ライフサイエンスコーパス: phenotypic variation

1 Many common diseases show wide phenotypic variation.

2 werful tool for mapping loci responsible for phenotypic variation.

3 g in a net increase or decrease in heritable phenotypic variation.

4 decipher the causal link between genetic and phenotypic variation.

5 can be targeted for reactivation leading to phenotypic variation.

6 control of gene expression and its links to phenotypic variation.

7 n-restricted bacterium that exhibits limited phenotypic variation.

8 scaling with size is a fundamental aspect of phenotypic variation.

9 ng collectively between 9.8 and 14.8% of the phenotypic variation.

10 lobally produced crop with broad genetic and phenotypic variation.

11 linkage group 5, which explained 51% of the phenotypic variation.

12 s an important and understudied reservoir of phenotypic variation.

13 rter incubation times tended to show greater phenotypic variation.

14 sible for adaptive divergence and underlying phenotypic variation.

15 on variants can contribute to within-species phenotypic variation.

16 fic locus that accounts for 52% of the total phenotypic variation.

17 e formation of circRNAs and further modulate phenotypic variation.

18 enetic model greatly increased the explained phenotypic variation.

19 at specific ages accounted for 23-43% of the phenotypic variation.

20 nding how methylation variants contribute to phenotypic variation.

21 w variation in the organelle genomes affects phenotypic variation.

22 and is thought to be a major determinant of phenotypic variation.

23 transgenerational inheritance of disease and phenotypic variation.

24 uantitative trait locus of largest effect on phenotypic variation.

25 d are likely to be important contributors to phenotypic variation.

26 enetically-determined limits on the range of phenotypic variation.

27 auses of global patterns of biodiversity and phenotypic variation.

28 variants responsible for transcriptional and phenotypic variation.

29 ivergence, thereby constraining the range of phenotypic variation.

30 ntitate the molecular pathways that underlie phenotypic variation.

31 tanding how genetic variation contributes to phenotypic variation.

32 approximating an inverse power-law of random phenotypic variation.

33 ression and indicated how they contribute to phenotypic variation.

34 enriched among loci that are associated with phenotypic variation.

35 ghts into the evolutionary forces that shape phenotypic variation.

36 ation may underlie a large fraction of human phenotypic variation.

37 the genetic and molecular basis of heritable phenotypic variation.

38 gene-expression levels are a major source of phenotypic variation.

39 abbage, turnip and oilseed, display enormous phenotypic variation.

40 role in translating genotypic variation into phenotypic variation.

41 LRD on chromosome C9 explaining ~18% of the phenotypic variation.

42 portant mediator of inter- and intra-species phenotypic variation.

43 utant cells that harbour a broad spectrum of phenotypic variation.

44 binding activities, which may contribute to phenotypic variation.

45 associated with altered gene expression and phenotypic variation.

46 or identifying all genetic associations with phenotypic variation.

47 ions, totally accounting for 55.4-82% of the phenotypic variation.

48 s is also one of the essential indicators of phenotypic variation.

49 etion within 22q13, demonstrates significant phenotypic variation.

50 l conditions, range changes, and patterns of phenotypic variation.

51 uding physiological, physical, genotypic and phenotypic variations.

52 e in drug discovery to evaluate drug-induced phenotypic variations.

53 r transposons to modulate transcriptomic and phenotypic variations.

54 nding protein Piwi and mediates silencing of phenotypic variations.

55 ted traits, and explained 5.00 11.89% of the phenotypic variations.

56 We show that most of the phenotypic variation accessible through co-option would

57 The proportion of phenotypic variation accounted for by all genotyped comm

58 ness and manipulate them to generate greater phenotypic variation across groups, thereby fueling cult

59 collectively explained 44%-59% of the total phenotypic variation across maize quantitative traits, a

60 t populations has long involved the study of phenotypic variation across plant geographic ranges and

61 genomic variation in the organelle to alter phenotypic variation alone and in epistatic interaction

62 iation in reproductive success is related to phenotypic variation among colonies in behavioural and e

63 Phenotypic variation among gene knockouts in S. cerevisi

64 Theory posits that the genotypic and phenotypic variation among individuals should also be im

65 uption of certain genes alters the heritable phenotypic variation among individuals.

