ライフサイエンスコーパス: phenotypic screening

1 nome-scale guide RNA libraries for unbiased, phenotypic screening.

2 ery of many new lead compounds identified by phenotypic screening.

3 tient groups defined by signs, symptoms, and phenotypic screening.

4 by classical mutagenesis techniques based on phenotypic screening.

5 Phenotypic screening against MCF7 mammary adenocarcinoma

6 mising class of antituberculosis agents from phenotypic screening against mycobacteria.

7 The phenotypic screening allowed identification of a mutant

8 monstrate the utility of this population for phenotypic screening and associated genomic characteriza

9 evelopment by random mutagenesis followed by phenotypic screening and by targeted gene disruption fol

10 ing stem cell proliferation responses with a phenotypic screening and by using specific knockdowns.

11 h available SALK T-DNA mutagenesis lines for phenotypic screening and identified two previously unrep

12 This phenotypic screening and subsequent analysis identified

13 s fully functionalized probes for integrated phenotypic screening and target identification.

14 rug target identification, drug repurposing, phenotypic screening, and side effect prediction.

15 These findings establish a genomics-based phenotypic screening approach capable of quickly connect

16 lop agents for the treatment of influenza, a phenotypic screening approach utilizing a cell protectio

17 n of the model described here as an unbiased phenotypic screening approach will help with our long te

18 as historically benefited from a whole-cell (phenotypic) screening approach to identify lead molecule

19 mutational studies, adaptive evolution, and phenotypic screening are powerful tools for creating new

20 bination of diversity-oriented synthesis and phenotypic screening as a strategy for the discovery of

21 es and random point mutagenesis, followed by phenotypic screening based on a yeast two-hybrid system.

22 al 5A (NS5A) protein have been identified by phenotypic screening campaigns using HCV subgenomic repl

23 or constructing conventional high-throughput phenotypic screening campaigns.

24 Our study demonstrates that high-throughput phenotypic screening can uncover rich genetic diversity

25 By using a combination of phenotypic screening, chemoproteomics, and biophysical s

26 f optimized MMP inhibitors that went through phenotypic screening consisting of thromboelastometry an

27 Phenotypic screening coupled with transcriptome sequenci

28 ogical processes and could be used for rapid phenotypic screening (e.g., to produce plants with super

29 These results demonstrate that phenotypic screening, followed by comprehensive MoA effo

30 ferred to as "SD70," initially identified by phenotypic screening for inhibitors of ligand and genoto

31 Phenotypic screening for resistant cultivars is however

32 Our findings underscore the benefits of phenotypic screening for targeting post-translational mo

33 Cyclotide MCoCP4 was selected by phenotypic screening from cells transformed with a mixtu

34 High-throughput cell-based phenotypic screening has become an increasingly importan

35 echanisms of actions of drugs, discovered by phenotypic screening, have been elucidated.

36 Successful optimization of a phenotypic screening hit based on a quinoline-4-carboxam

37 veloped by combining ligand-based design and phenotypic screening in an iterative manner.

38 We have conducted a phenotypic screening in endothelial cells exposed to ele

39 f the inactive E96A mutant cDNA, followed by phenotypic screening in Escherichia coli, led to isolati

40 By integrating image-based phenotypic screening in HeLa cells with high-resolution

41 age-gated K+ channel, Kat1, is combined with phenotypic screening in Saccharomyces cerevisiae and ele

42 These results demonstrate the utility of phenotypic screening in the identification of residues c

43 Phenotypic screening in zebrafish revealed that the expr

44 ed at viral or host factors and results from phenotypic screenings in cellular assay systems for vira

45 However, it is equally applicable to general phenotypic screening involving helminths and other compl

46 Phenotypic screening is a powerful method in both neglec

47 Small molecule in vivo phenotypic screening is used to identify drugs or biolog

48 ghlights recent advances and progress toward phenotypic screening methodologies over the past several

49 Here we develop high-content phenotypic screening methods for the systematic identifi

50 Phenotypic screening of a GBS transposon insertion libra

51 line has recently disclosed the results of a phenotypic screening of an internal library, publishing

52 Genotypic and phenotypic screening of C. difficile isolates revealed m

53 ion, opening new options for region-specific phenotypic screening of complex physiological phenomena

54 or develop chemical scaffolds identified by phenotypic screening of compound libraries, specific pha

55 Here, we show that phenotypic screening of drug libraries in zebrafish scn1

56 ith severe hypercholesterolemia, followed by phenotypic screening of family members.

57 of genetic materials to mammalian cells for phenotypic screening of gene expression and gene silenci

58 tes the potential for using yeast to perform phenotypic screening of genetically encoded cyclotide-ba

59 limitation in important areas, including the phenotypic screening of human genes in transgenic mice b

60 ontargeted therapies are drugs identified by phenotypic screening of natural products or chemical lib

61 lar cell-surface receptors, and we have used phenotypic screening of radiation hybrid cell lines to i

62 Phenotypic screening of representative examples against

63 By high-throughput phenotypic screening of small molecules, we identified c

64 ular cell barcoding to enable direct in vivo phenotypic screening of small-molecule libraries.

65 From the phenotypic screening of the AstraZeneca corporate compou

66 of the receptor gene in the human genome by phenotypic screening of the G3 human-hamster radiation h

67 ly precise localization might be achieved by phenotypic screening of the hybrids to facilitate positi

68 Phenotypic screening of the library identified disruptio

69 ble to infect Chinese hamster cells, we used phenotypic screening of the T31 mouse/hamster radiation

70 Phenotypic screening of U. maydis mutants deleted for ge

71 In the pursuit of new antimalarial leads, a phenotypic screening of various commercially sourced com

72 By using whole-transcriptome analyses and phenotypic screenings of the marine bacterium Phaeobacte

73 Phenotypic screening offers a powerful approach to ident

74 ased screening on pteridine reductase 1 with phenotypic screening on Trypanosoma brucei for hit ident

75 d the use of these workhorse collections for phenotypic screening or genetic mapping.

76 identification of new lead compounds include phenotypic screening or target-based approaches.

77 Large-scale phenotypic screening presents challenges and opportuniti

78 fully functionalized compound libraries into phenotypic screening programs should facilitate the disc

79 Phenotypic screening provides a means to discover small

80 Target-directed screening and whole-cell phenotypic screening represent two complementary approac

81 Cell-based phenotypic screening revealed that noncytotoxic concentr

82 Finally, comprehensive phenotypic screening showed a broader pathological pheno

83 which compounds discovered using cell-based phenotypic screening strategies might exert their effect

84 Through phenotypic screening, systems analysis, and rigorous exp

85 usually reported as G6PD "normal" by current phenotypic screening tests.

86 We recently identified a compound through phenotypic screening that blocked infectivity of this in

87 study addresses three inherent challenges in phenotypic screening: the identification of the molecula

88 rovides a compelling example of the power of phenotypic screening to identify leads engaging novel ta

89 this study demonstrates the power of in vivo phenotypic screening to identify new classes of 'cancer

90 bine fragment-based chemical proteomics with phenotypic screening to identify small molecules that pr

91 e, it is often a challenge in small molecule phenotypic screening to infer the causality between a pa

92 Using genome-wide ENU mutagenesis and phenotypic screening, we have identified a mouse line th

93 ving random transposon mutagenesis and rapid phenotypic screening, we identified a murine cytomegalov

94 Herein, we have combined phenotypic screening with a biased target-specific scree

95 d from chemically induced mouse mutations by phenotypic screening with slit lamp examination.

96 ation of causative mutations concurrent with phenotypic screening, without the need to outcross mutan