ライフサイエンスコーパス: phenyl group

1 o a diradical intermediate stabilized by the phenyl group.

2 erocycles, which can be either a methyl or a phenyl group.

3 s is attached to the para position of the 20-phenyl group.

4 ue to a conformational change of the pendant phenyl group.

5 orm the related o-benzyne through shift of a phenyl group.

6 aches the diene in an exo fashion syn to the phenyl group.

7 her remote from the 4'-position on the 3beta-phenyl group.

8 stability to the cyclopropenylium core as a phenyl group.

9 rporate a 4-hydroxy substituent on the omega-phenyl group.

10 r-95' are responsible for the binding of the phenyl group.

11 ctures, e.g., the two ester groups and the 6-phenyl group.

12 adentate pyridinophane ligand containing one phenyl group.

13 nd possible hydrophobic association with the phenyl group.

14 atoms in the 3'- or 4'-position of the free phenyl group.

15 functionalizing the alpha-methyl over alpha-phenyl group.

16 ls 0 and 2) between the amide moiety and the phenyl group.

17 between the carbonyl oxygen and the flanking phenyl group.

18 r rotors bearing three, five, six, and seven phenyl groups.

19 with high regiocontrol on the ferrocenyl and phenyl groups.

20 op in SFG signal is also observed for the PS phenyl groups.

21 s oriented s-trans to both the isopropyl and phenyl groups.

22 e porphyrin; the other meso-substituents are phenyl groups.

23 t this is due to the basic properties of the phenyl groups.

24 to the ortho-positions of both adjacent meso-phenyl groups.

25 a dimethyl amino or one of seven substituted phenyl groups.

26 yl groups could bias the conformation of the phenyl groups.

27 FMN plus one phenyl group, and FMN plus two phenyl groups.

28 ural isomers which differ in the position of phenyl groups.

29 by proper substitution of its benzamido and phenyl groups.

30 -substituted with meta- and para-derivatized phenyl groups [(1S)-substituted 1, 4-dideoxy-1,4-imino-D

31 The introduction of a methyl (2b) or phenyl group (2c) on the 2'-position of 4'-imidazolyl ri

32 s are displaced along their long axes by one phenyl group (~4.3 A).

33 bon next to the carbene center is a nonbulky phenyl group, a variety of substitution patterns should

34 The addition of phenyl groups about the fulvene raised the reduction pot

35 ar the S1' subsite; substitutions off of the phenyl group accessed S1' and other distant binding regi

36 ic substitution of the ortho-position of the phenyl group adjacent to the oxime, forming a quinoline

37 group is cation-stabilizing relative to the phenyl group, albeit the 1,5 triazole is significantly d

38 imal and that a p-hydroxyl group on the N(1)-phenyl group also enhances affinity and selectivity for

39 udied all have a weaker coupling between the phenyl group and a much weaker dependence of the molecul

40 -seven 2-phenylquinolines substituted at the phenyl group and C4 of the quinoline were synthesized an

41 N-acetyl-(d)-glucosamine bearing a 4-methoxy phenyl group and different amino acid esters on the phos

42 idine, metalation was initiated alpha to the phenyl group and led finally to a fused tricyclic adduct

43 Alterations of the phenyl group and of the oxalamide linker indicated that

44 t exclusively in a conformation in which the phenyl group and silicon atom are anti and the side chai

45 g in the axial or equatorial location of the phenyl group and the angle of rotation about the Si-CPh

46 nd the length of the alkyl chain between the phenyl group and the piperazine ring influenced binding

47 se from hydrophobic interactions between the phenyl group and the purine/pyrimidine site.

48 has a two methylene linker between the 3beta-phenyl group and the remote phenyl group, has an IC(50)

49 group, amplification of SERS signals by the phenyl group and thus shielding of the background noise

50 lity appended with a 3,5-bis(trifluoromethyl)phenyl group and was able to mediate transmembrane chlor

51 t pharmacophore groups, including phenol and phenyl groups and a hydrophobic moiety.

52 kephalin contains the interesting motions of phenyl groups and of side chains relative to the backbon

53 nificantly, we find that the presence of the phenyl groups and the NO ligand leads to substantial mix

54 r chiral recognition compared to that with a phenyl group, and an anion with an isobutyl group has th

55 eric compounds corresponding to FMN plus one phenyl group, and FMN plus two phenyl groups.

