ライフサイエンスコーパス: phenotyping

1 esting that it may be a viable candidate for phenotyping.

2 ty that were identified without posttraining phenotyping.

3 or single-molecule FRET-based conformational phenotyping.

4 llowed prospectively with extensive clinical phenotyping.

5 quantitative high-throughput plant metabolic phenotyping.

6 ing, with detailed clinical and radiological phenotyping.

7 that are not uncovered from deletion-mutant phenotyping.

8 with aggregated amylin were used for in vivo phenotyping.

9 raits are an important requirement for plant phenotyping.

10 faced by the field of metabolic network flux phenotyping.

11 LOF variants in an exome cohort by iterative phenotyping.

12 mography, respiratory cultures, and clinical phenotyping.

13 esonance imaging (MRI)-based neuroanatomical phenotyping.

14 ification (PFBC), enabling genotype-specific phenotyping.

15 gle cell with tandem multiparameter cellular phenotyping.

16 s deficiency, which is detected by long-term phenotyping.

17 sing computational methods for computational phenotyping.

18 ation in the challenging context of detailed phenotyping.

19 116 868 controls through billing code-based phenotyping.

20 enriched for ADHD (305 members with clinical phenotyping, 213 with DTI, and 193 with rsfMRI data).

21 tructive pulmonary disease, (2) inflammatory phenotyping, (3) exacerbation prediction, and (4) treatm

22 allow the identification of such extremes by phenotyping a training population of limited size and pr

23 of subgroups requires additional behavioral phenotyping, a confound to mechanistic studies.

24 The semantic features approach to tumor phenotyping, accomplished by visual assessment of radiol

25 A phenotyping algorithm mining electronic medical records

26 ture-homology based PolyPhen-2 (Polymorphism Phenotyping) analysis predicted 9 of 23 nsSNPs (K4T, E31

27 alyzing human facial abnormalities, detailed phenotyping, anatomical and molecular atlases, global an

28 XLF-deficient patients and performed immune phenotyping and antigen receptor repertoire analysis of

29 This index provides a tool for clinical phenotyping and assessment of therapeutic response for m

30 ances in imaging modalities that can improve phenotyping and contribute to the understanding of the u

31 ing Sensor (SP-IRIS) that allows multiplexed phenotyping and digital counting of various populations

32 fied and subjected to flow cytometric immune-phenotyping and functional assays.

33 Phenotyping and functional immune measurements were perf

34 Large-scale phenotyping and genome analysis further show strong indu

35 Future research will also focus on deep phenotyping and genotyping of diverse racial ancestry, g

36 ng, genetics, lifestyle measures, biological phenotyping and health records, this imaging is expected

37 fat or chow diets and subjected to metabolic phenotyping and metabolomics analysis of skeletal muscle

38 anipulations used in rodents with behavioral phenotyping and multimodal neuroimaging measures used in

39 ency of other etiologies using deep clinical phenotyping and next generation sequencing.

40 tments of organoids followed by quantitative phenotyping and phosphoprotein analyses uncover key chan

41 onents are being used for computational deep phenotyping and precision medicine as well as integratio

42 objective was to study whether simultaneous phenotyping and quantification of histamine release migh

43 Among participants in the Clinical Phenotyping and Resource Biobank (C-PROBE) study and the

44 From initial phenotyping and risk stratification to providing vital d

45 pment of high-throughput screening for plant phenotyping and the quantification of biologically or co

46 overy of new ion-channel-targeted drugs, and phenotyping and use of stem cell-derived cardiomyocytes

47 activity imaging with high-content molecular phenotyping and volume registration at cellular resoluti

48 We performed platelet phenotyping and whole-exome sequencing (WES) on all pati

49 Deep phenotyping and whole-exome sequencing in 41 probands wi

50 tions, followed by sampling, genotyping, and phenotyping, and ending in analytical methods and interp

51 t these goals, expand training in Plasmodium phenotyping, and perform large-scale field phenotyping s

52 for MTP using exome sequencing, ontological phenotyping, and similarity regression.

