ライフサイエンスコーパス: phenoxyl radical

1 ic cleavage of the alcohol OH group from the phenoxyl radical.

2 TBP to give [Cu(II)2(UN-O(-))(OH)](2+) and a phenoxyl radical.

3 on of OR with NADP+ prior to the exposure to phenoxyl radicals.

4 The phenoxyl radical 1 was generated in high yields by flash

5 Similarly, the phenoxyl radical 2,4,6-tBu3C6H2O* and excess TEMPO* each

6 full characterization of the 4-(nitrophenyl)phenoxyl radical, 2,6-di-(t)butyl-4-(4'-nitrophenyl) phe

7 h in competition with beta-scission to yield phenoxyl radical and acetophenone.

8 lable and crystallographically characterized phenoxyl radical and is the only example in which the pa

9 lving a sigma lone pair on the oxygen of the phenoxyl radical and the O-H bond of phenol.

10 emarkably augmented EPR-detectable etoposide phenoxyl radicals and enhanced etoposide-induced topoiso

11 nce of H2O2 and GSH caused the generation of phenoxyl radicals and GS* radicals, of which only the la

12 dium azide, suggesting the potential role of phenoxyl radicals and/or their derivatives.

13 )), i.e., the first 1H(+)/1e(-) (catechol--> phenoxyl radical) and the second 1H(+)/1e(-) (phenoxyl r

14 The anisotropic coupling tensors of the phenoxyl radical are resolved in the photoinduced D-band

15 Phenoxyl radicals are intermediates of one-electron oxid

16 Phenoxyl radicals are readily reduced by thiols, ascorba

17 nisms involving the evolution of the primary phenoxyl radical ArO are proposed to rationalise these e

18 hypothesis that HRP can be inactivated by a phenoxyl radical attack.

19 (GSH) to eliminate EPR-detectable etoposide phenoxyl radicals, (b) the ability of etoposide phenoxyl

20 contrast, when ascorbic acid reduced the DCF phenoxyl radical back to its parent molecule, it formed

21 neration of reactive intermediates, possibly phenoxyl radicals but not H2O2, is responsible for the E

22 lving the reduction of the resorufin-derived phenoxyl radical by the drugs' hydroquinone moiety back

23 Reduction of the phenoxyl radical by the quencher radical was examined as

24 Phenoxyl radical (C(6)H(5)O) was prepared photochemicall

25 mpartments from which APEX2-generated biotin-phenoxyl radicals cannot escape.

26 d II with the obligate generation of the DCF phenoxyl radical (DCF(.)).

27 Birch) reduction/protonation/reoxidation (by phenoxyl radical)/deprotonation cycle.

28 chromane, a hindered phenolic compound whose phenoxyl radicals do not oxidize endogenous thiols, effe

29 We hypothesize that etoposide phenoxyl radicals (etoposide-O(.)) formed from etoposide

30 essions were determined for beta-scission of phenoxyl radical from 1-phenyl-2-phenoxyethanol-1-yl, Ph

31 henoxyl radical) and the second 1H(+)/1e(-) (phenoxyl radical--> quinone) free radical scavenging mec

32 as increase of the quinoid character of the phenoxyl radical in polar media.

33 -tyrosine cross-link to the stability of the phenoxyl radical in the enzyme, while highlighting the i

34 ectrochemical oxidations in each case is the phenoxyl radical in which the phenolic proton has transf

35 nce for MPO-dependent formation of etoposide phenoxyl radicals in growth factor-mobilized CD34(+) cel

36 AT, a second molar equiv of 2 couples to the phenoxyl radical initially formed, giving a Cu(II)-OO-(A

37 by phenolic toxins following metabolism into phenoxyl radical intermediates.

38 lectron oxidation of etoposide by MPO to its phenoxyl radical is important for converting this antica

39 e-electron oxidation products of phenol, its phenoxyl radicals, is involved in the oxidative effects.

40 Subsequently, AOH(*) reduces the phenoxyl radical (kET = 5.5 x 10(9) M(-1) s(-1)), formin

41 This value is higher than related isolated phenoxyl radicals, making this a useful reagent for hydr

42 lic compounds resulting in the generation of phenoxyl radicals may be an important contributor to the

43 uces Fe(IV) horizontal lineO, Cu(II)-OH, and phenoxyl radical moieties, analogous to the chemistry ca

44 MPO-catalyzed production of etoposide phenoxyl radicals observed directly in HL-60 cells by el

45 The results indicate that phenoxyl radical of 2,2,5,7,8-pentamethyl-6-hydroxychrom

46 NADPH quenched directly the EPR signal of phenoxyl radical of a phenolic antitumor drug, etoposide

47 OR catalyzed quenching of EPR signal of the phenoxyl radical of a vitamin E homolog, 2,2,5,7,8-penta

48 approximately 500 nm, which we assign to the phenoxyl radical of compound 1.

49 Previous studies demonstrated that the phenoxyl radical of etoposide can be produced by action

50 by EPR spectroscopy and equilibrated with a phenoxyl radical of known stability in order to determin

51 tes lead to generation of kinetically stable phenoxyl radical of the incarcerated 4-hydroxy-diphenyla

52 Phenoxyl radicals of etoposide did not inactivate the OR

53 radicals with higher redox potential, e.g., phenoxyl radicals of etoposide, oxidize NADPH directly.

54 Phenoxyl radicals of phenol can also inactivate OR likel

55 d with DTNB was protected from inhibition by phenoxyl radicals of phenol.

56 R was inhibited irreversibly when exposed to phenoxyl radicals of phenol.

57 ), for (i) benzyl radical plus toluene, (ii) phenoxyl radical plus phenol, and (iii) methoxyl radical

58 troxide and thiyl radicals generated through phenoxyl radical recycling by peroxidase.

59 ein-derived (tyrosyl) radicals and etoposide phenoxyl radicals, respectively, we established that car

60 e of the dimer, the first for a para-coupled phenoxyl radical, revealed a bond length of 1.6055(23) A

61 radical, 2,6-di-(t)butyl-4-(4'-nitrophenyl) phenoxyl radical ((t)Bu2NPArO(*)) is described.

62 tin-phenol substrate, APEX2 generates biotin-phenoxyl radicals that covalently tag proximal endogenou

63 nd protonated products and the corresponding phenoxyl radicals to form.

64 noxyl radicals, (b) the ability of etoposide phenoxyl radicals to oxidize GSH and protein thiols (aft

65 ar redox reaction of the cyclohexadienyl and phenoxyl radicals to yield a carbocation/phenoxide pair,

66 adish peroxidase (HRP) can be inactivated by phenoxyl radicals upon reaction with H(2)O(2)/phenol, we

67 d, detected significant perturbations of the phenoxyl radical vibrational bands.

68 LYP/cc-pVTZ) led to a detailed assignment of phenoxyl radical vibrations.

69 rO-C bond homolysis to give para-substituted phenoxyl radicals, which can be observed directly in las

70 lic moiety with reactive radicals yields its phenoxyl radical, whose reactivity may determine the pro

71 utyl phenol is oxidized to the corresponding phenoxyl radical with a second-order rate constant of 0.

72 tributed to the coupling between a liberated phenoxyl radical with an iron-ligated phenolic coupling

73 adical scavenging and/or by MPO results in a phenoxyl radical with low reactivity toward lipids, its

74 Phenoxyl radicals with higher redox potential, e.g., phe

75 This report describes reactions of phenoxyl radicals with human NADPH-cytochrome P-450 oxid