56 ows exclusive bond insertion to the adjacent phenyl group, and no evidence of Wolff rearrangement.

57 tion fragment resulting from the loss of the phenyl group, and this ion is not observed in the invers

58 CF(3), 4-OCF(3), 4-SO(2)Me, and 4-Cl) at the phenyl group are well-tolerated, and small alkyl substit

59 ontaining para-trifluoromethyl, t-butyl, and phenyl groups are a novel class of peroxisome proliferat

60 Bonds that are trans to phenyl groups are longer (Ir-C av = 2.071 A, Ir-N av = 2

61 structure of 9a shows that the isopropyl and phenyl groups are mutually cis and that the tolyl moiety

62 roups opposite each other, whereas all three phenyl groups are opposite pyridyl or pyrazolyl groups i

63 d by water in the nanolog complexes, and the phenyl groups are organized in a manner that attempts to

64 the quinoxaline ring; quinoxaline pendants (phenyl groups) are found to favor helical arrangements i

65 ole, Asp(32) carboxylic acid, and C-terminal phenyl groups arrayed about a common backbone configurat

66 rties on the position of substituents on the phenyl groups as compared to those observed in substitut

67 e lower potency of 14 (beta-orientation of 8-phenyl group) as compared to 8a (alpha-orientation) was

68 rent linkers to a nucleobase, nucleoside, or phenyl group, as a side-chain extension at the C22 posit

69 -ene precursors incorporates either a 3-endo-phenyl group, as an acid precursor, or a 3-endo-phenyldi

70 oration of two fluorine atoms in the central phenyl group, as in 20 and 21, is extremely advantageous

71 This effect may be profound: a 3,5-bis-CF3 phenyl group at C(5) in 1,3-dioxane displays a pronounce

72 Whereas one might expect an axial phenyl group at C(5) of 1,3-dioxane to adopt a conformat

73 of 2a with a 3-thiophene or an unsubstituted phenyl group at C-6 were the most potent inhibitors.

74 nyl group and a 4-[2-(trimethylsilyl)ethynyl]phenyl group at diametrically opposed beta-positions (2,

75 enyl group or a 4-[2-(trimethylsilyl)ethynyl]phenyl group at the 12-position, and a 4-iodophenyl grou

76 The introduction of a bulky phenyl group at the 3'-position exerted a profound influ

77 When the furanones had a phenyl group at the 3-position (X(3)), alternative photo

78 Attachment of a phenyl group at the 4'-position of 6a or the equivalent

79 by changing the substituents attached to the phenyl group at the 4-position of the quinoline ring of

80 In contrast, the introduction of a phenyl group at the 5'-position of 6a did not cause any

81 quence allows for a facile introduction of a phenyl group at the ortho position of phenols and anilin

82 This demonstrates the ability of the phenyl group at the PS/PA-18 interface to rearrange itse

83 le rings or one indole ring and two aromatic phenyl groups at a fixed distance of six polyethylene gl

84 oration of heterocycles at the C-5 position, phenyl groups at C-4, and a variety of differently subst

85 methyl, isopropyl, tert-butyl, adamantyl, or phenyl groups at C5 is reported here, starting by coupli

86 n DAG-lactones with identical functionalized phenyl groups at either the sn-1 or sn-2 position are co

87 3,2-b]carbazole with differently substituted phenyl groups at nitrogen atoms is reported.

88 trical strap, attached to ortho positions of phenyl groups at opposing meso positions of the porphyri

89 pha]quinoxaline ureas containing substituted phenyl groups at the 3-position was developed.

90 The 3-(dimethylamino)phenyl groups at the alpha position prove to be importan

91 ns and para-substituted (Br, NO(2), ethynyl) phenyl groups at the C(10) and C(15) meso positions.