66 afish Danio rerio, we show that selection on phenotypic variation among intact fertile sperm within a

67 Heightened phenotypic variation among mutant animals is a well-know

68 for locating candidate mutations underlying phenotypic variations among these F. vesca accessions an

69 age at maturity in humans, explained 39% of phenotypic variation, an unexpectedly large proportion f

70 rovide a gateway for understanding bacterial phenotypic variation and adaptation.

71 iRNAs and target genes contribute to natural phenotypic variation and annotated roles and interaction

72 ens is a Gammaproteobacterium that undergoes phenotypic variation and can have both pathogenic and mu

73 importance for host survival and involved in phenotypic variation and differences in disease risk.

74 y and genetically--although the link between phenotypic variation and differences in genetic architec

75 Thus, local DNA dynamics contributes to phenotypic variation and disease in the human population

76 ctions, and systems properties that underlie phenotypic variation and disease risk in humans, model o

77 uce heritable epigenetic changes that affect phenotypic variation and disease risk in many species.

78 Although central to many studies of phenotypic variation and disease susceptibility, charact

79 ng the molecular mechanisms underlying human phenotypic variation and disease susceptibility.

80 Such modifications can bias phenotypic variation and enhance organism-environment fi

81 ially expressible phenotypes so as to retain phenotypic variation and expression.

82 Faces show elevated phenotypic variation and lower between-trait correlation

83 eral strategy (termed FABMOS) for tuning the phenotypic variation and mean expression of cell populat

84 Predation can affect both phenotypic variation and population productivity in the

85 on can modulate gene expression, and thereby phenotypic variation and susceptibility to complex disea

86 ggesting that drift alone cannot explain the phenotypic variation and that selection likely plays an

87 Diseases are, arguably, extreme phenotypic variations and are often attributable to one

88 cts on the evolution of living organisms, on phenotypic variations and on disease processes.

89 itive effect (550.4 +/- 68.0 g, 11.5% of the phenotypic variation) and a QTL at a similar position ac

90 show that many loci of small effect underlie phenotypic variation, and identify five genomic regions

91 pontin were discovered, explaining 22-59% of phenotypic variation, and indicating a regulation of phe

92 luence the transmission and the upholding of phenotypic variation, and population dynamics.

93 geneity affects key cancer pathways, driving phenotypic variation, and poses a significant challenge

94 heir target genes that contribute to natural phenotypic variation, and the underlying regulatory netw

95 na accessions underlie the plant's extensive phenotypic variation, and until now these have been inte

96 Causes of phenotypic variation are fundamental to evolutionary eco

97 change and show that these three sources of phenotypic variation are surprisingly similar in their r

98 ." It is also poorly understood whether such phenotypic variations are shaped by early specification

99 However, it remains largely unclear how phenotypic variation arises in the first place and thus

100 ed in the heterologous "backbone." To assess phenotypic variation as a result of reassortment, we exa

101 s taxes the HSP90 system, unmasking the same phenotypic variation as does direct inhibition of HSP90.

102 ion provided a unique opportunity to observe phenotypic variation as new allelic combinations arose t

103 ied are unlikely to contribute to functional phenotypic variation, as there is a significant depletio

104 elucidating disease mechanism and causes of phenotypic variation, as well as in the development of t

105 Here, we discuss patterns of phenotypic variation associated with imprinting, evidenc

106 at a similar position accounted 14.5% of the phenotypic variation at 12 weeks of age.

