ライフサイエンスコーパス: phenoxy

1 1, 4-naphthoquinones and 2,3-bis(substituted phenoxy)-1, 4-naphthoquinones may suggest an approach fo

2 1a, N2O2(red) = N,N'-bis(3,5-di-tert-butyl-2-phenoxy)-1,2-phenylenediamide, L = THF) was explored wit

3 ibrary of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives was initially deve

4 ure-activity relationships for a series of 3-phenoxy-1,4-diarylazetidin-2-ones were investigated, lea

5 A small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquino

6 luding trans-4-(3-hydroxy-4-methoxyphenyl)-3-phenoxy-1-(3,4,5-trimethoxyphenyl)azetidin- 2-one (78b)

7 78b) and trans-4-(3-amino-4-methoxyphenyl)-3-phenoxy-1-(3,4,5-trimethoxyphenyl)azetidin-2- one (90b).

8 The 15(R)-16-phenoxy-17,18, 19,20-tetranor-LXA4 methyl ester (15-epi-

9 aspirin triggered 15-epi-LXA4, and 15(S)-16-phenoxy-17,18,19,20-tetranor-LXA4 methyl ester (16-pheno

10 alpha(1E,3S*), 4alpha]-7-[3[(3-hydroxy-4-(4'-phenoxy)-1butenyl)-7-oxabicycl o-[2.2.1]heptan-2-yl]-5-h

11 fonyl) benzamide), 931126 (2; 4-oxo-4-{2-[(5-phenoxy-1H-indol-2-yl)carbonyl]hydrazino}-N-(4-phenylbut

12 is, and structure-activity relationship of 1-phenoxy-2-aminoindanes as inhibitors of the Na(+)/H(+) e

13 Aligning 1-phenoxy-2-aminoindanes onto the X-ray structure of 13d t

14 , 4-(4-methylphenoxy)-2-butyn-1-amine, and 4-phenoxy-2-butyn-1-amine.

15 diphenoxy-2-lambda(5)-phosphaquinolines or 2-phenoxy-2-lambda(5)-phosphaquinolin-2-ones under transit

16 Two diastereomeric 5-bromo-4-phenyl-2-phenoxy-2-oxo-1,3,2-dioxophosphepanes have been synthesi

17 used to study the contraction of 4-phenyl-2-phenoxy-2-oxo-1,3,2-dioxophosphorinan-5-yl radicals.

18 [(3,5-disubstituted anilino)carbonyl]methyl] phenoxy] -2-methylproprionic acid derivative (RSR13), du

19 en ([6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-2-(4-hydroxyphenyl)]b enzo[b]thiophene hydrochl

20 e ([6-hydroxy-3-[4-[2-(1-piperidinyl)-ethoxy]phenoxy]-2-(4-methoxyphenyl)]be nzo[b]thiophene) is a se

21 1-[4-[[(3, 5-dimethylanilino)carbonyl]methyl]phenoxy]-2-methylcyclopentane carbox ylic acid (11), exh

22 f 2,4-[[(3,5-dimethylanilino)carbonyl]methyl]phenoxy]-2-methylpropionic acid (RSR13, efaproxiral) 100

23 2-[4-[[(3,5-dimethylanilino) carbonyl]methyl]phenoxy]-2-methylpropionic acid, a synthetic allosteric

24 (2-[4-[[3,5-dimethylanilino) carbonyl]methyl]phenoxy]-2-methylproprionic acid) intravenously before o

25 [4-(1-methyl-4-trifluoromethyl -2-imidazolyl)phenoxy]-2-propanol dihydrochloride (CGP-20712A) prevent

26 [4-(1-methyl-4-trifluoromethy l-2-imidazolyl)phenoxy]-2-propanol], which showed no agonistic activity

27 [4-(1-methyl-4-trifluormet hyl-2-imidazolyl)-phenoxy]-2-propanolmethanesulfonate (CGP20712A), betaxol

28 [4-(1-methyl-4-trifluormet hyl-2-imidazolyl)-phenoxy]-2-propanolmethanesulphonate (CGP 20712A) and at

29 methy l)phenyl]-1,3-thiazol-5-yl}methyl)thio]phenoxy}-2-methylpropanoic acid (1), a potent PPARpan ag

30 A series of 2-phenoxy-3-phenylpropanoic acids has been prepared which

31 udies on the acyclic analog 8 provided the 2-phenoxy-3-pyridylurea analog 18 with improved antiischem

32 pulcherosine (5-[4"-(2-carboxy-2-aminoethyl)phenoxy]3, 3'-dityrosine) by high resolution NMR spectro

33 covery of (R)-4-[2-cyano-5-(3-pyridylmethoxy)phenoxy]-4-(2-methylphenyl)b utanoi c acid (12m).