92 erfluorinated meso-phenylporphyrins with one phenyl group bearing a substituent in the ortho position

93 In the assembly of these molecules, the phenyl groups block the herringbone motif and further gu

94 bridge added between the position 5 and the phenyl group bound to the position 6 dramatically increa

95 wed to explain the axial predominance of the phenyl group by a larger polarization of the Si-Ph than

96 Bioisosteric replacement of the aromatic phenyl group by a thiophene moiety produced some of the

97 SAR studies of 1d showed that the 3-phenyl group can be replaced by a pyridyl group, and a s

98 has a 3,5-dialkoxy substitution on the imide phenyl groups (CBI-35CH), leading to "molecular pockets"

99 ophobic substituent differs in length by one phenyl group compared to that of oritavancin, N'-4-[(4-c

100 tuents such as tert-butyl, compound 33, or a phenyl group, compound 29, resulted in inactive FPT inhi

101 Specific phenyl group conformations are shown to be critical to t

102 Waals interactions with mAb 2E2, whereas the phenyl group contributes to the binding primarily via hy

103 hiral surfaces lined with nitrate anions and phenyl groups create multiple binding sites for guest an

104 ondary alkyl, and acyl groups exchanged, but phenyl groups did not.

105 S protecting group can serve as an efficient phenyl group donor for o-bromophenols via Pd-catalyzed C

106 phenyltin efficiently transferred up to four phenyl groups during fluoride-promoted couplings with ar

107 e varied pairwise among the electron-neutral phenyl groups, electron-rich 4-(N,N-dimethylamino)phenyl

108 lucose of Globo H with the fluoro, azido, or phenyl group elicited IgG antibody response to specifica

109 Inclusion of a 6-phenyl group enhanced A3 receptor selectivity: Compound

110 ogen bond donors in the para position of the phenyl group enhanced NR1A/2B potency.

111 The phenyl groups feature substituents with increasing elect

112 chain length between N-1 of indole and the 2-phenyl group from n = 1 through n = 3 leads to a fairly

113 tructured N-terminal region, deletion of the phenyl group from Phe3 yielded a peptide that reduced bi

114 de to promote transfer of one, two, or three phenyl groups from the organogermanes.

115 ne films when vapor deposited, DPT's pendant phenyl groups frustrate crystal growth, yielding amorpho

116 een the exo N atom of the sugar moiety and a phenyl group furthermore increased the observed apparent

117 l ligand (2) consisting of a noncoordinating phenyl group gave only low molecular weight branched oli

118 phosphorus center, along with ferrocenyl and phenyl groups, generating phosphines of the general stru

119 opyridinyl (MPTP) analogues in which the C-4 phenyl group has been replaced with various 4-azaaryl mo

120 ion of 17a is anomalous, suggesting that the phenyl group has more than a simple steric effect.

121 etween the 3beta-phenyl group and the remote phenyl group, has an IC(50) value of 5.14 nM at the DAT.

122 Other substituents on the phenyl group, HS-Ph-X, where X = -F, -CH3, -OCH3, also s

123 ation of the acidities and the effect of the phenyl group in acetonitrile, and the position of the C=

124 e findings demonstrate the importance of the phenyl group in modulating the chaperoning efficacy and

125 clopentenones containing a 4-(methylsulfonyl)phenyl group in the 3-position and a phenyl ring in the

126 contrast, analogs of alpha-GalCer containing phenyl group in the lipid tail could neither induce NKT

127 ose to the alpha-carbon and the other with a phenyl group in the same location.

128 t of the antiviral potency by inclusion of a phenyl group in the side chain of these compounds.

129 fluences the position of the syn-pseudoaxial phenyl group in the TADDOL structure.

130 rates of the free rotation available to the phenyl groups in 2,4-diphenyl-1,3(Z)-pentadiene compared

131 03 (S)) analogues, containing 7- and N(6)-NH phenyl groups in 7-deazaadenine, robustly inhibited AdK

132 -Pylm, Ph-Pylm, and t-Bu-Pylm insert their 4-phenyl groups in either the CB[7] or CB[8] cavity.

133 The migratory aptitudes of the varied phenyl groups in rearrangement-displacements of 13 with

134 enabled by introduction of para-substituted phenyl groups in the equatorial (eq) dithiolene ligand a

135 The strong trans influence of the phenyl groups in the meridional isomers leads to the obs

136 udes six compounds bearing 2,5-disubstituted phenyl groups in the side chain (with little, if any, di

137 ared to the constraint to coplanarity of the phenyl groups in the title compound.

