ライフサイエンスコーパス: phenotypic

1 al growth factor (anti-VEGF) drugs can cause phenotypic alteration and maturation of the tumor's vasc

2 Genomic and phenotypic analyses of FCGR3A/CD16 Fc-receptor profiles

3 Phenotypic analyses of these mutant lines indicate that

4 Phenotypic analyses of Trl and Atro clones suggest that

5 Phenotypic analysis of mouse models of human diseases is

6 Furthermore, phenotypic analysis of naturally occurring polymorphic N

7 Phenotypic analysis of pbpC mutants (encoding PBP 3) sho

8 Phenotypic analysis of resistance-associated substitutio

9 Gene expression and mutant phenotypic analysis of SWIB5 and SWIB family members sug

10 We performed phenotypic analysis of two independent L. japonicus muta

11 atal DA dynamics, reversal of characteristic phenotypic and behavioral abnormalities, and prevention

12 ts were indistinguishable from Columbia-0 at phenotypic and biochemical levels, whereas the ndufs8.1

13 a novel approach, we simultaneously detected phenotypic and derived taxonomic change in a natural bac

14 or zebrafish (Danio rerio) genetic, genomic, phenotypic and developmental data.

15 Longitudinal phenotypic and epigenetic characterization of the memory

16 sed in vitro polarization assays, as well as phenotypic and functional analysis of STAT1-mutated pati

17 Our results emphasize a phenotypic and functional heterogeneity in an apparently

18 Phenotypic and genetic analyses of TF mutants enable the

19 This paper showed the occurrence of both phenotypic and genetic components in masculinization wit

20 spring with important consequences for their phenotypic and genetic diversity.

21 mpers a single species description but their phenotypic and genetic features suggest that they repres

22 We consider the phenotypic and genetic interrelationships between epigen

23 To investigate phenotypic and genotypic alterations before and after bo

24 Rued et al. combine phenotypic and genotypic analyses of mutant strains that

25 Phenotypic and genotypic characteristics in these patien

26 ssociated resources using subjects' clinical phenotypic and genotypic criteria.

27 deas that could improve understanding of the phenotypic and genotypic differences that exist between

28 izes new information published since 2010 on phenotypic and genotypic resistance mechanisms in C. dif

29 We adopted phenotypic and metagenomic approaches to investigate pho

30 ytes presented with profound transcriptomic, phenotypic, and functional differences.

31 A few phenotypic assays have been described but have not been

32 elopment due to evolved trade-offs can yield phenotypic benefits, whereas slow development from low t

33 ata demonstrate that progesterone mediates a phenotypic change in BAT, which contributes to the gesta

34 The rate of phenotypic change in seed size was also strongly positiv

35 bound state of cry1, but the reason for this phenotypic change is unclear.

36 stand the relationship between genotypic and phenotypic change.

37 Exogenous IL-2 restores the phenotypic changes and overall gene-expression effects e

38 abscission, and its inactivation resulted in phenotypic changes identical to SCCRO inactivation.

39 ble to identify several major time-dependent phenotypic changes in blood immune cell subsets that occ

40 Astrocytes undergo important phenotypic changes in many neurological disorders, inclu

41 lutamine as metabolic tracers, we probed the phenotypic changes in metabolism following a single copy

42 uires additional traits/mutations to trigger phenotypic changes that enhance migration and are hypoth

43 a mechanism for the shift in signalling and phenotypic changes we observed after prolonged exposure

44 s as observed in IPF facilitates profibrotic phenotypic changes.

45 Detailed phenotypic characterisation of developing and mature gra

46 The clearest phenotypic characteristic of microbial cells is their sh

47 gesting systemic low-grade inflammation as a phenotypic characteristic of this early-onset NCD.

48 Associations of phenotypic characteristics (freckles, nevi, phenotypic i

49 iagnosis and improved survival; however, the phenotypic characteristics and underlying genetics assoc

50 t FOXO1 is continuously required for all the phenotypic characteristics of memory-effector T cells su

51 Radiomics aims to quantify phenotypic characteristics on medical imaging through th

52 n to airway inflammatory phenotype and other phenotypic characteristics.

