ライフサイエンスコーパス: phenothiazine

1 -(benzo)oxa(or thia)zine and the antioxidant phenothiazine).

2 c acid) and the electron transfer donor PTZ (phenothiazine).

3 iolates terminally omega-functionalized with phenothiazine.

4 ink directly to the two folded conformers of phenothiazine.

5 t by virtue of its binding properties toward phenothiazine.

6 dent binding of calmodulin (CaM) to the drug phenothiazine.

7 henol, S-propyl propane 1-thiosulfinate, and phenothiazine.

8 ipase-C inhibitor U73122, and anti-psychotic phenothiazines.

9 uncategorized mechanism, pyridoacridones and phenothiazines.

10 b(2)m)(2+)-Pro(6)-NH(2), where PTZ is 3-(10H-phenothiazine-10)propanoyl and (Ru(II)b'(2)m)(2+) is bis

11 2,5-diene-1,4-diylidene-expanded TCBD-linked phenothiazines 3-7 exhibit multiredox waves.

12 The computational studies on phenothiazines 3-7 exhibit substantial stabilization of

13 The single-photon absorption on phenothiazines 3-7 reveals that substitution of 1,1,4,4-

14 s of unsymmetrical and symmetrical push-pull phenothiazines (3-7) were designed and synthesized by th

15 is(methylene)diphosphonate with 10-hexyl-10H-phenothiazine-3-carbaldehyde.

16 nylenediamine) to form 3,7-Bis(dibutylamino)-phenothiazine-5'-ium chloride and the absorbance of this

17 the crude cell lysates were loaded onto the phenothiazine affinity column in the presence of a Ca(2+

18 ic respiratory chains from Mtb and show that phenothiazine analogs specifically inhibit NADH:menaquin

19 Several phenothiazines analogs are highly tuberculocidal in vitr

20 Phenothiazine analogues, trifluoperazine, Compound 1, an

21 Use of a novel spin-labeled phenothiazine and detection of isotope-filtered nuclear

22 The phenothiazine and diaryl sulfide quaternary compounds we

23 (N,N-dimethylaminopentyl)-2-(trifluoromethyl)phenothiazine and exon 3- (exon 4 for FMO4) deleted FMOs

24 y annihilation between the radical cation of phenothiazine and the radical anion of phenylquinoline s

25 ive interference with the detergents and the phenothiazines and negative interference with dextran su

26 ce with the aminoglycosides, ampholytes, and phenothiazines and negative interference with SDS, citri

27 Related phenothiazines and pimozide also inhibited HCV infection

28 However, phenothiazines and pimozide exhibited improved genotype

29 he ground state polarizabilities of cyanine, phenothiazine, and arylmethine derivatives calculated us

30 The dihydroacridine, phenothiazine, and carbazole analogues were also potent,

31 inohexyl)-5-chloro-1-naphthalenesulfonamide, phenothiazine, and chlorpromazine, resulted in rapid apo

32 hiophenol, S-propyl propane 1-thiosulfinate, phenothiazine, and thioformaldehyde, an elusive and high

33 s (SSRI), tricyclics, other antidepressants, phenothiazines, and antihistamines; results were very si

34 ogy, the effects of haloperidol, clotiapine, phenothiazines, and citalopram (including escitalopram)

35 e models, use of barbiturates, meprobamates, phenothiazines, and lithium was associated with an incre

36 nitrogen heterocycles, including carbazole, phenothiazines, and tetrahydroquinoline.

37 donating substituents, such as the S-atom in phenothiazines, another important class of RTA.

38 tive, homogeneous assay for the detection of phenothiazine antidepressants was employed.

39 henols (e.g., tannic acid and tea extracts), phenothiazines, antihistamines, statins, and antimalaria

40 f an antiparasitic agent, pentamidine, and a phenothiazine antipsychotic, chlorpromazine.

41 roughput screening, we previously identified phenothiazine antipsychotics as modulators of the human

42 gic receptors that are the primary target of phenothiazine antipsychotics.

