ライフサイエンスコーパス: phenotypic screen

1 ed for apicoplast biogenesis identified in a phenotypic screen.

2 est and efforts in prosecuting mycobacterial phenotypic screens.

3 the many compounds discovered in whole-cell phenotypic screens.

4 larly when these compounds are identified in phenotypic screens.

5 d predicted the molecular targets underlying phenotypic screens.

6 y subjected to a limited number of secondary phenotypic screens.

7 e hypomorphic epi-mutants in high-throughput phenotypic screens.

8 ified recently by their altered behaviors in phenotypic screens.

9 ing rates or distributions of mutations from phenotypic screens.

10 fication of the receptor deletion as well as phenotypic screens.

11 olecular targets, or to create libraries for phenotypic screens.

12 phosphoramide mustards using biochemical and phenotypic screens.

13 tient groups defined by signs, symptoms, and phenotypic screening.

14 by classical mutagenesis techniques based on phenotypic screening.

15 nome-scale guide RNA libraries for unbiased, phenotypic screening.

16 ery of many new lead compounds identified by phenotypic screening.

17 This series was identified from a phenotypic screen against the blood stage of Plasmodium

18 minopyrimidines (TAPs), which emerged from a phenotypic screen against the blood stages of Pf.

19 Phenotypic screening against MCF7 mammary adenocarcinoma

20 mising class of antituberculosis agents from phenotypic screening against mycobacteria.

21 Phenotypic screens allow the identification of small mol

22 This multipronged phenotypic screen allowed us to reveal beta-oxidation pr

23 The phenotypic screening allowed identification of a mutant

24 model-directed discovery, interpretations of phenotypic screens, analysis of network properties and s

25 avin riboswitches, which was identified in a phenotypic screen and acts as a structurally distinct sy

26 model system, we performed a high-throughput phenotypic screen and defined compounds that overcame di

27 as an inhibitor of HIV-1 infectivity using a phenotypic screen and derivatives of this compound were

28 These compounds were discovered from a TNBC phenotypic screen and possess a unique dual inhibition p

29 This phenotypic screen and subsequent analysis identified ARA

30 monstrate the utility of this population for phenotypic screening and associated genomic characteriza

31 evelopment by random mutagenesis followed by phenotypic screening and by targeted gene disruption fol

32 ing stem cell proliferation responses with a phenotypic screening and by using specific knockdowns.

33 h available SALK T-DNA mutagenesis lines for phenotypic screening and identified two previously unrep

34 This phenotypic screening and subsequent analysis identified

35 s fully functionalized probes for integrated phenotypic screening and target identification.

36 ter than traditional compound collections in phenotypic screens and against difficult targets.

37 st new tuberculosis drug leads discovered by phenotypic screens and genome sequencing are highly lipo

38 in genetic background, so that results from phenotypic screens and other related experiments might n

39 al assaying of this important gene family in phenotypic screens and their use in biochemical and stru

40 rug target identification, drug repurposing, phenotypic screening, and side effect prediction.

41 enome-wide miRNA mimic and hairpin inhibitor phenotypic screens, and miRNA-mRNA transcriptomics analy

42 These findings establish a genomics-based phenotypic screening approach capable of quickly connect

43 lop agents for the treatment of influenza, a phenotypic screening approach utilizing a cell protectio

44 n of the model described here as an unbiased phenotypic screening approach will help with our long te

45 as historically benefited from a whole-cell (phenotypic) screening approach to identify lead molecule

46 mutational studies, adaptive evolution, and phenotypic screening are powerful tools for creating new

47 ing human disorders are genetically complex, phenotypic screens are difficult to design.

48 targeted knockdown strategies combined with phenotypic screens are powerful approaches to delineate

49 bination of diversity-oriented synthesis and phenotypic screening as a strategy for the discovery of

50 Using unbiased phenotypic screens as an alternative to target-based app

51 es and random point mutagenesis, followed by phenotypic screening based on a yeast two-hybrid system.

52 , polA, and hfq, were isolated with the same phenotypic screen, but they do not affect the beta-galac

53 crease the efficiency, scale and accuracy of phenotypic screens by maximizing their discriminatory po

54 al 5A (NS5A) protein have been identified by phenotypic screening campaigns using HCV subgenomic repl

55 or constructing conventional high-throughput phenotypic screening campaigns.