53 Here, we performed a multiparametric phenotypic characterization and unbiased analysis of hum

54 er1/peptide transporter family, LjNPF8.6 The phenotypic characterization carried out in independent L

55 Transcriptome analysis and phenotypic characterization determined that regulatory C

56 Our phenotypic characterization highlights the suitability o

57 for rapid label-free separation and on-chip phenotypic characterization of circulating tumor cells f

58 Phenotypic characterization of this mutant showed that C

59 All participants underwent detailed clinical phenotypic characterization, including serum biomarker a

60 system, with a strong link between multiple phenotypic characters: pectoral fin shape, swimming beha

61 iatric disorders, how paradigm shifts in the phenotypic classification of patients would empower the

62 e loss of language abilities with three main phenotypic clinical presentations, including logopenic,

63 These phenotypic commonalities have been proposed to stem from

64 In summary, FOXP1 is a downstream phenotypic commonality of gene mutations and predicts ou

65 ed two, four, and eight nested groups (i.e., phenotypic communities).

66 We describe an intriguing tension between phenotypic complexity and evolvability that may have imp

67 st how the traits of the primary case, group phenotypic composition and group size interact to facili

68 al to perform genetic discovery, explore the phenotypic consequences for disease-associated variants,

69 cumulative effects may result in downstream phenotypic consequences in sudemycin-treated mutant cell

70 ject', a systematic effort to understand the phenotypic consequences of complete disruption of genes

71 Additionally, we assess the phenotypic consequences of genomic copy-number alteratio

72 rategies to study the diverse functional and phenotypic consequences of mutations at the base-pair re

73 However, the signaling and phenotypic consequences of non-specific sodium permeatio

74 inct individuals and sheds light on possible phenotypic consequences of such variation on complex tra

75 genetic coupling exists and investigate its phenotypic consequences.

76 tful imitations provides notable examples of phenotypic convergence and are often invoked as classic

77 ion of fangblenny venom has seemingly led to phenotypic convergence via the formation of a diverse ar

78 Hey2 overexpression is sufficient to induce phenotypic conversion of endothelial cells.

79 The phenotypic conversion of F4/80(int)CD206(+) macrophages

80 Higher FIX expression and improved phenotypic correction were achieved with the haploid AAV

81 red genetic influences mediated the moderate phenotypic correlation (mean r = 0.46) between support a

82 ritable aspects of the default mode network (phenotypic correlation, rhop = -0.12; P = .03).

83 However, when the phenotypic correlations were partitioned into genetic an

84 115 associated loci and these links reflect phenotypic correlations.

85 We used genotypic and phenotypic data from 10 760 individuals aged 50 years th

86 and querying of large amounts of genetic and phenotypic data is crucial to contemporary clinical gene

87 ologic, pharmacogenomic, transcriptomic, and phenotypic data related to drug response.

88 OpenSimRoot integrates plant phenotypic data with environmental metadata to support e

89 viding an intuitive interface to genetic and phenotypic databases.

90 dual genetic variations requires an accurate phenotypic description and classification.

91 struggled for years with accurate, objective phenotypic detection of carbapenemase activity in Entero

92 , no specific inhibitor is available for the phenotypic detection of OXA-48.

93 loinsufficiency of BMP2 could be the primary phenotypic determinant in individuals with predicted tru

94 Phenotypic differences between patients with mutations i

95 ble molecular explanation for the observable phenotypic differences between the mouse and human skin

96 on for the role of the human Y chromosome in phenotypic differences between the sexes in health and d

97 These phenotypic differences in response to social conditions

98 RNA-sequencing of human gliomas and identify phenotypic differences in TAMs of distinct lineages.

99 Among Anopheles mosquito species, these phenotypic differences include vectorial capacity, as it

100 These genetic and phenotypic differences indicate that the European isolat

101 both Uganda and the UK, but the substantial phenotypic differences might reflect fundamental differe

102 Phenotypic differences within populations and between cl

103 Given the phenotypic differences, it was assumed that the differen

104 To determine if there are persistent phenotypic distinctions between SA (as defined by 2014 A

105 RATIONALE: Phenotypic distinctions between severe asthma (SA) and n

106 odel to study the coevolutionary dynamics of phenotypic diversity and contingent cooperation.

