) was conducted to

84 e applied to human subjects in the form of a phenome-wide association study (PheWAS).

85 The phenome-wide association study approach implicated sodiu

86 We performed a phenome-wide association study for a genetic risk score

87 Lastly, a phenome-wide association study identified a link between

88 Phenome-wide association study identified atrial fibrill

89 Initially, we conducted a phenome-wide association study in 3,401 nicotine-exposed

90 netics in allergy and asthma, we performed a phenome-wide association study in 974 Turkish children s

91 are also assessed for pleiotropy using the "phenome-wide association study" approach, testing each S

92 In a phenome-wide association study, a 10 single-nucleotide p

93 s from Mount Sinai Hospital (MSH) to compute phenome-wide associations between birth month and CVD.

94 otyping Consortium is creating a genome- and phenome-wide catalog of gene function by characterizing

95 he opportunity to systemically integrate the phenome-wide data available for genetic association anal

96 We examined phenome-wide profiles of associations for the entire dis

97 udy of disease phenotypic relationships on a phenome-wide scale is limited because large-scale machin

98 stematic study of disease relationships on a phenome-wide scale is limited due to the lack of large-s

99 Using a phenome-wide scan of psychiatric diagnoses, we found sig

100 , angina, and pre-infarction syndrome passed phenome-wide significance and their seasonal patterns ma

101 king behaviors and identified multiple novel phenome-wide significant and suggestive findings related

102 schemia had consistent patterns but were not phenome-wide significant.