53 we applied whole-genome sequencing, detailed phenotyping, and statistical modeling to predict biometr

54 t years using systems approaches for disease phenotyping, applied to data ranging from the molecular

55 This new phenotyping approach provides an avenue to determine the

56 y, a culture-independent and non-destructive phenotyping approach, so called Raman Deuterium Stable I

57 al variation in human populations, metabolic phenotyping approaches are increasingly being applied to

58 Image-based phenotyping approaches enable multidimensional character

59 Robust phenotyping approaches sensitive to defects in the CTLA-

60 We developed dynamic precision phenotyping approaches using (11)C with positron emissio

61 We developed a phenotyping assay to aid drug selection based on viral t

62 In combination with improved and automated phenotyping assays and functional genomic studies, genom

63 within metabolic pathways and confirmed with phenotyping assays.

64 se observations led to increased interest in phenotyping asthma.

65 Phenomics, which ideally involves in-depth phenotyping at the whole-organism scale, may enhance our

66 ve disorders frequently appears at odds with phenotyping based on clinically-directed, macroscopic re

67 icrofluidic channel, allowing for mechanical phenotyping based on single-cell deformability.

68 sclerosis, and systemic immune and metabolic phenotyping before and 6 months after the initiation of

69 The concept of phenotyping, being the definition of disease subtypes on

70 marily on recent cluster analyses, molecular phenotyping, biomarkers, and differential responses to t

71 Patients underwent phenotyping by echocardiography and plasma N-terminal pr

72 Phenotyping by pulmonary hypertension and endothelin-1 l

73 We also demonstrate that phenotyping can be done in the F1 generation by inbreedi

74 future studies aimed at assessing whether NK phenotyping can be translated into the clinical practice

75 training datasets by this type of in silico phenotyping can lead to significant improvements in pred

76 s, we propose that image-based mitochondrial phenotyping can provide biomarkers for assessing cancer

77 seed is tracked by an identifier and, after phenotyping, can be planted, sorted, or individually sto

78 Specifically, we foresee applications in phenotyping cells within tumor microenvironments, recogn

79 (WT) and FXR knockout (KO) mice followed by phenotyping characterization as well as BA and microbiot

80 on is necessary to perform automated mechano-phenotyping (classification) of breast cancer: from onse

81 xt-generation sequencing techniques and deep-phenotyping (clinics, magnetic resonance imaging, positr

82 g the guidelines for the International Mouse Phenotyping Consortium (IMPC), whose goal is to produce

83 As part of the International Mouse Phenotyping Consortium effort to generate and phenotypic

84 ress this challenge, the International Mouse Phenotyping Consortium is creating a genome- and phenome

85 Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing lo

86 As part of the International Mouse Phenotyping Consortium, we undertook a hearing loss scre

87 recombination bins as markers along with the phenotyping data for 17 drought tolerance related traits

88 tilizing a large scale high-throughput mouse phenotyping data set from the Wellcome Trust Sanger Inst

89 Ca4 pseudomolecule with the above mentioned phenotyping data, and the candidate genes from the refin

90 ructure and high-dimensionality of metabolic phenotyping data.

91 al research frequently involves the study of phenotyping data.

92 omic, transcriptomic, proteomic and cellular phenotyping data.

93 Metabolic phenotyping demonstrated both basal metabolic rate and f

94 and lipidomics screening-e.g., for clinical phenotyping, drug screening and toxicity testing.

95 arise following the expanding worldwide root phenotyping effort.

96 on mutagenesis of the genome and large-scale phenotyping efforts.

97 Using recently developed phenotyping facilities, potted plants of a cross between

98 participants (discovery cohort) had detailed phenotyping for AMD; other eye conditions; cardiovascula

99 graphic recordings at home and had extensive phenotyping for diabetes, hypertension, metabolic syndro

100 vein traits are an important aspect of plant phenotyping for ecological and genetic research.

101 vide a powerful resource for high-throughput phenotyping for genetic and clinical research.