107 variants but may substantially contribute to phenotypic diversity and evolution.

108 ns and that there exists an optimal level of phenotypic diversity best promoting contingent cooperati

109 Our results show that phenotypic diversity coevolves with contingent cooperati

110 y at high temporal resolution by calculating phenotypic diversity estimates from flow cytometry (FCM)

111 Phenotypic diversity is considered beneficial to the evo

112 e of different modes of evolution in shaping phenotypic diversity remains a hotly debated question.

113 natural selection, and enables the extensive phenotypic diversity that is frequently observed among p

114 nalysis of their environmental distribution, phenotypic diversity, and concordance with host fossil r

115 odel does not assume any prescribed level of phenotypic diversity, but rather lets it be an evolvable

116 rstanding the coevolution of cooperation and phenotypic diversity.

117 -lymphoid tissue distribution but also their phenotypic diversity.

118 selection and contribute to the evolution of phenotypic diversity.

119 ide approach are illuminating the drivers of phenotypic diversity.

120 evolution of life cycle complexity promotes phenotypic diversity.

121 ook a multimodality approach to evaluate the phenotypic effects and metabolic changes that occur with

122 Here, we investigated the phenotypic effects of JAK2 deficiency.

123 s response and impaired sensorimotor gating, phenotypic effects that were associated with dysregulate

124 ociated sequence markers and their predicted phenotypic effects, hemagglutinin (HA) clade classificat

125 theory that links genotypic changes to their phenotypic effects.

126 We conducted a thorough phenotypic evaluation of CIV-H3N2 in order to assess its

127 Phenotypic evidence suggests that stabilizing selection,

128 redictions for coupling versus uncoupling of phenotypic evolution of tadpole and adult life-history p

129 ology associated with heterogeneous clinical phenotypic expression.

130 patients with disorders that had overlapping phenotypic features (30 patients) (median score, 0.21 vs

131 e allowed to grow long-term (14-35 days) and phenotypic features of perfused microtumours compared wi

132 ated the association of genome variation and phenotypic features of the infecting S. epidermidis isol

133 Consistent with our phenotypic findings, we observed a higher IFN-gamma prod

134 Phenotypic follow-up in five individuals with GRIA1 muta

135 ionally, the model captured intermediate and phenotypic gene expression data.

136 Humans challenge the phenotypic, genetic, and cultural makeup of species by a

137 We documented five distinct phenotypic groups by combining reproductive behavior wit

138 Disruption of pntA resulted in phenotypic growth defects observed under low light inten

139 of such a mutation depends on the degree of phenotypic heritability between generations, called phen

140 eviations from which can be used to identify phenotypic heterogeneities and inter-cellular interactio

141 Phenotypic heterogeneity altered the evolutionary dynami

142 erall, the results show that quantifying CTC phenotypic heterogeneity can help inform the choice betw

143 eral mechanisms underlying the generation of phenotypic heterogeneity have been elucidated, the speed

144 Phenotypic heterogeneity in Tourette syndrome is partly

145 We uncovered previously unreported phenotypic heterogeneity of human cDC2s among individual

146 rent yeast species by commercially available phenotypic identification platforms.

147 lelic alterations of HR-related genes have a phenotypic impact on other cancers remains to be fully e

148 rican- and Asian-lineage ZIKV have different phenotypic impacts on host immune responses.

149 phenotypic characteristics (freckles, nevi, phenotypic index) and MC1R status with incident amelanot

150 , presence of many freckles, a sun-sensitive phenotypic index, and prior amelanotic melanoma increase

151 development of DNA biobanks linked to dense phenotypic information enables such an experiment to be

152 Our approach enables researchers to unlock phenotypic information from digital pathology datasets t

153 We present detailed phenotypic information on seven unrelated individuals wi

154 Here, we constructed a T2D phenotypic-linkage network (T2D-PLN), by integrating div

155 st prion [URE3], it enhances propagation and phenotypic manifestation of another prion, [PSI(+) ].