107 Heritability, defined as the proportion of phenotypic variation attributable to genetic variation,

108 n of novel modifiers of Min, we assessed the phenotypic variation between 27 F1 crosses between diffe

109 enetically modified mouse models has exposed phenotypic variation between investigators and instituti

110 Xenorhabdus bovienii exhibits phenotypic variation between orange-pigmented primary fo

111 berry skins were analysed in order to assess phenotypic variation between six grapevines belonging to

112 of large effect have been shown to underlie phenotypic variation between species.

113 sets can be leveraged to accurately predict phenotypic variation between strains, often with greater

114 We found significant (p < 0.05) phenotypic variation between the 27 F1 Collaborative cro

115 Random monoallelic expression can lead to phenotypic variation beyond the phenotypic variation dic

116 subspecies and harbor extensive genetic and phenotypic variation both within and between these subsp

117 in understanding the genetic architecture of phenotypic variation, but it is almost entirely focused

118 usands of genomic regions that contribute to phenotypic variation, but narrowing these regions to the

119 Genetic epilepsy is a common disorder with phenotypic variation, but the basis for the variation is

120 e likely to be involved in the modulation of phenotypic variation by LLERCPs.

121 Phenotypic variation by P. falciparum mediates the evasi

122 tic variation, transcriptional variation and phenotypic variation can be built.

123 ative trait loci (QTL) with small effects on phenotypic variation can be difficult to detect and anal

124 The resulting phenotypic variation can be triggered during development

125 Intraspecific phenotypic variation can strongly impact community and e

126 cell-to-cell variation in gene expression ('phenotypic variation') can determine a population's grow

127 Marked phenotypic variation characterizes isolates of Toxoplasm

128 t the system distribution exhibits increased phenotypic variation compared to individual component di

129 nd that a prediction model explaining 10% of phenotypic variation could have clinical utility for dec

130 sistant peanut and to evaluate genotypic and phenotypic variation, crosses were made between high ole

131 e the contribution of variability to overall phenotypic variation, current methods may miss important

132 can lead to phenotypic variation beyond the phenotypic variation dictated by genotypic variation.

133 of migration timing, suggestive of a loss of phenotypic variation due to natural selection.

134 bly of DISC1-S704C may underlie the observed phenotypic variation due to the polymorphism.

135 ontrol of cell specification lead to natural phenotypic variation during megasporogenesis.

136 ltimately gross limb morphology, to generate phenotypic variation during prenatal development.

137 ted which parameters play a critical role in phenotypic variation, enabling us to determine (using ph

138 itude of genetic effects, and proportions of phenotypic variation explained) of lipid traits across p

139 ng cell cycle, epigenetic modifications, and phenotypic variations following pharmacological treatmen

140 lain at least 26% (standard deviation 5%) of phenotypic variation for all epilepsy and 27% (standard

141 of the contribution of genetic variation to phenotypic variation for complex traits becomes increasi

142 ify the contribution of genetic variation to phenotypic variation for complex traits.

143 s 1, 2, 6, 7, and 9 and explained 55% of the phenotypic variation for Delta(13)C.

144 d 0.434 and 0.550 (both at p < 0.001) of the phenotypic variation for Fv/Fm and field survival respec

145 ommon SNPs explains only a small fraction of phenotypic variation for human complex traits and contri

146 predictive power of geographic structure and phenotypic variation for patterns of neutral genetic var

147 e relationship between genetic variation and phenotypic variation for quantitative traits is necessar

148 locus (QTL) explaining more than 70% of the phenotypic variation for the trait.

149 articularly well suited to the dissection of phenotypic variation generated by rare alleles and loci

150 ay give rise to the overwhelming majority of phenotypic variation, greatly narrowing the scope of the

151 Although phenotypic variation has been noted in the context of an

152 Zero phenotypic variation, however, is impossible, because ra

153 should have an important role in determining phenotypic variation; however, this hypothesis has not b

154 s of this model, we surveyed the genomic and phenotypic variation in 161 natural isolates.