102 to individualize assays for tumor molecular phenotyping, given variations in the differentiation sta

103 These SNP assays, supported by accurate phenotyping, haplotype analyses and pedigree tracking in

104 ndreds of thousands of patients, large-scale phenotyping has become the bottleneck in disease phenoty

105 Phenotyping has become the rate-limiting step in using l

106 Deep phenotyping has been defined as the precise and comprehe

107 This deep phenotyping has revealed unanticipated heterogeneity of

108 atric disorders in conjunction with in-depth phenotyping holds promise for providing insights into th

109 the potential of field-based high throughput phenotyping (HTP) on a large recombinant population of r

110 in their medical history, and comprehensive phenotyping identified at least 1 new risk factor in 60

111 Detailed ocular phenotyping identified early-onset (aged </=3 years) vis

112 chemical, cell biological, and physiological phenotyping, identified the gene expression signature of

113 Machine learning in conjunction with deep phenotyping improves prediction accuracy in cardiovascul

114 Our studies demonstrate virtues of deep phenotyping in a spatially distributed organ system.

115 ging radiomics shows promise for image-based phenotyping in assessing the risk of breast cancer recur

116 wfound success, confirming the importance of phenotyping in asthma.

117 The application of metabolic phenotyping in clinical and epidemiological studies is l

118 ts underscore the importance of longitudinal phenotyping in cognitive neuroscience.

119 e Symposium entitled "Lumpers and Splitters: Phenotyping in Critical Illness," we highlight promising

120 Based on phenotyping in four environments, 11 potentially signifi

121 nimal and cellular models, longitudinal deep phenotyping in large patient cohorts, and growing intere

122 Past studies of blood T-cell phenotyping in patients with atopic dermatitis (AD) have

123 cobacterium tuberculosis drug susceptibility phenotyping in the vast majority of new and retreatment

124 Phenotyping infected cells reveals that SIV has a signif

125 We conclude that mechanical phenotyping is a powerful approach to study the mechanis

126 cting quantitative trait loci (QTL) with HTP phenotyping is as accurate and effective as traditional

127 ms are relevant to yield and efficiency, but phenotyping is challenging.

128 Clinical phenotyping is currently used to guide pharmacological t

129 onment plant growth and automated multimodal phenotyping is described.

130 armacotherapy, and the concurrently included phenotyping is essential for phenotype-specific therapy.

131 Phenotyping is important to understand plant biology, bu

132 Airway inflammatory phenotyping is increasingly applied to subjects with ast

133 Although large-scale knockout phenotyping is under progress by international collabora

134 The challenges of phenotyping, mapping quantitative trait loci (QTLs), and

135 Hp phenotyping may serve as a clinically useful tool in the

136 LC-MS-based metabolic phenotyping (metabotyping) in urine samples confirmed th

137 Using clinical phenotyping, metadata, and multimodal neuroimaging data

138 is study evaluated a comprehensive metabolic phenotyping method in breast cancer tissue that uses des

139 However, few cell wall phenotyping methodologies have proven sufficiently preci

140 ally efficient, cost-effective, and accurate phenotyping methods required to dissect the genetic arch

141 enerally, we suggest that such computational phenotyping might help characterizing deficits and refin

142 l developments at the level of cell capture, phenotyping, molecular biology, and bioinformatics promi

143 out-of-box experience for a well-established phenotyping need: imaging rosette-shaped plants.

144 e National Ophthalmic Disease Genotyping and Phenotyping Network (eyeGENE((R))) was established in an

145 Reverse phenotyping of 12 affected individuals from eight famili

146 ; (2) gene-function prediction; (3) skeletal phenotyping of 120 knockout mice with deletions of genes

147 We performed comprehensive phenotyping of 120 lymphocyte subsets by high dimensiona

148 Phenotyping of 137 unrelated deletion and reciprocal dup

149 be the systematic generation, genotyping and phenotyping of 711 iPS cell lines derived from 301 healt

150 Automated deep-phenotyping of a mutation in the master transcriptional

151 Using a combination of genetic crosses, phenotyping of a trait underlying ecological isolation,

152 Phenotyping of all patients was based on fundoscopy, spe

153 Phenotyping of Arabidopsis mutants in JA, SA, and ROS si

154 Phenotyping of AvCystatin-Mreg revealed increased expres

155 utilization of genome sequencing in clinical phenotyping of bacteria is challenging due to the lack o

156 Thus, parallel phenotyping of barcoded mutants unlocks the power of rev

157 g for scalable, integrated, high-dimensional phenotyping of both animal tissues and human clinical sa

158 in a three-generation pedigree with in-depth phenotyping of both sleep EEG and metabolic traits in 48

159 ric imaging to further improve diagnosis and phenotyping of cancer.