56 Our study demonstrates that high-throughput phenotypic screening can uncover rich genetic diversity

57 Phenotypic screens can identify molecules that are at on

58 Chemical libraries paired with phenotypic screens can now readily identify compounds wi

59 By using a combination of phenotypic screening, chemoproteomics, and biophysical s

60 f optimized MMP inhibitors that went through phenotypic screening consisting of thromboelastometry an

61 Phenotypic screening coupled with transcriptome sequenci

62 onditions were compared with high-throughput phenotypic screen data, and the initial in silico model

63 A simple F1 adult phenotypic screen demonstrated that most adult tissues c

64 knockout mice were subjected to a systematic phenotypic screen designed to uncover alterations in emb

65 ogical processes and could be used for rapid phenotypic screening (e.g., to produce plants with super

66 These results demonstrate that phenotypic screening, followed by comprehensive MoA effo

67 indicators (GCaMPs) to develop a cell-based phenotypic screen for compounds that modulate Ca(2+) sig

68 A cell-based phenotypic screen for inhibitors of biofilm formation in

69 nse method of random gene inactivation and a phenotypic screen for limitation of ASFV replication in

70 In a phenotypic screen for lymphomagenesis, we tested candida

71 identical phenotype was discovered during a phenotypic screen for mutations induced by chemical muta

72 Here, we describe a phenotypic screen for small molecules that reverse TDP-4

73 ferred to as "SD70," initially identified by phenotypic screening for inhibitors of ligand and genoto

74 Phenotypic screening for resistant cultivars is however

75 Our findings underscore the benefits of phenotypic screening for targeting post-translational mo

76 Phenotypic screens for bactericidal compounds against dr

77 Phenotypic screens for bactericidal compounds are starti

78 We conducted phenotypic screens for small molecules that inhibit TGF-

79 st commonly employed two general strategies: phenotypic screens for spontaneous or induced mutations

80 tablish the practicality of loss-of-function phenotypic screens for the identification of genomic loc

81 Cyclotide MCoCP4 was selected by phenotypic screening from cells transformed with a mixtu

82 High-throughput cell-based phenotypic screening has become an increasingly importan

83 High-throughput phenotypic screens have re-emerged as screening tools in

84 Phenotypic screens have the advantage of the whole organ

85 echanisms of actions of drugs, discovered by phenotypic screening, have been elucidated.

86 Successful optimization of a phenotypic screening hit based on a quinoline-4-carboxam

87 In addition, a phenotypic screen identifies T0 plants with the expected

88 Herein we describe a high throughput, phenotypic screen in cells that led to the discovery of

89 veloped by combining ligand-based design and phenotypic screening in an iterative manner.

90 We have conducted a phenotypic screening in endothelial cells exposed to ele

91 f the inactive E96A mutant cDNA, followed by phenotypic screening in Escherichia coli, led to isolati

92 By integrating image-based phenotypic screening in HeLa cells with high-resolution

93 age-gated K+ channel, Kat1, is combined with phenotypic screening in Saccharomyces cerevisiae and ele

94 These results demonstrate the utility of phenotypic screening in the identification of residues c

95 Phenotypic screening in zebrafish revealed that the expr

96 This study underscores the power of phenotypic screens in the development and characterizati

97 ntimalarial compounds, previously found in a phenotypic screen, into a PfHsp90-specific pocket.

98 However, it is equally applicable to general phenotypic screening involving helminths and other compl

99 Phenotypic screening is a powerful method in both neglec

100 Small molecule in vivo phenotypic screening is used to identify drugs or biolog

101 A central challenge in designing phenotypic screens is choosing suitable imaging biomarke

102 ecules previously identified in a C. elegans phenotypic screen likely to be enriched for feeding regu

103 ghlights recent advances and progress toward phenotypic screening methodologies over the past several

104 Here we develop high-content phenotypic screening methods for the systematic identifi

105 As part of our large-scale phenotypic screen, mice deficient for the Arl3 gene were

106 A phenotypic screen of a compound library for antiparasiti

107 A phenotypic screen of a set of S. lycopersicum M82 x Sola

108 Utilizing a phenotypic screen of an approved drug collection, we fou

109 ced short palindromic repeats (CRISPR)-based phenotypic screen of class I and II HDAC genes.

110 psis (Arabidopsis thaliana) reverse genetics phenotypic screen of more than 5,000 mutants.

111 racteristic traits was explored to perform a phenotypic screen of near-isogenic short-culm mutant lin

112 In a phenotypic screen of the wild-derived mouse strain MOLF/

113 Phenotypic screening of a GBS transposon insertion libra

114 line has recently disclosed the results of a phenotypic screening of an internal library, publishing

115 Genotypic and phenotypic screening of C. difficile isolates revealed m

116 ion, opening new options for region-specific phenotypic screening of complex physiological phenomena

117 or develop chemical scaffolds identified by phenotypic screening of compound libraries, specific pha

118 Here, we show that phenotypic screening of drug libraries in zebrafish scn1

119 ith severe hypercholesterolemia, followed by phenotypic screening of family members.

120 of genetic materials to mammalian cells for phenotypic screening of gene expression and gene silenci

121 tes the potential for using yeast to perform phenotypic screening of genetically encoded cyclotide-ba

122 limitation in important areas, including the phenotypic screening of human genes in transgenic mice b

123 ontargeted therapies are drugs identified by phenotypic screening of natural products or chemical lib

124 lar cell-surface receptors, and we have used phenotypic screening of radiation hybrid cell lines to i

125 Phenotypic screening of representative examples against

126 By high-throughput phenotypic screening of small molecules, we identified c

127 ular cell barcoding to enable direct in vivo phenotypic screening of small-molecule libraries.