155 bution should provide a better fit to random phenotypic variation in a large series of single-gene kn

156 ed the molecular mechanisms of graft-induced phenotypic variation in anatomy, morphology and producti

157 eoffs might be a general mechanism promoting phenotypic variation in any pathogen for which hosts var

158 eir relative timing along development shapes phenotypic variation in body size and development time.

159 (SNPs) in as many genes for association with phenotypic variation in carbon isotope discrimination, f

160 ate effects of common SNPs explain 22-46% of phenotypic variation in childhood intelligence in the th

161 Genetic association analyses of phenotypic variation in circulating white blood cell (WB

162 y account for only a small proportion of the phenotypic variation in complex traits.

163 We aimed to characterize phenotypic variation in constipated patients through hig

164 n the DBH promoter act additively to control phenotypic variation in DBH levels, and that two additio

165 Species often harbour large amounts of phenotypic variation in ecologically important traits, a

166 ur findings provide structural insights into phenotypic variation in EI due to KRT10 mutations.

167 aptation with the potential to influence the phenotypic variation in extant Native American populatio

168 resented a relatively small component of the phenotypic variation in flowering time, but were suffici

169 We examined intraspecific phenotypic variation in freeze resistance of Populus bal

170 that epigenetic effects could contribute to phenotypic variation in genetically depauperate invasive

171 It is also of interest to assess how phenotypic variation in gut microbial BTP bioconversion

172 ly recognized as an important contributor to phenotypic variation in health and disease.

173 In this article, I argue that phenotypic variation in hosts arising from environmental

174 y occurring allelic variants associated with phenotypic variation in HR.

175 ences are among the most obvious examples of phenotypic variation in humans.

176 into environmental and genetic influences on phenotypic variation in humans.

177 By identifying loci underlying phenotypic variation in intra- and interspecific crosses

178 dy outlines the major sources of genetic and phenotypic variation in iPS cells and establishes their

179 The molecular mechanisms underlying phenotypic variation in isogenic bacterial populations r

180 ed a pervasive role in shaping genotypic and phenotypic variation in modern humans.

181 Chemical mutagenesis efficiently generates phenotypic variation in otherwise homogeneous genetic ba

182 ted by Lango Allen el al. explained 7.94% of phenotypic variation in our sample.

183 Cardiovascular disease (CVD) influences phenotypic variation in Parkinson's disease (PD), and is

184 intron 1 that accounts for </= 15% of total phenotypic variation in platelet function.

185 complex I and IV activity, may explain some phenotypic variation in PMS individuals.

186 l complex activity abnormalities may explain phenotypic variation in PMS symptoms.

187 ecombinant inbred lines, we reveal extensive phenotypic variation in response to ambient temperature

188 variation that is primarily responsible for phenotypic variation in species.

189 ow these relate to geography and patterns of phenotypic variation in the genus as a whole.

190 Observed phenotypic variation in the lateral root branching densi

191 rienced by one generation can translate into phenotypic variation in the next generation.

192 ste receptor TAS2R38 explain the majority of phenotypic variation in the PROP phenotype.

193 This phenomenon is the result of phenotypic variation in the propensity of individual spo

194 e, and uterine and neonatal environments, in phenotypic variation in the response to estrogens; to di

195 om these pathways positively correlated with phenotypic variation in the S. arcanum accessions indica

196 loci together can explain as much as 20% of phenotypic variation in the surveyed population and incl

197 cause of these syndromes and the often wide phenotypic variation in their presentations will improve

198 ne craniosynostosis explained nearly all the phenotypic variation in these kindreds, with highly sign

199 allohexaploids and monitored karyotypic and phenotypic variation in this population over the first s

200 ese variants accounted for a large amount of phenotypic variation in this study.

201 riation, thus reducing the attention paid to phenotypic variation in those same diverging lineages.

202 quantitative trait (QT) loci associated with phenotypic variation in uterine growth and leukocyte inf

203 l redundancy has 'locked up' a wide range of phenotypic variation in wheat.