160 By expanding high-throughput deep phenotyping of cells beyond protein epitopes to include

161 CT lung images has been shown to improve the phenotyping of COPD by allowing for the visualization an

162 undefined, we performed a thorough skeletal phenotyping of Cpdm mice on the basis of nondecalcified

163 eloped as radiotracers for the detection and phenotyping of diseases such as cancer.

164 Metabolic phenotyping of Foxp3-expressing IL-17A(+), ex-Th17 and i

165 In a longitudinal prospective study, ex vivo phenotyping of fresh peripheral blood mononuclear cells

166 utomated image analysis can be used for fast phenotyping of functionally diverse cell populations wit

167 et function is central to the cardiovascular phenotyping of genetically modified mice.

168 in murine HSC function by a novel definitive phenotyping of HSCs.

169 phenoSeeder, which enables the handling and phenotyping of individual seeds of very different sizes.

170 satile, high-content, and scalable molecular phenotyping of intact tissues, we developed a method usi

171 ted robust methodologies for the broad-based phenotyping of knockouts through a pipeline comprising 2

172 TMPRSS2:ERG phenotyping of larger studies is required to determine c

173 High content, quantitative phenotyping of larval locomotor behaviours provides a fr

174 Additional phenotyping of male mice revealed PTSD-associated behavi

175 apse microscopic-photography allows in-depth phenotyping of microorganisms.

176 raightforward manner, opening the way to the phenotyping of molecular and mechanical aspects of shoot

177 Phylogenetic analysis and phenotyping of multiple patient isolates provides eviden

178 Phenotyping of Nbeal2-deficient neutrophils showed a sev

179 Extensive phenotyping of NK cells populations and functional tests

180 Deep phenotyping of our cohort revealed differences between t

181 ique is developed for high-throughput stress phenotyping of plants.

182 High-dimensional ex vivo phenotyping of platelet and coagulation can now power mu

183 that were recruited to the UK Genotyping and Phenotyping of Platelets (GAPP) study.

184 iation and to enable its wide application in phenotyping of pluripotent stem cells for large scale st

185 Extensive phenotyping of quantitative immune variables, sequence-b

186 of less than 20 cM through the creation and phenotyping of recombinant offspring arising from novel

187 essed in 1,059 subjects of all ages, whereas phenotyping of regulatory molecules was undertaken in 12

188 nation, thus offering a glimpse of how dense phenotyping of serological responses coupled with bioinf

189 Mechanical phenotyping of single cells is an emerging tool for cell

190 gether, these protocols and solutions enable phenotyping of subcellular components and tracing cellul

191 Detailed phenotyping of the cells expressing RORgammat, the trans

192 g of proliferative leaf tissue with in-depth phenotyping of the fourth leaf at later stages of develo

193 dies for neuromyelitis optica, allows better phenotyping of the heterogeneous inflammatory optic neur

194 act than a point mutation, it would confound phenotyping of the KI mice.

195 of genotype-phenotype associations and deep phenotyping of the movement disorders related to mitocho

196 ical, laboratory, ECG, and echocardiographic phenotyping of the study participants.

197 heterogeneous population, and a more precise phenotyping of these cells may help delineate different

198 nology facilitated concurrent generation and phenotyping of transgenic lines, allowing multiple lines

199 e has a frequency of up to 0.6%, and reverse phenotyping of unrelated families corroborates late and/

200 ughput analytical platform for the metabolic phenotyping of urine from large sample cohorts.