138 spectroscopy, demonstrating the presence of phenyl groups, indicative of the grafted layer as well a

139 important contacts with RNase A, whereas the phenyl group interacts with Ang.

140 to the oxy group and sandwiched between two phenyl groups involving a unique ...c.g.phenyl interacti

141 ersion of Au144 to Au99 occurs only when the phenyl group is directly attached to the thiol, suggesti

142 ed adenosines, A-3CPh and A-4CPh, in which a phenyl group is linked to the adenosine such that it may

143 As follows from QTAIM analysis, the phenyl group is more stable when it is located in the ax

144 l-6-oxoverdazyl radicals 1[n], in which each phenyl group is substituted with three alkylsulfanyl gro

145 miempirical MNDO calculations shows that the phenyl group is twisted 89 degrees from the plane of cen

146 -carbon-to-o-phenyl linkages to the flanking phenyl groups, is described.

147 The phenyl group itself is situated near the S1' subsite; su

148 introduction of an aminomethyl group on the phenyl group led to monomer X, which was found to therma

149 adenine binding pocket; however, none of the phenyl groups lie in the same position as adenine in S1d

150 from the omega-phenyl group to the benzyl or phenyl group located on the 4-position of the piperidine

151 ivatives, when bearing a 4-alkyl but not a 4-phenyl group, maintained affinity for adenosine receptor

152 *)/H) self-exchange reactions reveal why the phenyl groups make the last of these reactions several o

153 dine-, and 2-quinoxaline-based olefins and a phenyl group nucleophile.

154 phenylcyclobutene, "outward" rotation of the phenyl group occurs exclusively.

155 substitution at the para position of the P1' phenyl group of 1 resulted in the identification of equi

156 Replacement of the 3-phenyl group of 29 with alternatives led to reduced affi

157 atom at the para position of the pendant 5'-phenyl group of 6c not only provided further improvement

158 elective Pt-catalyzed hydrogenation of the 5-phenyl group of a 4,5-diphenyloxazolidine under acidic c

159 t His102 interacts directly with the pendant phenyl group of diazepam, and further implications for t

160 a pendant phenyl moiety, analogous to the 5-phenyl group of flunitrazepam, which are proposed to ove

161 Both the hydroxyl group and phenyl group of HveA-Y23 contribute to HSV entry.

162 r nitrogen atom in the space occupied by the phenyl group of MPTP leads to a dramatic decrease in sub

163 The common halogenated phenyl group of nonpeptide ligands was a determinant of

164 tituted 1,2-dibenzamidobenzenes in which the phenyl group of one benzoyl group (A-ring) was substitut

165 e, 2-hydroxy-2,4-pentadienoate, in which the phenyl group of phenylenolpyruvate is replaced with a do

166 this study, analogues in which the terminal phenyl group of the dibemethin was replaced with a 2-pyr

167 drogen bonding distance to the 6-(p-hydroxy)-phenyl group of the excited coelenteramide is a likely c

168 ding pocket of CDK2, and the position of the phenyl group of the inhibitor enables the inhibitor to m

169 The effect of this chelation is to place the phenyl group of the inhibitor into the important S1 spec

170 ps such as methoxy, vinyl, or chloro and the phenyl group of the other benzoyl group (B-ring) was sub

171 yl (14) substituents in each position of the phenyl group of the phenylcarbamoyl moieties, and with N

172 dine analogue (1-NAP-lobelane), in which the phenyl groups of lobelane were replaced with 1-naphthyl

173 the detailed PCA analyses indicate that the phenyl groups of PS tended to move away from the surface

174 ne of the meso-phenyl groups, while the meso-phenyl groups of the third NCP (3) are substituted with

175 peptide acetals via nucleophilic attack of a phenyl group on an endocyclic acyliminium ion 4 was expl

176 Accordingly, a phenyl group on the asymmetric center in the homologated

177 ctivity, while substitution with a methyl or phenyl group on the chain was well tolerated.