34 derivatives of 3, 2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine (4) and 2-(2-(dimethylaminome

35 [methyl-(11)C]N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine) is a recently developed radiolig

36 [methyl-(11)C]N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine)) ( approximately 1.2).

37 carboxylic group readily splits off from the phenoxy-acetate radical anion to give carbon dioxide.

38 hylphenyl)-1,3-thiazol-5-yl)-methylsulfany l)phenoxy-acetic acid (GW501516)] and RA.

39 (3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy] acetic acid sodium hydrate) or SR 59,230 (3-(2-

40 hyl)phenyl]-1,3-thiazol-5-yl]methylsu lfanyl]phenoxy]acetic acid), significantly reduced ischemia-ind

41 methyl-thiazol-5-ylmethylsulfanyl]-2-m ethyl-phenoxy}-acetic acid (GW0742)-induced up-regulation of A

42 Phenoxy acid herbicides are important groundwater contam

43 als of environmental concern--including some phenoxy acid herbicides, organophosphorus insecticides,

44 segment) and 1,10-bis[p-(benzylammoniomethyl)phenoxy]alkane bis(hexafluorophosphate)s (AyA, y = numbe

45 ated Wang linker derivative ((4-bromomethyl)-phenoxy-allyl acetate) (6) to give after ester hydrolysi

46 noic acid (rac-9), is formed by closure of a phenoxy-allyloxy intermediate 17 collapsing to a cyclopr

47 mpound bearing a N,N-bis(3,5-di-tert-butyl-2-phenoxy)amide ligand is reported.

48 cysteines of peptides couple covalently with phenoxy amino squarate moieties presented on self-assemb

49 ch tautomerism, were equal in potency to the phenoxy analogues and demonstrated selectivity for the l

50 A series of amino and phenoxy analogues have been synthesized, and although th

51 and that a trans configuration between the 3-phenoxy and 4-phenyl rings is generally optimal.

52 supported by terphenyl ligands appended with phenoxy and imine donors were synthesized.

53 c) ketones within the HS to form initially a phenoxy and ketyl radical.

54 roduct consistent with the cross-reaction of phenoxy and naphthoxy radicals.

55 ubsequent SAR studies have revealed that the phenoxy and phenylsulfanyl analogues of 6c, 3-(1-carboxy

56 his system hydrogenates functionalized alpha-phenoxy and related amides at room temperature under 4 a

57 g., methyl, hydroxy, amino, methoxy, phenyl, phenoxy) and electron withdrawing (e.g., fluorine, chlor

58 results suggested the presence of methoxyl, phenoxy, and substituted phenoxy radicals as precursors

59 2-(3,5-dimethylphenyl)pyrrolidin-1-yl)methyl)phenoxy)benzami de], JSPA071B [(S)-3-fluoro-4-(4-((2-(3,

60 4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide], and naloxone.

61 ne ((+/-)-N-methyl-gamma-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride; FLX) are frequ

62 -((2-hydroxyethoxy)methyl)-5-(3-(substituted-phenoxy)benzyl)uracils as inhibitors of murine liver uri

63 2-hydroxy-3-propyl-4-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl) ethanone (4).

64 tigated; homologues 4-[4-(3-(trifluoromethyl)phenoxy)butyl]-1H-imidazole and 4-[2-(3-(trifluoromethyl

65 4-[4-[[(1,1-Dimethylethyl)-oxidoimino]methyl]phenoxy]butyl]triphenylphosp honium bromide (MitoPBN) pr

66 tivation of a pyrone C-Br or C-Cl bond and a phenoxy C-H bond.

67 The most potent member of the series, the 7'-phenoxy compound 14, binds to the delta site with a Ki o

68 In addition, the phenoxy compounds, which were not inhibitors of NQO1 enz

69 methoxy, ethyl, ethoxy, isopropoxy, phenyl, phenoxy, cyclohexyl, and cyclohexoxy substituents.

70 [1-[4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy]cyclopentanecarboxyli c acid] with different D-

71 ing sites in 1,10-bis[p-(benzylammoniomethyl)phenoxy]decane bis(hexafluorophosphate) (A10A) were show

72 Both inhibitors and the phenoxy derivative of 3 have activity against P. aerugin

73 All of the new phenoxy derivatives have potent in vitro antimalarial ac

74 Hence, benzyloxy, benzylamino, and phenoxy derivatives of 5-phenyl-3-isoxazolecarboxylic ac

75 value of 1.1 for the unsubstituted adduct 8-phenoxy-dG (Ph-O-dG).