156 -277 mimic injection partially rescued these phenotypic manifestations.

157 ases, including insight into their disparate phenotypic manifestations.

158 It is our hope that the use of phenotypic maps such as these will further the understan

159 , we used the hemolytic activity of LLO as a phenotypic marker to screen for spontaneous virulence-at

160 ess angioblast characteristics by expressing phenotypic markers for endothelial and mesenchymal cells

161 This implies that phenotypic markers give a more precise view of mutation

162 +)PD-1(-) memory CD4(+) T cells, which share phenotypic markers with regulatory T cells, were enriche

163 flux from macrophages, and expression of SMC phenotypic markers.

164 Here we use geometric morphometrics and phenotypic matrix statistics to compare rates of craniof

165 methods to extract genetic interactions from phenotypic measurement.

166 However, these have been based primarily on phenotypic measurements and omit potential gains by inte

167 ing purposes, we also examined as predictors phenotypic measures as apps (for suicide risk (CFI-S, Co

168 pic heritability between generations, called phenotypic memory.

169 during early development produces persistent phenotypic, metabolic and molecular changes that are evi

170 , straightforward, inexpensive, and specific phenotypic method for the detection of carbapenemase pro

171 A plethora of phenotypic methods exist for the detection of carbapenem

172 and reveal limitations of both genotypic and phenotypic methods.

173 t generation prosthetics, utilizing in vitro phenotypic models would benefit from the development of

174 Phenotypic mutations are amino acid changes caused by mi

175 s effective as high doses, and (iii) neither phenotypic nor inherited antibiotic resistance generated

176 a major contributor to genome evolution and phenotypic novelty.

177 ing of gene regulatory networks can generate phenotypic novelty.

178 Our phenotypic observations further suggested that Afh mutan

179 We correlated phenotypic observations with haplotypes of genomic regio

180 the linking of viral genetic differences to phenotypic or clinical outcomes, are highlighted as well

181 what proportion of variants associated with phenotypic or transcriptomic traits in the human brain a

182 he respective roles, signaling pathways, and phenotypic outcomes of hUII and URP in the UT system.

183 of NRF1 or NRF2 results in vastly different phenotypic outcomes, implying that they play different r

184 strains of oligomers could be significant in phenotypic outcomes.

185 ic strains of Abeta, which may have profound phenotypic outcomes.

186 Here, we show a spatially-dependent phenotypic overlap between hypertrophic chondrocytes and

187 table ectopic mineralization disorders, with phenotypic overlap with generalized arterial calcificati

188 re clinically distinct, there is significant phenotypic overlap.

189 ntal health (mean rA = 0.54), reflecting the phenotypic pattern.

190 Analyzing phenotypic patterns may increase productivity in genetic

191 abolism respond to genetic, environmental or phenotypic perturbations?

192 the population levels depending on specific phenotypic plastic responses of a plant to herbivory.

193 ntegrating information on genetic variation, phenotypic plasticity and climatic niche modeling to eva

194 recently because of the potential to explore phenotypic plasticity and, specifically, how demographic

195 Phenotypic plasticity describes the phenotypic variation

196 raits, the dominant source of variability is phenotypic plasticity during development and adult life.

197 Afh mutants failed to exhibit the necessary phenotypic plasticity for adapting to temporal changes a

198 s of multiple phenotypes and two measures of phenotypic plasticity in a maize nested association mapp

199 The phenotypic plasticity of these traits was quantified as

200 Both groups of species show little phenotypic plasticity or potential for evolutionary chan

201 Rather, smaller cell size, a high degree of phenotypic plasticity, and increased protrusive activity

202 Macrophages exhibit phenotypic plasticity, as they have the ability to switc

203 Phenotypic plasticity, both within and across generation

204 h considerable debate on the degree to which phenotypic plasticity, introgressive hybridization and i

205 olecular mechanisms mediating behavioral and phenotypic plasticity.