128 From the phenotypic screening of the AstraZeneca corporate compou

129 of the receptor gene in the human genome by phenotypic screening of the G3 human-hamster radiation h

130 ly precise localization might be achieved by phenotypic screening of the hybrids to facilitate positi

131 Phenotypic screening of the library identified disruptio

132 ble to infect Chinese hamster cells, we used phenotypic screening of the T31 mouse/hamster radiation

133 Phenotypic screening of U. maydis mutants deleted for ge

134 In the pursuit of new antimalarial leads, a phenotypic screening of various commercially sourced com

135 In phenotypic screens of Ca(2+) chelator and Mn(2+) toxicit

136 uberculosis (Mtb) have been advanced through phenotypic screens of extensive compound libraries.

137 ead-one stock solution strategy that enabled phenotypic screens of the resulting library.

138 Phenotypic screening offers a powerful approach to ident

139 ased screening on pteridine reductase 1 with phenotypic screening on Trypanosoma brucei for hit ident

140 vity suitable for clinical use, we performed phenotypic screens on a NINDS small molecule library of

141 d the use of these workhorse collections for phenotypic screening or genetic mapping.

142 identification of new lead compounds include phenotypic screening or target-based approaches.

143 Large-scale phenotypic screening presents challenges and opportuniti

144 fully functionalized compound libraries into phenotypic screening programs should facilitate the disc

145 Phenotypic screens provide an effective platform to iden

146 Phenotypic screening provides a means to discover small

147 Target-directed screening and whole-cell phenotypic screening represent two complementary approac

148 s for a hit compound that has emerged from a phenotypic screen resulting in indazole-based compounds.

149 g of 95 isolates identified by a preliminary phenotypic screen revealed that the lesions in them caus

150 Cell-based phenotypic screening revealed that noncytotoxic concentr

151 Finally, comprehensive phenotypic screening showed a broader pathological pheno

152 The set of genes identified in this phenotypic screen shows only limited overlap with those

153 which compounds discovered using cell-based phenotypic screening strategies might exert their effect

154 Through phenotypic screening, systems analysis, and rigorous exp

155 usually reported as G6PD "normal" by current phenotypic screening tests.

156 We recently identified a compound through phenotypic screening that blocked infectivity of this in

157 richia coli by employing an extensive set of phenotypic screens that allow us to monitor the function

158 entification of the molecular targets from a phenotypic screen, the confirmation of the in vivo relev

159 With the use of a phenotypic screen, the deletion frequency of identical r

160 study addresses three inherent challenges in phenotypic screening: the identification of the molecula

161 EC50) values using image-based readouts from phenotypic screens, thereby allowing rigorous comparison

162 de (CCT251236), identified using an unbiased phenotypic screen to detect inhibitors of the HSF1 stres

163 the NMNAT2-MSD platform provides a sensitive phenotypic screen to detect NMNAT2 in neurons.

164 We developed a phenotypic screen to isolate genes that contribute to th

165 rovides a compelling example of the power of phenotypic screening to identify leads engaging novel ta

166 this study demonstrates the power of in vivo phenotypic screening to identify new classes of 'cancer

167 bine fragment-based chemical proteomics with phenotypic screening to identify small molecules that pr

168 e, it is often a challenge in small molecule phenotypic screening to infer the causality between a pa

169 lian cells has provided the means to perform phenotypic screens to determine the functions of genes.

170 jected to a battery of primary and secondary phenotypic screens to identify photosynthesis-related mu

171 fication and validation, to target-based and phenotypic screens, to clinical trials.

172 ries from a high-throughput resistance-based phenotypic screen using Mycobacterium bovis BCG over-exp

173 Cell-based phenotypic screens using small molecule inhibitors is an

174 In parallel, a phenotypic screen was performed for compounds that alter

175 A high-throughput, phenotypic screen was used to identify a small molecule

176 A phenotypic screen was used to search for drug-like molec

177 Using an antisense-based phenotypic screen, we discovered the role of calpains in

178 Using an inbred mouse neuronal phenotypic screen, we find that CAST/Ei mouse adult dors

179 Using RNA-mediated genetic interference in a phenotypic screen, we identified a conserved nonmuscle m

180 From an unbiased cell-based circadian phenotypic screen, we identified KL001, a small molecule

181 Using a phenotypic screen, we identified resveratrol as an agent

182 Using a phenotypic screen, we identify a small molecule, disperg

183 Using genome-wide ENU mutagenesis and phenotypic screening, we have identified a mouse line th

184 ving random transposon mutagenesis and rapid phenotypic screening, we identified a murine cytomegalov

185 ies glycosphingolipid (GSL) synthesis, via a phenotypic screen, which previously yielded iGb(3) synth

186 Phenotypic screens, which focus on measuring and quantif

187 Herein, we have combined phenotypic screening with a biased target-specific scree

188 d from chemically induced mouse mutations by phenotypic screening with slit lamp examination.

189 es from all 80 lineages were subjected to 39 phenotypic screens, with newly arising mutations detecte

190 ation of causative mutations concurrent with phenotypic screening, without the need to outcross mutan