76 A simple and regioselective synthesis of phenoxy esters and phenylthio esters is reported.

77 he ability of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine-HCl, an AEBS-specific ligand, to comp

78 with acetoxymethyl ester of 1,2-bis (2-amino-phenoxy) ethane N:, N:, N:, N:-tetra-acetic acid (BAPTA-

79 revented by calcium chelator 1,2-bis(2-amino phenoxy)ethane-N,N,N', N'-tetraacetic acid.

80 ne-permeant calcium chelator 1,2-bis(2-amino phenoxy)ethane-N,N,N',N'-tetraacetic acid-tetrakis (acet

81 reas the O isostere 4-[2-(3-(trifluoromethyl)phenoxy)ethyl]-1H-imidazole is an antagonist as is the S

82 rmamidine) and B-TPMF (N-{7-[1-(4-tert-butyl-phenoxy)ethyl]-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}-N'-

83 thanol,alpha-[1-[2,6-dimethoxy-4-(2-propenyl)phenoxy]ethyl]- acetate, (5) licarin C; benzofuran,2,3-d

84 ol; alpha-[1-[2,6-dimethoxy-4-(2-propen-1-yl)phenoxy]ethyl]-3,4-dimethoxy-1-acetate, (3) odoratisol A

85 N-[2-[5-methyl-3-(2-chlorophenylsulfonyloxy)phenoxy]ethyl]-N- methyl-4 -aminopyridine (1), has been

86 and CGP-20712 [1-[2-((3-carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethy l-2-

87 ptor antagonist 1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl -2-

88 compounds with carbonyl substitutions of the phenoxy group (ester, amide, or ketone moieties) demonst

89 stabilization mechanisms associated with its phenoxy group located in the membrane hydrocarbon core.

90 The para-position of the 4-phenoxy group of the thieno[2,3-c]pyridine lead is found

91 lubilizing group at the para-position of the phenoxy group to increase the aqueous solubility of this

92 assay clustered among compounds in which the phenoxy group was substituted at the 3, 4, or 5 position

93 of the 1,7 bromine atoms in the bay area by phenoxy groups, which is a generally applied reaction fo

94 eplacing all but one phenylseleno group with phenoxy groups.

95 formation is accompanied by the loss of both phenoxy groups.

96 l-5-[7-[4-[(4S)-4-methyl-1,3-oxazolidin-2-yl]phenoxy]heptyl]-1,2-oxazole (W84) and gallamine.

97 uminum phosphide and ethylene dibromide; the phenoxy herbicide (2,4,5-trichlorophenoxy)acetic acid (2

98 Likewise, phenoxy herbicides may have adverse metabolic effects in

99 -(mercaptoethyl)-6-(3-(2-(methylamino)propyl)phenoxy)hexanamide [3, (+)-METH HSMO9] and its use to pr

100 ride (6FDA) with bis[omega-[4-(4-cyanophenyl)phenoxy]hexyl] 4,4'-diamino-2,2'-biphenyldicarboxylate (

101 Azole phenoxy hydroxyureas are a new class of 5-lipoxygenase (

102 Ti(CH2SiMe3)2Me and (FI)Ti(CH2CMe3)2Me (FI = phenoxy-imine), have been synthesized and structurally c

103 same media lead to the conclusions that (1) phenoxy is less reactive overall than 1-naphthoxy toward

104 examined the effects of 15-epi-16-(p-fluoro)-phenoxy-lipoxin A(4) methyl ester, an aspirin-triggered

105 table analog of ATL, 15-epi-16-(para-fluoro)-phenoxy-lipoxin A4 analog (ATLa), inhibits neutrophil re

106 15-epi-16-(p-fluoro)phenoxy-LXA(4) (ATLa(1)) blocked the secretion of TNF-al

107 15-epi-LXA(4), a new 15-epi-16-(p-trifluoro)phenoxy-LXA(4) analog (ATLa(2)), as well as LXB(4), and

108 tion of LXA(4) analog (15-epi-16-para-fluoro-phenoxy-LXA(4), 10 microg/day) significantly reduced the

109 y-LXA4 approximately 5(S)-methyl-LXB4 >/= 16-phenoxy-LXA4 > 5(R)-methyl-LXB4.