43 lanation for the recurring identification of phenothiazines as a class of drugs with anticancer effec

44 gs with the biosensor identified an array of phenothiazines as inhibitors of myosin-II associated S10

45 to previously reported dihydrophenazines and phenothiazines as photoredox catalysts to gain insight i

46 donor-bridge-acceptor system consisting of a phenothiazine-based donor linked to a naphthalene-monoim

47 Fluphenazine (Prolixin(R)) is a potent phenothiazine-based dopamine receptor antagonist, first

48 o tune the reduction potential of metal-free phenothiazine-based photoredox catalysts and demonstrate

49 conformation of calmodulin changes, and the phenothiazine--CaM complex dissociates.

50 z[b,f]azepine, dihydroacridine, phenoxazine, phenothiazine, carbazole, and diphenylamine analogues we

51 ng of the MPC cores and the oxidation of the phenothiazine centers.

52 twisted approximately 77.5 degrees from the phenothiazine central ring.

53 a diode (660-nm) laser in combination with a phenothiazine chloride dye is efficient in controlling i

54 Further computational optimization of phenothiazines, combined with in vitro screening, led to

55 synthesis and characterization of five novel phenothiazine-containing cruciforms (5-9).

56 trate the suitability of the phenoxazine and phenothiazine core and also of the phenylpiperazine moie

57 cule gamma-carboline fragment of dimebon and phenothiazine core of methylene blue (MB) linked by 1-ox

58 The phenothiazine derivatives acetophenazine, fluphenazine,

59 methacrylate was investigated using several phenothiazine derivatives and other related compounds as

60 between cCSQ and tricyclic antidepressants, phenothiazine derivatives, anthracyclines, and many othe

61 d that several pharmaceutical drugs, such as phenothiazine derivatives, tricyclic antidepressants, an

62 ur results showed that several antipsychotic phenothiazine derivatives, tricyclic antidepressants, an

63 g P (partition coefficient) values among the phenothiazine derivatives.

64 support a unique mode of inhibition in which phenothiazines disrupt the S100A4/myosin-IIA interaction

65 ular electron transfer (ET) between the free phenothiazine donor (PH) and its cation radical (PH*+) p

66 In the presence of phenothiazine donors (or in the absence of an external d

67 ntaining CH(3)CN electrolytes with iodide or phenothiazine donors.

68 Methylene blue (MB), a phenothiazine dye that crosses the blood-brain barrier,

69 ron oxidation relative to diphenylamines and phenothiazines (E degrees ranging from 0.59 to 1.38 V vs

70 goproline assembly bearing in linear array a phenothiazine electron donor, a tris(bipyridine)rutheniu

71 assembly formed a linear array containing a phenothiazine electron donor, a tris(bipyridine)rutheniu

72 chromophore (C2+) with one or more appended phenothiazine electron donors (D) and a diquat-type elec

73 rays of a Ru(II)-bipyridyl chromophore and a phenothiazine electron-transfer donor have been synthesi

74 e that tricyclic derivatives of acridine and phenothiazine exhibit half-maximal inhibition of PrP(Sc)

75 The phenothiazine family of compounds, as well as the flavon

76 Haloperidol, sertindole, clotiapine, phenothiazines, fluoxetine, citalopram (including escita

77 be immobilized on a solid support containing phenothiazine from the C-terminal domain of the fusion p

78 Consequently, since phenothiazines generally possess high bioavailability an

79 Substituted phenothiazines have low molecular weight, are not highly

80 Four aromatic amine ring systems-phenothiazine, iminodibenzyl, iminostilbene, and dipheny

81 es of 9-fluoreneone, 9,10-anthraquinone, and phenothiazine is described.

82 the presence of Ca2+, a recognition site for phenothiazine is exposed on calmodulin, allowing the bin

83 rical validations, we repurposed an existing phenothiazine-like antipsychotic drug, trifluoperazine,

84 High scores were noted for several phenothiazine-like antipsychotic drugs, including triflu

85 that first-trimester exposure to low-potency phenothiazines, lithium, certain anticonvulsants, and be

86 s of MPCs where alcohol, carboxylic acid, or phenothiazine moieties had been incorporated into the mo

87 effects of acetopromazine suggests that the phenothiazine moiety has the closest contact to the bind

88 t compound, BPQ-PTZ, which contains a single phenothiazine moiety.