201 the HIV(RNA/Gag) assay also allows parallel phenotyping of viral reservoirs, including reactivated l

202 To facilitate fine-scale phenotyping of whole specimens, we describe here a set o

203 mated platform suitable for large-scale deep-phenotyping of zebrafish mutant lines, which uses optica

204 Computational phenotyping offers a promising way to convert the sparse

205 ut is limited, we expect that automated seed phenotyping on a single-seed basis can contribute valuab

206 loped to conduct high-throughput large-scale phenotyping on animals, plants and humans, aiming to bri

207 ddition, we evaluated the effect of detailed phenotyping on these genetic associations.

208 evealing significant improvements on disease phenotyping over current computational approaches.

209 uch as analyzing drug-target interactions or phenotyping patients in personalized medicine applicatio

210 Phenotyping patients into pathophysiologically homogeneo

211 eliability and advantage of ML-enabled image-phenotyping pipeline by identifying previously reported

212 A machine learning (ML)-enabled image-phenotyping pipeline for the genetic studies of abiotic

213 R/Cas9-based high-throughput mutagenesis and phenotyping pipeline in zebrafish.

214 strates a promising path for integrating the phenotyping pipeline into genomic prediction, and provid

215 netic knockouts generated using standardized phenotyping pipelines and new statistical analyses aimed

216 Overall, the Bellwether Phenotyping Platform and PlantCV software detected signi

217 Development of a phenotyping platform capable of noninvasive biochemical

218 Here, the Bellwether Phenotyping Platform for controlled-environment plant gr

219 d self-propelled field-based high-throughput phenotyping platform for tall dense canopy crops, such a

220 Using a standardized phenotyping platform that incorporates high-resolution 3

221 The automated phenotyping platform WIWAM was used to impose stress ear

222 field-grown material using a high-resolution phenotyping platform.

223 na) accessions using PHENOPSIS, an automated phenotyping platform.

224 Even though high-throughput phenotyping platforms have been developed for controlled

225 The recent advent of in-depth immune phenotyping projects in large-scale cohorts has allowed

226 In conclusion, our longitudinal deep-phenotyping provides novel insights into how the genetic

227 s (NPs) enables rapid quantitative molecular phenotyping (QMP) of the surface of freshly excised tiss

228 utic reagent for FNAIT intervention and as a phenotyping reagent to identify women at risk for immuni

229 evelop a comprehensive visually-aided morpho-phenotyping recognition (VAMPIRE) tool to analyze irregu

230 nce of pathogenic variants through extensive phenotyping, reduce discordances in public databases of

231 n for most diseases; their selection through phenotyping reinforced with molecular strategies offers

232 From the Clinical Phenotyping Resource and Biobank Core (CPROBE) cohort of

233 Toxicodynamic phenotyping revealed an effect of PERC on bodyweight los

234 Phenotyping revealed differences in flagellum structure,

235 Additionally, deep phenotyping revealed overlapping behavioral problems (AS

236 diography, with emphasis on their role in HF phenotyping, risk stratification, and optimizing clinica

237 udy demonstrates the utility of periostin in phenotyping severe asthma.

238 Blood phenotyping shows only TH2 skewing in patients with earl

239 mework sets the foundation for computational phenotyping strategies to pre-screen large populations f

240 crofluidic neutrophil sorting and functional phenotyping strategy for type 2 diabetes mellitus (T2DM)

241 m phenotyping, and perform large-scale field phenotyping studies in order to prioritize blood stage v

242 rein is fit-for-use in large scale metabolic phenotyping studies, challenging the assertion that such

243 ere evaluated by use of the same recombinant phenotyping system and extensive assay replicates in two

244 Although new developments in phenotyping techniques are exciting, we are limited by t

245 g few selected components is key to targeted phenotyping techniques in systems biology.

246 y facilitated by recent developments in root phenotyping techniques.

247 shed summary statistics from high-throughput phenotyping technologies.

248 nfection), using neurological and behavioral phenotyping tests and histology.

249 systems through a broad set of standardized phenotyping tests.