110 ] and the omega end [15-epi-16-(para-fluoro)-phenoxy-LXA4 (ATLa2)] were recoverable to approximately

111 Neither LXA4 nor 16-phenoxy-LXA4 affected monocyte-mediated cytotoxicity.

112 rder of 15(R/S)-methyl-LXA4 > 16-para-fluoro-phenoxy-LXA4 approximately 5(S)-methyl-LXB4 >/= 16-pheno

113 15R/S-methyl-LXA4 and 16-phenoxy-LXA4 each attenuated (IC50 approximately 10 nM)

114 d 15-epi-LXA4 were equal in activity, and 16-phenoxy-LXA4 was more potent than native LXA4.

115 Both 15(R/S)-methyl-LXA4 and 16-phenoxy-LXA4 were approximately 1 log molar more potent

116 y-17,18,19,20-tetranor-LXA4 methyl ester (16-phenoxy-LXA4) were each as potent as equimolar applicati

117 19,20-tetranor-LXA4 methyl ester (15-epi-16-phenoxy-LXA4), an analogue of aspirin triggered 15-epi-L

118 0.05) cells/100 micron length of venule (16-phenoxy-LXA4-Me, 15-cyclohexyl-LXA4-Me, and 15-R/S- meth

119 t stable lipoxin A4 (LXA4) analogs (i.e., 16-phenoxy-LXA4-Me, 15-cyclohexyl-LXA4-Me, and 15-R/S-methy

120 as (3S,4R)-3 contains a [3,4-(methylenedioxy)phenoxy]methyl group.

121 )-4-(4-Fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl] piperidine [(3S,9R)-3, paroxetine] is a

122 fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-3 ,5-dimethyl-pyridine) and studied test

123 f 3-(4-fluorophenyl)-2-[[3,4-(methylenedioxy)phenoxy]methyl]nortropane+ ++ (4).

124 ,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy)methylphosphonic acid (MB07344), which distribut

125 IPY dyes bearing alkoxy or nonfunctionalized phenoxy moieties are characterized by a highly efficient

126 3-(dimethylamino)propoxy)benzo[d]oxazol-2-yl)phenoxy]-N,N-dimethylpropa n-1-amine} and E6446 {6-[3-(p

127 agonist naltrindole (1) possessing a phenyl, phenoxy, or benzyloxy group at the 4'-, 5'-, 6'-, or - 7

128 ation of an alpha-chloroaldehyde or an alpha-phenoxy- or alpha-acetoxy ketone with a substituted benz

129 een an acetate methyl group deuteron and the phenoxy oxygen of YZ*.

130 Topical application with the 15-epi-16-phenoxy-para-fluoro-LXA(4) stable analog (ATLa) dramatic

131 ed of three covalently linked 1,6,7,12-tetra(phenoxy)perylene-3,4:9,10-bis(dicarboximide) (PDI) units

132 gamma/delta agonist (R)-3-{4-[3-(4-chloro-2-phenoxy-phenoxy)-butoxy]-2-ethyl-phenyl}-propionic acid

133 5-(1H-Indol-5-yl)-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazole (antibiotic 75b) was ef

134 (HA 966, 15 mg/kg), 7-chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(H)-quinolinone) (L-701,324, 40 mg/kg),

135 methyl 2-(4-{4-[(2-thiiranylpropyl)sulfonyl]phenoxy}phenyl)acetate (3) and 2-(4-{4-[(2-thiiranylprop

136 (3) and 2-(4-{4-[(2-thiiranylpropyl)sulfonyl]phenoxy}phenyl)acetic acid (4), and show that compound 3

137 1,2,4]triazine (RTI-4229-707), 5-methyl-3-(4-phenoxy-phenylethynyl-[1,2,4]triazine (RTI-4229-766), an

138 paB ligand, and by 4-[4-(methanesulfonamido) phenoxy] phenylsulfonyl methylthiirane, an MT1-MMP inhib

139 he structural modification of the tert-butyl phenoxy portion of lead compound 1 and the subsequent di

140 eners were a l-aspartic acid diisoamyl ester phenoxy prodrug and a l-phenylalanine propyl ester phosp

141 The ortho-alkylated derivatives of phenoxy products possessing the ester functionality unde

142 xo-4,5-dihydro-1H-1,2,4-triazol-3- yl]propyl}phenoxy)propanoic acid (LY518674).