204 ver, it remains unknown whether they display phenotypic variations in different cortical regions.

205 es of investigations (ranging from examining phenotypic variation, in vitro enzymatic assays, and yea

206 n and that these variations predict specific phenotypic variations, in particular, nuclear size and a

207 Significant phenotypic variation including ploidy is present across

208 se variants constitute candidates underlying phenotypic variation, including tandem duplications and

209 We show that larger phenotypic variation increases connectivity among predat

210 We provide new tools to understand how phenotypic variation influences population dynamics and

211 Extensive phenotypic variation is a common feature among village c

212 g causal relationships between genotypic and phenotypic variation is a key focus of evolutionary biol

213 One such cause of phenotypic variation is a maternal effect, which is the

214 Non-genetic phenotypic variation is common in biological organisms.

215 Phenotypic variation is common in most pathogens, yet th

216 For most animals, phenotypic variation is continuous; here we explore whet

217 major questions remain unanswered: How much phenotypic variation is genetic; how much of the genetic

218 The realization that genetic and phenotypic variation is key to successful establishment

219 human genetic association studies, in which phenotypic variation is often driven by numerous variant

220 ponses are possible if selectable or plastic phenotypic variation is produced by epigenetic differenc

221 hypothetical mechanism accounting for mutant phenotypic variation is progenitor cells variably choosi

222 Phenotypic variation is ubiquitous in biology and is oft

223 NVs in horses and their subsequent impact on phenotypic variation is unknown.

224 egulation, one of the two primary sources of phenotypic variation, is challenging on a genome-wide sc

225 riation within plant genomes, its effects on phenotypic variation, its degree of dependence on genoty

226 dditional wave 3 isolates revealed that this phenotypic variation likely evolved over time rather tha

227 Constraints on phenotypic variation limit the capacity of organisms to

228 only a few species (i.e., specialists), low phenotypic variation maximizes intake rates, while the o

229 ue habitat characteristics and intraspecific phenotypic variation may allow pikas to exist in areas o

230 re of spiders, but also shaped the amount of phenotypic variation observed among individuals.

231 instability might also account for the high phenotypic variation observed in human FRAS1 patients.

232 trait encompassing some of the most visible phenotypic variation observed in humans.

233 ay contribute to the resulting generation of phenotypic variations observed in complex congenital bra

234 one levels and signaling might underlie such phenotypic variation occurring even within the same spec

235 The phenotypic variation of a given trait explained by each

236 Phenotypic plasticity describes the phenotypic variation of a trait when a genotype is expos

237 ts on gene expression are a major factor for phenotypic variation of complex traits and disease susce

238 We conclude that the phenotypic variation of regenerant plants, unlike that o

239 detected as significant contributors to the phenotypic variation of the first three traits, explaini

240 and are unlikely to explain the majority of phenotypic variations of common diseases.

241 eritance, and then quantify the influence of phenotypic variation on population dynamics.

242 de no understanding of the influence of this phenotypic variation on population dynamics.

243 Non-genetic phenotypic variations play a critical role in the adapti

244 8 expression has a nonlinear relationship to phenotypic variation, predicting levels of robustness am

245 therefore critical to quantify the degree of phenotypic variation present within populations, individ

246 main-effect QTLs (M-QTLs) with up to 42.33% phenotypic variation (PVE) and 10 epistatic QTLs (E-QTLs

247 The extent to which phenotypic variation reflects heterogeneity in disease p

248 ch are pervasive in CSSs, limit the range of phenotypic variation regardless of the extent of DNA seq

249 plotypes under selection are associated with phenotypic variations related to cardiovascular health.

250 ant structural variants (SVs) are in shaping phenotypic variation remains unclear.