250 Taking advantage of an accurate phenotyping that combined Fv/Fm and field survival, resi

251 These paralleled molecular approaches to phenotyping that developed an understanding that not all

252 We thus formalize a clinical approach to phenotyping that is lacking in standard regression techn

253 ness of a transcriptomics-driven approach to phenotyping that segments patients who may benefit the m

254 nt Phenotiki, an affordable system for plant phenotyping that, relying on off-the-shelf parts, provid

255 imaging with late gadolinium enhancement in phenotyping the left ventricular to identify those at hi

256 Phenotyping the retinal periphery using the categories d

257 ors of metabolism, we combined deep clinical phenotyping (the comprehensive characterization of the d

258 me of brain imaging, 1.5 years after initial phenotyping, the high-BI group showed persistently eleva

259 We recruited 200 Italian T2D families phenotyping them for primary insomnia and sleep hours pe

260 However, in metabolic phenotyping, there is currently no accepted approach for

261 ematic framework enabling robust and quicker phenotyping through ground-based systems.

262 Immune phenotyping, thymic output, and telomere length were ass

263 ation of genomics, computational biology and phenotyping to characterize VIR's 147 chickpea accession

264 urce settings and for non-fluorescence based phenotyping to enable light microscopic imaging modaliti

265 genome-wide transcriptomics and single-cell phenotyping to explore the response kinetics to BRAF inh

266 l RNA interference and automated single-cell phenotyping to generate a large genetic interaction map

267 employed for both in vitro and in vivo tumor phenotyping to identify the tumorigenicity of the CCSCs.

268 monstrating the potential of radiomics-based phenotyping to improve the stratification and response a

269 We used high-throughput phenotyping to investigate morphological, fitness, and g

270 ing a multipronged approach to plant disease phenotyping to more fully understand the roles of T3Es i

271 fore necessitate the use of high-dimensional phenotyping to open new possibilities for better clinica

272 ncing approach, together with neutralization phenotyping, to investigate the rate and complexity of e

273 ferentiated human counterparts using defined phenotyping, to make sure the cells are relevant and com

274 Through extensive phenotyping together with exon capture array and targete

275 exosomes as a potential multiprotein marker phenotyping tool that could be useful in breast cancer d

276 ture, including neural connectivity and cell phenotyping tools and neural recording and imaging tools

277 by a lack of physiological understanding and phenotyping tools.

278 formed with objective, holistic craniofacial phenotyping using dense surface models of the face and h

279 that cannot be readily identified by classic phenotyping, using 25 mul of blood.

280 Here, we describe a platform for phenotyping variant libraries in transfectable mammalian

281 This work also highlights the importance of phenotyping versus genotyping when a strong inhibitor su

282 Toxicodynamic phenotyping was also performed.

283 Cell phenotyping was conducted immediately prior to transplan

284 Adaptive trait phenotyping was coupled with FST outlier tests and slidi

285 In a novel approach to phenotyping, we have utilized audio recordings and cogni

286 d metabolomics, genetics, and detailed human phenotyping, we identified dimethylguanidino valeric aci

287 enomics, systems genetics, and digestibility phenotyping, we propose target haplotypes for fine-tunin

288 e behavioral, neuroanatomical, and molecular phenotyping, we provide multiple lines of functional evi

289 xpansion, sufficient tetramer(+) T cells for phenotyping were detected in 83% of Art v 125-36 -reacti

290 dividual plants can be determined via direct phenotyping, which has a time and labour cost.

291 Biedl syndrome had undergone detailed ocular phenotyping, which included fundus examination, Goldmann

292 for smartphones in large-scale computational phenotyping, which is a goal for computational psychiatr

293 chieved an overall improvement in eye colour phenotyping, which provides a better separation of manua

294 Image-based phenotyping, which represents quantification of the tumo

295 itable cell control and simultaneous voltage phenotyping, which should enable applications in bioscie

296 AMS and BSS, we performed extensive clinical phenotyping, whole exome and candidate gene sequencing,

297 with asthma necessitating Step 2 treatment, phenotyping with aeroallergen sensitization and blood eo

298 s illustrate the power of combining in-depth phenotyping with transcriptomics in mapping populations

299 accessions was evaluated using an end-to-end phenotyping workflow.

300 PCR, whole muscle cell patch clamp, motility phenotyping (Worminator), and dsRNA for RNAi for functio