89 xed monolayer MPCs can contain as many as 10 phenothiazines/MPC; these electron donors are electroact

90 were selected for the HTS based on the known phenothiazine Ndh inhibitors, trifluoperazine and thiori

91 d hypothermia (33-35 degrees C for 1 h) with phenothiazine neuroleptics (chlorpromazine & promethazin

92 ociation between the use of antidepressants, phenothiazines, or antihistamines and breast cancer.

93 ociation exists between the RuL3(2+) and the phenothiazine prior to photoexcitation.

94 Two backbones consisting of electron rich phenothiazine (PTZ) and electron deficient anthraquinone

95 idge-acceptor (D-B-A) molecules comprising a phenothiazine (PTZ) donor, an oligo(2,7-fluorene) (FL(n)

96 es of donor-bridge-acceptor molecules having phenothiazine (PTZ) donors, 2,7-oligofluorene (FL(n)) br

97 ve a redox-separated (RS) state containing a phenothiazine (PTZ) radical cation at the Pra(Ptzpn) sit

98 or-bridge-acceptor (D-B-A) system, where D = phenothiazine (PTZ), B = p-oligophenylene, and A = peryl

99 r-bridge-acceptor (D-B-A) systems, where D = phenothiazine (PTZ), B = p-phenylene (Ph(n)), n = 1-4, a

100 w electron shuttling mediator, unsubstituted phenothiazine (PTZ), was studied.

101 onductance through an acid oxidant triggered phenothiazine (PTZ-) based radical junction using the me

102 either a dimethylamino-pyridine (DMAP) or a phenothiazine-pyridine ligand (PTZP) are simultaneously

103 nd [Mn(4)O(4)(O(2)PPh(2))(6)](+), 1(+), with phenothiazine (pzH).

104 53% efficiency an excited state containing a phenothiazine radical cation and an anthraquinone radica

105 neric representation: P(br)P*+, in which two phenothiazine redox centers are interlinked by p-phenyle

106 rom aminoglycosides, ampholytes, detergents, phenothiazines, reducing agents, and miscellaneous subst

107 End-capping with butterfly shaped phenothiazine restrained the formation of molecular aggr

108 ized structural features, which consist of a phenothiazine ring and a pyrrolidinyl group joined by a

109 Furthermore, new modulators with phenothiazine ring exhibited the best chemosensitizing a

110 tein-ligand interaction is pi-pi stacking of phenothiazine ring with indole group of Trp82.

111 However, the phenothiazine rings are twisted 46.5 degrees relative to

112 groups are twisted 82.5 degrees from the two phenothiazine rings, indicating a lack of electron deloc

113 stability to commonly used diphenylamine and phenothiazine RTAs had significantly greater reactivity

114 egeneration by a donor, D, such as iodide or phenothiazine, sensitizers are present in an environment

115 eneration of the affinity column because the phenothiazine-silica support matrix is stable for long p

116 Y337 may sterically hinder the binding of phenothiazines such as ethopropazine, which contains a b

117 e TNA triphosphate analogue (1,3-diaza-2-oxo-phenothiazine, tCfTP) that maintains Watson-Crick base p

118 ne blue (MB, methylthioninium chloride) is a phenothiazine that crosses the blood brain barrier and a

119 Thioridazine is a member of the class of phenothiazines that act, in part, by inhibiting respirat

120 goes a conformational change upon binding to phenothiazines that alters the fluorescence properties o

121 Although we found no difference between phenothiazines, thioxanthenes, or other conventional ant

122 coated MPCs and to those functionalized with phenothiazine to analyze the coupling between the diffus

123 A shift to lower energy wavelengths of phenothiazine was observed upon the addition of the elec

124 nylene)bis(ethene-2,1-diyl)bis(10-hexyl-10H -phenothiazine) was reacted with several different aromat

125 new glucose oxidase mediator, unsubstituted phenothiazine, was discovered.

126 By combining hypothermia with phenothiazines, we significantly enhanced the neuroprote

127 ady-state kinetics and inhibitory actions of phenothiazines were characterized.

128 Phenothiazines were identified by virtual screening as p

129 al RNA binding by six commercially available phenothiazines, while too few to establish a true struct

130 generate the light-emitting excited state of phenothiazine within a potential window not obtainable w

131 Phenothiazine XFs may have potential in array-type senso