143 2-(4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469) is among the most highly

144 he 7-position of a 2-(4-[(2-quinoxalinyl)oxy]phenoxy)propionic acid, generated the most highly and br

145 sult, (2R)-7-(3-[2-chloro-4-(4-fluorophenoxy)phenoxy]propoxy)-2-ethylchromane-2- carboxylic acid (48)

146 -2-amine (R-like)] related to riluzole and a phenoxy-propranol-amine moiety [(RS)-1-(3,4-difluorophen

147 to the local anesthetic receptor through its phenoxy-propranol-amine moiety, with consequent use-depe

148 n of N-(3-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)propyl) 3-(5-hydroxy-1,4-dihydro-1,4-dioxonaphth

149 em seems optimal and an N(2)-(3-(substituted-phenoxy)propyl) moiety results in high affinity, (c) tha

150 = 0.54 mg/kg) and 4-[3-[4-(trifluoromethyl)-phenoxy]propyl]-1H-imidazole (10c, UCL 1409; Ki = 14 nM,

151 SC-57461A (8d, 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid) are described.

152 mor effect of a novel 30-compound library of phenoxy pyridine and phenyl sulfanyl pyridine derivative

153 -(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)-pyridine-2-carboxyllic acid methyamide-4-methyl

154 butyl-[1,4]diazepane-1-carbonyl)-4-(3-fluoro-phenoxy)-pyrrolidin-1-y l]-ethanone, a hydroxyproline-ba

155 ved transient (150 ns) that we assign to the phenoxy radical and a shorter-lived (3-20 ns) transient

156 For almost 100 years, phenoxy radical coupling has been known to proceed in na

157 oxidant, effects stereoselective bimolecular phenoxy radical coupling in vitro.

158 irigent proteins impart stereoselectivity to phenoxy radical coupling reactions in plants and, thus,

159 regio- and stereospecificity of bimolecular phenoxy radical coupling reactions, of especial importan

160 These results suggest that bimolecular phenoxy radical couplings in nature can be catalyzed by

161 protein dimers, suggesting that the ROIs are phenoxy radical derivatives of the amino acid tyrosine (

162 mechanism involving generation of a reactive phenoxy radical intermediate by an electron transfer pro

163 the escape of the one-electron product, the phenoxy radical leading to polymeric products.

164 selected geometry parameters, and charge on phenoxy radical oxygen q(O).

165 Because O2(-)/phenoxy radical reactions can lead to more highly oxidiz

166 let photoelectron spectroscopy bands for the phenoxy radical to generate the phenyloxenium ion 1.

167 ereoselective and regiospecific control over phenoxy radical-radical coupling appears to have evolved

168 How stereoselective monolignol-derived phenoxy radical-radical coupling reactions are different

169 Control over phenoxy radical-radical coupling reactions in vivo in va

170 enido dinickel(II) adduct upon addition of a phenoxy radical.

171 vant since recent studies have revealed that phenoxy radicals and electrophilic quinones, specificall

172 esence of methoxyl, phenoxy, and substituted phenoxy radicals as precursors for formation of major pr

173 hemistry of CDOM, we suggest that coproduced phenoxy radicals could represent a viable oxidative sink

174 itically important for oxidative coupling of phenoxy radicals to form polymers.

175 The resulting phenoxy radicals undergo 1,5- and 1,6-hydrogen shifts in

176 The methoxy-substituted phenoxy radicals undergo a complex series of reactions,

177 nt of one of the two o-methoxy groups at the phenoxy residue of the potent, but not subtype-selective

178 luoroalkyl substituents at position 2 of the phenoxy ring 1-4 were synthesized.

179 The impact of substitution on the phenoxy ring and on the nitrogen atom at the 4-position

180 Replacement of the phenoxy ring in 1 with either simple aliphatic or cycloa

181 ulations also highlight the ability of the 8-phenoxy substituent to lower N(7) basicity and predict a

182 However, those with hydroxy and phenoxy substituents were poor inhibitors of NQO1 enzyme

183 We report here the synthesis of 7-phenoxy-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazin

184 hip (SAR) studies demonstrated that (i) meta-phenoxy substitution of the N-1-benzyl group is importan

185 Importantly, electron-poor phenoxy substrates also worked well.

186 icient Rh(III)-catalyzed ortho-alkylation of phenoxy substrates with diazo compounds has been achieve

187 the characteristic ortho heterodisubstituted phenoxy substructure of 1, the S enantiomer of the dihyd

188 Synthesis of such compounds with a phenoxy tether using the 4-hydroxybenzimidazole 11 was p

189 afforded N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfona mide (PF-

190 ed at the meta- and ortho-positions of the 4-phenoxy to retain a good in vitro potency.

191 isodityrosine (3-[4'-(2-carboxy-2-aminoethyl)phenoxy]tyrosine), a non-fluorescent product of L-tyrosi