251 However, its phenotypic variation remains unexplained.

252 y discovered interpersonal and intrapersonal phenotypic variations, renders the identification of BPD

253 Asymmetries may also generate phenotypic variation required for successful exploitatio

254 veral complex traits, obscuring the specific phenotypic variation responsible for community-level eff

255 ata support the hypothesis that A. fumigatus phenotypic variation significantly contributes to diseas

256 specific and that genetic effects can exceed phenotypic variation stemming from fine-scale location-b

257 an gut microbes can lead to inter-individual phenotypic variations such as digestive capacity.

258 In addition, phenotypic variation suggests that the observed polymorp

259 itional QTL mapping may help to explain more phenotypic variation than either alone, thereby uncoveri

260 ionary constraint is a bias or limitation in phenotypic variation that a biological system produces.

261 phometricity is defined as the proportion of phenotypic variation that can be explained by macroscopi

262 e, some modifiers are an important source of phenotypic variation that can elucidate how genes functi

263 First, the estimated fraction of phenotypic variation that could, in principle, be explai

264 ulation designs that will identify causes of phenotypic variation that have been hidden to date.

265 of individual components, thereby increasing phenotypic variation that selection could act on and fac

266 copies of a gene (homoeologs), and to expose phenotypic variation that was previously hidden by funct

267 ons result in ephemeral, but also heritable, phenotypic variations that are important for infection s

268 of a clonally aged population and uncovered phenotypic variations that subject the cells to natural

269 ve improved our ability to document cellular phenotypic variation, the fundamental mechanisms that ge

270 nt cooperators to elevate their potential of phenotypic variation, thereby increasing their opportuni

271 se resources is mapping the genetic basis of phenotypic variation through genome-wide association (GW

272 thought to influence the buffering of random phenotypic variation through the scale-free topology of

273 general stochastic model, that the degree of phenotypic variation, thus evolvability, escalates with

274 or model for the analysis of interindividual phenotypic variation to a genetic state space model for

275 threshold for heat avoidance and linked this phenotypic variation to a polymorphism in the neuropepti

276 We found most phenotypic variation to be quantitative and identified p

277 evolution is how organisms exhibit suitable phenotypic variation to rapidly adapt in novel selective

278 t variation in susceptibility helps maintain phenotypic variation, using experiments conducted with a

279 By linking genetic variation to phenotypic variation via environmental stress, the Hsp90

280 dual strains exhibit genotypic and potential phenotypic variation via HFMs, deletions, short sequence

281 In such a scenario, modern human genetic and phenotypic variation was primarily generated through suc

282 this tradeoff can help explain the extensive phenotypic variation we observed in field-collected path

283 going Chlamydomonas research and explain the phenotypic variation, we mapped the genetic diversity wi

284 To identify the genes driving this extensive phenotypic variation, we performed a genome-wide associa

285 identify the genes that may be driving this phenotypic variation, we profiled ER stress-induced gene

286 iation in many of these genes contributes to phenotypic variation were obtained.

287 the focal phenotype, this introduces natural phenotypic variation, which can interfere with the recog

288 This remarkable control over phenotypic variation, which cannot be easily achieved wi

289 individuals can differ in their potential of phenotypic variation, which is characterized by the numb

290 n between recombination, gene expression and phenotypic variation, which may enhance crop genetic imp

291 xplained by genotype, and the interaction of phenotypic variation with hepcidin is unknown.

292 cant QTLs explained 8.20-27.00% of the total phenotypic variation, with the LOD ranging from 3.85-12.

293 ly present genes contribute substantially to phenotypic variation within a eukaryote species, these g

294 espread and stochastic mechanism to generate phenotypic variation within a population and thereby con

295 riations are hypothesized to drive important phenotypic variation within a species.

296 Such phenotypic variation within disorders implies the existe

297 quences for understanding normal genetic and phenotypic variation within individuals, and they have s

298 adaptive diversification between species and phenotypic variation within populations.

299 Manually locating data on phenotypic variation within the approximately 270,000 av

300 le reason to believe that a lack of suitable phenotypic variation would prevent associative learning