178 he two peptide backbone substituents and the phenyl group on the cyclopropane rings in 7-9were specif

179 We also report the influence of the meso-phenyl group on the emission properties of the aggregate

180 dities of 1d and 1e, the large effect of the phenyl group on the gas-phase acidity of 1e, the strong

181 D)Cl]2 and P(OPh)3 by cyclometalation of the phenyl group on the ligand and have shown such species t

182 The cycloadducts with a 4-(dimethylamino)phenyl group on the maleimide nitrogen atom undergo retr

183 Pd atom placed at the opposite side to the 2-phenyl group on the nearest stereogenic center of the py

184 The introduction of a methyl of phenyl group on the nitrogen of the pyrazolyl ring of 14

185 used to explore the optimal location of the phenyl group on the side chains.

186 angement involving migration of the allyl or phenyl group on the silicon atom to the adjacent enone c

187 as the gamma-hydroxyl and the remaining two phenyl groups on the butenolide ring essentially orthogo

188 itro substituents as acceptor groups and two phenyl groups on the phenolate moiety.

189 figuration places strongly trans influencing phenyl groups opposite each other, whereas all three phe

190 through ortho-substitution on the benzyloxy phenyl group or through replacement of the ether oxygen

191 ning vicinal dimethyl groups and an adjacent phenyl group or trisubstituted alkene are exceptionally

192 hydride particles modified with immobilised phenyl groups or larger ligands followed trends predicte

193 gh stabilizing weak interactions between its phenyl group (or cyclohexyl group) and the carboxylate g

194 ents (H and CH3) were found to bind with the phenyl group oriented in the plane of the quinazoline ri

195 f the greater relative migratory aptitude of phenyl groups over alkyl groups, and provides an efficie

196 orpholino) were bound to the enzyme with the phenyl group perpendicular to the quinazoline ring and p

197 ion-based kinetic resolutions and a role the phenyl groups play in that selectivity.

198 e, but strict structural requirements at the phenyl group position of the unit A delta-hydroxy octadi

199 hanges in chain length or replacement of the phenyl group producing greatly decreased values of k(cat

200 enolic functionalities on two of the opposed phenyl groups prove to be remarkable catalysts for the r

201 (C6-C9)-acyl chains with a distal phenyl group proved to be the most potent inhibitors.

202 nal 2-pyridyl substituent and the acyl chain phenyl group provide key anchoring interactions and conf

203 eplacements or substituents for the terminal phenyl group provided effective inhibitors (e.g., 5c, ar

204 triazolyl alcohols 3h,i,k-m migration of the phenyl group rather than the corresponding heteroaromati

205 ing substituents at the para position of the phenyl group (RBpT).

206 dihydroxylated TPHP, RDP with the loss of a phenyl group (RDP-[Phe]) and RDP oligomers were detected

207 Mansyl probes, which have an extra phenyl group relative to dansyl, were found to locate de

208 Parallel theoretical calculations, with the phenyl groups replaced by methyl groups, yield informati

209 elling case for its broader application as a phenyl group replacement in scenarios where the aromatic

210 This established that the migrating phenyl group required an orientation facing the enone be

211 R2 and R5 positions of the 2,5-disubstituted phenyl group, respectively.

212 stituents at the 4-position of the central N-phenyl group resulted in compounds with improved potency

213 Replacing the 2-ethyl substituent with a phenyl group results in a compound that retains 5-HT(6)

214 Appropriate substitution of the phenyl group results in ligands with particularly high a

215 substituents on the para position of the C-2 phenyl group retained the activity of the initial analog

216 t an extension from the meta-position on the phenyl group (ring-5) would improve interactions with th

217 zene in search of evidence on the effects of phenyl group rotation and chromophore aggregation of oli

218 e analogs (BCNAs) with a p-alkyl-substituted phenyl group seem to require aromatic ring stacking inte

219 lene is stabilized more by a naphthyl than a phenyl group (singlets, 26.6 versus 24.4; and triplets,

220 methyl)phenyl or 3,5-bis(pentafluorosulfanyl)phenyl groups strongly suppresses the byproduct formatio

221 ed capsule is narrow, but still accommodates phenyl groups such as those presented by p-quaterphenyl

222 enylporphyrin (ZnTPP) with the 5 and 15 meso-phenyl groups tethered by a 1,4-phenylenebis(butyl-4-oxy

223 o the adenosine such that it may replace the phenyl group that is eliminated by the Phe56Ala mutation

224 ted state has two interchangeably equivalent phenyl groups that have different formal oxidation state

225 C, favoring the conformation having an axial phenyl group, that is in only modest agreement with the

226 Owing to the steric hindrance of the axle phenyl group, the threading of the guest was seen to occ

227 Analysis of the flipping modes of the mobile phenyl groups, their rotational rates, and transition te

228 ficulties encountered in the conversion of a phenyl group to a carboxylic acid will be discussed.