206 pulations: the genomic storage effect due to phenotypic plasticity.

207 an be challenging due to the highly variable phenotypic presentation and limited correlation has been

208 There are 2 predominate phenotypic presentations of the disease: transthyretin f

209 (+) CD25(high) cells that display a Th1/Th17 phenotypic profile, as reflected by heightened interfero

210 Unique phenotypic profiles were also evident at the lowest clus

211 s to ascertain the impact of this peptide on phenotypic properties of P. gingivalis related to virule

212 However, the viral phenotypic properties that contribute to disease progres

213 ogic disparity with rates of change suggests phenotypic rates are primarily shaped by ecologic factor

214 0 ng/L E2beta during SSC development altered phenotypic ratios and SSC.

215 This highly sensitive phenotypic readout of enhancer function in a native geno

216 l fate and their relationships with specific phenotypic readouts.

217 ene clusters that jointly encompass many key phenotypic regulatory Type II MADS-box gene clades (SEP1

218 ntly associated with body weight in terms of phenotypic relative growth.

219 Phenotypic rescue was evaluated using non-invasive, huma

220 After adjusting for phenotypic resistance profile, low body mass index (<18.

221 onferring loci accounted for the majority of phenotypic resistance to first- and second-line drugs in

222 We report that transcriptional and phenotypic responses correlate with each other in genera

223 stage specificity that together delineate a phenotypic roadmap of disease progression culminating in

224 sociations were identified between tiredness phenotypic scores and polygenic profile scores for BMI,

225 These compounds were discovered from a TNBC phenotypic screen and possess a unique dual inhibition p

226 s for a hit compound that has emerged from a phenotypic screen resulting in indazole-based compounds.

227 de (CCT251236), identified using an unbiased phenotypic screen to detect inhibitors of the HSF1 stres

228 By using whole-transcriptome analyses and phenotypic screenings of the marine bacterium Phaeobacte

229 vity suitable for clinical use, we performed phenotypic screens on a NINDS small molecule library of

230 fication and validation, to target-based and phenotypic screens, to clinical trials.

231 uct size and induction conditions to optimal phenotypic selection, we show that eYHB-based alleles ar

232 for each output may be one means to achieve phenotypic selectivity.

233 ability to control oxidative stress and the phenotypic severity of SCD.

234 UTX NC knockout (FKO) demonstrates enhanced phenotypic severity over males (MKOs), due to partial re

235 e to the antiandrogen drug enzalutamide by a phenotypic shift from androgen receptor (AR)-dependent l

236 sessment of mPCs over two decades, we find a phenotypic shift has occurred in mPC with the emergence

237 genes contribute to phenotypic variability, phenotypic shifts, and progression to more aggressive di

238 They were used to quantify and stratify phenotypic similarities among genetic perturbations.

239 L-ORD shows striking phenotypic similarities to age-related macular degenerat

240 ng the E3 ubiquitin ligase RNF146 that shows phenotypic similarities to CCD.

241 Phenotypic similarity scores were significantly lower am

242 To describe an expanded phenotypic spectrum and longitudinal outcome in 256 LGI1

243 ll allow better definition of the associated phenotypic spectrum and the exploration of potential tar

244 prevalence of ACAN mutations and broaden the phenotypic spectrum in patients with idiopathic short st

245 y reported candidacy of MPDZ by presenting a phenotypic spectrum of congenital hydrocephalus associat

246 Our finding expands the phenotypic spectrum of genetic variation in SLC1A3 and h

247 We further expand the phenotypic spectrum of KMT2B-related disorders and show

248 The phenotypic spectrum of the m.3243A > G mutation has sinc

249 B4A mutations are known to result in a broad phenotypic spectrum, ranging from primary dystonia (DYT4

250 STAT1 pathway is a crucial modulator of this phenotypic spectrum.

251 de in an intermediate epithelial/mesenchymal phenotypic state.

252 Two methods discriminated phenotypic subgroups, namely, a sum across 7 traits and

253 Some cross-modal correlations were purely phenotypic, such as that between axial diffusivity of th

254 Compared to the results of phenotypic susceptibility testing, the sensitivity of th

255 a cellular reporter to directly monitor the phenotypic switch in drug-resistant bacteria with tempor

256 ments, stiff, soft, or suspension, induced a phenotypic switch in prostate cancer cells via mechanotr

257 rtantly, such a mechanotransduction-mediated phenotypic switch in prostate cancer cells was accompani

258 ignals and that this modification leads to a phenotypic switch in the bacterial colonizers.

259 White adipose tissue (WAT) can undergo a phenotypic switch, known as browning, in response to env

260 tors of vascular smooth muscle cells (VSMCs) phenotypic switch, one of the main events responsible fo

261 to evaluate the role of miR-125a-5p in VSMCs phenotypic switch.

262 variants associated with a transcriptomic or phenotypic trait presents a far greater challenge.

263 19 independent radiomic features quantifying phenotypic traits and 2 conventional features (metabolic

264 l propensity being conditional on individual phenotypic traits and local contexts.

265 nal exposure to early-life stress on several phenotypic traits in their offspring in a functionally r

266 ty analysis techniques were used to evaluate phenotypic traits involved with light interception, phot

267 that collagen-binding cells may change their phenotypic traits.

268 and we assessed the associated genotypic and phenotypic traits.

269 cate beetle lineages following a predictable phenotypic trajectory during their parasitic adaptation

270 njury is necessary for the repair macrophage phenotypic transition and subsequently for proper and co

271 e resource for understanding the genomic and phenotypic underpinnings of bacterial evolution.

272 is home to individuals with a broad range of phenotypic values for eye and skin color due to the mix

273 researchers to explore the multidimensional phenotypic variability among neurons and to correlate ge

274 Given the phenotypic variability associated with regulatory gene m

275 n order to systematically detect the role of phenotypic variability in enteropathogenic E. coli (EPEC

276 Phenotypic variability is a hallmark of diseases involvi

277 We show that the increase in phenotypic variability is due to stochastic conversion o

278 rther analyzed separately to account for the phenotypic variability of different disease-causing vari

279 myeloid tumor-suppressor genes contribute to phenotypic variability, phenotypic shifts, and progressi

280 ins contribute to epigenetically inheritable phenotypic variability.

281 ivation, which correlates with and may drive phenotypic variability.

282 The 63 loci explain approximately 39% of the phenotypic variance in MPB and highlight several plausib

283 ltimately gross limb morphology, to generate phenotypic variation during prenatal development.

284 into environmental and genetic influences on phenotypic variation in humans.

285 We show that larger phenotypic variation increases connectivity among predat

286 only a few species (i.e., specialists), low phenotypic variation maximizes intake rates, while the o

287 ue habitat characteristics and intraspecific phenotypic variation may allow pikas to exist in areas o

288 Phenotypic plasticity describes the phenotypic variation of a trait when a genotype is expos

289 of individual components, thereby increasing phenotypic variation that selection could act on and fac

290 copies of a gene (homoeologs), and to expose phenotypic variation that was previously hidden by funct

291 Such phenotypic variation within disorders implies the existe

292 show that many loci of small effect underlie phenotypic variation, and identify five genomic regions

293 ied are unlikely to contribute to functional phenotypic variation, as there is a significant depletio

294 8 expression has a nonlinear relationship to phenotypic variation, predicting levels of robustness am

295 nt cooperators to elevate their potential of phenotypic variation, thereby increasing their opportuni

296 gene-expression levels are a major source of phenotypic variation.

297 Many common diseases show wide phenotypic variation.

298 e formation of circRNAs and further modulate phenotypic variation.

299 of a clonally aged population and uncovered phenotypic variations that subject the cells to natural

300 e in drug discovery to evaluate drug-induced phenotypic variations.

301 r transposons to modulate transcriptomic and phenotypic variations.