229 metal catalyzed partial hydrogenation of the phenyl group to an enol ether.

230 tion of substituents around the NH group and phenyl group to improve the selectivity and potency of P

231 Complex 1 efficiently transfers its phenyl group to PhSiH3, with formation of Ph2SiH2 and [C

232 y substituent was transferred from the omega-phenyl group to the benzyl or phenyl group located on th

233 MgCl and related reagents with transfer of a phenyl group to the nitrido ligand.

234 is linked to the para-position of one ZnTPP phenyl group to yield ZnTPP-PDI2.

235 strate computationally that by shifting from phenyl groups to "space efficient" acetylene moieties as

236 ations of the phenyl or the para-substituted-phenyl groups to C-1 with displacement of chloride ion.

237 iol ligand (1) in the asymmetric addition of phenyl groups to cyclic alpha,beta-unsaturated ketones.

238 chloride is capable of delivering all of its phenyl groups to the product.

239 thylaniline is replaced by an isopropyl or a phenyl group, trisolvated monomers are formed instead of

240 Although phenyl groups turned out to provide significantly less s

241 ed trans-stilbene is distorted, with the two phenyl groups twisted, while the geometry of the excited

242 pounds corresponding to hydroxy-FMN plus one phenyl group, two apparently isomeric compounds correspo

243 The classic 4-azido-3-iodo-phenyl group was appended to either the C-1 or C-5 posit

244 The 8-phenyl group was introduced by Grignard addition to keto

245 nsporter (VAChT), a heteroaromatic ring or a phenyl group was introduced into the carbonyl-containing

246 ortho positions of two trans-positioned meso-phenyl groups, was synthesized from (3,3'-diethyl-4,4'-d

247 Phenyl groups weaken binding when close to the amine but

248 Multiple organic acids containing phenyl groups were also greatly increased in the presenc

249 e substituent on the aldehyde from methyl to phenyl groups were investigated by comparison of the tra

250 ylsilylbractazonine through migration of the phenyl group, whereas treatment of thebaine with strong

251 the phenol side chains in the NPXY motifs to phenyl groups (which cannot be phosphorylated) has major

252 to the viscosity-dependent twisting of the 5-phenyl group, which gives access to the dark nonemissive

253 BD acceptor unit is substituted with a donor phenyl group, which increases the twisting of the TCBD u

254 ed by an oxalamide to a p-halide-substituted phenyl group, which target this site, specifically, a ca

255 or nitro (2) substituents on one of the meso-phenyl groups, while the meso-phenyl groups of the third

256 Replacement of the C-2 phenyl group with a 3,5-substituted thiophene led to imp

257 le moiety is linked by a 1,3-bis(aminomethyl)phenyl group with a 5-(2-aminoethyl)- (18) or a 5-(2-dim

258 awal and a van der Waal's interaction of the phenyl group with a hydrophobic surface at the mouth of

259 iperone and found that replacement of the N1-phenyl group with a methyl group only slightly decreased

260 a unique preference for migration of the cis-phenyl group with formation of bicyclo[3.1.0]hexanone ph

261 dramatically improved by substituting the 2-phenyl group with halogens in the meta position or by re

262 gauged as a function of substituents on the phenyl group with p-OH, p-OMe, p-H, p-CF3, p-CN, and p-N

263 lled the "meshes" of the nanoribbon, possess phenyl groups with decyloxy solubilizing chains on each

264 Phenyl groups with different substituents were used to c

265 lored as well as the effect of replacing the phenyl groups with larger aromatic rings, 1-naphthalene

266 s lead to low-spin complexes while the bulky phenyl group yields high-spin complexes.